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Book: The University of Texas M.D. Anderson Cancer Center

Dodd, Gerald D / Linton, Otha W

a history of diagnostic imaging

2006

Institution	University of Texas M.D. Anderson Cancer Center
Author's details	by Gerald D. Dodd, Otha W. Linton
MeSH term(s)	Cancer Care Facilities/history ; Diagnostic Imaging/history
Keywords	Texas
Language	English
Size	169 p. :, ill., ports.
Publisher	University of Texas M.D. Anderson Cancer Center
Publishing place	Texas
Document type	Book
ISBN	9781890705060 ; 1890705063
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: An İnnovative Method of Monitoring Patient Respiratory Function while Weaning from Mechanical Ventilation.

Tocut, Milena / Linton, David / Zandman-Goddard, Gisele

The Israel Medical Association journal : IMAJ

2023 Volume 25, Issue 10, Page(s) 706–707

MeSH term(s)	Humans ; Respiration, Artificial ; Ventilator Weaning ; Respiration
Language	English
Publishing date	2023-10-17
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article ; Online: Housing insecurity among black women surviving intimate partner violence during the COVID-19 pandemic: an intersectional qualitative approach.

Willie, Tiara C / Linton, Sabriya L / Whittaker, Shannon / Phillips, Karlye A / Knight, Deja / Gray, Mya C / Gardner, Gretta / Overstreet, Nicole M

BMC public health

2024 Volume 24, Issue 1, Page(s) 501

Abstract: Background: Housing instability is highly prevalent among intimate partner violence (IPV) survivors, and the coupling consequences of structural racism, sexism, classism, and the COVID-19 pandemic, may create more barriers to safe and adequate housing, ... ...

Abstract	Background: Housing instability is highly prevalent among intimate partner violence (IPV) survivors, and the coupling consequences of structural racism, sexism, classism, and the COVID-19 pandemic, may create more barriers to safe and adequate housing, specifically for Black women IPV survivors. In particular, the consequences of the COVID-19 pandemic had the potential to amplify disadvantages for Black women IPV survivors, yet very little research has acknowledged it. Therefore, the current study sought to assess the experiences of housing insecurity among Black women experiencing intimate partner violence (IPV) while navigating racism, sexism, and classism during the COVID-19 pandemic. Methods: From January to April 2021, we conducted in-depth interviews with 50 Black women experiencing IPV in the United States. Guided by intersectionality, a hybrid thematic and interpretive phenomenological analytic approach was used to identify sociostructural factors shaping housing insecurity. Results: Our findings demonstrate the various ways in which the COVID-19 pandemic shaped Black women IPV survivors' ability to obtain and sustain safe housing. We derived five themes to capture factors contributing to housing experiences: challenges with separate and unequal neighborhoods; pandemic-related economic inequalities; economic abuse limitations; and strategies to maintain housing. Conclusions: Obtaining and maintaining safe housing during the COVID-19 pandemic was difficult for Black women IPV survivors who were also navigating racism, sexism, and socioeconomic position. Interventions are needed to reduce the impact of these intersecting systems of oppression and power to facilitate the resources necessary for Black women IPV survivors to identify safe housing.
MeSH term(s)	Humans ; Female ; Pandemics ; Housing Instability ; COVID-19/epidemiology ; Intersectional Framework ; Intimate Partner Violence ; Housing
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-17965-5
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Article ; Online: The development of the W A + E R (water immersion agency plus expectations and relief) scale.

Cooper, Megan / Pollock, Danielle / Warland, Jane / McLinton, Sarven

Midwifery

2022 Volume 109, Page(s) 103298

Abstract: Background: Some research attention has been paid to women's experiences of water immersion for labour and/or birth. Development of a psychometric scale specific to water immersion may provide further insight into women's experiences.: Aim: The ... ...

