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Article ; Online: Selective C-H Activation at a Molecular Rhodium Sigma-Alkane Complex by Solid/Gas Single-Crystal to Single-Crystal H/D Exchange.

Chadwick, F Mark / Krämer, Tobias / Gutmann, Torsten / Rees, Nicholas H / Thompson, Amber L / Edwards, Alison J / Buntkowsky, Gerd / Macgregor, Stuart A / Weller, Andrew S

Journal of the American Chemical Society

2016 Volume 138, Issue 40, Page(s) 13369–13378

Abstract: ... platform, selective alkane C-H activation occurs, as probed by H/D exchange using D ... The controlled catalytic functionalization of alkanes via the activation of C-H bonds is ... a significant challenge. Although C-H activation by transition metal catalysts is often suggested to operate via ...

Abstract	The controlled catalytic functionalization of alkanes via the activation of C-H bonds is a significant challenge. Although C-H activation by transition metal catalysts is often suggested to operate via intermediate σ-alkane complexes, such transient species are difficult to observe due to their instability in solution. This instability may be controlled by use of solid/gas synthetic techniques that enable the isolation of single-crystals of well-defined σ-alkane complexes. Here we show that, using this unique platform, selective alkane C-H activation occurs, as probed by H/D exchange using D
Language	English
Publishing date	2016-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.6b07968
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Article: Historic Washington, D.C., hospital reopens in new $96 million facility. The George Washington University Hospital attracts fanfare.

Rees, Tom

Profiles in healthcare marketing

2002 Volume 18, Issue 5, Page(s) 23–7, 3

Abstract: ... hospital building in Washington, D.C. The new facility was introduced to the Washington community ...

Abstract	A diverse gathering of political leaders, entertainment and sports personalities and government officials attended the grand opening ceremony of George Washington University Hospital's brand-new 371-bed hospital building in Washington, D.C. The new facility was introduced to the Washington community by a series of tours for the media, physicians, nurses, hospital employees and their families.
MeSH term(s)	Academic Medical Centers/economics ; Academic Medical Centers/organization & administration ; Community-Institutional Relations ; District of Columbia ; Hospital Design and Construction ; Marketing of Health Services/organization & administration ; Mass Media
Language	English
Publishing date	2002-09
Publishing country	United States
Document type	Journal Article
ISSN	1040-7480
ISSN	1040-7480
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Article: Limnantheoside C (20-hydroxyecdysone 3-O-beta-D-glucopyranosyl-[1-->3]-beta-D-xylopyranoside), a phytoecdysteroid from seeds of Limnanthes alba (limnanthaceae).

Meng, Y / Whiting, P / Sik, V / Rees, H H / Dinan, L

Zeitschrift fur Naturforschung. C, Journal of biosciences

2001 Volume 56, Issue 11-12, Page(s) 988–994

Abstract: A new ecdysteroid glycoside, limnantheoside C (20-hydroxyecdysone 3-O-beta-D-glucopyranosyl-[-->3 ... beta-D-xylopyranoside [1]), together with limnantheoside A (20-hydroxyecdysone 3-O-beta-D ...

Abstract	A new ecdysteroid glycoside, limnantheoside C (20-hydroxyecdysone 3-O-beta-D-glucopyranosyl-[-->3]-beta-D-xylopyranoside [1]), together with limnantheoside A (20-hydroxyecdysone 3-O-beta-D-xylopyranoside [2]) and 20-hydroxyecdysone (3) have been isolated by bioassay/RIA-directed HPLC analyses of a methanol extract of the seedmeal of Limnanthes alba Hartw. ex Benth. The structure of the novel ecdysteroid glycoside (1) was determined unambiguously by UV, LSIMS and a combination of 1D- and 2D-NMR experiments. These three compounds are isolated from Limnanthes alba for the first time.
MeSH term(s)	Animals ; Brassicaceae/chemistry ; Cell Line ; Drosophila melanogaster/drug effects ; Ecdysone/analogs & derivatives ; Ecdysone/chemistry ; Ecdysone/isolation & purification ; Ecdysteroids/chemistry ; Ecdysteroids/pharmacology ; Glycosides/chemistry ; Glycosides/pharmacology ; Models, Molecular ; Molecular Structure ; Radioimmunoassay ; Saponins/chemistry ; Saponins/isolation & purification ; Seeds/chemistry
Chemical Substances	Ecdysteroids ; Glycosides ; Saponins ; limnantheoside C ; Ecdysone (3604-87-3)
Language	English
Publishing date	2001-11
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	124636-7
ISSN	1865-7125 ; 0939-5075 ; 0341-0382 ; 0341-0471
ISSN (online)	1865-7125
ISSN	0939-5075 ; 0341-0382 ; 0341-0471
DOI	10.1515/znc-2001-11-1214
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Article ; Online: Method dependency of maximum oxygen uptake rate and its repeatability in the Gulf killifish, Fundulus grandis.

