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Article ; Online: Screening and evaluation of antioxidants for retinal pigment epithelial cell protection: L-ergothioneine as a novel therapeutic candidate through NRF2 activation.

Gu, Sijie / Wu, Siqi / Lin, Zesong / Han, Zhuo / Mo, Kunlun / Huang, Huaxing / Li, Mingsen / Li, Gen / Ouyang, Hong / Wang, Li

Experimental eye research

2024 Volume 242, Page(s) 109862

Abstract: ... against oxidative stress and identified L-ergothioneine (EGT) as a potent cytoprotective agent. L ...

Abstract	The continual exposure of retinal tissues to oxidative stress leads to discernible anatomical and physiological alterations. Specifically, the onslaught of oxidative damage escalates the irreversible death of retinal pigmented epithelium (RPE) cells, pinpointed as the fundamental pathological event in dry age-related macular degeneration (AMD). There is a conspicuous lack of effective therapeutic strategies to counteract this degenerative process. This study screened a library of antioxidants for their ability to protect RPE cells against oxidative stress and identified L-ergothioneine (EGT) as a potent cytoprotective agent. L-ergothioneine provided efficient protection against oxidative stress-damaged RPE and maintained cell redox homeostasis and normal physiological functions. It maintained the normal structure of the retina in mice under oxidative stress conditions. Transcriptomic analysis revealed that EGT counteracted major gene expression changes induced by oxidative stress. It upregulated antioxidant gene expression and inhibited NRF2 translocation. The inhibition of NRF2 abolished EGT's protective effects, suggesting that NRF2 activation contributes to its mechanism of action. In conclusion, we identified EGT as a safe and effective small-molecule compound that is expected to be a novel antioxidative agent for treating AMD.
MeSH term(s)	Retinal Pigment Epithelium/drug effects ; Retinal Pigment Epithelium/metabolism ; Retinal Pigment Epithelium/pathology ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/genetics ; Animals ; Ergothioneine/pharmacology ; Antioxidants/pharmacology ; Oxidative Stress/drug effects ; Mice ; Mice, Inbred C57BL ; Macular Degeneration/drug therapy ; Macular Degeneration/metabolism ; Macular Degeneration/pathology ; Cells, Cultured ; Humans ; Blotting, Western ; Disease Models, Animal ; Gene Expression Regulation/drug effects ; Reactive Oxygen Species/metabolism
Chemical Substances	NF-E2-Related Factor 2 ; Ergothioneine (BDZ3DQM98W) ; Antioxidants ; Nfe2l2 protein, mouse ; Reactive Oxygen Species
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2024.109862
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Zs.A 163: Show issues

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Article ; Online: Therapeutic Targeting of TIM-4-L with Engineered T Cells for Acute Myeloid Leukemia.

Cieniewicz, Brandon / Oliveira, Edson / Saxton, Mike / Torabi, Damoun / Bhatta, Ankit / Kukutla, Phanidhar / Arballo, Alexander / Yang, Zhuo / Yu, Bi / Fate, Maria / Ning, Hongxiu / Corey, Lawrence / Maiti, Abhishek / Corey, Daniel

Clinical cancer research : an official journal of the American Association for Cancer Research

2024 Volume 30, Issue 9, Page(s) 1878–1888

Abstract: ... evaluated the anti-leukemic activity of TIM-4-L-directed T-cell therapy in preclinical AML ... models.: Experimental design: We performed FACS analysis on 33 primary AML bone marrow specimens and correlated TIM-4-L ... cell lines, we further tested the anti-leukemic effects of TIM-4-L-directed engineered T cells in vitro and ...

