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  1. Article ; Online: Immune Response of

    Trevijano-Contador, Nuria / Zaragoza, Oscar

    Journal of fungi (Basel, Switzerland)

    2018  Volume 5, Issue 1

    Abstract: In many aspects, the immune response against pathogens in insects is similar to the innate immunity in mammals. This has caused a strong interest in the scientific community for the use of this model in research of host⁻pathogen interactions. In recent ... ...

    Abstract In many aspects, the immune response against pathogens in insects is similar to the innate immunity in mammals. This has caused a strong interest in the scientific community for the use of this model in research of host⁻pathogen interactions. In recent years, the use of
    Language English
    Publishing date 2018-12-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof5010003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Role of IL-17 in Morphogenesis and Dissemination of

    Trevijano-Contador, Nuria / Roselletti, Elena / García-Rodas, Rocío / Vecchiarelli, Anna / Zaragoza, Óscar

    Microorganisms

    2022  Volume 10, Issue 2

    Abstract: Cryptococcus ... ...

    Abstract Cryptococcus neoformans
    Language English
    Publishing date 2022-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10020373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Role of IL-17 in Morphogenesis and Dissemination of Cryptococcus neoformans during Murine Infection

    Trevijano-Contador, Nuria / Roselletti, Elena / García-Rodas, Rocío / Vecchiarelli, Anna / Zaragoza, Óscar

    Microorganisms. 2022 Feb. 05, v. 10, no. 2

    2022  

    Abstract: Cryptococcus neoformans is a pathogenic yeast that can form Titan cells in the lungs, which are fungal cells of abnormally large size. The factors that regulate Titan cell formation in vivo are still unknown, although an increased proportion of these ... ...

    Abstract Cryptococcus neoformans is a pathogenic yeast that can form Titan cells in the lungs, which are fungal cells of abnormally large size. The factors that regulate Titan cell formation in vivo are still unknown, although an increased proportion of these fungal cells of infected mice correlates with induction of Th2-type responses. Here, we focused on the role played by the cytokine IL-17 in the formation of cryptococcal Titan cells using Il17a⁻/⁻ knockout mice. We found that after 9 days of infection, there was a lower proportion of Titan cells in Il17a⁻/⁻ mice compared to the fungal cells found in wild-type animals. Dissemination to the brain occurred earlier in Il17a⁻/⁻ mice, which correlated with the lower proportion of Titan cells in the lungs. Furthermore, knockout-infected mice increased brain size more than WT mice. We also determined the profile of cytokines accumulated in the brain, and we found significant differences between both mouse strains. We found that in Il17a⁻/⁻, there was a modest increase in the concentrations of the Th1 cytokine TNF-α. To validate if the increase in this cytokine had any role in cryptococcal morphogenesis, we injected wild-type mice with TNF-α t and observed that fungal cell size was significantly reduced in mice treated with this cytokine. Our results suggest a compensatory production of cytokines in Il17a⁻/⁻ mice that influences both cryptococcal morphology and dissemination.
    Keywords Cryptococcus neoformans ; brain ; interleukin-17 ; mice ; morphogenesis ; yeasts
    Language English
    Dates of publication 2022-0205
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10020373
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Characterization of a selective, iron-chelating antifungal compound that disrupts fungal metabolism and synergizes with fluconazole.

    Corrales, Jeanne / Ramos-Alonso, Lucia / González-Sabín, Javier / Ríos-Lombardía, Nicolás / Trevijano-Contador, Nuria / Engen Berg, Henriette / Sved Skottvoll, Frøydis / Moris, Francisco / Zaragoza, Oscar / Chymkowitch, Pierre / Garcia, Ignacio / Enserink, Jorrit M

    Microbiology spectrum

    2024  Volume 12, Issue 2, Page(s) e0259423

    Abstract: Fungal infections are a growing global health concern due to the limited number of available antifungal therapies as well as the emergence of fungi that are resistant to first-line antimicrobials, particularly azoles and echinocandins. Development of ... ...

