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Article ; Online: Comment on "Female toads engaging in adaptive hybridization prefer high-quality heterospecifics as mates".

Braun, Michael J / Wilkinson, Gerald S / Cade, Brian S

2020 Volume 370, Issue 6513

Abstract: Chen and Pfennig (Reports, 20 March 2020, p. 1377) analyze the fitness consequences of hybridization in toads but do not account for differences in survival among progeny. Apparent fitness effects depend on families with anomalously low survival, yet ... ...

Abstract	Chen and Pfennig (Reports, 20 March 2020, p. 1377) analyze the fitness consequences of hybridization in toads but do not account for differences in survival among progeny. Apparent fitness effects depend on families with anomalously low survival, yet survival is crucial to evolutionary fitness. This and other analytical shortcomings demonstrate that a conclusion of adaptive mate choice is not yet justified.
MeSH term(s)	Animals ; Biological Evolution ; Female ; Hybridization, Genetic ; Nucleic Acid Hybridization ; Reproduction ; Sexual Behavior, Animal
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abd3905
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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Article ; Online: A Self-Healing System for Polydicyclopentadiene Thermosets.

Lee, Young Bum / Suslick, Benjamin A / de Jong, Derek / Wilson, Gerald O / Moore, Jeffrey S / Sottos, Nancy R / Braun, Paul V

Advanced materials (Deerfield Beach, Fla.)

2023 Volume 36, Issue 11, Page(s) e2309662

Abstract: Self-healing offers promise for addressing structural failures, increasing lifespan, and improving durability in polymeric materials. Implementing self-healing in thermoset polymers faces significant manufacturing challenges, especially due to the ... ...

Abstract	Self-healing offers promise for addressing structural failures, increasing lifespan, and improving durability in polymeric materials. Implementing self-healing in thermoset polymers faces significant manufacturing challenges, especially due to the elevated temperature requirements of thermoset processing. To introduce self-healing into structural thermosets, the self-healing system must be thermally stable and compatible with the thermoset chemistry. This article demonstrates a self-healing microcapsule-based system stable to frontal polymerization (FP), a rapid and energy-efficient manufacturing process with a self-propagating exothermic reaction (≈200 °C). A thermally latent Grubbs-type complex bearing two N-heterocyclic carbene ligands addresses limitations in conventional G2-based self-healing approaches. Under FP's elevated temperatures, the catalyst remains dormant until activated by a Cu(I) co-reagent, ensuring efficient polymerization of the dicyclopentadiene (DCPD) upon damage to the polyDCPD matrix. The two-part microcapsule system consists of one capsule containing the thermally latent Grubbs-type catalyst dissolved in the solvent, and another capsule containing a Cu(I) coagent blended with liquid DCPD monomer. Using the same chemistry for both matrix fabrication and healing results in strong interfaces as demonstrated by lap-shear tests. In an optimized system, the self-healing system restores the mechanical properties of the tough polyDCPD thermoset. Self-healing efficiencies greater than 90% via tapered double cantilever beam tests are observed.
Language	English
Publishing date	2023-12-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202309662
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Article ; Online: Progenitor cell-derived extracellular vesicles: an emerging diagnostic and therapeutic tool for renal disease.

Braun, Gerald S / Moeller, Marcus J

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2015 Volume 30, Issue 3, Page(s) 339–341

Language	English
Publishing date	2015-03
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfv027
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Phylogenetic definitions for 25 higher-level clade names of birds

George Sangster / Edward L. Braun / Ulf S. Johansson / Rebecca T. Kimball / Gerald Mayr / Alexander Suh

Avian Research, Vol 13, Iss , Pp 100027- (2022)

2022

Abstract: Knowledge of the higher-level phylogenetic relationships of birds has grown substantially during the past two decades due to the application of genomic data. However, the nomenclature of higher-level taxa has not become more stable, due to the lack of ... ...

Abstract	Knowledge of the higher-level phylogenetic relationships of birds has grown substantially during the past two decades due to the application of genomic data. However, the nomenclature of higher-level taxa has not become more stable, due to the lack of regulation of taxon names above the level of superfamily by the ICZN, and the usage of rank-based nomenclature, which is not tied to clades in a phylogeny. Lack of regulation and the instability of rank-based nomenclature impede effective communication among systematists. We review support for higher-level avian clades using a set of 10 phylogenomic data sets, and identify clades that are supported by congruency of at least four of these. We provide formal definitions of the names of these clades based on the rules of the recently published PhyloCode. The names of 25 clades are here defined using minimum-crown-clade (n = 23), minimum-clade (n = 1) and maximum-crown-clade (n = 1) definitions. Five new names are introduced here: Dinocrypturi, Pteroclimesites, Musophagotides, Phaethoquornithes and Pelecanes. We also review diagnostic apomorphies of the relevant clades, and identify known synonyms and homonyms. By establishing a formal link between higher-level taxon names and well-supported phylogenetic hypotheses, our phylogenetic definitions will provide a solid basis for the stabilization of avian higher-level nomenclature.
Keywords	Aves ; Congruence ; PhyloCode ; Phylogenetic nomenclature ; Phylogenomics ; Rankless taxonomy ; Zoology ; QL1-991
Subject code	005
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Phylogenetic definitions for 25 higher-level clade names of birds

