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  1. Article ; Online: Robert Letsinger and the Evolution of Oligonucleotide Synthesis.

    Egli, Martin

    ACS omega

    2023  Volume 8, Issue 36, Page(s) 32222–32230

    Abstract: This retrospective summarizes a presentation given at the symposium "Bob Letsinger, PhD-100 Years of History" on September 28, 2021 as part of the 17th annual meeting of the Oligonucleotide Therapeutics Society (OTS). In it I look back at my encounters ... ...

    Abstract This retrospective summarizes a presentation given at the symposium "Bob Letsinger, PhD-100 Years of History" on September 28, 2021 as part of the 17th annual meeting of the Oligonucleotide Therapeutics Society (OTS). In it I look back at my encounters with Robert Lewis Letsinger (1921-2014) while at Northwestern University as Assistant Professor between 1995 and 2000.
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05177
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  2. Book ; Online ; E-Book: Nucleic acids in chemistry and biology

    Blackburn, G. Michael / Egli, Martin / Gait, Michael J. / Watts, Jonathan K.

    edited by G. Michael Blackburn, Martin Egli, Michael J. Gait and Jonathan K. Watts

    2022  

    Institution Royal Society of Chemistry
    Keywords Nucleic acids
    Subject code QP620 ; 572.8
    Language English
    Size 1 Online-Ressource ( 818 Seiten), Illustrationen
    Edition Fourth edition
    Publisher Royal Society of Chemistry
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Previous edition: 2006 ; Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030696605
    ISBN 1-83916-324-0 ; 978-1-83916-324-1 ; 9781788019040 ; 1788019040
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Becoming a Crystallographer

    Martin Egli

    Molecular Frontiers Journal, Vol 07, Iss Supp02, Pp 62-

    2023  Volume 76

    Abstract: What do you want to be when you grow up?” is a common question posed to children, and answers such as firefighter, policeman, athlete, doctor, or teacher are probably just as common. Some, like Oliver Sacks, recall an early fascination with metals, the ... ...

    Abstract “What do you want to be when you grow up?” is a common question posed to children, and answers such as firefighter, policeman, athlete, doctor, or teacher are probably just as common. Some, like Oliver Sacks, recall an early fascination with metals, the periodic table, and chemical reactions that planted the seeds for the later pursuit of the natural sciences or medicine (neurology in his case). We are familiar with memories of chemists that include their first chemistry set, followed by complaints by parents over strange smells and close calls due to particularly exothermic reactions. For others, including myself, a future in research remained more obscure until a later period in adolescence or perhaps even the undergraduate years. Rather than seeking out a field, the field finds you. In actuality, teachers and mentors with expertise in and enthusiasm for a field exert a force that charts a path toward scientific research throughout life. Here, I stress the importance of terrific teachers and mentors from high school onwards to the undergraduate, Ph.D., and postdoc years for setting me on a track (and on occasion preventing me from derailing) to research in structural chemistry and molecular mechanism using crystallography as the main tool.
    Keywords Biography ; Chemical Bond ; Diffraction ; DNA ; ETH Zürich ; Mentor ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher World Scientific Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Chemistry, structure and function of approved oligonucleotide therapeutics.

    Egli, Martin / Manoharan, Muthiah

    Nucleic acids research

    2023  Volume 51, Issue 6, Page(s) 2529–2573

    Abstract: Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), RNA interference (RNAi) and an RNA ... ...

    Abstract Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), RNA interference (RNAi) and an RNA aptamer against a protein. Among the diseases targeted by this new class of drugs are homozygous familial hypercholesterolemia, spinal muscular atrophy, Duchenne muscular dystrophy, hereditary transthyretin-mediated amyloidosis, familial chylomicronemia syndrome, acute hepatic porphyria, and primary hyperoxaluria. Chemical modification of DNA and RNA was central to making drugs out of oligonucleotides. Oligonucleotide therapeutics brought to market thus far contain just a handful of first- and second-generation modifications, among them 2'-fluoro-RNA, 2'-O-methyl RNA and the phosphorothioates that were introduced over 50 years ago. Two other privileged chemistries are 2'-O-(2-methoxyethyl)-RNA (MOE) and the phosphorodiamidate morpholinos (PMO). Given their importance in imparting oligonucleotides with high target affinity, metabolic stability and favorable pharmacokinetic and -dynamic properties, this article provides a review of these chemistries and their use in nucleic acid therapeutics. Breakthroughs in lipid formulation and GalNAc conjugation of modified oligonucleotides have paved the way to efficient delivery and robust, long-lasting silencing of genes. This review provides an account of the state-of-the-art of targeted oligo delivery to hepatocytes.
    MeSH term(s) Humans ; Morpholinos/pharmacology ; Muscular Dystrophy, Duchenne/drug therapy ; Muscular Dystrophy, Duchenne/genetics ; Oligonucleotides, Antisense/chemistry ; Oligonucleotides, Antisense/metabolism ; Oligonucleotides, Antisense/therapeutic use ; RNA/chemistry ; RNA Interference
    Chemical Substances Morpholinos ; Oligonucleotides, Antisense ; RNA (63231-63-0)
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad067
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  5. Article ; Online: How the α-helix got its name.

