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Article ; Online: Contraceptive efficacy of intrauterine devices.

Thonneau, Patrick F / Almont, Thierry / Almont, Thierry E

American journal of obstetrics and gynecology

2008 Volume 198, Issue 3, Page(s) 248–253

Abstract: To compare the contraceptive efficacy of various types of intrauterine devices (IUD; copper devices, Nova-T, intrauterine contraceptive systems, levonorgestrel-releasing devices), we reviewed all relevant publications on this subject that have been ... ...

Abstract	To compare the contraceptive efficacy of various types of intrauterine devices (IUD; copper devices, Nova-T, intrauterine contraceptive systems, levonorgestrel-releasing devices), we reviewed all relevant publications on this subject that have been published over the last 2 decades. The first point to be highlighted by this review is the excellent effectiveness of IUDs, with a global cumulative pregnancy rate <2% at 5 years, whatever the type of device used. We observed a large variation in efficacy rate according to the type of IUD and also according to study design. Nevertheless, of all the types of IUDs, the levonorgestrel-releasing IUD and to a lesser extent the TCu380A IUD seem to be the most effective, with a cumulative pregnancy rate at 5 years of <0.5% for the levonorgestrel-releasing IUD and between 0.3% and 0.6% for the TCu380A IUD.
MeSH term(s)	Equipment Design ; Female ; Humans ; Intrauterine Devices ; Treatment Outcome
Language	English
Publishing date	2008-03
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2007.10.787
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Article: Testicular cancer variations in time and space in Europe.

Huyghe, Eric / Plante, Pierre / Thonneau, Patrick F

European urology

2007 Volume 51, Issue 3, Page(s) 621–628

Abstract: Objectives: Testicular cancer (TC) is the most common malignancy in young men. A review of all published articles on TC incidence revealed an increased incidence in Northern and Central Europe. We extended the analysis to the whole of Europe by using ... ...

Abstract	Objectives: Testicular cancer (TC) is the most common malignancy in young men. A review of all published articles on TC incidence revealed an increased incidence in Northern and Central Europe. We extended the analysis to the whole of Europe by using all data available, notably from registries. Methods: We performed a PubMed search and selected articles dealing with TC incidence. We obtained additional information from data of European registries through the eight volumes of the Cancer Incidence in Five Continents, IARC Scientific Publications. Results: Since the Second World War, TC incidence has been increasing in nearly all European countries. It has doubled in several countries, including France, since 1970. We observed that the increase followed a gradient: the highest rate is centred in Denmark and Germany, and decreases progressively in a centrifugal manner. Conclusions: TC incidence is increasing throughout Europe, but wide discrepancies exist between the different countries. The reasons for such a phenomenon are still unclear although environmental factors are strongly suspected, which could have an impact on male fertility. From a public health perspective, further research using cases collected through national and regional population-based registers and case-control studies must be strongly encouraged.
MeSH term(s)	Europe ; Humans ; Incidence ; Male ; Registries ; Testicular Neoplasms/epidemiology ; Time Factors
Language	English
Publishing date	2007-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	193790-x
ISSN	1421-993X ; 0302-2838
ISSN (online)	1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2006.08.024
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Article: Cryptorchidism: incidence, risk factors, and potential role of environment; an update.

Thonneau, Patrick F / Gandia, Peggy / Mieusset, Roger / Candia, Peggy

Journal of andrology

2003 Volume 24, Issue 2, Page(s) 155–162

MeSH term(s)	Animals ; Cryptorchidism/epidemiology ; Cryptorchidism/etiology ; Environmental Pollution/adverse effects ; Humans ; Incidence ; Male ; Risk Factors
Language	English
Publishing date	2003-02-17
Publishing country	United States
Document type	Comment ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604624-1
ISSN	1939-4640 ; 0196-3635
ISSN (online)	1939-4640
ISSN	0196-3635
DOI	10.1002/j.1939-4640.2003.tb02654.x
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Article ; Online: Cumulative parenthood rates in 1735 couples: impact of male factor infertility.