Sangster, George / Braun, Edward L. / Johansson, Ulf S. / Kimball, Rebecca T. / Mayr, Gerald / Suh, Alexander

Avian research. 2022,

2022

Abstract	Knowledge of the higher-level phylogenetic relationships of birds has grown substantially during the past two decades due to the application of genomic data. However, the nomenclature of higher-level taxa has not become more stable, due to the lack of regulation of taxon names above the level of superfamily by the ICZN, and the usage of rank-based nomenclature, which is not tied to clades in a phylogeny. Lack of regulation and the instability of rank-based nomenclature impede effective communication among systematists. Here we review support for higher-level avian clades using a set of 10 phylogenomic data sets, and identify clades that are supported by congruency of at least four of these. We provide formal definitions of the names of these clades based on the rules of the recently published PhyloCode. The names of 25 clades are here defined using minimum-crown-clade (n = 23), minimum-clade (n = 1) and maximum-crown-clade (n = 1) definitions. Four new names are introduced here: Dinocrypturi, Pteroclimesites, Musophagotides and Pelecanes. We also review diagnostic apomorphies of the relevant clades, and identify known synonyms and homonyms. By establishing a formal link between higher-level taxon names and well-supported phylogenetic hypotheses, our phylogenetic definitions will provide a solid basis for the stabilization of avian higher-level nomenclature.
Keywords	birds ; genomics ; phylogeny ; research
Language	English
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2806572-4
ISSN	2053-7166
ISSN	2053-7166
DOI	10.1016/j.avrs.2022.100027
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online ; Thesis: Beobachtungsstudie zur Bedeutung des ionisierten Magnesiums bei chronischer Niereninsuffizienz

Basten, Magdalena Isabel [Verfasser] / Brandenburg, Vincent Matthias [Akademischer Betreuer] / Braun, Gerald S. [Akademischer Betreuer]

2018

Author's details	Magdalena Isabel Basten ; Vincent Matthias Brandenburg, Gerald S. Braun
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek der RWTH Aachen
Publishing place	Aachen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Time on previous renal replacement therapy is associated with worse outcomes of COVID-19 in a regional cohort of kidney transplant and dialysis patients.

Villa, Luigi / Krüger, Thilo / Seikrit, Claudia / Mühlfeld, Anja S / Kunter, Uta / Werner, Cornelius / Kleines, Michael / Schulze-Hagen, Maximilian / Dreher, Michael / Kersten, Alexander / Marx, Nikolaus / Floege, Jürgen / Rauen, Thomas / Braun, Gerald S

Medicine

2021 Volume 100, Issue 10, Page(s) e24893

Abstract: Abstract: Chronic renal replacement therapy by either a kidney transplant (KTX) or hemodialysis (HD) predisposes patients to an increased risk for adverse outcomes of COVID-19. However, details on this interaction remain incomplete. To provide further ... ...

Abstract	Abstract: Chronic renal replacement therapy by either a kidney transplant (KTX) or hemodialysis (HD) predisposes patients to an increased risk for adverse outcomes of COVID-19. However, details on this interaction remain incomplete. To provide further characterization, we undertook a retrospective observational cohort analysis of the majority of the hemodialysis and renal transplant population affected by the first regional outbreak of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) in Germany. In a region of 250,000 inhabitants we identified a total of 21 cases with SARS-CoV-2 among 100 KTX and 260 HD patients, that is, 7 KTX with COVID-19, 14 HD with COVID-19, and 3 HD with asymptomatic carrier status. As a first observation, KTX recipients exhibited trends for a higher mortality (43 vs 18%) and a higher proportion of acute respiratory distress syndrome (ARDS) (57 vs 27%) when compared to their HD counterparts. As a novel finding, development of ARDS was significantly associated with the time spent on previous renal replacement therapy (RRT), defined as the composite of dialysis time and time on the transplant (non-ARDS 4.3 vs ARDS 10.6 years, P = .016). Multivariate logistic regression analysis showed an OR of 1.7 per year of RRT. The association remained robust when analysis was confined to KTX patients (5.1 vs 13.2 years, P = .002) or when correlating the time spent on a renal transplant alone (P = .038). Similarly, longer RRT correlated with death vs survival (P = .0002). In conclusion our data suggest renal replacement vintage as a novel risk factor for COVID-19-associated ARDS and death. The findings should be validated by larger cohorts.
MeSH term(s)	Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/mortality ; Female ; Germany/epidemiology ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Kidney Transplantation/mortality ; Logistic Models ; Male ; Middle Aged ; Renal Dialysis/statistics & numerical data ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
Language	English
Publishing date	2021-03-16
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024893
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Article: Interaction of atypical cadherin Fat1 with SoHo adaptor proteins CAP/ponsin and ArgBP2

Braun, Gerald S / Andrzej Kuszka / CÃ©cile Dau / Wilhelm Kriz / Marcus J. Moeller

Biochemical and biophysical research communications. 2016 Mar. 25, v. 472

2016

Abstract: Mammalian Fat1 is a giant atypical cadherin/tumor suppressor involved in the regulation of cellular orientation, migration, and growth. Fat1 is implicated in the development of the brain, eye, and kidney. Altered expression or mutations of FAT1 are also ... ...

