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  1. Article ; Online: New Technologies Based on Stem Cell-Therapies in Regenerative Medicine and Reproductive Biology.

    Kurpisz, Maciej

    Cells

    2022  Volume 12, Issue 1

    Abstract: Stem cells seem to hold major promise for contemporary medicine, one which could almost be more significant than a discovery of DNA and ultimate its relevance for organismal integration in the past century [ ... ]. ...

    Abstract Stem cells seem to hold major promise for contemporary medicine, one which could almost be more significant than a discovery of DNA and ultimate its relevance for organismal integration in the past century [...].
    MeSH term(s) Regenerative Medicine ; Stem Cell Transplantation ; Biology
    Language English
    Publishing date 2022-12-26
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12010095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Epigenetic markers in the embryonal germ cell development and spermatogenesis.

    Odroniec, Amadeusz / Olszewska, Marta / Kurpisz, Maciej

    Basic and clinical andrology

    2023  Volume 33, Issue 1, Page(s) 6

    Abstract: Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis. During spermatogenesis, key spermatogenic events such as stem cell self-renewal and commitment to meiosis, ...

    Abstract Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis. During spermatogenesis, key spermatogenic events such as stem cell self-renewal and commitment to meiosis, meiotic recombination, meiotic sex chromosome inactivation, followed by cellular and chromatin remodeling of elongating spermatids occur, leading to sperm cell production. All the mentioned events are at least partially controlled by the epigenetic modifications of DNA and histones. Additionally, during embryonal development in primordial germ cells, global epigenetic reprogramming of DNA occurs. In this review, we summarized the most important epigenetic modifications in the particular stages of germ cell development, in DNA and histone proteins, starting from primordial germ cells, during embryonal development, and ending with histone-to-protamine transition during spermiogenesis.
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2732675-5
    ISSN 2051-4190
    ISSN 2051-4190
    DOI 10.1186/s12610-022-00179-3
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  3. Book ; Conference proceedings: Proceedings of Symposium for Reproductive Immunology

    Kurpisz, Maciej

    Kazimierz Dolny n. Wisła, Poland, May 11, 1995

    (Central European journal of immunology ; 21,2)

    1996  

    Institution Symposium for Reproductive Immunology
    Author's details guest ed.: Maciej Kurpisz
    Series title Central European journal of immunology ; 21,2
    Collection
    Keywords Reproduction / immunology / congresses ; Pregnancy / immunology / congresses ; Endometriosis / immunology / congresses
    Language English
    Size S. [79] - 207 : Ill., graph. Darst.
    Publishing place Warsaw
    Publishing country Poland
    Document type Book ; Conference proceedings
    HBZ-ID HT007750677
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 1940 -21- verfügbar in Königswinter Königswinter

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  4. Article: Proteomic approach towards identification of seminal fluid biomarkers from individuals with severe oligozoospermia, cryptozoospermia and non-obstructive azoospermia: a pilot study.

    Nowicka-Bauer, Karolina / Kamieniczna, Marzena / Olszewska, Marta / Kurpisz, Maciej Krzysztof

    Translational andrology and urology

    2023  Volume 12, Issue 10, Page(s) 1497–1510

    Abstract: Background: Infertility becomes a global problem that affects to the same extent females and males. As reasons of male infertility can differ among individuals, the accurate diagnostics is essential for effective treatment. The most problematic both in ... ...

    Abstract Background: Infertility becomes a global problem that affects to the same extent females and males. As reasons of male infertility can differ among individuals, the accurate diagnostics is essential for effective treatment. The most problematic both in diagnostics and in treatment are disturbances of spermatogenesis. Seminal fluid is rich in proteins that potentially can serve as markers for male infertility and among them, markers of spermatogenesis which are highly desired.
    Methods: To find biomarkers of spermatogenesis, we applied comparative proteomics using nano ultra performance liquid chromatography and tandem mass spectrometry (nanoUPLC-MS/MS) followed by single-sample Western blotting (WB) using seminal fluid samples from males with different types of infertility including non-obstructive azoospermia (NOA), cryptozoospermia (C) and severe oligozoospermia (SO). Then, the extensive survey on the identified proteins and their function in male reproductive system has been done.
    Results: The proteomic approach has enabled to identified five seminal fluid proteins being potential markers of spermatogenesis disorders: ADGRG2, RAB3B, LTF, SLC2A3 and spermine synthase (SMS). Among them ADGRG2 seems to be strongly involved in male infertility. In addition, WB indicated that the distribution of LTF, SLC2A3 and SMS was not coherent among the individuals, especially in a group with NOA. Functional annotation analysis and search in proteomics databases revealed that vast majority of the proteins originated from extracellular environment.
    Conclusions: The presented data point out several proteins that potentially can become biomarkers of male infertility. The data suggest, however, different mechanisms behind the male infertility indicating that the etiology is more complex. We assume that recognition of these mechanisms may lead to the creation of specific protein panel helpful in the management of male infertility and therefore, further studies are required.
    Language English
    Publishing date 2023-10-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau-23-130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of miR-195 inhibition on human skeletal muscle-derived stem/progenitor cells.