    Abstract Fungal infections are a growing global health concern due to the limited number of available antifungal therapies as well as the emergence of fungi that are resistant to first-line antimicrobials, particularly azoles and echinocandins. Development of novel, selective antifungal therapies is challenging due to similarities between fungal and mammalian cells. An attractive source of potential antifungal treatments is provided by ecological niches co-inhabited by bacteria, fungi, and multicellular organisms, where complex relationships between multiple organisms have resulted in evolution of a wide variety of selective antimicrobials. Here, we characterized several analogs of one such natural compound, collismycin A. We show that NR-6226C has antifungal activity against several pathogenic
    MeSH term(s) Animals ; Humans ; Antifungal Agents/pharmacology ; Fluconazole/pharmacology ; Iron ; Candida ; Mycoses/microbiology ; Candida albicans ; Anti-Infective Agents/pharmacology ; Azoles/pharmacology ; Candida glabrata ; Iron Chelating Agents/pharmacology ; Drug Resistance, Fungal ; Microbial Sensitivity Tests ; Mammals
    Chemical Substances Antifungal Agents ; Fluconazole (8VZV102JFY) ; Iron (E1UOL152H7) ; Anti-Infective Agents ; Azoles ; Iron Chelating Agents
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02594-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cell Wall Integrity Pathway Involved in Morphogenesis, Virulence and Antifungal Susceptibility in

    de Oliveira, Haroldo Cesar / Rossi, Suelen Andreia / García-Barbazán, Irene / Zaragoza, Óscar / Trevijano-Contador, Nuria

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 10

    Abstract: Due to its location, the fungal cell wall is the compartment that allows the interaction with the environment and/or the host, playing an important role during infection as well as in different biological functions such as cell morphology, cell ... ...

    Abstract Due to its location, the fungal cell wall is the compartment that allows the interaction with the environment and/or the host, playing an important role during infection as well as in different biological functions such as cell morphology, cell permeability and protection against stress. All these processes involve the activation of signaling pathways within the cell. The cell wall integrity (CWI) pathway is the main route responsible for maintaining the functionality and proper structure of the cell wall. This pathway is highly conserved in the fungal kingdom and has been extensively characterized in
    Language English
    Publishing date 2021-10-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7100831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immune Response of Galleria mellonella against Human Fungal Pathogens

    Nuria Trevijano-Contador / Oscar Zaragoza

    Journal of Fungi, Vol 5, Iss 1, p

    2018  Volume 3

    Abstract: In many aspects, the immune response against pathogens in insects is similar to the innate immunity in mammals. This has caused a strong interest in the scientific community for the use of this model in research of host–pathogen interactions. In recent ... ...

    Abstract In many aspects, the immune response against pathogens in insects is similar to the innate immunity in mammals. This has caused a strong interest in the scientific community for the use of this model in research of host–pathogen interactions. In recent years, the use of Galleria mellonella larvae, an insect belonging to the Lepidoptera order, has emerged as an excellent model to study the virulence of human pathogens. It is a model that offers many advantages; for example, it is easy to handle and establish in every laboratory, the larvae have a low cost, and they tolerate a wide range of temperatures, including human temperature 37 °C. The immune response of G. mellonella is innate and is divided into a cellular component (hemocytes) and humoral component (antimicrobial peptides, lytic enzymes, and peptides and melanin) that work together against different intruders. It has been shown that the immune response of this insect has a great specificity and has the ability to distinguish between different classes of microorganisms. In this review, we delve into the different components of the innate immune response of Galleria mellonella, and how these components manifest in the infection of fungal pathogens including Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Histoplasma capsulatum.
    Keywords Galleria mellonella ; fungal pathogens ; innate immunity ; cellular response ; humoral response ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Role of IL-17 in Morphogenesis and Dissemination of Cryptococcus neoformans during Murine Infection

    Nuria Trevijano-Contador / Elena Roselletti / Rocío García-Rodas / Anna Vecchiarelli / Óscar Zaragoza

    Microorganisms, Vol 10, Iss 373, p

    2022  Volume 373

    Abstract: Cryptococcus neoformans is a pathogenic yeast that can form Titan cells in the lungs, which are fungal cells of abnormally large size. The factors that regulate Titan cell formation in vivo are still unknown, although an increased proportion of these ... ...

