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Article ; Online: Acupuncture for the prevention of chemotherapy-induced nausea and vomiting in cancer patients: A systematic review and meta-analysis.

Yan, Yuqian / López-Alcalde, Jesús / Zhang, Linxin / Siebenhüner, Alexander R / Witt, Claudia M / Barth, Jürgen

2023 Volume 12, Issue 11, Page(s) 12504–12517

Abstract: Purpose: To assess the effectiveness and safety of acupuncture for the prevention of chemotherapy-induced nausea and vomiting (CINV), with a specific intention on exploring sources of between-study variation in treatment effects.: Methods: MEDLINE, ... ...

Abstract	Purpose: To assess the effectiveness and safety of acupuncture for the prevention of chemotherapy-induced nausea and vomiting (CINV), with a specific intention on exploring sources of between-study variation in treatment effects. Methods: MEDLINE, EMBASE, Cochrane CENTRAL, CINAHL, Chinese Biomedical Literature Database, VIP Chinese Science and Technology Periodicals Database, China National Knowledge Infrastructure, and Wanfang were searched to identify randomized controlled trials (RCTs) that compared acupuncture to sham acupuncture or usual care (UC). The main outcome is complete control (no vomiting episodes and/or no more than mild nausea) of CINV. GRADE approach was used to rate the certainty of evidence. Results: Thirty-eight RCTs with a total of 2503 patients were evaluated. Acupuncture in addition to UC may increase the complete control of acute vomiting (RR, 1.13; 95% CI, 1.02 to 1.25; 10 studies) and delayed vomiting (RR, 1.47; 95% CI, 1.07 to 2.00; 10 studies) when compared with UC only. No effects were found for all other review outcomes. The certainty of evidence was generally low or very low. None of the predefined moderators changed the overall findings, but in an exploratory moderator analysis we found that an adequate reporting of planned rescue antiemetics might decrease the effect size of complete control of acute vomiting (p = 0.035). Conclusion: Acupuncture in addition to usual care may increase the complete control of chemotherapy-induced acute vomiting and delayed vomiting but the certainty of evidence was very low. Well-designed RCTs with larger sample sizes, standardized treatment regimens, and core outcome measures are needed.
MeSH term(s)	Humans ; Antineoplastic Agents/adverse effects ; Vomiting/chemically induced ; Vomiting/prevention & control ; Nausea/chemically induced ; Nausea/prevention & control ; Antiemetics/therapeutic use ; Neoplasms/drug therapy ; Acupuncture Therapy
Chemical Substances	Antineoplastic Agents ; Antiemetics
Language	English
Publishing date	2023-05-24
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5962
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CHARMS and PROBAST at your fingertips: a template for data extraction and risk of bias assessment in systematic reviews of predictive models.

Fernandez-Felix, Borja M / López-Alcalde, Jesus / Roqué, Marta / Muriel, Alfonso / Zamora, Javier

BMC medical research methodology

2023 Volume 23, Issue 1, Page(s) 44

Abstract: Background: Systematic reviews of studies of clinical prediction models are becoming increasingly abundant in the literature. Data extraction and risk of bias assessment are critical steps in any systematic review. CHARMS and PROBAST are the standard ... ...

Abstract	Background: Systematic reviews of studies of clinical prediction models are becoming increasingly abundant in the literature. Data extraction and risk of bias assessment are critical steps in any systematic review. CHARMS and PROBAST are the standard tools used for these steps in these reviews of clinical prediction models. Results: We developed an Excel template for data extraction and risk of bias assessment of clinical prediction models including both recommended tools. The template makes it easier for reviewers to extract data, to assess the risk of bias and applicability, and to produce results tables and figures ready for publication. Conclusion: We hope this template will simplify and standardize the process of conducting a systematic review of prediction models, and promote a better and more comprehensive reporting of these systematic reviews.
MeSH term(s)	Humans ; Prognosis ; Systematic Reviews as Topic ; Bias
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041362-2
ISSN	1471-2288 ; 1471-2288
ISSN (online)	1471-2288
ISSN	1471-2288
DOI	10.1186/s12874-023-01849-0
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Article ; Online: Comparability of Patients in Trials of eHealth and Face-to-Face Psychotherapeutic Interventions for Depression: Meta-synthesis.