    Nowaczyk, Magdalena / Malcher, Agnieszka / Zimna, Agnieszka / Rozwadowska, Natalia / Kurpisz, Maciej

    Kardiologia polska

    2022  Volume 80, Issue 7-8, Page(s) 813–824

    Abstract: Background: The application of a circulating miR-195 inhibitor could be a helping factor in the in vitro model of human skeletal muscle-derived stem/progenitor cells (SkMDS/PCs). Previously, microRNA-195 (miR-195) expression has been reported to be a ... ...

    Abstract Background: The application of a circulating miR-195 inhibitor could be a helping factor in the in vitro model of human skeletal muscle-derived stem/progenitor cells (SkMDS/PCs). Previously, microRNA-195 (miR-195) expression has been reported to be a negative factor for myogenesis.
    Aims: The study aimed to obtain anti-apoptotic and anti-aging effects in in vitro cultured myoblasts and to improve their ability to form myotubes by suppressing miR-195 expression.
    Methods: Human wild-type (WT) SkMDS/PC cells incubated with control (nonspecific) miRNA inhibitor and miR-195-inhibited SkMDS/PCs were studied. Functional assays (myotube formation and cell aging), antioxidant, and myogenic gene expression analyses were performed at two time points, at the seventh and eleventh cell passages.
    Results: Myotube formation was found to be almost 2-fold higher in the miR-195-inhibited SkMDS/PCs population (P < 0.05) compared to WT cells. miR-195 inhibition did not appear to affect cell aging or rejuvenate human SkMDS/PCs. Antioxidant (SOD3 and FOXO) gene expression was augmented in the miR-195-inhibited SkMDS/PCs population, but no positive effect on the remaining antioxidant genes (SOD1, SOD2, and catalase) was observed. A significant increase in MyoD gene expression with a concomitant decrease in MyoG (P < 0.05) was further documented in miR-195- -inhibited SkMDS/PCs compared to WT cells (the eleventh cell passage).
    Conclusions: The performed studies may lead to the preconditioning of myogenic stem cells to extend their potential for pro-regenerative activity. The miR-195 inhibitor may serve as a conditioning factor augmenting selective antioxidant gene expression and proliferative potential of SkMDS/PCs, but it does not have an impact on cell aging and/ or apoptosis.
    MeSH term(s) Antioxidants ; Cell Differentiation/genetics ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal ; Myoblasts/metabolism ; Stem Cells/metabolism
    Chemical Substances Antioxidants ; MIRN195 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2022-05-13
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2022.0127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 598: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 474: Show issues

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  6. Book: Immunology of human reproduction

    Kurpisz, Maciej / Fernandez, Nelson

    1995  

    Author's details Maciej Kurpisz ; Nelson Fernandez
    Keywords Reproduction / immunology ; Zeugung ; Immunologie ; Fortpflanzung
    Subject Klinische Immunologie ; Reproduktion
    Language English
    Size XXII, 509 S. : Ill., graph. Darst.
    Publisher Bios Scientific Publ
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007235870
    ISBN 1-872748-59-7 ; 978-1-872748-59-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 3760 order for loan Magazin

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  7. Article: Is the sperm DNA status the best predictor of both natural and assisted conception?

    Fraczek, Monika / Kurpisz, Maciej

    Translational andrology and urology

    2017  Volume 6, Issue Suppl 4, Page(s) S594–S596

    Language English
    Publishing date 2017-03-21
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau.2017.06.03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Effect of acute isooxic hypercapnia on oxidative activity of systemic neutrophils in endotoxemic rabbits.

    Billert, Hanna / Bednarek, Ewa / Kusza, Krzysztof / Ponichter, Mirosław / Kurpisz, Maciej

    Central-European journal of immunology

    2021  Volume 46, Issue 1, Page(s) 47–53

    Abstract: Introduction: Whether carbon dioxide (CO: Material and methods: Twenty-four endotoxemic rabbits were mechanically ventilated with standard or CO: Results: Following 180 min of hypercapnic ventilation, opsonized zymosan (OZ)-stimulated neutrophils ... ...

