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Article ; Online: Imp7 siRNA nanoparticles protect against mechanical ventilation-associated liver injury by inhibiting HMGB1 production and NETs formation.

Ding, Ning / Xiao, Hui / Zhen, Lixiao / Li, Huiqing / Zhang, Zengzhen / Ge, Junke

Biochimica et biophysica acta. Molecular basis of disease

2024 Volume 1870, Issue 4, Page(s) 167085

Abstract: Mechanical ventilation (MV) has the potential to induce extra-pulmonary organ damage by adversely affecting the lungs and promoting the secretion of inflammatory cytokines. High-mobility group box 1 protein (HMGB1) is a pro-inflammatory mediator in ... ...

Abstract	Mechanical ventilation (MV) has the potential to induce extra-pulmonary organ damage by adversely affecting the lungs and promoting the secretion of inflammatory cytokines. High-mobility group box 1 protein (HMGB1) is a pro-inflammatory mediator in ventilator-induced lung injury (VILI), but its effect on MV-associated liver injury and the mechanisms are poorly understood. In the present study, mice were subjected to high-volume MV (20 ml/kg) to induce VILI. MV-induced HMGB1 prompted neutrophil extracellular traps (NETs) formation and PANoptosis within the liver. Inhibiting NETs formation by DNase I or PAD4 inhibitor, or by HMGB1 neutralizing ameliorated the liver injury. HMGB1 activated neutrophils to form NETs through TLR4/MyD88/TRAF6 pathway. Importantly, Importin7 siRNA nanoparticles inhibited HMGB1 release and protected against MV-associated liver injury. These data provide evidence of MV-induced HMGB1 prompted NETs formation and PANoptosis in the liver via the TLR4/MyD88/TRAF6 pathway. HMGB1 is a potential therapeutic target for MV-associated liver injury.
MeSH term(s)	Mice ; Animals ; Extracellular Traps/metabolism ; Respiration, Artificial ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; RNA, Small Interfering/metabolism ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; TNF Receptor-Associated Factor 6/metabolism ; Liver/metabolism ; Ventilator-Induced Lung Injury/prevention & control ; Ventilator-Induced Lung Injury/drug therapy ; Ventilator-Induced Lung Injury/metabolism
Chemical Substances	HMGB1 Protein ; RNA, Small Interfering ; Toll-Like Receptor 4 ; Myeloid Differentiation Factor 88 ; TNF Receptor-Associated Factor 6
Language	English
Publishing date	2024-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2024.167085
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Article: Associations between obesity and hyperuricemia combing mendelian randomization with network pharmacology.

Panlu, Kailai / Zhou, Zizun / Huang, Lin / Ge, Lei / Wen, Chengping / Lv, Huiqing

Heliyon

2024 Volume 10, Issue 6, Page(s) e27074

Abstract: Objective: Obesity has become a global health issue and a risk factor for hyperuricemia. However, the associations between obesity and hyperuricemia are sometimes confounding. In the present study, we performed mendelian randomization (MR) analysis to ... ...

Abstract	Objective: Obesity has become a global health issue and a risk factor for hyperuricemia. However, the associations between obesity and hyperuricemia are sometimes confounding. In the present study, we performed mendelian randomization (MR) analysis to study their relationship and investigate the underlying mechanism by network pharmacology. Method: Body mass index (BMI) and uric acid related to single nucleotide polymorphism were selected as instrumental variables for MR analysis. Three robust analytical methods are used for bidirectional MR analysis such as inverse-variance weighting, weighted median and MR-Egger regression. Then, we further performed sensitivity analysis to evaluate the horizontal pleiotropy, heterogeneities, and stability. The targets related to obesity and hyperuricemia were collected, screened and further conducted for Kyoto Encyclopedia of Genes and Genomes pathway enrichment to explore the mechanism of obesity and hyperuricemia using network pharmacology. Results: The positive causality was indicated between BMI and hyperuricemia based on inverse variance-weighted analysis [odds ratio:1.23, 95% confidence interval: 1.11 to 1.30 for each standard deviation increase in BMI (4.6 kg/m Conclusions: Our MR analysis supported the causal association between obesity and hyperuricemia based on availablegenome-wide association analysis summary statistics. Obesity leads to hyperuricemia via
Language	English
Publishing date	2024-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27074
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Article ; Online: Long-term groundwater geochemical evolution induced by coal mining activities-a case study of floor confined limestone aquifer in Yaoqiao Coal Mine, Jiangsu, China.

