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  1. Article ; Online: Comment on: A review of the use of time-varying covariates in the Fine-Gray subdistribution hazard competing risk regression model by Peter C. Austin, Aurélien Latouche, and Jason P. Fine.

    Mori, Shunsuke

    Statistics in medicine

    2020  Volume 39, Issue 20, Page(s) 2689–2691

    MeSH term(s) Humans ; Proportional Hazards Models ; Survival Analysis
    Language English
    Publishing date 2020-08-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.8558
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1756: Show issues Location:
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  2. Article: Leukocytapheresis for rheumatoid arthritis cases that are super-resistant to any class of biological drugs and tofacitinib.

    Mori, Shunsuke

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2020  Volume 59, Issue 6, Page(s) 102920

    Abstract: Many biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) are currently available as treatment options for rheumatoid arthritis (RA), but a subset of RA patients shows inadequate responses to any of these ... ...

    Abstract Many biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) are currently available as treatment options for rheumatoid arthritis (RA), but a subset of RA patients shows inadequate responses to any of these DMARDs. This phenomenon, which we call super-resistance, is becoming a serious concern. In this study, I present two cases of super-resistant RA in which patients failed to respond to treatment with bDMARDs of any class as well as to tsDMARD therapy with tofacitinib. In these cases, leukocytapheresis (LCAP), a treatment that removes overabundant leukocytes from the body, rapidly induced low disease activity and made patients subsequently responsive to previously ineffective DMARDs. My experience with the present cases suggests that LCAP is worth considering as an alternative therapeutic option for the management of RA patients with super-resistance to DMARD therapies.
    MeSH term(s) Aged ; Antirheumatic Agents/pharmacology ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Female ; Humans ; Leukapheresis/methods ; Male ; Middle Aged ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use
    Chemical Substances Antirheumatic Agents ; Piperidines ; Protein Kinase Inhibitors ; Pyrimidines ; tofacitinib (87LA6FU830)
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2020.102920
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    Zs.A 1739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Detection and Quantification of Calcium Ions in the Endoplasmic Reticulum and Cytoplasm of Cultured Cells Using Fluorescent Reporter Proteins and ImageJ Software.

    Saito, Shunsuke / Mori, Kazutoshi

    Bio-protocol

    2023  Volume 13, Issue 16, Page(s) e4738

    Abstract: This protocol describes a method for detecting and quantifying calcium ions in the endoplasmic reticulum (ER) and cytoplasm of cultured cells using fluorescent reporter proteins and ImageJ software. Genetically engineered fluorescent reporter proteins, ... ...

    Abstract This protocol describes a method for detecting and quantifying calcium ions in the endoplasmic reticulum (ER) and cytoplasm of cultured cells using fluorescent reporter proteins and ImageJ software. Genetically engineered fluorescent reporter proteins, such as G-CEPIA1er and GCaMP6f, localize to intracellular regions of interest (i.e., ER and cytoplasm) and emit green fluorescence upon binding to calcium ions. In this way, the fluorescence brightness of cells transfected with expression vectors for these reporters reflects the calcium ion concentration in each intracellular region. Here, we describe procedures for observing cultured cells expressing these fluorescent reporters under a fluorescence microscope, analyzing the obtained image using the free image analysis software ImageJ (https://imagej.net/ij/index.html), and determining the average fluorescence brightness of multiple cells present in the image. The current method allows us to quickly and easily quantify calcium ions on an image containing multiple cells and to determine whether there are relative differences in intracellular calcium ion concentration among experiments with different conditions. Key features Detection and quantification of calcium ions in the ER and cytoplasm using fluorescent reporter proteins Quick and easy verification of measurement results using ImageJ Simultaneous comparison between various experimental conditions (drug treatment, mutants, etc.).
    Language English
    Publishing date 2023-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4738
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  4. Article ; Online: Nonvolatile Isomorphic Valence Transition in SmTe Films.

    Hatayama, Shogo / Mori, Shunsuke / Saito, Yuta / Fons, Paul J / Shuang, Yi / Sutou, Yuji

    ACS nano

    2024  Volume 18, Issue 4, Page(s) 2972–2981

    Abstract: The burgeoning field of optoelectronic devices necessitates a mechanism that gives rise to a large contrast in the electrical and optical properties. A SmTe film with a NaCl-type structure demonstrates significant differences in resistivity (over ... ...