Abstract	Mammalian Fat1 is a giant atypical cadherin/tumor suppressor involved in the regulation of cellular orientation, migration, and growth. Fat1 is implicated in the development of the brain, eye, and kidney. Altered expression or mutations of FAT1 are also associated with cancer and facioscapulohumeral muscular dystrophy (FSHD). Yet, the mechanistic functions of this pathway remain incompletely understood. Here, we report the identification of Sorbin-homology (SoHo) proteins as novel interaction partners of Fat1 by virtue of a yeast-two-hybrid screen. SoHo proteins play diverse roles as adaptor proteins in cell signaling, cell adhesion and sarcomere architecture, including altered expression in cancer and FSHD. Specifically, we found SoHo proteins CAP/ponsin-1 and -2 (Sorbs1) and ArgBP2 (Sorbs2) to interact with the cytoplasmic domain of Fat1. We mapped the interaction to a prolin-rich classic type II PXXP motif within Fat1 and to the three Src-homology (SH3) domains within SoHo proteins using mutant expression in yeast, pulldown assays, and cell culture. Functionally, endogenous ponsin-2 expression of NRK-52E cells at cellular leading edges was lost upon knockdown of Fat1. In summary, our data point to an interaction of Fat1 with SoHo proteins that is able to recruit SoHo proteins to sites of Fat1 expression.
Keywords	brain ; cadherins ; cell adhesion ; cell culture ; eyes ; kidneys ; mammals ; muscular dystrophy ; mutants ; mutation ; neoplasms ; sarcomeres ; yeasts ; Cell junction ; Leading edge ; PXXP ; Yeast-two-hybrid ; Pulldown ; Knockdown
Language	English
Dates of publication	2016-0325
Size	p. 88-94.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2016.02.069
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online ; Thesis: Ionenkanäle während der Nephrogenese

Braun, Gerald S

Expressionsmuster und funktionelle Bedeutung

2003

Author's details	vorgelegt von Gerald S. Braun
Language	German
Size	Online-Ressource
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Diss--München, 2003
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Interaction of atypical cadherin Fat1 with SoHo adaptor proteins CAP/ponsin and ArgBP2.

Braun, Gerald S / Kuszka, Andrzej / Dau, Cécile / Kriz, Wilhelm / Moeller, Marcus J

Biochemical and biophysical research communications

2016 Volume 472, Issue 1, Page(s) 88–94

Abstract	Mammalian Fat1 is a giant atypical cadherin/tumor suppressor involved in the regulation of cellular orientation, migration, and growth. Fat1 is implicated in the development of the brain, eye, and kidney. Altered expression or mutations of FAT1 are also associated with cancer and facioscapulohumeral muscular dystrophy (FSHD). Yet, the mechanistic functions of this pathway remain incompletely understood. Here, we report the identification of Sorbin-homology (SoHo) proteins as novel interaction partners of Fat1 by virtue of a yeast-two-hybrid screen. SoHo proteins play diverse roles as adaptor proteins in cell signaling, cell adhesion and sarcomere architecture, including altered expression in cancer and FSHD. Specifically, we found SoHo proteins CAP/ponsin-1 and -2 (Sorbs1) and ArgBP2 (Sorbs2) to interact with the cytoplasmic domain of Fat1. We mapped the interaction to a prolin-rich classic type II PXXP motif within Fat1 and to the three Src-homology (SH3) domains within SoHo proteins using mutant expression in yeast, pulldown assays, and cell culture. Functionally, endogenous ponsin-2 expression of NRK-52E cells at cellular leading edges was lost upon knockdown of Fat1. In summary, our data point to an interaction of Fat1 with SoHo proteins that is able to recruit SoHo proteins to sites of Fat1 expression.
MeSH term(s)	Amino Acid Sequence ; Animals ; COS Cells ; Cadherins/chemistry ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line ; Cercopithecus aethiops ; Gene Knockdown Techniques ; Mice ; Microfilament Proteins/chemistry ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Mutagenesis, Site-Directed ; Protein Interaction Domains and Motifs ; Rats ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Two-Hybrid System Techniques ; src Homology Domains
Chemical Substances	Cadherins ; Fath protein, mouse ; Microfilament Proteins ; Recombinant Fusion Proteins ; Sorbs2 protein, mouse ; ponsin
Language	English
Publishing date	2016-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2016.02.069
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Zs.A 116: Show issues

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