Abstract	Purpose: Disruption of lipid bilayer asymmetry is a common feature observed in cancer cells and offers novel routes for therapeutic targeting. We used the natural immune receptor TIM-4 to interrogate for loss of plasma membrane phospholipid polarity in primary acute myelogenous leukemia (AML) samples and evaluated the anti-leukemic activity of TIM-4-L-directed T-cell therapy in preclinical AML models. Experimental design: We performed FACS analysis on 33 primary AML bone marrow specimens and correlated TIM-4-L expression frequency and intensity with molecular disease characteristics. Using Kasumi-1 and MV-4-11 AML cell lines, we further tested the anti-leukemic effects of TIM-4-L-directed engineered T cells in vitro and in vivo. Results: We found that 86% of untreated AML blasts displayed upregulation of cell surface TIM-4-L. These observations were agnostic to AML genetic classification, as samples with mutations in TP53, ASXL1, and RUNX1 displayed TIM-4-L upregulation similar to that seen in favorable and intermediate subtypes. TIM-4-L dysregulation was also stably present in AML cell lines. To evaluate the potential of targeting upregulated TIM-4-L with adoptive T-cell therapy, we constructed TIM-4-L-directed engineered T cells, which demonstrated potent anti-leukemic effects, effectively eliminating AML cell lines with a range of endogenous TIM-4-L expression levels both in vitro and in vivo. Conclusions: These results highlight TIM-4-L as a highly prevalent target on AML across a range of genetic classifications and novel target for T-cell-based therapy in AML. Further investigations into the role of TIM-4-L in AML pathogenesis and its potential as an anti-leukemic target for clinical development are warranted.
MeSH term(s)	Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/metabolism ; Mice ; Animals ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Female ; Male ; Middle Aged ; Adult ; Aged ; Immunotherapy, Adoptive/methods
Chemical Substances	TIMD4 protein, human ; Membrane Proteins
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-23-3044
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Zs.A 4223: Show issues

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Article: Assessment of the Original Height of L

Zhuo, P P / Wang, M W / Yu, X Y / Wan, L / Tan, S L / Chen, J M / Xia, W T

Fa yi xue za zhi

2018 Volume 34, Issue 4, Page(s) 359–362

Abstract: Objectives: To explore the assessment method of original height of L: Methods: A total of 154 ... Conclusions: It is more appropriate to evaluate the original height of L₁ or L₂ single vertebrae by comparing ...

Abstract	Objectives: To explore the assessment method of original height of L Methods: A total of 154 normal thoracic and lumbar X-ray films were collected, and 140 cases were used as experimental group while 14 cases as validation group. The heights of anterior （ Results: In the 140 normal subjects, Conclusions: It is more appropriate to evaluate the original height of L₁ or L₂ single vertebrae by comparing with the height of the anterior edge of the upper and lower adjacent vertebral bodies.
MeSH term(s)	Aged ; Fractures, Compression ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Middle Aged ; Spinal Fractures/surgery ; Thoracic Vertebrae/diagnostic imaging
Language	Chinese
Publishing date	2018-08-25
Publishing country	China
Document type	Journal Article
ISSN	1004-5619
ISSN	1004-5619
DOI	10.12116/j.issn.1004-5619.2018.04.003
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Article ; Online: Predictive modeling of methylmercury in rice (Oryza sativa L.) and species-sensitivity-distribution-based derivation of the threshold of soil mercury in karst mountain areas.

Hao, Wanbin / Xu, Xiaohang / Qiu, Guangle / Dong, Xian / Zhu, Fang / Han, Jialiang / Liang, Longchao / Chen, Zhuo

Environmental geochemistry and health

2024 Volume 46, Issue 5, Page(s) 157

Abstract: The bioavailable mercury (Hg) in the soil is highly active and can affect the formulation of methyl-Hg (MeHg) in soil and its accumulation in rice. Herein, we predicted the concentration of MeHg in rice using bioavailable Hg extracted from soils; ... ...

Abstract	The bioavailable mercury (Hg) in the soil is highly active and can affect the formulation of methyl-Hg (MeHg) in soil and its accumulation in rice. Herein, we predicted the concentration of MeHg in rice using bioavailable Hg extracted from soils; additionally, we determined the threshold value of soil Hg in karst mountain areas based on species sensitivity distribution. The bioavailable Hg was extracted using calcium chloride, hydrochloric acid (HCl), diethylenetriaminepentaacetic acid mixture, ammonium acetate, and thioglycolic acid. Results showed that HCl is the best extractant, and the prediction model demonstrated good predictability of the MeHg concentration in rice based on the HCl-extractable Hg, pH, and soil organic matter (SOM) data. Compared with the actual MeHg concentration in rice, approximately 99% of the predicted values (n = 103) were within the 95% prediction range, indicating the good performance of the rice MeHg prediction model based on soil pH, SOM, and bioavailable Hg in karst mountain areas. Based on this MeHg prediction model, the safety threshold of soil Hg was calculated to be 0.0936 mg/kg, which is much lower than the soil pollution risk screening value of agricultural land (0.5 mg/kg), suggesting that a stricter standard should be applied regarding soil Hg in karst mountain areas. This study presents the threshold of soil Hg pollution for rice safety in karst mountain areas, and future studies should target this threshold range.
MeSH term(s)	Methylmercury Compounds ; Mercury ; Oryza ; Soil ; Agriculture
Chemical Substances	Methylmercury Compounds ; Mercury (FXS1BY2PGL) ; Soil
Language	English
Publishing date	2024-04-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-024-01944-1
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Zs.A 4723: Show issues

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Article ; Online: Chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L.

