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Article: COVID-19 focused series: diagnosis and forecast of COVID-19.

Xu, Tao / Cheng, Jing / Yang, Zifeng / Guan, Wenda / Zeng, Zhiqi

2023 Volume 15, Issue 3, Page(s) 1503–1505

Language	English
Publishing date	2023-03-27
Publishing country	China
Document type	Editorial
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-141
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Article ; Online: Suboptimal peak inspiratory flow rate: a noticeable risk factor for inhaler concordance in patients with chronic airway diseases.

Meng, Weiwei / Xiong, Ruoyan / Zhao, Zhiqi / Zeng, Huihui / Chen, Yan

BMJ open respiratory research

2024 Volume 11, Issue 1

Abstract: Background: Inhaler concordance and the peak inspiratory flow rate (PIFR) are important determinants of treatment effects in patients with chronic airway diseases. Adequate PIFR is required for driving aerosol medication into the lower respiratory tract. ...

Abstract	Background: Inhaler concordance and the peak inspiratory flow rate (PIFR) are important determinants of treatment effects in patients with chronic airway diseases. Adequate PIFR is required for driving aerosol medication into the lower respiratory tract. However, the relationship between them has not been discussed previously. This study aimed to describe the characteristics of inhaler concordance and PIFR in Chinese patients with chronic airway diseases and discuss the associated variables and the relationship between them. Methods: In this single-centre, observational study, a total of 680 patients with chronic airway diseases were enrolled from July 2021 to April 2023. We collected data on the socio-demographic and clinical variables of inhaler concordance using the test of adherence to inhalers (TAI) and PIFR. Multivariate logistic regression was conducted to examine variables related to inhaler concordance and PIFR. Results: A total of 49.4% of patients had low concordance. Patients with chronic obstructive pulmonary disease (COPD) were more concordant than patients with asthma (mean TAI score: 43.60 vs 41.20; p<0.01), while there was no difference in concordance between the asthma-COPD overlap group and the asthma or COPD group. Suboptimal PIFR (adjusted OR, 1.61; 95% CI 1.04 to 2.51) increased the risk of poor concordance among all patients, while triple therapy (adjusted OR, 0.60; 95% CI 0.35 to 0.86) reduced the risk. A total of 54.9% of patients had suboptimal PIFR. Older age, lower educational level, use of dry powder inhalers and lower forced expiratory volume in 1 s % predicted were significantly correlated with insufficient PIFR. Subgroup analysis revealed a greater proportion of patients with insufficient PIFR during exacerbation than during the stable phase (61.7% vs 43.5%, p<0.001). Conclusion: Inhaler concordance was low, and suboptimal PIFR was a risk factor for poor concordance among Chinese patients with chronic airway diseases. In addition, current inhalation devices may not be suitable, and PIFR reassessment should be considered for patients with COPD during exacerbation. Trial registration number: The study was registered in chictr.org.cn (ChiCTR2100052527) on 31 October 2021.
MeSH term(s)	Humans ; Respiratory Aerosols and Droplets ; Pulmonary Disease, Chronic Obstructive/therapy ; Asthma/drug therapy ; Dry Powder Inhalers ; Risk Factors
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2023-001981
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Article: Influence of Carbonation on the Properties of Steel Slag-Magnesium Silicate Hydrate (MSH) Cement.

Zeng, Tian / Hu, Zhiqi / Huang, Chengran / Chang, Jun

Materials (Basel, Switzerland)

2023 Volume 16, Issue 20

Abstract: Magnesium silicate hydrate (MSH) cement has the advantages of low energy consumption, minimal environmental pollution, carbon negativity, and reduced alkalinity, but excessive drying shrinkage inhibits its application. This paper analyzed the influence ... ...