    Abstract The burgeoning field of optoelectronic devices necessitates a mechanism that gives rise to a large contrast in the electrical and optical properties. A SmTe film with a NaCl-type structure demonstrates significant differences in resistivity (over 10
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c07960
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  5. Article ; Online: Redeployment of odontode gene regulatory network underlies dermal denticle formation and evolution in suckermouth armored catfish.

    Mori, Shunsuke / Nakamura, Tetsuya

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 6172

    Abstract: Odontodes, i.e., teeth and tooth-like structures, consist of a pulp cavity and dentin covered by a mineralized cap. These structures first appeared on the outer surface of vertebrate ancestors and were repeatedly lost and gained across vertebrate clades; ...

    Abstract Odontodes, i.e., teeth and tooth-like structures, consist of a pulp cavity and dentin covered by a mineralized cap. These structures first appeared on the outer surface of vertebrate ancestors and were repeatedly lost and gained across vertebrate clades; yet, the underlying genetic mechanisms and trajectories of this recurrent evolution remain long-standing mysteries. Here, we established suckermouth armored catfish (Ancistrus sp.; Loricariidae), which have reacquired dermal odontodes (dermal denticles) all over most of their body surface, as an experimental model animal amenable to genetic manipulation for studying odontode development. Our histological analysis showed that suckermouth armored catfish develop dermal denticles through the previously defined odontode developmental stages. De novo transcriptomic profiling identified the conserved odontode genetic regulatory network (oGRN) as well as expression of paired like homeodomain 2 (pitx2), previously known as an early regulator of oGRN in teeth but not in other dermal odontodes, in developing dermal denticles. The early onset of pitx2 expression in cranial dermal denticle placodes implies its function as one of the inducing factors of the cranial dermal denticles. By comprehensively identifying the genetic program for dermal odontode development in suckermouth armored catfish, this work illuminates how dermal odontodes might have evolved and diverged in distinct teleost lineages via redeployment of oGRN.
    MeSH term(s) Animals ; Biological Evolution ; Catfishes/genetics ; Dental Pulp Calcification ; Gene Regulatory Networks ; Tooth/metabolism
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10222-y
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  6. Article ; Online: Redeployment of odontode gene regulatory network underlies dermal denticle formation and evolution in suckermouth armored catfish

    Shunsuke Mori / Tetsuya Nakamura

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 16

    Abstract: Abstract Odontodes, i.e., teeth and tooth-like structures, consist of a pulp cavity and dentin covered by a mineralized cap. These structures first appeared on the outer surface of vertebrate ancestors and were repeatedly lost and gained across ... ...

    Abstract Abstract Odontodes, i.e., teeth and tooth-like structures, consist of a pulp cavity and dentin covered by a mineralized cap. These structures first appeared on the outer surface of vertebrate ancestors and were repeatedly lost and gained across vertebrate clades; yet, the underlying genetic mechanisms and trajectories of this recurrent evolution remain long-standing mysteries. Here, we established suckermouth armored catfish (Ancistrus sp.; Loricariidae), which have reacquired dermal odontodes (dermal denticles) all over most of their body surface, as an experimental model animal amenable to genetic manipulation for studying odontode development. Our histological analysis showed that suckermouth armored catfish develop dermal denticles through the previously defined odontode developmental stages. De novo transcriptomic profiling identified the conserved odontode genetic regulatory network (oGRN) as well as expression of paired like homeodomain 2 (pitx2), previously known as an early regulator of oGRN in teeth but not in other dermal odontodes, in developing dermal denticles. The early onset of pitx2 expression in cranial dermal denticle placodes implies its function as one of the inducing factors of the cranial dermal denticles. By comprehensively identifying the genetic program for dermal odontode development in suckermouth armored catfish, this work illuminates how dermal odontodes might have evolved and diverged in distinct teleost lineages via redeployment of oGRN.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Photoinduced Nonvolatile Displacive Transformation and Optical Switching in MnTe Semiconductors.

    Mori, Shunsuke / Tanimura, Hiroshi / Ichitsubo, Tetsu / Sutou, Yuji

    ACS applied materials & interfaces

    2023  Volume 15, Issue 36, Page(s) 42730–42736

    Abstract: MnTe is considered a promising candidate for next-generation phase change materials owing to the reversible and nonvolatile phase transformation between its α and β' phases by irradiation of a nanosecond laser or application of a pulse voltage. In this ... ...