Abstract	Background: Some research attention has been paid to women's experiences of water immersion for labour and/or birth. Development of a psychometric scale specific to water immersion may provide further insight into women's experiences. Aim: The objective of this paper is to share the development, and preliminary psychometric evaluation, of the Water immersion Agency plus Expectations and Relief (WA+ER) scale for assessing women's experiences of using water for labour and/or birth. Methods: Items for the WA+ER scale were informed by a thorough literature review, and review by midwifery experts. An online survey was conducted, and 17 items were rated on a 7-point Likert scale (from entirely disagree to entirely agree) by 740 women who had used water immersion for labour and/or birth. Results: An initial exploratory factor analysis was conducted to determine the initial structure of the scale. A confirmatory factor analysis showed that the initial 17-items were not a 'good fit' but with further statistical exploration, a good fit was achieved with 11-items. Results identified three factors with good reliability: Sense of Agency (4 items; α = 0.87;), Expectations (3 items; α = 0.83) and Relief (4 items α = 0.82). A confirmatory factor analysis confirmed good model fit (CFI=0.93; GFI=0.91; AGFI=0.85; TLI=0.90). Conclusions: The WA+ER scale is a statistically and theoretically sound tool for measuring women's experiences of labouring and/or birthing in water. Additional testing is required to further assess the validity and reliability of the scale and to determine the appropriateness of its use in other populations.
MeSH term(s)	Female ; Humans ; Immersion ; Male ; Motivation ; Parturition ; Pregnancy ; Reproducibility of Results ; Surveys and Questionnaires ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2022-03-04
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1036567-9
ISSN	1532-3099 ; 0266-6138
ISSN (online)	1532-3099
ISSN	0266-6138
DOI	10.1016/j.midw.2022.103298
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Zs.A 2662: Show issues

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Article ; Online: Mortality after non-surgically treated acute type A aortic dissection is higher than previously reported.

Teurneau-Hermansson, Karl / Ede, Jacob / Larsson, Mårten / Linton, Gustaf / von Rosen, David / Sjögren, Johan / Wierup, Per / Nozohoor, Shahab / Zindovic, Igor

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2024 Volume 65, Issue 2

Abstract: Objectives: It has been commonly accepted that untreated acute type A aortic dissection (ATAAD) results in an hourly mortality rate of 1-2% during the 1st 24 h after symptom onset. The data to support this statement rely solely on patients who have been ...

Abstract	Objectives: It has been commonly accepted that untreated acute type A aortic dissection (ATAAD) results in an hourly mortality rate of 1-2% during the 1st 24 h after symptom onset. The data to support this statement rely solely on patients who have been denied surgical treatment after reaching surgical centres. The objective was to perform a total review of non-surgically treated (NST) ATAAD and provide contemporary mortality data. Methods: This was a regional, retrospective, observational study. All patients receiving one of the following diagnoses: International Classification of Diseases (ICD)-9 4410, 4411, 4415, 4416 or ICD-10 I710, I711, I715, I718 in an area of 1.9 million inhabitants in Southern Sweden during a period of 23 years (January 1998 to November 2021) were retrospectively screened. The search was conducted using all available medical registries so that every patient diagnosed with ATAAD in our region was identified. The charts and imaging of each screened patient were subsequently reviewed to confirm or discard the diagnosis of ATAAD. Results: Screening identified 2325 patients, of whom 184 NST ATAAD patients were included. The mortality of NST ATAAD was 47.3 ± 4.4%, 55.0 ± 4.4%, 76.7 ± 3.7% and 83.9 ± 4.3% at 24 h, 48 h, 14 days and 1 year, respectively. The hourly mortality rate during the 1st 24 h after symptom onset was 2.6%. Conclusions: This study observed higher mortality than has previously been reported. It emphasizes the need for timely diagnosis, swift management and emergent surgical treatment for patients suffering an acute type A aortic dissection.
MeSH term(s)	Humans ; Retrospective Studies ; Aortic Dissection/surgery ; Treatment Outcome ; Time Factors ; Registries ; Acute Disease ; Aortic Aneurysm, Thoracic/diagnosis ; Aortic Aneurysm, Thoracic/surgery
Language	English
Publishing date	2024-02-02
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezae039
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Zs.A 2303: Show issues

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Article ; Online: The FoxOs are in the ApoM house.