Aemissegger, Vera / Lopez-Alcalde, Jesus / Witt, Claudia M / Barth, Jürgen

Journal of medical Internet research

2022 Volume 24, Issue 9, Page(s) e36978

Abstract: Background: Depressive disorders (DDs) are a public health problem. Face-to-face psychotherapeutic interventions are a first-line option for their treatment in adults. There is a growing interest in eHealth interventions to maximize accessibility for ... ...

Abstract	Background: Depressive disorders (DDs) are a public health problem. Face-to-face psychotherapeutic interventions are a first-line option for their treatment in adults. There is a growing interest in eHealth interventions to maximize accessibility for effective treatments. Thus, the number of randomized controlled trials (RCTs) of eHealth psychotherapeutic interventions has increased, and these interventions are being offered to patients. However, it is unknown whether patients with DDs differ in internet-based and face-to-face intervention trials. This information is essential to gain knowledge about eHealth trials' external validity. Objective: We aimed to compare the baseline characteristics of patients with DDs included in the RCTs of eHealth and face-to-face psychotherapeutic interventions with a cognitive component. Methods: In this meta-epidemiological study, we searched 5 databases between 1990 and November 2017 (MEDLINE, Embase, PsycINFO, Google Scholar, and the database of Cuijpers et al). We included RCTs of psychotherapeutic interventions with a cognitive component (eg, cognitive therapy, cognitive behavioral therapy [CBT], or interpersonal therapy) delivered face-to-face or via the internet to adults with DDs. Each included study had a matching study for predefined criteria to allow a valid comparison of characteristics and was classified as a face-to-face (CBT) or eHealth (internet CBT) intervention trial. Two authors selected the studies, extracted data, and resolved disagreements by discussion. We tested whether predefined baseline characteristics differed in face-to-face and internet-based trials using a mixed-effects model and testing for differences with z tests (statistical significance set at .05). For continuous outcomes, we also estimated the difference in means between subgroups with 95% CI. Results: We included 58 RCTs (29 matching pairs) with 3846 participants (female: n=2803, 72.9%) and mean ages ranging from 20-74 years. White participants were the most frequent (from 63.6% to 100%). Other socioeconomic characteristics were poorly described. The participants presented DDs of different severity measured with heterogeneous instruments. Internet CBT trials had a longer depression duration at baseline (7.19 years higher, CI 95% 2.53-11.84; 10.0 vs 2.8 years; P=.002), but the proportion of patients with previous depression treatment was lower (24.8% vs 42%; P=.04). Subgroup analyses found no evidence of differences for the remaining baseline characteristics: age, gender, education, living area, depression severity, history of depression, actual antidepressant medication, actual physical comorbidity, actual mental comorbidity, study dropout, quality of life, having children, family status, and employment. We could not compare proficiency with computers due to the insufficient number of studies. Conclusions: The baseline characteristics of patients with DDs included in the RCTs of eHealth and face-to-face psychotherapeutic interventions are generally similar. However, patients in eHealth trials had a longer duration of depression, and a lower proportion had received previous depression treatment, which might indicate that eHealth trials attract patients who postpone earlier treatment attempts. Trial registration: PROSPERO CRD42019085880; https://tinyurl.com/4xufwcyr.
MeSH term(s)	Adult ; Aged ; Child ; Cognitive Behavioral Therapy ; Depression/therapy ; Female ; Humans ; Middle Aged ; Telemedicine ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2022-09-14
Publishing country	Canada
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/36978
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Current State of Research About Chinese Herbal Medicines (CHM) for the Treatment of Coronavirus Disease 2019 (COVID-19): A Scoping Review.