Abstract	Magnesium silicate hydrate (MSH) cement has the advantages of low energy consumption, minimal environmental pollution, carbon negativity, and reduced alkalinity, but excessive drying shrinkage inhibits its application. This paper analyzed the influence of steel slag (SS) dosage, carbon dioxide partial pressure, and carbonation curing time on the compressive strength, shrinkage rate, and phase composition of MSH cement. Various analysis methods, including X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and mercury intrusion porosimetry (MIP), were used to study the hydration products and microstructure. The results showed that under normal curing conditions, MSH cement mixed with different steel slag contents experienced a decline in strength at all ages. However, the greater the amount of SS incorporated, the lesser the degree of drying shrinkage. The compressive strength of all groups was improved, and the drying shrinkage was reduced by carbonation treatment. The samples with 5%, 10%, and 15% SS content exhibited shrinkage rates of 2.19%, 1.74%, and 1.60%, respectively, after 28 days of curing. The reason was that after carbonation treatment, hydrated magnesium carbonates (HMCs) were generated in the SS-MSH cement, and a Ca-Mg-C amorphous substance formed by hydration and carbonation of C
Language	English
Publishing date	2023-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16206737
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Article: Epidemiology dynamic of the common respiratory virus in winter-spring, 2018-2023 in Guangdong province, China.

Liang, Jingyi / Wang, Yangqianxi / Liu, Yong / Li, Qianying / Zeng, Zhiqi / Yang, Zifeng / Hon, Chitin

Journal of thoracic disease

2023 Volume 15, Issue 12, Page(s) 7165–7167

Language	English
Publishing date	2023-12-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-833
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Article ; Online: Integrated analysis of SKA1-related ceRNA network and SKA1 immunoassays in HCC: A study based on bioinformatic.

Zeng, Fanjing / Xu, Zhiqi / Zhuang, Peng

Medicine

2023 Volume 102, Issue 38, Page(s) e34826

Abstract: Hepatocellular carcinoma (HCC) poses a global health challenge. Effective biomarkers are required for early diagnosis to improve survival rates of patients with HCC. Spindle and kinetochore-associated complex subunits 1 (SKA1) is essential for proper ... ...

Abstract	Hepatocellular carcinoma (HCC) poses a global health challenge. Effective biomarkers are required for early diagnosis to improve survival rates of patients with HCC. Spindle and kinetochore-associated complex subunits 1 (SKA1) is essential for proper chromosome segregation in the mitotic cell cycle. Previous studies have shown that overexpression of SKA1 is associated with a poor prognosis in various cancers. The expression, prognostic value, and clinical functions of SKA1 in HCC were evaluated with several bioinformatics web portals. Additionally, we identified target long non-coding RNAs (lncRNAs) and microRNAs by analyzing messenger RNA (mRNA)-miRNA and miRNA-lncRNA interaction data and elucidated the potential competing endogenous RNA (ceRNA) mechanism associated with SKA1. High SKA1 expression was associated with poor prognosis in patients with HCC. Furthermore, multivariate Cox regression analysis revealed that SKA1 expression was an independent prognostic factor for HCC. GO and KEGG analyses showed that SKA1 is related to the cell cycle checkpoints, DNA replication and repair, Rho GTPases signaling, mitotic prometaphase, and kinesins. Gene set enrichment analysis revealed that high levels of SKA1 are associated with cancer-promoting pathways. DNA methylation of SKA1 in HCC tissues was lower than that in normal tissues. Ultimately, the following 9 potential ceRNA-based pathways targeting SKA1 were identified: lncRNA: AC026401.3, Small Nucleolar RNA Host Gene 3 (SNHG3), and AC124798.1-miR-139-5p-SKA1; lncRNA: AC26356.1, Small Nucleolar RNA Host Gene 16 (SNHG16), and FGD5 Antisense RNA 1-miR-22-3p-SKA1; lncRNA: Cytoskeleton Regulator RNA (CYTOR), MIR4435-2 Host Gene, and differentiation antagonizing non-protein coding RNA-miR-125b-5p-SKA1. SKA1 expression levels significantly correlated with immune cell infiltration and immune checkpoint genes in the HCC tissues. SKA1 is a potential prognostic biomarker for HCC. This study provides a meaningful direction for research on SKA1-related mechanisms, which will be beneficial for future research on HCC-related molecular biological therapies and targeted immunotherapy.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/genetics ; RNA, Long Noncoding/genetics ; RNA, Small Nucleolar ; Liver Neoplasms/genetics ; MicroRNAs/genetics ; Computational Biology ; Immunoassay ; Chromosomal Proteins, Non-Histone/genetics
Chemical Substances	RNA, Long Noncoding ; RNA, Small Nucleolar ; MicroRNAs ; SKA1 protein, human ; Chromosomal Proteins, Non-Histone ; MIRN139 microRNA, human
Language	English
Publishing date	2023-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034826
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Article ; Online: Pre-oxidized and composite strategy greatly boosts performance of polyacrylonitrile/LLZO nanofibers for lithium-metal batteries.