    Abstract Cryptococcus neoformans is a pathogenic yeast that can form Titan cells in the lungs, which are fungal cells of abnormally large size. The factors that regulate Titan cell formation in vivo are still unknown, although an increased proportion of these fungal cells of infected mice correlates with induction of Th2-type responses. Here, we focused on the role played by the cytokine IL-17 in the formation of cryptococcal Titan cells using Il17a −/− knockout mice. We found that after 9 days of infection, there was a lower proportion of Titan cells in Il17a −/− mice compared to the fungal cells found in wild-type animals. Dissemination to the brain occurred earlier in Il17a −/− mice, which correlated with the lower proportion of Titan cells in the lungs. Furthermore, knockout-infected mice increased brain size more than WT mice. We also determined the profile of cytokines accumulated in the brain, and we found significant differences between both mouse strains. We found that in Il17a −/− , there was a modest increase in the concentrations of the Th1 cytokine TNF-α. To validate if the increase in this cytokine had any role in cryptococcal morphogenesis, we injected wild-type mice with TNF-α t and observed that fungal cell size was significantly reduced in mice treated with this cytokine. Our results suggest a compensatory production of cytokines in Il17a −/− mice that influences both cryptococcal morphology and dissemination.
    Keywords Cryptococcus neoformans ; C57BL76J ; Il17a −/− ; IL17 ; Titan cells ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  8. Article ; Online: Expanding the use of alternative models to investigate novel aspects of immunity to microbial pathogens.

    Trevijano-Contador, Nuria / Zaragoza, Oscar

    Virulence

    2014  Volume 5, Issue 4, Page(s) 454–456

    MeSH term(s) Animals ; Bacterial Translocation ; Female ; Larva/growth & development ; Male ; Moths/immunology ; Moths/microbiology ; Pseudomonas/physiology ; Serratia/physiology
    Keywords covid19
    Language English
    Publishing date 2014-04-09
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.4161/viru.28775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Fungal Cell Wall:

    Garcia-Rubio, Rocio / de Oliveira, Haroldo C / Rivera, Johanna / Trevijano-Contador, Nuria

    Frontiers in microbiology

    2020  Volume 10, Page(s) 2993

    Abstract: The fungal cell wall is located outside the plasma membrane and is the cell compartment that mediates all the relationships of the cell with the environment. It protects the contents of the cell, gives rigidity and defines the cellular structure. The ... ...

    Abstract The fungal cell wall is located outside the plasma membrane and is the cell compartment that mediates all the relationships of the cell with the environment. It protects the contents of the cell, gives rigidity and defines the cellular structure. The cell wall is a skeleton with high plasticity that protects the cell from different stresses, among which osmotic changes stand out. The cell wall allows interaction with the external environment since some of its proteins are adhesins and receptors. Since, some components have a high immunogenic capacity, certain wall components can drive the host's immune response to promote fungus growth and dissemination. The cell wall is a characteristic structure of fungi and is composed mainly of glucans, chitin and glycoproteins. As the components of the fungal cell wall are not present in humans, this structure is an excellent target for antifungal therapy. In this article, we review recent data on the composition and synthesis, influence of the components of the cell wall in fungi-host interaction and the role as a target for the next generation of antifungal drugs in yeasts (
    Language English
    Publishing date 2020-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2019.02993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fungal morphogenetic changes inside the mammalian host.

    Trevijano-Contador, Nuria / Rueda, Cristina / Zaragoza, Oscar

    Seminars in cell & developmental biology

    2016  Volume 57, Page(s) 100–109

    Abstract: One of the main features of the majority of pathogenic fungi is the ability to switch between different types of morphological forms. These changes include the transition between cells of different shapes (such as the formation of pseudohyphae and hyphae) ...

    Abstract One of the main features of the majority of pathogenic fungi is the ability to switch between different types of morphological forms. These changes include the transition between cells of different shapes (such as the formation of pseudohyphae and hyphae), or the massive growth of the blastoconidia and formation of titan cells. Morphological changes occur during infection, and there is extensive evidence that they play a key role in processes required for disease, such as adhesion, invasion and dissemination, immune recognition evasion, and phagocytosis avoidance. In the present review, we will provide an overview of how morphological transitions contribute to the development of fungal disease, with special emphasis in two cases: Candida albicans as an example of yeast that switches between blastoconidia and filaments, and Cryptococcus neoformans as an example of a fungus that changes the size without modifying the shape of the cell.
    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2016.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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