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Article ; Online: General autophagy-dependent and -independent lipophagic processes collaborate to regulate the overall level of lipophagy in yeast.

Kang, Na / Tan, Jinling / Yan, Sisi / Lin, Leiying / Gao, Qiang

2024

Abstract: Lipophagy in the ... ...

Abstract	Lipophagy in the yeast
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2024.2325297
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Zs.A 6741: Show issues

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Article: High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal

Zhou, Sisi / Yan, Jun / Song, Kang / Ge, Ri-Li

Biomedicines

2023 Volume 11, Issue 11

Abstract: Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE. The intestinal hypoxia-inducible factor 2 alpha ( ...

Abstract	Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE. The intestinal hypoxia-inducible factor 2 alpha (
Language	English
Publishing date	2023-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11112992
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Article ; Online: Identification of a Novel Peptide with Alcohol Dehydrogenase Activating Ability from Ethanol-Induced

Chen, Sisi / Yi, Juanjuan / Kang, Qiaozhen / Song, Mo / Raubenheimer, David / Lu, Jike

Journal of agricultural and food chemistry

2024 Volume 72, Issue 11, Page(s) 5746–5756

Abstract: Alcohol dehydrogenase (ADH) is a crucial rate-limiting enzyme in alcohol metabolism. Our previous research found that ethanol-induced intracellular extracts ... ...

Abstract	Alcohol dehydrogenase (ADH) is a crucial rate-limiting enzyme in alcohol metabolism. Our previous research found that ethanol-induced intracellular extracts of
MeSH term(s)	Mice ; Animals ; Ethanol/metabolism ; Lactococcus lactis/metabolism ; Blood Alcohol Content ; Alcohol Dehydrogenase/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; Molecular Docking Simulation ; NF-E2-Related Factor 2/metabolism ; Liver/metabolism
Chemical Substances	Ethanol (3K9958V90M) ; Blood Alcohol Content ; Alcohol Dehydrogenase (EC 1.1.1.1) ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c07632
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Zs.A 1172: Show issues

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Article ; Online: Deciphering the molecular pathways underlying dopaminergic neuronal damage in Parkinson's disease associated with SARS-CoV-2 infection.

Xu, Qiuhan / Jiang, Sisi / Kang, Ruiqing / Wang, Yiling / Zhang, Baorong / Tian, Jun

Computers in biology and medicine

2024 Volume 171, Page(s) 108200

Abstract: Background: The COVID-19 pandemic caused by SARS-CoV-2 has led to significant global morbidity and mortality, with potential neurological consequences, such as Parkinson's disease (PD). However, the underlying mechanisms remain elusive.: Methods: To ... ...

Abstract	Background: The COVID-19 pandemic caused by SARS-CoV-2 has led to significant global morbidity and mortality, with potential neurological consequences, such as Parkinson's disease (PD). However, the underlying mechanisms remain elusive. Methods: To address this critical question, we conducted an in-depth transcriptome analysis of dopaminergic (DA) neurons in both COVID-19 and PD patients. We identified common pathways and differentially expressed genes (DEGs), performed enrichment analysis, constructed protein‒protein interaction networks and gene regulatory networks, and employed machine learning methods to develop disease diagnosis and progression prediction models. To further substantiate our findings, we performed validation of hub genes using a single-cell sequencing dataset encompassing DA neurons from PD patients, as well as transcriptome sequencing of DA neurons from a mouse model of MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced PD. Furthermore, a drug-protein interaction network was also created. Results: We gained detailed insights into biological functions and signaling pathways, including ion transport and synaptic signaling pathways. CD38 was identified as a potential key biomarker. Disease diagnosis and progression prediction models were specifically tailored for PD. Molecular docking simulations and molecular dynamics simulations were employed to predict potential therapeutic drugs, revealing that genistein holds significant promise for exerting dual therapeutic effects on both PD and COVID-19. Conclusions: Our study provides innovative strategies for advancing PD-related research and treatment in the context of the ongoing COVID-19 pandemic by elucidating the common pathogenesis between COVID-19 and PD in DA neurons.
MeSH term(s)	Animals ; Mice ; Humans ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/therapeutic use ; Molecular Docking Simulation ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Disease Models, Animal
Chemical Substances	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (9P21XSP91P)
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2024.108200
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Zs.A 653: Show issues

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Article ; Online: Long-Term High-Fat Diet Inhibits the Recovery of Myocardial Mitochondrial Function After Chronic Hypoxia Reoxygenation in Rats.

Yan, Jun / Song, Kang / Zhou, Sisi / Ge, Ri-Li

High altitude medicine & biology

2021 Volume 22, Issue 3, Page(s) 327–334

Abstract: Yan, Jun, Kang Song, Sisi Zhou, and Ri-Li Ge. Long-term high-fat diet inhibits the recovery ...

