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  1. Article ; Online: Cultural Survival in B. F. Skinner: Possibilities for Conceptual Refinement.

    Brunkow, Fernanda / Dittrich, Alexandre

    Behavior and social issues

    2021  Volume 30, Issue 1, Page(s) 774–786

    Abstract: The concept of cultural survival is fundamental when describing the selection processes involved in cultural evolution. However, its application by Skinner was inconsistent. As a result, distinct and sometimes contradictory interpretations regarding what ...

    Abstract The concept of cultural survival is fundamental when describing the selection processes involved in cultural evolution. However, its application by Skinner was inconsistent. As a result, distinct and sometimes contradictory interpretations regarding what it means for a culture to survive occasionally emerge in the behavior-analytic literature. In this article, we aim to identify the stimuli that prompted Skinner to emit the verbal response "cultural survival." Our analysis suggests two problems: (a) the concept of cultural survival is used by Skinner to identify both the effects of cultural practices on the physical survival ofmembers of the culture and their effects on the survival of specific sets of social reinforcement contingencies via operant reinforcement, and (b) the concept is applied to two different phenomena-namely, first, the relation between the complete range of social reinforcement contingencies maintained by the human species and the physical survival of humankind, and, second, the relation between specific sets of these contingencies and the physical survival of particular groups. Finally, we argue for the importance of the precise identification of the groups and social contingencies that compose any "culture" submitted to a behavioral analysis.
    Supplementary information: The online version contains supplementary material available at 10.1007/s42822-020-00044-w.
    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2065362-1
    ISSN 2376-6786 ; 1064-9506
    ISSN (online) 2376-6786
    ISSN 1064-9506
    DOI 10.1007/s42822-020-00044-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites.

    Uitterlinden, Andre G / Arp, Pascal P / Paeper, Bryan W / Charmley, Patrick / Proll, Sean / Rivadeneira, Fernando / Fang, Yue / van Meurs, Joyce B J / Britschgi, Theresa B / Latham, John A / Schatzman, Randall C / Pols, Huibert A P / Brunkow, Mary E

    American journal of human genetics

    2004  Volume 75, Issue 6, Page(s) 1032–1045

    Abstract: Osteoporosis has a strong genetic component, but the genes involved are poorly defined. We studied whether the sclerosteosis/van Buchem disease gene (SOST) is an osteoporosis-risk gene by examining its association with bone-mineral density (BMD). ... ...

    Abstract Osteoporosis has a strong genetic component, but the genes involved are poorly defined. We studied whether the sclerosteosis/van Buchem disease gene (SOST) is an osteoporosis-risk gene by examining its association with bone-mineral density (BMD). Mutations in SOST result in sclerosteosis, and alterations in the SOST gene expression may be causal in the closely related van Buchem disease. We used a set of eight polymorphisms from the SOST gene region to genotype 1,939 elderly men and women from a large population-based prospective-cohort study of Dutch whites. A 3-bp insertion (f=0.38) in the presumed SOST promoter region (SRP3) was associated with decreased BMD in women at the femoral neck (FN) (P=.05) and lumbar spine (LS) (P=.01), with evidence of an allele-dose effect in the oldest age group (P=.006). Similarly, a G variant (f=0.40) in the van Buchem deletion region (SRP9) was associated with increased BMD in men at the FN (P=.007) and LS (P=.02). In both cases, differences between extreme genotypes reached 0.2 SD. We observed no genotype effects on fracture risk, for the 234 osteoporotic fractures validated during 8.2 years of follow-up and for the 146 vertebral prevalent fractures analyzed. We did not find association between any of several frequent haplotypes across the SOST gene region and BMD. We did find evidence of additive effects of SRP3 with the COLIA1 Sp1 polymorphism but not with haplotypes of 3' polymorphisms in the vitamin-D receptor gene. The SOST-COLIA1 additive effect increased with age and reached 0.5 SD difference in BMD at LS in the oldest age group (P=.02). The molecular mechanism whereby these moderate SOST genotype effects are mediated remains to be elucidated, but it is likely to involve differences in regulation of SOST gene expression.
    MeSH term(s) Adaptor Proteins, Signal Transducing ; Aged ; Analysis of Variance ; Bone Density/genetics ; Bone Morphogenetic Proteins/genetics ; Bone Morphogenetic Proteins/metabolism ; Cohort Studies ; DNA Primers ; Female ; Gene Frequency ; Genetic Markers/genetics ; Genotype ; Haplotypes/genetics ; Humans ; Linkage Disequilibrium ; Male ; Middle Aged ; Netherlands ; Odds Ratio ; Osteoporosis/genetics ; Polymorphism, Genetic ; Promoter Regions, Genetic/genetics ; Regression Analysis ; Sequence Analysis, DNA ; Spinal Injuries/genetics ; Spinal Injuries/pathology ; White People
    Chemical Substances Adaptor Proteins, Signal Transducing ; Bone Morphogenetic Proteins ; DNA Primers ; Genetic Markers ; SOST protein, human
    Language English
    Publishing date 2004-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
    DOI 10.1086/426458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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