Chen, Ge / Sun, Yajun / Xu, Zhimin / Yuan, Huiqing / Yi, Haizhe

Environmental science and pollution research international

2023 Volume 30, Issue 42, Page(s) 96252–96271

Abstract: Groundwater chemical composition can be changed due to long-term coal mining activities, but it was unclear how it was induced in Taiyuan Formation limestone (TFL) regarding the lack of relevant quantitative studies. The aim of this research is to ... ...

Abstract	Groundwater chemical composition can be changed due to long-term coal mining activities, but it was unclear how it was induced in Taiyuan Formation limestone (TFL) regarding the lack of relevant quantitative studies. The aim of this research is to improve understanding of the chemical composition changes in groundwater of L
MeSH term(s)	Coal Mining ; Environmental Monitoring/methods ; Water Pollutants, Chemical/analysis ; Groundwater/chemistry ; Calcium Carbonate/analysis ; Water/analysis ; China ; Coal/analysis
Chemical Substances	Water Pollutants, Chemical ; Calcium Carbonate (H0G9379FGK) ; Water (059QF0KO0R) ; Coal
Language	English
Publishing date	2023-08-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-29106-3
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Article ; Online: KAS-seq profiling captures transcription dynamics during oocyte maturation.

An, Huiqing / Wang, Xiuwan / Li, Jiashuo / Sun, Hongzheng / Zhu, Shuai / Ge, Juan / Han, Longsen / Shen, Bin / Wang, Qiang

Journal of ovarian research

2024 Volume 17, Issue 1, Page(s) 23

Abstract: In fully grown oocytes, the genome is considered to be globally transcriptionally silenced. However, this conclusion is primarily derived from the results obtained through immunofluorescence staining or inferred from the highly condensed state of ... ...

Abstract	In fully grown oocytes, the genome is considered to be globally transcriptionally silenced. However, this conclusion is primarily derived from the results obtained through immunofluorescence staining or inferred from the highly condensed state of chromosomes, lacking more direct evidence. Here, by using a kethoxal-assisted single-stranded DNA sequencing (KAS-seq) approach, we investigated the landscape of single-strand DNA (ssDNA) throughout the genome and provided a readout of the activity and dynamics of transcription during oocyte meiotic maturation. In non-surrounded nucleolus (NSN) oocytes, we observed a robust KAS-seq signal, indicating the high transcriptional activity. In surrounded nucleolus (SN) oocytes, the presence of ssDNA still persists although the KAS-seq signal was relatively weak, suggesting the presence of transcription. Accompanying with the meiotic resumption, the transcriptional activity gradually decreased, and global repression was detected in matured oocytes. Moreover, we preformed the integrative genomics analysis to dissect the transcriptional dynamics during mouse oocyte maturation. In sum, the present study delineates the detailed transcriptional activity during mammalian oocyte maturation.
MeSH term(s)	Animals ; Mice ; Oocytes ; Genomics ; Mammals
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2455679-8
ISSN	1757-2215 ; 1757-2215
ISSN (online)	1757-2215
ISSN	1757-2215
DOI	10.1186/s13048-023-01342-8
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Article ; Online: Electrical impedance tomography captures heterogeneous lung ventilation that may be associated with ineffective inspiratory efforts.

Pan, Qing / Jia, Mengzhe / Ge, Huiqing / Zhao, Zhanqi

Critical care (London, England)

2021 Volume 25, Issue 1, Page(s) 303

MeSH term(s)	Dielectric Spectroscopy/methods ; Dielectric Spectroscopy/statistics & numerical data ; Electric Impedance/therapeutic use ; Humans ; Inspiratory Capacity/physiology ; Lung/diagnostic imaging ; Lung/physiopathology ; Respiration, Artificial/instrumentation ; Respiration, Artificial/methods
Language	English
Publishing date	2021-08-21
Publishing country	England
Document type	Letter
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-021-03732-0
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Article ; Online: Systemic cytokines inhibition with Imp7 siRNA nanoparticle ameliorates gut injury in a mouse model of ventilator-induced lung injury.

Ding, Ning / Xiao, Hui / Zhen, Lixiao / Li, Huiqing / Zhang, Zengzhen / Ge, Junke / Jia, Haiyan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 165, Page(s) 115237

Abstract: Mechanical ventilation (MV) may negatively affect the lungs and cause the release of inflammatory mediators, resulting in extra-pulmonary organ dysfunction. Studies have revealed systemically elevated levels of proinflammatory cytokines in animal models ... ...