Abstract	Yan, Jun, Kang Song, Sisi Zhou, and Ri-Li Ge. Long-term high-fat diet inhibits the recovery of myocardial mitochondrial function after chronic hypoxia reoxygenation in rats.
MeSH term(s)	Animals ; Diet, High-Fat/adverse effects ; Hypoxia ; Mitochondria, Heart ; Myocardium ; Rats ; Rats, Sprague-Dawley
Language	English
Publishing date	2021-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2076262-8
ISSN	1557-8682 ; 1527-0297
ISSN (online)	1557-8682
ISSN	1527-0297
DOI	10.1089/ham.2021.0056
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Zs.A 5674: Show issues

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Article ; Online: Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis.

Zhao, Jing / Ma, Wan / Wang, Sisi / Zhang, Kang / Xiong, Qingqing / Li, Yunqin / Yu, Hong / Du, Huahua

Redox biology

2024 Volume 72, Page(s) 103160

Abstract: Iron overload can lead to oxidative stress and intestinal damage and happens frequently during blood transfusions and iron supplementation. However, how iron overload influences intestinal mucosa remains unknown. Here, the aim of current study was to ... ...

Abstract	Iron overload can lead to oxidative stress and intestinal damage and happens frequently during blood transfusions and iron supplementation. However, how iron overload influences intestinal mucosa remains unknown. Here, the aim of current study was to investigate the effects of iron overload on the proliferation and differentiation of intestinal stem cells (ISCs). An iron overload mouse model was established by intraperitoneal injection of 120 mg/kg body weight iron dextran once a fortnight for a duration of 12 weeks, and an iron overload enteroid model was produced by treatment with 3 mM or 10 mM of ferric ammonium citrate for 24 h. We found that iron overload caused damage to intestinal morphology with a 64 % reduction in villus height/crypt depth ratio, and microvilli injury in the duodenum. Iron overload mediated epithelial function by inhibiting the expression of nutrient transporters and enhancing the expression of secretory factors in the duodenum. Meanwhile, iron overload inhibited the proliferation of ISCs and regulated their differentiation into secretory mature cells, such as goblet cells, through inhibiting Notch signaling pathway both in mice and enteroid. Furthermore, iron overload caused oxidative stress and ferroptosis in intestinal epithelial cells. In addition, ferroptosis could also inhibit Notch signaling pathway, and affected the proliferation and differentiation of ISCs. These findings reveal the regulatory role of iron overload on the proliferation and differentiation of ISCs, providing a new insight into the internal mechanism of iron overload affecting intestinal health, and offering important theoretical basis for the scientific application of iron nutrition regulation.
Language	English
Publishing date	2024-04-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2024.103160
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Article ; Online: Probiotic properties and proteomics analysis of ethanol-induced Lactococcus lactis subsp. lactis IL1403.

Chen, Sisi / Yi, Juanjuan / Suo, Keke / Kang, Qiaozhen / Lu, Laizheng / Lu, Jike

World journal of microbiology & biotechnology

2023 Volume 39, Issue 8, Page(s) 197

Abstract: Our previous study indicated that ethanol-induced intracellular extracts (E-IEs) of Lactococcus lactis subsp. Lactis IL1403 (L. lactis IL1403) alleviated hangovers more effectively in mice than untreated intracellular extracts (U-IEs), but the material ... ...

Abstract	Our previous study indicated that ethanol-induced intracellular extracts (E-IEs) of Lactococcus lactis subsp. Lactis IL1403 (L. lactis IL1403) alleviated hangovers more effectively in mice than untreated intracellular extracts (U-IEs), but the material basis was unclear. Considering that stress-related proteins might play a significant role, the effects of ethanol induction on probiotic properties of L. lactis IL1403 and the associated stress response mechanism were initially explored in this study. E-IEs of L. lactis IL1403 showed better biological activities, significantly increased bacteria survival rates in oxidative stress environments, increased ADH activity, and enhanced proliferation in RAW264.7 and AML-12 cells. Proteomic analyses revealed that 414 proteins were significantly changed in response to ethanol induction. The expression of proteins involved in the universal stress response, DNA repair, oxidative stress response, and ethanol metabolism was rapidly upregulated under ethanol stress, and quantitative real-time PCR (qRT-PCR) results were consistent with proteomic data. KEGG pathway analysis indicated that citrate metabolism, starch and sucrose metabolism, and pyruvate metabolism were significantly enriched during ethanol stress to increase energy requirements and survival rates of stressed cells. Based on this observation, the active induction is an effective strategy for increasing the biological activity of L. lactis IL1403. Exploring the molecular mechanism and material basis of their functions in vivo can help us understand the adaptive regulatory mechanism of microorganisms.
MeSH term(s)	Animals ; Mice ; Lactococcus lactis/genetics ; Lactococcus lactis/metabolism ; Ethanol/metabolism ; Proteomics
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2023-05-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-023-03627-y
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Article ; Online: The spectrum of opportunistic infections and malignancies among women on antiretroviral therapy in Ethiopia.

Getaneh, Yimam / Getnet, Fentabil / Rashid, Abdur / Kang, Li / Chu, Qingfei / Li, Sisi / Yi, Feng / Shao, Yiming

Emerging microbes & infections

2023 Volume 12, Issue 2, Page(s) 2271065

Abstract: Abbreviations: AIDS: acquired immune deficiency syndrome; CI: confidence interval; EPHI: Ethiopian Public Health Institute; HAART: highly active antiretroviral therapy; HIV: human immunodeficiency virus; HR: hazard ratio; Mg/dl: milligram per deciliter; ...