Linton, MacRae F / Yancey, Patricia G / Leuthner, Zoe M / Brown, Jonathan D

The Journal of clinical investigation

2022 Volume 132, Issue 7

Abstract: ... with insulin resistance contained lower levels of S1P. Apolipoprotein M (ApoM), a protein constituent of HDL that binds ...

Abstract	The prevalence of metabolic syndrome continues to increase globally and heightens the risk for cardiovascular disease (CVD). Insulin resistance is a core pathophysiologic mechanism that causes abnormal carbohydrate metabolism and atherogenic changes in circulating lipoprotein quantity and function. In particular, dysfunctional HDL is postulated to contribute to CVD risk in part via loss of HDL-associated sphingosine-1-phosphate (S1P). In this issue of the JCI, Izquierdo et al. demonstrate that HDL from humans with insulin resistance contained lower levels of S1P. Apolipoprotein M (ApoM), a protein constituent of HDL that binds S1P and controls bioavailability was decreased in insulin-resistant db/db mice. Gain- and loss-of-function mouse models implicated the forkhead box O transcription factors (FoxO1,3,4) in the regulation of both ApoM and HDL-associated S1P. These data have important implications for potential FoxO-based therapies designed to treat lipid and carbohydrate abnormalities associated with human metabolic disease and CVD.
MeSH term(s)	Animals ; Apolipoproteins M/metabolism ; Forkhead Transcription Factors/genetics ; Insulin Resistance ; Lipoproteins, HDL/metabolism ; Metabolic Diseases ; Mice
Chemical Substances	ApoM protein, mouse ; Apolipoproteins M ; Forkhead Transcription Factors ; Lipoproteins, HDL
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI158471
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Article: ON THE GRANTING OF THE M.D. DEGREE.

Linton, E

Science (New York, N.Y.)

1905 Volume 22, Issue 574, Page(s) 875–876

Language	English
Publishing date	1905-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.22.574.875
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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Article ; Online: Synthetic protein circuits for programmable control of mammalian cell death.

Xia, Shiyu / Lu, Andrew C / Tobin, Victoria / Luo, Kaiwen / Moeller, Lukas / Shon, D Judy / Du, Rongrong / Linton, James M / Sui, Margaret / Horns, Felix / Elowitz, Michael B

Cell

2024

Abstract: Natural cell death pathways such as apoptosis and pyroptosis play dual roles: they eliminate harmful cells and modulate the immune system by dampening or stimulating inflammation. Synthetic protein circuits capable of triggering specific death programs ... ...

Abstract	Natural cell death pathways such as apoptosis and pyroptosis play dual roles: they eliminate harmful cells and modulate the immune system by dampening or stimulating inflammation. Synthetic protein circuits capable of triggering specific death programs in target cells could similarly remove harmful cells while appropriately modulating immune responses. However, cells actively influence their death modes in response to natural signals, making it challenging to control death modes. Here, we introduce naturally inspired "synpoptosis" circuits that proteolytically regulate engineered executioner proteins and mammalian cell death. These circuits direct cell death modes, respond to combinations of protease inputs, and selectively eliminate target cells. Furthermore, synpoptosis circuits can be transmitted intercellularly, offering a foundation for engineering synthetic killer cells that induce desired death programs in target cells without self-destruction. Together, these results lay the groundwork for programmable control of mammalian cell death.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2024.03.031
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article ; Online: Intercostal Nerve Cryoablation Reduces Opioid Use and Length of Stay Without Increasing Adverse Events: A Retrospective Cohort Study of 5442 Patients Undergoing Surgical Correction of Pectus Excavatum.