Tang, Xiaolong / Liu, Lin / Li, Yan / Hao, Siyu / Zhao, Yueshui / Wu, Xu / Li, Mingxing / Chen, Yu / Deng, Shuai / Gou, Shuang / Cai, Dan / Chen, Meijuan / Li, Xiaobing / Sun, Yuhong / Gu, Li / Li, Wanping / Wang, Fang / Zhang, Zhuo / Yao, Lei /

Shen, Jing / Xiao, Zhangang / Du, Fukuan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 166, Page(s) 115315

Abstract: Polygonum perfoliatum L. is an herbal medicine that has been extensively used ...

Abstract	Polygonum perfoliatum L. is an herbal medicine that has been extensively used in traditional Chinese medicine to treat various health conditions ranging from ancient internal to surgical and gynecological diseases. Numerous studies suggest that P. perfoliatum extract elicits significant anti-tumor, anti-inflammatory, anti-bacterial, and anti-viral effects. Nevertheless, the underlying mechanisms of its anti-liver cancer effects remain poorly understood. Our study suggests that P. perfoliatum stem extract (PPLA) has a favorable safety profile and exhibits a significant anti-liver cancer effect both in vitro and in vivo. We identified that PPLA activates the cGMP-PKG signaling pathway, and key regulatory genes including ADRA1B, PLCB2, PRKG2, CALML4, and GLO1 involved in this activation. Moreover, PPLA modulates the expression of genes responsible for the cell cycle. Additionally, we identified four constituents of PPLA, namely taxifolin, myricetin, eriodictyol, and pinocembrin, that plausibly act via the cGMP-PKG signaling pathway. Both in vitro and in vivo experiments confirmed that PPLA, along with its constituting compounds taxifolin, myricetin, and eriodictyol, exhibit potent anti-cancer activities and hold the promise of being developed into therapeutic agents.
MeSH term(s)	Humans ; Polygonum/chemistry ; Plants, Medicinal ; Carcinoma, Hepatocellular/drug therapy ; Anti-Inflammatory Agents/chemistry ; Liver Neoplasms/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry
Chemical Substances	Anti-Inflammatory Agents ; Plant Extracts
Language	English
Publishing date	2023-08-12
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115315
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Ud II Zs.198: Show issues

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Article ; Online: L-AP Alleviates Liver Injury in Septic Mice by Inhibiting Macrophage Activation via Suppressing NF-κB and NLRP3 Inflammasome/Caspase-1 Signal Pathways.

Liu, Linling / Lin, Lan / Wang, Yingling / Yan, Xin / Li, Ruli / He, Min / Li, He / Zhuo, Caili / Li, Lingyu / Zhang, Die / Wang, Xuemei / Huang, Wenjing / Li, Xinyue / Mao, Yan / Chen, Hongying / Wu, Sisi / Jiang, Wei / Zhu, Ling

Journal of agricultural and food chemistry

2024 Volume 72, Issue 15, Page(s) 8460–8475

Abstract: ... for which effective treatments are still lacking. l-Ascorbic acid 6-palmitate (L-AP), a food additive, can inhibit ... liver damage has not been fully explored. We aimed to investigate L-AP's antisepticemia action and the possible ... that L-AP treatment significantly increased survival in cecal ligation and puncture-induced WT mice and ...