Lu, Zhiqi / Li, Ji / An, Jiaqi / Zeng, Xiaoyue / Lan, Jinle / Yu, Yunhua / Yang, Xiaoping

Journal of colloid and interface science

2024 Volume 664, Page(s) 882–892

Abstract: The active cyano-group in polyacrylonitrile has severe passivation of lithium anode under larger current density, which restricts the wide application of polyacrylonitrile(PAN) in lithium metal batteries. Herein, in order to address the excessive ... ...

Abstract	The active cyano-group in polyacrylonitrile has severe passivation of lithium anode under larger current density, which restricts the wide application of polyacrylonitrile(PAN) in lithium metal batteries. Herein, in order to address the excessive passivation of lithium metal by PAN, inspired by the pre-oxidation of carbon fibers, PAN was pre-oxidized at 230 °C, which transformed part of the cyano group into a more chemically stable cyclized structure. The electrochemical and mechanical properties of the composite solid electrolyte were effectively improved by introducing the fast ionic conductor Li
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.03.058
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Article ; Online: A NiMOF integrated with conductive materials for efficient bifunctional electrocatalysis of urea oxidation and oxygen evolution reactions.

Xie, Xiaopei / Xu, Liqiang / Zeng, Qingsheng / Zhang, Zhaona / Xu, Zhiqi / Yin, Chuanxia / Wang, Xinxing

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 6, Page(s) 2565–2574

Abstract: The development of urea oxidation reaction (UOR) and oxygen evolution reaction (OER) bifunctional electrocatalysts has dual significance in promoting hydrogen energy production and urea-rich wastewater treatment. Herein, a carboxylated multi-walled ... ...

Abstract	The development of urea oxidation reaction (UOR) and oxygen evolution reaction (OER) bifunctional electrocatalysts has dual significance in promoting hydrogen energy production and urea-rich wastewater treatment. Herein, a carboxylated multi-walled carbon nanotube (MWCNT-COOH)-ferrocene carboxylic acid (Fc-COOH) modulated NiMOF hybrid material (MWCNT-NiMOF(Fc)) has been synthesized for dual electrocatalysis of the UOR and OER. The material characterization results indicated that MWCNT-COOH and Fc-COOH were integrated into the framework structure of the NiMOF. The direct interaction between the NiMOF and MWCNT/Fc facilitated electron transfer in the hybrid material and led to lattice strain, which improved the charge transfer kinetics, promoted the exposure of more unsaturated Ni sites, and increased the electrochemically active surface area. These factors together enhanced the electrocatalytic activity of MWCNT-NiMOF(Fc) towards the UOR and OER. Using a glassy carbon electrode as the substrate, MWCNT-NiMOF(Fc) exhibited low potential requirements, low Tafel slopes, and high stability. In overall urea and water splitting electrolysis cells, the excellent UOR and OER dual functional catalytic ability and enormous practical application potential of the MWCNT-NiMOF(Fc) modified foam nickel electrode were further demonstrated. On the basis of the above research, the influence of a KOH environment on urea electrolysis was further studied, and the urea electrolysis products were analyzed, promoting a more comprehensive understanding of the catalytic performance of MWCNT-NiMOF(Fc) for urea oxidation. This study provides a new approach for developing high-performance NiMOF-based electrocatalysts for challenging bifunctional UOR/OER applications, and has potential application value in hydrogen production from urea-containing wastewater electrolysis.
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt03456a
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Article: Reliability and validity test and application of the Chinese version of the Feeling of Satisfaction with Inhaler.

Meng, Weiwei / Zhao, Zhiqi / Xiong, Ruoyan / Zhong, Yanjun / Zeng, Huihui / Chen, Yan

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2024 Volume 48, Issue 12, Page(s) 1854–1864

Abstract: Objectives: Inhaler satisfaction is an important factor affecting inhaler adherence and the efficacy of inhalers in chronic airway diseases. Using a scientific and effective method to assess patients' satisfaction with inhalers is of great significance ... ...