Abstract	Abbreviations: AIDS: acquired immune deficiency syndrome; CI: confidence interval; EPHI: Ethiopian Public Health Institute; HAART: highly active antiretroviral therapy; HIV: human immunodeficiency virus; HR: hazard ratio; Mg/dl: milligram per deciliter; TB: tuberculosis; PCP: pneumocystis carinii pneumonia; ZJU: Zhejiang University.
MeSH term(s)	Humans ; Female ; Ethiopia/epidemiology ; AIDS-Related Opportunistic Infections/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Acquired Immunodeficiency Syndrome/drug therapy ; Neoplasms ; Antiretroviral Therapy, Highly Active
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2023.2271065
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Article ; Online: Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.

Ding, Fengfei / Sun, Qian / Long, Carter / Rasmussen, Rune Nguyen / Peng, Sisi / Xu, Qiwu / Kang, Ning / Song, Wei / Weikop, Pia / Goldman, Steven A / Nedergaard, Maiken

Brain : a journal of neurology

2024

Abstract: Progressive neuronal loss is a hallmark feature distinguishing neurodegenerative diseases from normal aging. However, the underlying mechanisms remain unknown. Extracellular K+ homeostasis is a potential mediator of neuronal injury since K+ elevations ... ...

Abstract	Progressive neuronal loss is a hallmark feature distinguishing neurodegenerative diseases from normal aging. However, the underlying mechanisms remain unknown. Extracellular K+ homeostasis is a potential mediator of neuronal injury since K+ elevations increase excitatory activity. The dysregulation of extracellular K+ and potassium channel expressions during neurodegeneration could contribute to this distinction. We here measured the cortical extracellular K+ concentration ([K+]e) in awake wildtype mice as well as murine models of neurodegeneration using K+-sensitive microelectrodes. Unexpectedly, aged wildtype mice exhibited significantly lower cortical [K+]e than young mice. In contrast, cortical [K+]e was consistently elevated in Alzheimer's disease (AD) (APP/PS1), amyotrophic lateral sclerosis (ALS) (SOD1G93A), and Huntington's disease (HD) (R6/2) models. Cortical resting [K+]e correlated inversely with neuronal density and the [K+]e buffering rate but correlated positively with the predicted neuronal firing rate. Screening of astrocyte-selective genomic datasets revealed a number of potassium channel genes that were downregulated in these disease models but not in normal aging. In particular, the inwardly rectifying potassium channel Kcnj10 was downregulated in ALS and HD models but not in normal aging, while Fxyd1 and Slc1a3, each of which acts as a negative regulator of potassium uptake, were each upregulated by astrocytes in both AD and ALS models. Chronic elevation of [K+]e in response to changes in gene expression and the attendant neuronal hyperexcitability may drive the neuronal loss characteristic of these neurodegenerative diseases. These observations suggest that the dysregulation of extracellular K+ homeostasis in a number of neurodegenerative diseases could be due to aberrant astrocytic K+ buffering, and as such highlight a fundamental role for glial dysfunction in neurodegeneration.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awae075
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Article ; Online: Fatty Acyl Coenzyme A Synthetase Fat1p Regulates Vacuolar Structure and Stationary-Phase Lipophagy in Saccharomyces cerevisiae.

Qiu, Fan / Kang, Na / Tan, Jinling / Yan, Sisi / Lin, Leiying / Cai, Lipeng / Goodman, Joel M / Gao, Qiang

Microbiology spectrum

2023 Volume 11, Issue 1, Page(s) e0462522

Abstract: During yeast stationary phase, a single spherical vacuole (lysosome) is created by the fusion of several small ones. Moreover, the vacuolar membrane is reconstructed into two distinct microdomains. Little is known, however, about how cells maintain ... ...

Abstract	During yeast stationary phase, a single spherical vacuole (lysosome) is created by the fusion of several small ones. Moreover, the vacuolar membrane is reconstructed into two distinct microdomains. Little is known, however, about how cells maintain vacuolar shape or regulate their microdomains. Here, we show that Fat1p, a fatty acyl coenzyme A (acyl-CoA) synthetase and fatty acid transporter, and not the synthetases Faa1p and Faa4p, is essential for vacuolar shape preservation, the development of vacuolar microdomains, and cell survival in stationary phase of the yeast Saccharomyces cerevisiae. Furthermore, Fat1p negatively regulates general autophagy in both log- and stationary-phase cells. In contrast, Fat1p promotes lipophagy, as the absence of
MeSH term(s)	Saccharomyces cerevisiae/metabolism ; Vacuoles/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Fatty Acids/metabolism ; Coenzyme A Ligases/genetics ; Coenzyme A Ligases/metabolism ; Autophagy ; Fatty Acid Transport Proteins/metabolism
Chemical Substances	Saccharomyces cerevisiae Proteins ; Fatty Acids ; Coenzyme A Ligases (EC 6.2.1.-) ; FAT1 protein, S cerevisiae ; Fatty Acid Transport Proteins
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.04625-22
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