Abstract	Mechanical ventilation (MV) may negatively affect the lungs and cause the release of inflammatory mediators, resulting in extra-pulmonary organ dysfunction. Studies have revealed systemically elevated levels of proinflammatory cytokines in animal models of ventilator-induced lung injury (VILI); however, whether these cytokines have an effect on gut injury and the mechanisms involved remain unknown. In this study, VILI was generated in mice with high tidal volume mechanical ventilation (20 ml/kg). Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 concentrations in serum and gut measured by ELISA showed significant elevation in the VILI mice. Significant increases in gut injury and PANoptosis were observed in the VILI mice, which were positively correlated with the serum levels of TNF-α, IL-1β, and IL-6. The VILI mice displayed intestinal barrier defects, decreased expressions of occludin and zonula occludin-1 (ZO-1), and increased expression of claudin-2 and the activation of myosin light chain (MLC). Importantly, intratracheal administration of Imp7 siRNA nanoparticle effectively inhibited cytokines production and protected mice from VILI-induced gut injury. These data provide evidence of systemic cytokines contributing to gut injury following VILI and highlight the possibility of targeting cytokines inhibition via Imp7 siRNA nanoparticle as a potential therapeutic intervention for alleviating gut injury following VILI.
MeSH term(s)	Mice ; Animals ; Cytokines/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6/metabolism ; RNA, Small Interfering/metabolism ; Occludin/metabolism ; Lung/pathology ; Ventilator-Induced Lung Injury/drug therapy ; Ventilator-Induced Lung Injury/pathology ; Mice, Inbred C57BL
Chemical Substances	Cytokines ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; RNA, Small Interfering ; Occludin
Language	English
Publishing date	2023-07-27
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115237
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Article ; Online: Assessment of respiratory system compliance under pressure control ventilation without an inspiratory pause maneuver.

Pan, Qing / Pan, Jie / Zhang, Zhongheng / Fang, Luping / Ge, Huiqing

Physiological measurement

2021 Volume 42, Issue 8

Abstract: ... ...

Abstract	Objective
MeSH term(s)	Humans ; Respiration, Artificial ; Respiratory System ; Ventilators, Mechanical
Language	English
Publishing date	2021-08-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1149545-5
ISSN	1361-6579 ; 0967-3334
ISSN (online)	1361-6579
ISSN	0967-3334
DOI	10.1088/1361-6579/ac1d3b
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Article ; Online: Characterizing Post-Fire Forest Structure Recovery in the Great Xing’an Mountain Using GEDI and Time Series Landsat Data

Simei Lin / Huiqing Zhang / Shangbo Liu / Ge Gao / Linyuan Li / Huaguo Huang

Remote Sensing, Vol 15, Iss 3107, p

2023 Volume 3107

Abstract: Understanding post-fire forest recovery is critical to the study of forest carbon dynamics. Many previous studies have used multispectral imagery to estimate post-fire recovery, yet post-fire forest structural development has rarely been evaluated in the ...

Abstract	Understanding post-fire forest recovery is critical to the study of forest carbon dynamics. Many previous studies have used multispectral imagery to estimate post-fire recovery, yet post-fire forest structural development has rarely been evaluated in the Great Xing’an Mountain. In this study, we extracted the historical fire events from 1987 to 2019 based on a classification of Landsat imagery and assessed post-fire forest structure for these burned patches using Global Ecosystem Dynamics Investigation (GEDI)-derived metrics from 2019 to 2021. Two drivers were assessed for the influence on post-fire structure recovery, these being pre-fire canopy cover (i.e., dense forest and open forest) and burn severity levels (i.e., low, moderate, and high). We used these burnt patches to establish a 25-year chronosequence of forest structural succession by a space-for-time substitution method. Our result showed that the structural indices suggested delayed recovery following the fire, indicating a successional process from the decomposition of residual structures to the regeneration of new tree species in the post-fire forest. Across the past 25-years, the dense forest tends toward greater recovery than open forest, and the recovery rate was faster for low severity, followed by moderate severity and high severity. Specifically, in the recovery trajectory, the recovery indices were 21.7% and 17.4% for dense forest and open forest, and were 27.1%, 25.8%, and 25.4% for low, moderate, and high burn severity, respectively. Additionally, a different response to the fire was found in the canopy structure and height structure since total canopy cover (TCC) and plant area index (PAI) recovered faster than relative height (i.e., RH75 and RH95). Our results provide valuable information on forest structural restoration status, that can be used to support the formulation of post-fire forest management strategies in Great Xing’an Mountain.
Keywords	GEDI metrics ; time-series Landsat data ; post-fire structure recovery ; burn severity ; pre-fire canopy cover ; Science ; Q
Subject code	550
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Aerosol delivery via invasive ventilation: a narrative review.