Title translation	中文版吸入药物满意度量表的信效度检验及应用.
Abstract	Objectives: Inhaler satisfaction is an important factor affecting inhaler adherence and the efficacy of inhalers in chronic airway diseases. Using a scientific and effective method to assess patients' satisfaction with inhalers is of great significance for improving clinical outcomes. The Feeling of Satisfaction with Inhaler-10 (FSI-10) is specifically designed to assess patients' inhaler satisfaction in chronic airway diseases, but the application research on this scale is not available in China. This study aims to evaluate the reliability and validity of the Chinese version of FSI-10, describe the current status of inhaler satisfaction and discuss the associated variables in Chinese patients with chronic airway disease. Methods: Based on the English version of FSI-10, items of the Chinese version of FSI-10 were determined after forward⁃backward translation and cultural adaption. Totally, 322 patients with chronic obstructive pulmonary disease (COPD) and asthma were enrolled from the Second Xiangya Hospital of Central South University from June to October 2022. We collected associated clinical variables and inhaler satisfaction using the Chinese version of FSI-10. The content validity of the scale was expressed by content validity index (CVI) and the construct validity was analyzed by exploratory factor analysis (EFA). The reliability of the scale was expressed by Cronbach's α coefficient, the split-half reliability and test-retest reliability. A multivariate logistic regression was conducted to examine variables related to inhaler satisfaction. Results: The reliability and validity analysis showed that the CVI was 0.983. One factor was extracted from the Chinese version of FSI-10 and the cumulative variance contribution rate was 73.114%. The Cronbach's α of the scale was 0.913, the Guttman's half-reliability coefficient was 0.905, and the test-retest reliability was 0.727 ( Conclusions: The Chinese version of FSI-10 has good reliability and validity in patients with COPD and asthma, which may be further promoted and applied in patients with chronic airway disease in China. Doctors should regularly evaluate the inhaler satisfaction of patients with chronic airway diseases, especially for those elder or with severe symptoms and a long course of illness.
MeSH term(s)	Humans ; Aged ; Reproducibility of Results ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Asthma/drug therapy ; Nebulizers and Vaporizers ; Personal Satisfaction
Language	Chinese
Publishing date	2024-03-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2168533-2
ISSN	1672-7347
ISSN	1672-7347
DOI	10.11817/j.issn.1672-7347.2023.230289
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Article ; Online: Interfacial construction of P25/Bi

Liu, Daohan / Zeng, Minli / Li, Zhen / Zhu, Zhiqi / Chen, Yu / Thummavichai, Kunyapat / Ola, Oluwafunmilola / Wang, Nannan / Zhu, Yanqiu

RSC advances

2023 Volume 13, Issue 13, Page(s) 8564–8576

Abstract: Photocatalysis provides an attractive approach to convert ... ...

Abstract	Photocatalysis provides an attractive approach to convert CO
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra00418j
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Article: The relationship between Parkinson's disease and gastrointestinal diseases.

Zeng, Jiaqi / Wang, Xinchan / Pan, Fei / Mao, Zhiqi

Frontiers in aging neuroscience

2022 Volume 14, Page(s) 955919

Abstract: An increasing number of studies have provided evidence for the hypothesis that the pathogenesis of Parkinson's disease (PD) may derive from the gut. Firstly, Lewy pathology can be induced in the enteric nervous system (ENS) and be transported to the ... ...

Abstract	An increasing number of studies have provided evidence for the hypothesis that the pathogenesis of Parkinson's disease (PD) may derive from the gut. Firstly, Lewy pathology can be induced in the enteric nervous system (ENS) and be transported to the central nervous system (CNS) via the vagal nerve. Secondly, the altered composition of gut microbiota causes an imbalance between beneficial and deleterious microbial metabolites which interacts with the increased gut permeability and the gut inflammation as well as the systemic inflammation. The activated inflammatory status then affects the CNS and promotes the pathology of PD. Given the above-mentioned findings, researchers start to pay attention to the connection between PD and gastrointestinal diseases including irritable bowel syndrome, inflammatory bowel disease (IBD), microscopic colitis (MC), gastrointestinal infections, gastrointestinal neoplasms, and colonic diverticular disease (CDD). This review focuses on the association between PD and gastrointestinal diseases as well as the pathogenesis of PD from the gut.
Language	English
Publishing date	2022-08-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2022.955919
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