Walschaerts, Marie / Bujan, Louis / Isus, François / Parinaud, Jean / Mieusset, Roger / Thonneau, Patrick

Human reproduction (Oxford, England)

2012 Volume 27, Issue 4, Page(s) 1184–1190

Abstract: Background: Most studies assessing the outcome of assisted reproductive technologies (ARTs) have reported live birth rates in couples by taking mainly the female factor into account. However, infertility is a couple's concern, and the majority of ... ...

Abstract	Background: Most studies assessing the outcome of assisted reproductive technologies (ARTs) have reported live birth rates in couples by taking mainly the female factor into account. However, infertility is a couple's concern, and the majority of publications do not take into consideration the true impact of male infertility on having the desired number of children. Methods: We carried out a follow-up study to evaluate the probability of having a child during treatments at the Toulouse Male Sterility Centre and after discontinuation from 2000 through 2008. Couples were followed for at least 4 years until discontinuation of treatment or delivery of a live infant. Results: We were able to contact 65% of the 1735 male partners by telephone. Of the 1131 respondents, 56% had become parents (60% if adoption is included), 28% after ART, 16% by natural pregnancy, 8% after non-ART treatment and 4% after ART in another centre. The cumulative rates of success reached 64% [95% confidence interval (CI), 60-67] for men ≤35 years and women ≤35 years after 9 years, and 31% (95% CI, 24-39) in older patients. With optimistic analysis, which assumes that patients for whom no information was available have the same chance of success in having a child as those whose reproductive outcome was known, the cumulative rate of success was 48% (95% CI, 45-50) in the 1735 couples. Conclusions: More than half of couples consulting for male infertility succeeded in having a child. Male age over 35 years old appears as a key risk factor as well as the woman's age, and these findings should encourage couples to attempt parenthood earlier.
MeSH term(s)	Age Factors ; Family Characteristics ; Female ; Follow-Up Studies ; Humans ; Infertility, Male/therapy ; Male ; Parents ; Pregnancy ; Pregnancy Rate ; Reproductive Techniques, Assisted ; Treatment Outcome
Language	English
Publishing date	2012-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632776-x
ISSN	1460-2350 ; 0268-1161 ; 1477-741X
ISSN (online)	1460-2350
ISSN	0268-1161 ; 1477-741X
DOI	10.1093/humrep/der466
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Article: Ectopic pregnancy in Africa: a population-based study.

Leke, Robert J / Goyaux, Nathalie / Matsuda, Tomohiro / Thonneau, Patrick F

Obstetrics and gynecology

2004 Volume 103, Issue 4, Page(s) 692–697

Abstract: Objective: To estimate the incidence of ectopic pregnancy in Yaounde, the capital of Cameroon (Central Africa).: Methods: In 2000, all women admitted for an ectopic pregnancy to health facilities in the city of Yaounde were systematically enrolled. ... ...