    Abstract MnTe is considered a promising candidate for next-generation phase change materials owing to the reversible and nonvolatile phase transformation between its α and β' phases by irradiation of a nanosecond laser or application of a pulse voltage. In this work, for a faster phase control of MnTe, the response of metastable β-MnTe thin films to femtosecond (fs) laser irradiation was investigated. Using ultrafast optical spectroscopy, we inferred transient phase transformation. Moreover, with an increase in laser-excitation fluence, a nonvolatile structural change from the β to α phase was experimentally observed by Raman spectroscopy and transmission electron microscopy without ablation damage on the sample. The observation results strongly suggest that the fs-laser-induced β → α phase transformation proceeds through the nucleation and growth mode without a large temperature increase.
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c07537
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  8. Article: Axillary web syndrome with vascular thrombosis and arterial intimal hyperplasia.

    Mizuno, Hayato / Takahagi, Shunsuke / Matsubara, Daiki / Kan, Takanobu / Mori, Keiichi / Arihiro, Koji / Tanaka, Akio

    JAAD case reports

    2023  Volume 34, Page(s) 32–35

    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2023.02.001
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  9. Article ; Online: Divergent synthesis of multi-substituted phenanthrenes

    Koyama, Ryosei / Anada, Masahiro / Sueki, Shunsuke / Makino, Kosho / Kojima, Tatsuhiro / Kawasaki-Takasuka, Tomoko / Mori, Keiji

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 28, Page(s) 3822–3825

    Abstract: We report an effective synthetic route to multi-substituted ... ...

    Abstract We report an effective synthetic route to multi-substituted phenanthrenes
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00797b
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  10. Article ; Online: Clinical disease activity is a major determinant of plasma D-dimer elevation in outpatients with rheumatoid arthritis: A hospital-based cross-sectional study.

    Mori, Shunsuke / Soejima, Hirofumi / Hokamaki, Jun / Tsujita, Kenichi

    Modern rheumatology

    2023  Volume 34, Issue 2, Page(s) 313–321

    Abstract: Objectives: To identify factors associated with plasma D-dimer levels in outpatients with rheumatoid arthritis (RA).: Methods: We consecutively recruited 460 RA patients who visited our hospital for routine follow-ups between June and October 2021. ... ...

    Abstract Objectives: To identify factors associated with plasma D-dimer levels in outpatients with rheumatoid arthritis (RA).
    Methods: We consecutively recruited 460 RA patients who visited our hospital for routine follow-ups between June and October 2021. Plasma D-dimer, RA-related characteristics, comorbidities, and cardiovascular and venous thromboembolism (VTE) risk factors were examined at enrolment. Patients with elevated D-dimer levels underwent whole-leg venous ultrasonography to diagnose deep vein thrombosis (DVT).
    Results: Participants had no DVT signs or symptoms. Among them, 252 (54.8%) were positive for plasma D-dimer (≥0.5 μg/ml) and 40 (8.7%) had high D-dimer levels (≥3 μg/ml). The mean was 1.07 μg/ml. After adjustments, age [odds ratio (OR) 1.88 per additional 10 years, P = .003], high and moderate clinical disease activity index (OR 8.79, P < .001), and the presence of comorbidities or cardiovascular/VTE risk factors (OR 2.94, P = .017) were identified as the factors independently associated with high D-dimer levels. Among patients with D-dimer levels ≥3 μg/ml, 10 (25%) had DVT in their lower limbs, and D-dimer levels were significantly higher in patients with DVT compared with those without it (mean 6.0  vs. 4.1 μg/ml, P < .001).
    Conclusions: Clinical disease activity is a major contributor to plasma D-dimer elevation in RA outpatients.
    MeSH term(s) Humans ; Child ; Venous Thromboembolism/diagnostic imaging ; Venous Thromboembolism/etiology ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/etiology ; Outpatients ; Cross-Sectional Studies ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnosis ; Fibrin Fibrinogen Degradation Products
    Chemical Substances fibrin fragment D ; Fibrin Fibrinogen Degradation Products
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1093/mr/road018
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