Brieske, Samantha D / Mullen, Sylvia C / Rees, Bernard B

Journal of fish biology

2024

Abstract: The maximum rate at which fish can take up oxygen from their environment to fuel aerobic metabolism is an important feature of their physiology and ecology. Methods to quantify maximum oxygen uptake rate ( ... ...

Abstract	The maximum rate at which fish can take up oxygen from their environment to fuel aerobic metabolism is an important feature of their physiology and ecology. Methods to quantify maximum oxygen uptake rate (ṀO
Language	English
Publishing date	2024-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	410564-3
ISSN	1095-8649 ; 0022-1112
ISSN (online)	1095-8649
ISSN	0022-1112
DOI	10.1111/jfb.15692
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Article: Limnantheoside C (20-Hydroxyecdysone 3-O-Beta-d-glucopyranosyl-[1-3]-Beta-D-xylopyranoside), a Phytoecdysteroid from Seeds of Limnanthes alba (Limnanthaceae)

Meng, Y. / Whiting, P. / SIK, V. / REES, H. H. / DINAN, L.

Zeitschrift für Naturforschung : Section C

2001 Volume 56, Issue 11/12, Page(s) 988

Language	German
Document type	Article
ZDB-ID	124636-7
ISSN	0341-0382 ; 0341-0471
Database	Current Contents Medicine

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Article ; Online: Biological nitrogen fixation in theory, practice, and reality: a perspective on the molybdenum nitrogenase system.

Threatt, Stephanie D / Rees, Douglas C

FEBS letters

2022 Volume 597, Issue 1, Page(s) 45–58

Abstract: Nitrogenase is the sole enzyme responsible for the ATP-dependent conversion of atmospheric dinitrogen into the bioavailable form of ammonia ( ... ...

Abstract	Nitrogenase is the sole enzyme responsible for the ATP-dependent conversion of atmospheric dinitrogen into the bioavailable form of ammonia (NH
MeSH term(s)	Nitrogenase/chemistry ; Nitrogenase/metabolism ; Nitrogen Fixation ; Molybdenum/chemistry ; Ammonia/chemistry ; Ammonia/metabolism ; Oxidation-Reduction ; Nitrogen/metabolism
Chemical Substances	Nitrogenase (EC 1.18.6.1) ; Molybdenum (81AH48963U) ; Ammonia (7664-41-7) ; Nitrogen (N762921K75)
Language	English
Publishing date	2022-11-28
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.14534
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Article ; Online: Investigation into novel mukanadin B, mukanadin D and mukanadin F derivatives as antagonists of 5-HT1A signalling.

Rees, Shaun / Rees, Tayla / van Rensburg, Michelle / Walker, Christopher / Pilkington, Lisa / Barker, David

ChemMedChem

2024 , Page(s) e202400102

Abstract: ... exploration. A library of thirteen novel mukanadin B and D derivatives with structural variation targeted ... assessed for serotonergic antagonism, in addition to natural products, mukanadin B, D, F and 9-hydroxy ...