Abstract	Objective: To estimate the incidence of ectopic pregnancy in Yaounde, the capital of Cameroon (Central Africa). Methods: In 2000, all women admitted for an ectopic pregnancy to health facilities in the city of Yaounde were systematically enrolled. Sociodemographic information on the women and their reproductive history was collected by questionnaire during a face-to-face interview. Medical and obstetrical data (clinical findings at hospital entry, medical history, type of surgery, and final vital status) were collected from gynecologic and surgical files and admission registers. Results: We recorded 320 cases of ectopic pregnancy in health facilities in the city of Yaounde and we estimated that 40100 live births occurred during the same study period (January to December 2000). The population-based incidence rate of ectopic pregnancy in the city of Yaounde was 0.79% (95% confidence interval 0.72%, 0.88%) in 2000. Three maternal deaths were recorded giving a mortality rate of 0.94% (95% confidence interval 0.32%, 2.72%). Conclusion: The 0.79% ectopic pregnancy incidence rate observed in this African country must be considered a minimum due to probable underestimation. Nevertheless, this rate is lower than that currently observed in industrialized countries. Late diagnosis, low percentage of conservative treatment, and subsequent maternal deaths are important findings that should encourage African gynecologists to promote ectopic pregnancy prevention programs and to improve the care given to women with ectopic pregnancy. Level of evidence: III
MeSH term(s)	Adolescent ; Adult ; Cameroon/epidemiology ; Female ; Health Surveys ; Hospitalization/statistics & numerical data ; Humans ; Incidence ; Patient Acceptance of Health Care/statistics & numerical data ; Pregnancy ; Pregnancy, Ectopic/diagnosis ; Pregnancy, Ectopic/epidemiology ; Pregnancy, Ectopic/therapy ; Prospective Studies ; Reproductive History ; Socioeconomic Factors
Language	English
Publishing date	2004-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/01.AOG.0000120146.48098.f2
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Article ; Online: Reduced maternal mortality in Tunisia and voluntary commitment to gender-related concerns.

Farhat, Essia Ben / Chaouch, Mohamed / Chelli, Hela / Gara, Mohamed F / Boukraa, Noureddine / Garbouj, Mounira / Hamrouni, Mongi / Fourati, Akthem / Calvez, Thierry / Thonneau, Patrick

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2012 Volume 116, Issue 2, Page(s) 165–168

Abstract: Objective: To estimate the number and causes of maternal deaths in Tunisia from 1999 to 2007, and compare the results with the last report (1993-1994).: Methods: Data on all deaths of women of reproductive age in the public (1999-2007) and private ( ... ...

Abstract	Objective: To estimate the number and causes of maternal deaths in Tunisia from 1999 to 2007, and compare the results with the last report (1993-1994). Methods: Data on all deaths of women of reproductive age in the public (1999-2007) and private (2006 only) health sectors were collected and assessed for whether the death was due to pregnancy. Number of live births was provided by the National Institute of Statistics. Results: Mean maternal mortality ratio (MMR) in Tunisia decreased from 68.9 per 100000 live births in 1993-1994 to 36.3 (95% confidence interval, 27.9-46.5) in 2005-2007 (P<0.001). Causes of maternal death did not change significantly during the study period (1999-2007): hemorrhage and hypertensive disorders were the main causes. The gap between urbanized and more rural regions observed in 1993-1994 had narrowed, although MMR remained higher in central and western regions than on the east coast. Conclusion: The improvement in MMR can be credited to the voluntary political commitment focused on gender-related concerns that has been made in Tunisia, including access to family planning; legalization of abortion; and creation of the National Board for Family and Population, and the Tunisian Safe Motherhood initiative in 1999.
MeSH term(s)	Abortion, Legal ; Adolescent ; Adult ; Family Planning Services/trends ; Female ; Health Services Accessibility/trends ; Humans ; Maternal Health Services/standards ; Maternal Health Services/trends ; Maternal Mortality/trends ; Middle Aged ; Pregnancy ; Rural Population/statistics & numerical data ; Tunisia/epidemiology ; Urban Population/statistics & numerical data ; Young Adult
Language	English
Publishing date	2012-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1016/j.ijgo.2011.10.010
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Article ; Online: Polyorchidism: presentation of 2 cases, review of the literature and a new management strategy.

Khedis, Mehdi / Nohra, Joe / Dierickx, Laurence / Walschaerts, Marie / Soulié, Michel / Thonneau, Patrick F / Plante, Pierre / Huyghe, Eric

Urologia internationalis

2008 Volume 80, Issue 1, Page(s) 98–101

Abstract: Objectives: To present 2 cases with polyorchidism, to review the literature about polyorchidism, and to propose a rational therapeutic algorithm.: Methods: In our institution, we encountered 2 patients with polyorchidism: The 1st patient had ... ...