Lin, Hui-Ling / Fink, James B / Ge, Huiqing

Annals of translational medicine

2021 Volume 9, Issue 7, Page(s) 588

Abstract: In comparison with spontaneously breathing non-intubated subjects, intubated, mechanically ventilated patients encounter various challenges, barriers, and opportunities in receiving medical aerosols. Since the introduction of mechanical ventilation as a ... ...

Abstract	In comparison with spontaneously breathing non-intubated subjects, intubated, mechanically ventilated patients encounter various challenges, barriers, and opportunities in receiving medical aerosols. Since the introduction of mechanical ventilation as a part of modern critical care medicine during the middle of the last century, aerosolized drug delivery by jet nebulizers has become a common practice. However, early evidence suggested that aerosol generators differed in their efficacies, and the introduction of newer aerosol technology (metered dose inhalers, ultrasonic nebulizer, vibrating mesh nebulizers, and soft moist inhaler) into the ventilator circuit opened up the possibility of optimizing inhaled aerosol delivery during mechanical ventilation that could meet or exceed the delivery of the same aerosols in spontaneously breathing patients. This narrative review will catalogue the primary variables associated with this process and provide evidence to guide optimal aerosol delivery and dosing during mechanical ventilation. While gaps exist in relation to the appropriate aerosol drug dose, discrepancies in practice, and cost-effectiveness of the administered aerosol drugs, we also present areas for future research and practice. Clinical practice should expand to incorporate these techniques to improve the consistency of drug delivery and provide safer and more effective care for patients.
Language	English
Publishing date	2021-04-27
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-20-5665
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Article ; Online: Estimated cardiorespiratory fitness and incident risk of cardiovascular disease in China.

Liu, Yuanjiao / Zhu, Jinghan / Guo, Ziye / Yu, Jiazhou / Zhang, Xuhui / Ge, Huiqing / Zhu, Yimin

BMC public health

2023 Volume 23, Issue 1, Page(s) 2338

Abstract: Background: Limited evidence is available on the association between estimated cardiorespiratory fitness (e-CRF) and incidence of cardiovascular disease (CVD) in Chinese population.: Methods: A total of 10,507 adults including 5084 men (48.4%) and ... ...

Abstract	Background: Limited evidence is available on the association between estimated cardiorespiratory fitness (e-CRF) and incidence of cardiovascular disease (CVD) in Chinese population. Methods: A total of 10,507 adults including 5084 men (48.4%) and 5423 (51.6%) women with a median age of 56.0 (25% quantile: 49, 75% quantile 63) years from the China Health and Retirement Longitudinal Study (CHARLS) was recruited in 2011 as baseline. The CVD incident events were followed-up until 2018. e-CRF was calculated from sex-specific longitudinal non-exercise equations and further grouped into quartiles. Cox proportional models were used to calculate hazard ratio (HR) and 95% confidence interval (CI) for incidence risks of CVD, heart disease and stroke. Results: During a median follow-up of 7 years, a total of 1862 CVD, 1409 heart disease and 612 stroke events occurred. In fully adjusted models, each one MET increment of e-CRF was associated with lower risk of CVD (HR = 0.91, 95%CI = 0.85-0.96 for males, HR = 0.87, 95%CI = 0.81-0.94 for females). Compared with the Quartile (Q)1 group, the HRs (95%CI) of the Q2, Q3 and Q4 groups were 0.84 (0.63-1.03), 0.72 (0.57-0.91) and 0.66 (0.51-0.87) for CVD in males. Females had HRs of 0.79 (0.66-0.96) in Q2, 0.71 (0.57-0.88) in Q3 and 0.58 (0.45-0.75) in Q4 for CVD. The associations between e-CRF and heart disease and stroke were slightly weaker than that for CVD in both males and females. Conclusions: Higher e-CRF decreases the incident risk of CVD, heart disease and stroke.
MeSH term(s)	Adult ; Male ; Humans ; Female ; Middle Aged ; Cardiorespiratory Fitness ; Cardiovascular Diseases/epidemiology ; Longitudinal Studies ; Physical Fitness ; Heart Diseases ; Stroke/epidemiology ; Risk Factors
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-16864-5
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