Abstract	Marine bromopyrrole alkaloids are a diverse family of natural products with a large array of biological applications. The mukanadin family is a group of molecules consisting of seven members (mukanadin A - G) that possess a range of biological activities. Inhibition of serotonergic signaling has been demonstrated by mukanadin B derivatives, presenting this chemical scaffold as a candidate for further SAR exploration. A library of thirteen novel mukanadin B and D derivatives with structural variation targeted at the pyrrole ring, central linker and hydantoin ring, were synthesized. These analogues were subsequently assessed for serotonergic antagonism, in addition to natural products, mukanadin B, D, F and 9-hydroxy mukanadin B. A collection of compounds exhibited significant 5-HT1A signaling, including five of the novel derivatives and two of the naturally occurring bromopyrroles, mukanadin B and F. Particular SAR information could be determined from these results, such as modification of the pyrrole ring being a well-tolerated strategy for improving serotonergic inhibition. Other changes to the pharmacophore led to significant reduction in activity such as saturation of the linker region, or no conclusive improvement in inhibitory activity such as a 9-OH group or replacement of the hydantoin ring with a triazole moiety.
Language	English
Publishing date	2024-04-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202400102
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Article: Small evolutionarily conserved RNA, resembling C/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the Prader-Willi deletion region, which Is highly expressed in brain.

de los Santos, T / Schweizer, J / Rees, C A / Francke, U

American journal of human genetics

2000 Volume 67, Issue 5, Page(s) 1067–1082

Abstract: ... mouse conserved region"). The HMCR sequence has features of a C/D box small nucleolar RNA (snoRNA) and ...

Abstract	Prader-Willi syndrome is a complex neurodevelopmental disorder caused by the inactivation or deletion of imprinted, paternally expressed genes in chromosome band 15q11.2. We report the identification and characterization of PWCR1, a novel imprinted gene within that region, and its mouse orthologue, Pwcr1, which was mapped to the conserved syntenic region on mouse chromosome 7. Expressed only from the paternal allele, both genes require the imprinting-center regulatory element for expression and are transcribed from the same strand. They are intronless and do not appear to encode a protein product. High human/mouse sequence similarity (87% identity) is limited to a 99-bp region called "HMCR" (for "human-mouse conserved region"). The HMCR sequence has features of a C/D box small nucleolar RNA (snoRNA) and is represented in an abundant small transcript in both species. Located in nucleoli, snoRNAs serve as methylation guidance RNAs in the modification of ribosomal RNA and other small nuclear RNAs. In addition to the nonpolyadenylated small RNAs, larger polyadenylated PWCR1 transcripts are found in most human tissues, whereas expression of any Pwcr1 RNAs is limited to mouse brain. Genomic sequence analysis reveals the presence of multiple copies of PWCR1 and Pwcr1 that are organized within local tandem-repeat clusters. On a multispecies Southern blot, hybridization to an HMCR probe encoding the putative snoRNA is limited to mammals.
MeSH term(s)	Alleles ; Animals ; Base Sequence ; Blotting, Southern ; Brain/metabolism ; Cell Line ; Chromosome Mapping ; Chromosomes, Human, Pair 15/genetics ; Cloning, Molecular ; Conserved Sequence/genetics ; Evolution, Molecular ; Fathers ; Female ; Gene Expression Profiling ; Genomic Imprinting ; Humans ; Male ; Mice ; Molecular Sequence Data ; Multigene Family/genetics ; Organ Specificity ; Phylogeny ; Prader-Willi Syndrome/genetics ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; RNA, Small Nucleolar/genetics ; Sequence Alignment ; Sequence Deletion/genetics ; RNA, Small Untranslated
Chemical Substances	RNA, Messenger ; RNA, Small Nucleolar ; RNA, Small Untranslated
Language	English
Publishing date	2000-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219384-x
ISSN	1537-6605 ; 0002-9297
ISSN (online)	1537-6605
ISSN	0002-9297
DOI	10.1086/303106
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Article ; Online: Quantitative PCR (qPCR) assay for the specific detection of the Chinese mystery snail (Cipangopaludina chinensis) in the UK.

Rees, Helen C / Measures, Gavin H / Kane, Steven D / Maddison, Ben C

PloS one

2023 Volume 18, Issue 10, Page(s) e0292163

Abstract: ... for the detection of C. chinensis and compared water samples tested for eDNA with results from manual survey ... Some samples which were qPCR negative for C. chinensis were positive by manual survey, and vice versa revealing ... eDNA analysis can therefore augment manual survey techniques for C. chinensis as a relatively quick and ...