Abstract	Objectives: To present 2 cases with polyorchidism, to review the literature about polyorchidism, and to propose a rational therapeutic algorithm. Methods: In our institution, we encountered 2 patients with polyorchidism: The 1st patient had bilateral double testis with testicular torsion, and the 2nd patient presented with an indolent scrotal mass. We also performed a literature search (PubMed) for other reports of polyorchidism. Results: Polyorchidism is a rare congenital anomaly that is not well known by most urologists. So far, as illustrated by our 2 cases, the management of polyorchidism is rarely conservative, and usually the supernumerary testis is removed without any evidence supporting this attitude. Rare cases are complicated by torsion (case 1), cryptorchidism, or testicular neoplasm. In case of torsion, the conservative approach depends on the viability of the twisted testis. In case of cryptorchidism, notably in children or young adults, conservative management should be proposed, if technically feasible. In case of signs of malignancy, orchiectomy must be performed. Conclusions: Conservative treatment is advised in all uncomplicated cases. Complicated cases need a careful management, but several situations can be managed conservatively. Based on the literature, we propose a simple, rational therapeutic algorithm.
MeSH term(s)	Adult ; Algorithms ; Cryptorchidism/diagnosis ; Cryptorchidism/therapy ; Humans ; Male ; Middle Aged ; Spermatic Cord Torsion/diagnosis ; Testicular Diseases/diagnosis ; Testicular Neoplasms/diagnosis ; Testis/abnormalities ; Testis/pathology ; Urology/methods
Language	English
Publishing date	2008
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000111738
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Article ; Online: Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France.

de La Rochebrochard, Elise / de Mouzon, Jacques / Thépot, François / Thonneau, Patrick

Fertility and sterility

2006 Volume 85, Issue 5, Page(s) 1420–1424

Abstract: Objective: To investigate paternal age effect mediated by biological modifications with use of data from assisted reproductive technologies.: Design: National IVF registry.: Setting: Fifty nine French IVF centers.: Patient(s): A total of 1,938 ... ...

Abstract	Objective: To investigate paternal age effect mediated by biological modifications with use of data from assisted reproductive technologies. Design: National IVF registry. Setting: Fifty nine French IVF centers. Patient(s): A total of 1,938 men whose partners were totally sterile, with bilateral tubal obstruction or absence of both tubes (to avoid bias sampling in analysis of paternal age) and treated by conventional IVF. Intervention(s): None. Main outcome measure(s): Risk of failure to conceive defined as absence of intrauterine pregnancy. Result(s): The odds ratio of failure to conceive for paternal age > or =40 years was 2.00 (95% confidence interval [CI]: 1.10-3.61) when the woman was 35-37 years old, 2.03 (95% CI: 1.12-3.68) for age 38-40 years, and 5.74 (95% CI: 2.16, 15.23) for age 41 years and over. Conclusion(s): As an increasing number of couples choose to postpone childbearing, they should be informed that paternal age over 40 years is an important risk factor for failure to conceive.
MeSH term(s)	Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Fathers/statistics & numerical data ; Female ; Fertilization in Vitro/statistics & numerical data ; France/epidemiology ; Humans ; Incidence ; Infertility, Female/epidemiology ; Infertility, Female/therapy ; Male ; Maternal Age ; Middle Aged ; Paternal Age ; Pregnancy ; Pregnancy Outcome/epidemiology ; Pregnancy Rate ; Registries ; Risk Assessment/methods ; Risk Factors ; Treatment Failure ; Treatment Outcome
Language	English
Publishing date	2006-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2005.11.040
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Article: Determinants of maternal deaths in induced abortion complications in Ivory Coast.

Thonneau, Patrick / Matsuda, Tomohiro / Goyaux, Nathalie / Djanhan, Yao / Yace-Soumah, Frederique / Welffens, Christiane

Contraception

2004 Volume 70, Issue 4, Page(s) 319–326

Abstract: Persistently high levels of maternal mortality have been reported in Abidjan, the capital of Ivory Coast, with a high prevalence of deaths related to complications of induced abortion. In order to assess the determinants of maternal deaths in induced- ... ...