    Abstract Introduction: Whether carbon dioxide (CO
    Material and methods: Twenty-four endotoxemic rabbits were mechanically ventilated with standard or CO
    Results: Following 180 min of hypercapnic ventilation, opsonized zymosan (OZ)-stimulated neutrophils showed lower CL vs. the control group (p = 0.004). Other parameters studied were not affected.
    Conclusions: Short-term isooxic hypercapnia in endotoxemic rabbits preserves circulating neutrophil count pattern and reactive oxygen species (ROS) generation, but it may reduce phagocytosis.
    Language English
    Publishing date 2021-04-18
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1336421-2
    ISSN 1644-4124 ; 1426-3912
    ISSN (online) 1644-4124
    ISSN 1426-3912
    DOI 10.5114/ceji.2021.105245
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1940: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Article ; Online: How much, if anything, do we know about sperm chromosomes of Robertsonian translocation carriers?

    Wiland, Ewa / Olszewska, Marta / Woźniak, Tomasz / Kurpisz, Maciej

    Cellular and molecular life sciences : CMLS

    2020  Volume 77, Issue 23, Page(s) 4765–4785

    Abstract: In men with oligozoospermia, Robertsonian translocations (RobTs) are the most common type of autosomal aberrations. The most commonly occurring types are rob(13;14) and rob(14;21), and other types of RobTs are described as 'rare' cases. Based on ... ...

    Abstract In men with oligozoospermia, Robertsonian translocations (RobTs) are the most common type of autosomal aberrations. The most commonly occurring types are rob(13;14) and rob(14;21), and other types of RobTs are described as 'rare' cases. Based on molecular research, all RobTs can be broadly classified into Class 1 and Class 2. Class 1 translocations produce the same breakpoints within their RobT type, but Class 2 translocations are predicted to form during meiosis or mitosis through a variety of mechanisms, resulting in variation in the breakpoint locations. This review seeks to analyse the available data addressing the question of whether the molecular classification of RobTs into Classes 1 and 2 and/or the type of DD/GG/DG symmetry of the involved chromosomes is reflected in the efficiency of spermatogenesis. The lowest frequency value calculated for the rate of alternate segregants was found for rob(13;15) carriers (Class 2, symmetry DD) and the highest for rob(13;21) carriers (Class 2, DG symmetry). The aneuploidy values for the rare RobT (Class 2) and common rob(14;21) (Class 1) groups together exhibited similarities while differing from those for the common rob(13;14) (Class 1) group. Considering the division of RobT carriers into those with normozoospermia and those with oligoasthenozoospermia, it was found that the number of carriers with elevated levels of aneuploidy was unexpectedly quite similar and high (approx. 70%) in the two subgroups. The reason(s) that the same RobT does not always show a similar destructive effect on fertility was also pointed out.
    MeSH term(s) Chromosome Segregation/genetics ; Chromosomes/genetics ; Heterozygote ; Humans ; Male ; Meiosis/genetics ; Spermatozoa/metabolism ; Translocation, Genetic
    Language English
    Publishing date 2020-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-020-03560-5
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Murine glial progenitor cells transplantation and synthetic PreImplantation Factor (sPIF) reduces inflammation and early motor impairment in ALS mice.

    Ambrożkiewicz, Karolina A / Kozłowska, Urszula / Haesler, Valerie / Barnea, Eytan R / Mueller, Martin / Kurpisz, Maciej

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 4016

    Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuronal disorder characterized by neuronal degeneration and currently no effective cure is available to stop or delay the disease from progression. Transplantation of murine glial-restricted ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a progressive motor neuronal disorder characterized by neuronal degeneration and currently no effective cure is available to stop or delay the disease from progression. Transplantation of murine glial-restricted precursors (mGRPs) is an attractive strategy to modulate ALS development and advancements such as the use of immune modulators could potentially extend graft survival and function. Using a well-established ALS transgenic mouse model (SOD1
    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; Animals ; Disease Models, Animal ; Inflammation ; Mice ; Mice, Transgenic ; Motor Disorders/drug therapy ; Motor Disorders/therapy ; Neuroglia/cytology ; Neuroglia/transplantation ; Peptides/pharmacology ; Stem Cell Transplantation ; Stem Cells/cytology
    Chemical Substances Peptides ; preimplantation factor, synthetic (3K6A6FJ98O)
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-08064-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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