Abstract	Liver injury and progressive liver failure are severe life-threatening complications in sepsis, further worsening the disease and leading to death. Macrophages and their mediated inflammatory cytokine storm are critical regulators in the occurrence and progression of liver injury in sepsis, for which effective treatments are still lacking. l-Ascorbic acid 6-palmitate (L-AP), a food additive, can inhibit neuroinflammation by modulating the phenotype of the microglia, but its pharmacological action in septic liver damage has not been fully explored. We aimed to investigate L-AP's antisepticemia action and the possible pharmacological mechanisms in attenuating septic liver damage by modulating macrophage function. We observed that L-AP treatment significantly increased survival in cecal ligation and puncture-induced WT mice and attenuated hepatic inflammatory injury, including the histopathology of the liver tissues, hepatocyte apoptosis, and the liver enzyme levels in plasma, which were comparable to NLRP3-deficiency in septic mice. L-AP supplementation significantly attenuated the excessive inflammatory response in hepatic tissues of septic mice in vivo and in cultured macrophages challenged by both LPS and ATP in vitro, by reducing the levels of NLRP3, pro-IL-1β, and pro-IL-18 mRNA expression, as well as the levels of proteins for p-I-κB-α, p-NF-κB-p65, NLRP3, cleaved-caspase-1, IL-1β, and IL-18. Additionally, it impaired the inflammasome ASC spot activation and reduced the inflammatory factor contents, including IL-1β and IL-18 in plasma/cultured superannuants. It also prevented the infiltration/migration of macrophages and their M1-like inflammatory polarization while improving their M2-like polarization. Overall, our findings revealed that L-AP protected against sepsis by reducing macrophage activation and inflammatory cytokine production by suppressing their activation in NF-κB and NLRP3 inflammasome signal pathways in septic liver.
MeSH term(s)	Mice ; Animals ; Inflammasomes/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Caspase 1/genetics ; Caspase 1/metabolism ; Interleukin-18 ; Macrophage Activation ; Signal Transduction ; Liver/metabolism ; Ascorbic Acid ; Sepsis/complications ; Sepsis/drug therapy ; Lipopolysaccharides/pharmacology
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NF-kappa B ; Caspase 1 (EC 3.4.22.36) ; Interleukin-18 ; Ascorbic Acid (PQ6CK8PD0R) ; Lipopolysaccharides
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c02781
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Zs.A 1172: Show issues

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Article ; Online: L-leucine promotes axonal outgrowth and regeneration via mTOR activation.

Ma, Chao / Teng, Long / Lin, Ge / Guo, Beibei / Zhuo, Run / Qian, Xiaowei / Guan, Tuchen / Wu, Ronghua / Liu, Yan / Liu, Mei

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2021 Volume 35, Issue 5, Page(s) e21526

Abstract: ... for the recovery of central nervous system injuries. In this study, we found that L-leucine ... regeneration. First, the effects of L-leucine on neurons were evaluated by cell apoptosis, survival, and death ... assays, and the results showed no changes in these processes after treatment. By live cell imaging, L ...

Abstract	Discovering safe and effective drugs that promote neuron regeneration is an essential strategy for the recovery of central nervous system injuries. In this study, we found that L-leucine, an essential amino acid obtained from both supplements and food sources, could dramatically boost axonal outgrowth and regeneration. First, the effects of L-leucine on neurons were evaluated by cell apoptosis, survival, and death assays, and the results showed no changes in these processes after treatment. By live cell imaging, L-leucine was found to remarkably increase axonal length and growth velocity after axotomy. We also verified that L-leucine enhanced p-mTOR/p-S6K activation in neurons by testing with an mTOR inhibitor, rapamycin. Thereafter, we investigated the effects of L-leucine on the spinal cord injury in vivo. A mouse model of spinal cord hemi-section was established, and L-leucine was administered by tail intravenous injection. Basso mouse scale values revealed that L-leucine could improve functional recovery after injury. It was also notable that L-leucine treatment promoted axon growth across chondroitin sulfate proteoglycan (CSPG) areas. Furthermore, we used CSPGs as inhibitory environmental cues and clarified that L-leucine significantly enhanced axonal outgrowth and regeneration by promoting p-mTOR and p-S6K activation. Therefore, our study is the first to report that L-leucine promotes axonal regeneration in vitro and in vivo and could be candidate drug for axonal re-growth and nervous functional recovery.
Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202001798RR
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Effects of dietary L-leucine supplementation on testicular development and semen quality in boars.

Lin, Yan / Li, Jiayi / Wang, Ke / Fang, Zhengfeng / Che, Lianqiang / Xu, Shengyu / Feng, Bin / Zhuo, Yong / Li, Jian / Wu, De

Frontiers in veterinary science

2022 Volume 9, Page(s) 904653

Abstract: Sperm and seminal plasma are rich in leucine, and leucine can promote the protein synthesis. This property makes it an interesting amino acid to increase sperm quality of human and livestock spermatogenesis. The goal of this study was to explore the ... ...