Abstract	Persistently high levels of maternal mortality have been reported in Abidjan, the capital of Ivory Coast, with a high prevalence of deaths related to complications of induced abortion. In order to assess the determinants of maternal deaths in induced-abortion complications, this study investigated women admitted to the gynecological departments of four reference hospitals throughout Ivory Coast. Information concerning abortion events was collected by means of a questionnaire during a confidential, face-to-face interview. Medical records were used to collect clinical data and final vital status. In our series, 60% of women declared that they induced abortion themselves at their home; a large majority mentioned "insertion of objects into the vagina" or "ingestion of traditional plants" for this purpose. On the other hand, 40% declared that abortion had been performed by a health worker, mostly at a health facility and by using surgical methods (dilatation and curettage). Less-educated women were more likely to have chosen to induce abortion themselves at home, and more-educated women had undergone abortion through a health professional. Our findings highlight the role of both women and health professionals in responsibility for induced abortion complications.
MeSH term(s)	Abortion, Induced/adverse effects ; Abortion, Induced/methods ; Abortion, Induced/mortality ; Adolescent ; Adult ; Age Factors ; Contraception/methods ; Cote d'Ivoire/epidemiology ; Dilatation and Curettage ; Educational Status ; Female ; Humans ; Maternal Mortality ; Middle Aged ; Pregnancy ; Self Care/adverse effects ; Self Medication/adverse effects
Language	English
Publishing date	2004-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80106-9
ISSN	0010-7824
ISSN	0010-7824
DOI	10.1016/j.contraception.2004.04.011
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Article: Polyorchidism: Presentation of 2 Cases, Review of the Literature and a New Management Strategy

Khedis, Mehdi / Nohra, Joe / Dierickx, Laurence / Walschaerts, Marie / Soulié, Michel / Thonneau, Patrick F. / Plante, Pierre / Huyghe, Eric

Urologia Internationalis

2008 Volume 80, Issue 1, Page(s) 98–101

Abstract: Objectives: To present 2 cases with polyorchidism, to review the literature about polyorchidism, and to propose a rational therapeutic algorithm. Methods: In our institution, we encountered 2 patients with polyorchidism: The 1st patient had bilateral ... ...

Institution	Department of Urology and Andrology, Rangueil Hospital Department of Nuclear Medicine and Radiology, Institute Claudius Regaud, and Human Fertility Research Group, EA 3694, Department of Urology and Andrology, Paule de Viguier Hospital, Toulouse, France
Abstract	Objectives: To present 2 cases with polyorchidism, to review the literature about polyorchidism, and to propose a rational therapeutic algorithm. Methods: In our institution, we encountered 2 patients with polyorchidism: The 1st patient had bilateral double testis with testicular torsion, and the 2nd patient presented with an indolent scrotal mass. We also performed a literature search (PubMed) for other reports of polyorchidism. Results: Polyorchidism is a rare congenital anomaly that is not well known by most urologists. So far, as illustrated by our 2 cases, the management of polyorchidism is rarely conservative, and usually the supernumerary testis is removed without any evidence supporting this attitude. Rare cases are complicated by torsion (case 1), cryptorchidism, or testicular neoplasm. In case of torsion, the conservative approach depends on the viability of the twisted testis. In case of cryptorchidism, notably in children or young adults, conservative management should be proposed, if technically feasible. In case of signs of malignancy, orchiectomy must be performed. Conclusions: Conservative treatment is advised in all uncomplicated cases. Complicated cases need a careful management, but several situations can be managed conservatively. Based on the literature, we propose a simple, rational therapeutic algorithm.
Keywords	Testicular neoplasms ; Polyorchidism ; Spermatic torsion ; Cryptorchidism
Language	English
Publishing date	2008-01-18
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Paper
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000111738
Database	Karger publisher's database

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