    Egli, Martin / Zhang, Shuguang

    Nature reviews. Molecular cell biology

    2022  Volume 23, Issue 3, Page(s) 165

    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-021-00449-4
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  6. Book: Schematherapie bei Depressionen

    Egli, Samy / Frieß, Elisabeth / Graf, Patricia / Höhn, David / Kopf-Beck, Johannes / Rein, Martin Ludwig / Ruderer, Amelie / Szesny-Mahlau, Nicole / Zimmermann, Petra / Keck, Martin Ekkehard

    ein Behandlungskonzept für das (teil)stationäre Setting

    (Therapeutische Praxis)

    2019  

    Author's details Samy Egli, Elisabeth Frieß, Patricia Graf, David Höhn, Johannes Kopf-Beck, Martin Ludwig Rein, Amelie Ruderer, Nicole Szesny-Mahlau, Petra Zimmermann, Martin Ekkehard Keck
    Series title Therapeutische Praxis
    Keywords Depression ; Schematherapie
    Subject Schemazentrierte emotiv-behaviorale Therapie ; SET ; Depressionen
    Language German
    Size 95 Seiten, Illustrationen, 29.7 cm x 21 cm
    Edition 1. Auflage
    Publisher Hogrefe
    Publishing place Göttingen
    Publishing country Germany
    Document type Book
    Note Literaturverzeichnis: Seite 91-95
    Accompanying material 1 CD-ROM
    HBZ-ID HT020236723
    ISBN 978-3-8017-2971-4 ; 3-8017-2971-0 ; 9783844429718 ; 9783840929717 ; 3844429719 ; 3840929717
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 A 1379 available for loan (reading room) Lesesaal EG
    2019 MO 37 <<[Begleitmaterial]>> order for loan Magazin

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  7. Article ; Online: Hiding in plain sight: three chemically distinct α-helix types - ERRATUM.

    Zhang, Shuguang / Egli, Martin

    Quarterly reviews of biophysics

    2022  Volume 55, Page(s) e11

    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 209912-3
    ISSN 1469-8994 ; 0033-5835
    ISSN (online) 1469-8994
    ISSN 0033-5835
    DOI 10.1017/S0033583522000099
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  8. Article ; Online: First prediction of sequence-specific recognition of double-helix nucleic acids by proteins.

    Egli, Martin / Zhang, Shuguang

    Nature reviews. Molecular cell biology

    2022  Volume 23, Issue 3, Page(s) 166

    Language English
    Publishing date 2022-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-022-00451-4
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  9. Article ; Online: Ned Seeman and the prediction of amino acid-basepair motifs mediating protein-nucleic acid recognition.

    Egli, Martin / Zhang, Shuguang

    Biophysical journal

    2022  Volume 121, Issue 24, Page(s) 4777–4787

    Abstract: Fifty years ago, the first atomic-resolution structure of a nucleic acid double helix, the mini-duplex (ApU) ...

    Abstract Fifty years ago, the first atomic-resolution structure of a nucleic acid double helix, the mini-duplex (ApU)
    MeSH term(s) Nucleic Acids/chemistry ; Nucleic Acid Conformation ; Proteins ; Arginine/chemistry ; Amino Acids ; Guanine ; Hydrogen Bonding
    Chemical Substances Nucleic Acids ; Proteins ; Arginine (94ZLA3W45F) ; Amino Acids ; Guanine (5Z93L87A1R)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2022.06.017
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  10. Article ; Online: Hiding in plain sight: three chemically distinct

    Zhang, Shuguang / Egli, Martin

    Quarterly reviews of biophysics

    2022  Volume 55, Page(s) e7

    Abstract: Linus Pauling in 1950 published a three-dimensional model for a universal protein secondary structure motif which he initially called the alpha-spiral. Jack Dunitz, then a postdoc in Pauling's lab suggested to Pauling that the term helix is more accurate ...

    Abstract Linus Pauling in 1950 published a three-dimensional model for a universal protein secondary structure motif which he initially called the alpha-spiral. Jack Dunitz, then a postdoc in Pauling's lab suggested to Pauling that the term helix is more accurate than spiral when describing the right-handed peptide and protein coiled structures. Pauling agreed, hence the rise of the alpha-helix, and, by extension, the ‘double helix’ structure of DNA. Although structural biologists and protein chemists are familiar with varying polar and apolar characters of amino acids in alpha-helices, to non-experts the three chemically distinct alpha-helix types classified here may hide in plain sight.
    MeSH term(s) Amino Acid Sequence ; Amino Acids/chemistry ; Protein Conformation, alpha-Helical ; Protein Structure, Secondary ; Proteins/chemistry
    Chemical Substances Amino Acids ; Proteins
    Language English
    Publishing date 2022-06-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 209912-3
    ISSN 1469-8994 ; 0033-5835
    ISSN (online) 1469-8994
    ISSN 0033-5835
    DOI 10.1017/S0033583522000063
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