Linton, Samuel C / Tian, Yao / Zeineddin, Suhail / Alayleh, Amin / De Boer, Chris / Goldstein, Seth D / Ghomrawi, Hassan M K / Abdullah, Fizan

Annals of surgery

2023 Volume 279, Issue 4, Page(s) 699–704

Abstract: Objective: To examine differences in opioid use, length of stay, and adverse events after minimally invasive correction of pectus excavatum (MIRPE) with and without intercostal nerve cryoablation.: Background: Small studies show that intraoperative ... ...

Abstract	Objective: To examine differences in opioid use, length of stay, and adverse events after minimally invasive correction of pectus excavatum (MIRPE) with and without intercostal nerve cryoablation. Background: Small studies show that intraoperative intercostal nerve cryoablation provides effective analgesia with no large-scale evaluations of this technique. Methods: The pediatric health information system database was used to perform a retrospective cohort study comparing patients undergoing MIRPE at children's hospitals before and after the initiation of cryoablation. The association of cryoablation use with inpatient opioid use was determined using quantile regression with robust standard errors. Difference in risk-adjusted length of stay between the cohorts was estimated using negative binomial regression. Odds of adverse events between the two cohorts were compared using logistic regression with a generalized estimating equation. Results: A total of 5442 patients underwent MIRPE at 44 children's hospitals between 2016 and 2022 with 1592 patients treated after cryoablation was introduced at their hospital. Cryoablation use was associated with a median decrease of 80.8 (95% CI: 68.6-93.0) total oral morphine equivalents as well as a decrease in estimated median length of stay from 3.5 [3.2-3.9] days to 2.5 [2.2-2.9] days ( P value: 0.016). Cryoablation use was not significantly associated with an increase in any studied adverse events. Conclusions: Introduction of cryoablation for perioperative analgesia was associated with decreased inpatient opioid use and length of stay in a large sample with no change in adverse events. This novel modality for perioperative analgesia offers a promising alternative to traditional pain management in thoracic surgery.
MeSH term(s)	Humans ; Child ; Cryosurgery/adverse effects ; Cryosurgery/methods ; Analgesics, Opioid/therapeutic use ; Length of Stay ; Retrospective Studies ; Pain, Postoperative/therapy ; Funnel Chest/surgery ; Intercostal Nerves/surgery ; Opioid-Related Disorders/etiology ; Minimally Invasive Surgical Procedures/methods
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000006113
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Article ; Online: Increase in Heat Resistance of Listeria monocytogenes Scott A by Sublethal Heat Shock.

Linton, R H / Pierson, M D / Bishop, J R

Journal of food protection

2019 Volume 53, Issue 11, Page(s) 924–927

Abstract: ... than nonheat shocked cells at 50 to 65°C. The optimal heat shock condition was 48°C for 20 min where D-values at 55°C ... to determine a z-value. Although D-values notably increased due to heat shocking, z-values remained constant ... Heat shocking at 48°C significantly increased D-value ratios for cells enumerated on nonselective vs ...

Abstract	Log phase cells of Listeria monocytogenes Scott A were heat shocked in trypticase soy + 0.6% yeast extract broth at 40, 44, and 48°C for 3, 10, and 20 min, followed by heating at 55°C for 50 min in order to determine an optimum heat shock response. Most heat shocking temperatures significantly increased thermal resistance (p ≤ 0.05). Increasing heat shock temperature and time allowed the organism to survive much longer than nonheat shocked cells at 50 to 65°C. The optimal heat shock condition was 48°C for 20 min where D-values at 55°C increased 2.3-fold in nonselective agar and 1.6-fold in selective agar. However, cells heat shocked at 48°C for 10 min gave more consistent results; these cells were heat processed at 50, 55, 60, and 65°C to determine a z-value. Although D-values notably increased due to heat shocking, z-values remained constant. Heat shocking at 48°C significantly increased D-value ratios for cells enumerated on nonselective vs. selective media. Heat shocking conditions may be created in pasteurization or minimal thermal processing of food allowing increased heat resistance of pathogenic and spoilage microorganisms.
Language	English
Publishing date	2019-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X-53.11.924
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