Abstract	Sperm and seminal plasma are rich in leucine, and leucine can promote the protein synthesis. This property makes it an interesting amino acid to increase sperm quality of human and livestock spermatogenesis. The goal of this study was to explore the effects of dietary leucine supplementation on testicular development and semen quality in boars from weaning to 10 months of age. 30 pure-bred, weaned Duroc boars (8.0 ± 1.0 kg) were randomly divided into two groups: control group (CON; fed the basal diet) and leucine group (LEU; fed the basal diet supplemented with 1.2% leucine); then, their body weight and testicular volume were recorded every 4 weeks. Testes were collected for histological and genes expression analysis from 150-day-old boars. Semen was collected and analyzed. Amino acids contents of blood plasma, seminal plasma, sperm, and testes were determined. Dietary supplementation with leucine increased the testicular volume and weight of boars, compared with CON. Sperm viability, sperm count per ejaculation, and average curve speed of sperm in leucine-supplemented boars were increased. Furthermore, leucine supplementation increased the blood plasma and seminal plasma leucine concentrations, and enhanced the gene expressions of branch chain amino acid transaminase, protein kinase B, mammalian target of rapamycin (
Language	English
Publishing date	2022-07-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2022.904653
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Article ; Online: Bruceine D may affect the phenylpropanoid biosynthesis by acting on ADTs thus inhibiting Bidens pilosa L. seed germination.

Tong, Yao / Yi, Shan-Chi / Liu, Shu-Yu / Xu, Lin / Qiu, Zhuo-Xun / Zeng, Dong-Qiang / Tang, Wen-Wei

Ecotoxicology and environmental safety

2022 Volume 242, Page(s) 113943

Abstract: ... from the residue of Brucea javanica (L.) seeds. Our previous research showed that Bruceine D prevented ... Bidens pilosa L. seed germination by suppressing the activity of key enzymes and the expression levels of key ... in phenylpropanoid biosynthesis. The decreased expression of ADTs and content of L-phenylalanine implicates ...

Abstract	Bruceine D is a natural quassinoid, which was successfully isolated in our research group from the residue of Brucea javanica (L.) seeds. Our previous research showed that Bruceine D prevented Bidens pilosa L. seed germination by suppressing the activity of key enzymes and the expression levels of key genes involved in the phenylpropanoid biosynthesis pathway. In this study, integrated analyses of non-targeted metabolomic and transcriptomic were performed. A total of 356 different accumulated metabolites (DAMs) were identified, and KEGG pathway analyses revealed that most of these DAMs were involved in phenylpropanoid biosynthesis. The decreased expression of ADTs and content of L-phenylalanine implicates that Bruceine D may suppress the downstream phenylpropanoid biosynthesis pathway by disrupting primary metabolism, that is, the phenylalanine biosynthesis pathway, thus inhibiting the final products, resulting in the interruption of B. pilosa seed germination. These results suggest that Bruceine D may inhibit the B. pilosa seed germination by suppressing phenylpropanoid biosynthesis through acting on ADTs.
MeSH term(s)	Bidens ; Germination ; Quassins/pharmacology ; Seeds
Chemical Substances	Quassins ; bruceine D (21499-66-1)
Language	English
Publishing date	2022-08-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113943
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Article ; Online: Potassium ameliorates cotton (Gossypium hirsutum L.) fiber length by regulating osmotic and K

Yu, Kai / Ju, Feiyan / Wang, Zhuo / Sun, Liyuan / Huo, Yuyang / Zhu, Junjun / Pang, Jiali / Ali, Saif / Chen, Weiping / Wang, Shanshan / Zhou, Zhiguo / Tang, Qiuxiang / Chen, Binglin

Physiologia plantarum

2022 Volume 175, Issue 1, Page(s) e13842

Abstract: Potassium (K) application can alleviate cotton salt stress, but the regulatory mechanisms affecting cotton fiber elongation and ion homeostasis are still unclear. A two-year field experiment was conducted to explore the effects of K on the osmolyte ... ...

Abstract	Potassium (K) application can alleviate cotton salt stress, but the regulatory mechanisms affecting cotton fiber elongation and ion homeostasis are still unclear. A two-year field experiment was conducted to explore the effects of K on the osmolyte contents (soluble sugar, K
MeSH term(s)	Gossypium/physiology ; Malates/metabolism ; Potassium/metabolism ; Salt Stress ; Cotton Fiber ; Homeostasis ; Sugars/metabolism ; Adenosine Triphosphatases/metabolism
Chemical Substances	malic acid (817L1N4CKP) ; Malates ; Potassium (RWP5GA015D) ; Sugars ; Adenosine Triphosphatases (EC 3.6.1.-)
Language	English
Publishing date	2022-12-21
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	2020837-6
ISSN	1399-3054 ; 0031-9317
ISSN (online)	1399-3054
ISSN	0031-9317
DOI	10.1111/ppl.13842
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