Abstract	Cipangopaludina chinensis Gray 1833 is an East Asian freshwater snail and invasive species in many parts of the world (Global Invasive Species Database, 2022). Within the UK, it was first found at the Pevensey Levels, Sussex, and has since been reported at a second site at Southampton Common, Hampshire. Both sites are designated as Sites of Special Scientific Interest (SSSI) for their wildlife importance. Although the impacts of this species within the UK have not yet been investigated several exotic parasites of the snail have been reported and research suggests that its presence can negatively impact native snail species. This is especially important at the Pevensey Levels due to the presence of the rare freshwater mollusc Anisus vorticulus (Little Whirlpool Rams's-horn snail). Here, we have developed a qPCR-based eDNA assay for the detection of C. chinensis and compared water samples tested for eDNA with results from manual survey of the ditches at the Pevensey Levels. Our eDNA analysis exhibited an overall observed percentage agreement of 80% with a kappa coefficient of agreement between manual and eDNA surveys of 0.59 (95% CI 0.31 to 0.88). Some samples which were qPCR negative for C. chinensis were positive by manual survey, and vice versa revealing the potential for improved overall detection rates when using a combination of manual and eDNA methodologies. eDNA analysis can therefore augment manual survey techniques for C. chinensis as a relatively quick and inexpensive tool for collecting presence and distribution data that could be used to inform further manual surveys and control measures within the ditches.
MeSH term(s)	Animals ; DNA, Environmental/analysis ; Introduced Species ; Polymerase Chain Reaction ; Snails/genetics ; Snails/parasitology ; United Kingdom
Chemical Substances	DNA, Environmental
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0292163
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Factors influencing decision-making processes for intensive care therapy goals: A systematic integrative review.

Kelly, Diane / Barrett, Jonathan / Brand, Gabrielle / Leech, Michelle / Rees, Charlotte

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

2024

Abstract: Background: Delivering intensive care therapies concordant with patients' values and preferences is considered gold standard care. To achieve this, healthcare professionals must better understand decision-making processes and factors influencing them.!## ...

Abstract	Background: Delivering intensive care therapies concordant with patients' values and preferences is considered gold standard care. To achieve this, healthcare professionals must better understand decision-making processes and factors influencing them. Aim: The aim of this study was to explore factors influencing decision-making processes about implementing and limiting intensive care therapies. Design: Systematic integrative review, synthesising quantitative, qualitative, and mixed-methods studies. Methods: Five databases were searched (Medline, The Cochrane central register of controlled trials, Embase, PsycINFO, and CINAHL plus) for peer-reviewed, primary research published in English from 2010 to Oct 2022. Quantitative, qualitative, or mixed-methods studies focussing on intensive care decision-making were included for appraisal. Full-text review and quality screening included the Critical Appraisal Skills Program tool for qualitative and mixed methods and the Medical Education Research Quality Instrument for quantitative studies. Papers were reviewed by two authors independently, and a third author resolved disagreements. The primary author developed a thematic coding framework and performed coding and pattern identification using NVivo, with regular group discussions. Results: Of the 83 studies, 44 were qualitative, 32 quantitative, and seven mixed-methods studies. Seven key themes were identified: what the decision is about; who is making the decision; characteristics of the decision-maker; factors influencing medical prognostication; clinician-patient/surrogate communication; factors affecting decisional concordance; and how interactions affect decisional concordance. Substantial thematic overlaps existed. The most reported decision was whether to withhold therapies, and the most common decision-maker was the clinician. Whether a treatment recommendation was concordant was influenced by multiple factors including institutional cultures and clinician continuity. Conclusion: Decision-making relating to intensive care unit therapy goals is complicated. The current review identifies that breadth of decision-makers, and the complexity of intersecting factors has not previously been incorporated into interventions or considered within a single review. Its findings provide a basis for future research and training to improve decisional concordance between clinicians and patients/surrogates with regards to intensive care unit therapies.
Language	English
Publishing date	2024-04-11
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1159493-7
ISSN	1878-1721 ; 1036-7314
ISSN (online)	1878-1721
ISSN	1036-7314
DOI	10.1016/j.aucc.2024.02.007
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