López-Alcalde, Jesús / Yan, Yuqian / Witt, Claudia M / Barth, Jürgen

Journal of alternative and complementary medicine (New York, N.Y.)

2020 Volume 26, Issue 7, Page(s) 557–570

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	China ; Coronavirus Infections/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Infection Control/methods ; Medicine, Chinese Traditional/methods ; Pandemics ; Phytotherapy/methods ; Pneumonia, Viral/drug therapy ; Republic of Korea ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal
Keywords	covid19
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1237383-7
ISSN	1557-7708 ; 1075-5535
ISSN (online)	1557-7708
ISSN	1075-5535
DOI	10.1089/acm.2020.0189
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sex as a Prognostic Factor in Systematic Reviews: Challenges and Lessons Learned.

Stallings, Elena / Antequera, Alba / López-Alcalde, Jesús / García-Martín, Miguel / Urrútia, Gerard / Zamora, Javier

Journal of personalized medicine

2021 Volume 11, Issue 6

Abstract: Sex is a common baseline factor collected in studies that has the potential to be a prognostic factor (PF) in several clinical areas. In recent years, research on sex as a PF has increased; however, this influx of new studies frequently shows conflicting ...

Abstract	Sex is a common baseline factor collected in studies that has the potential to be a prognostic factor (PF) in several clinical areas. In recent years, research on sex as a PF has increased; however, this influx of new studies frequently shows conflicting results across the same treatment or disease state. Thus, systematic reviews (SRs) addressing sex as a PF may help us to better understand diseases and further personalize healthcare. We wrote this article to offer insights into the challenges we encountered when conducting SRs on sex as a PF and suggestions on how to overcome these obstacles, regardless of the clinical domain. When carrying out a PF SR with sex as the index factor, it is important to keep in mind the modifications that must be made in various SR stages, such as modifying the PF section of CHARMS-PF, adjusting certain sections of QUIPS and extracting data on the sex and gender terms used throughout the studies. In this paper, we provide an overview of the lessons learned from carrying out our reviews on sex as a PF in different disciplines and now call on researchers, funding agencies and journals to realize the importance of studying sex as a PF.
Language	English
Publishing date	2021-05-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11060441
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Article ; Online: Development and evaluation of a search filter to identify prognostic factor studies in Ovid MEDLINE.

Stallings, Elena / Gaetano-Gil, Andrea / Alvarez-Diaz, Noelia / Solà, Ivan / López-Alcalde, Jesús / Molano, Daniel / Zamora, Javier

BMC medical research methodology

2022 Volume 22, Issue 1, Page(s) 107

Abstract: Background: Systematic reviews (SRs) are valuable resources as they address specific clinical questions by summarizing all existing relevant studies. However, finding all information to include in systematic reviews can be challenging. Methodological ... ...

Abstract	Background: Systematic reviews (SRs) are valuable resources as they address specific clinical questions by summarizing all existing relevant studies. However, finding all information to include in systematic reviews can be challenging. Methodological search filters have been developed to find articles related to specific clinical questions. To our knowledge, no filter exists for finding studies on the role of prognostic factor (PF). We aimed to develop and evaluate a search filter to identify PF studies in Ovid MEDLINE that has maximum sensitivity. Methods: We followed current recommendations for the development of a search filter by first identifying a reference set of PF studies included in relevant systematic reviews on the topic, and by selecting search terms using a word frequency analysis complemented with an expert panel discussion. We evaluated filter performance using the relative recall methodology. Results: We constructed a reference set of 73 studies included in six systematic reviews from a larger sample. After completing a word frequency analysis using the reference set studies, we compiled a list of 80 of the frequent methodological terms. This list of terms was evaluated by the Delphi panel for inclusion in the filter, resulting in a final set of 8 appropriate terms. The consecutive connection of these terms with the Boolean operator OR produced the filter. We then evaluated the filter using the relative recall method against the reference set, comparing the references included in the SRs with our new search using the filter. The overall sensitivity of the filter was calculated to be 95%, while the overall specificity was 41%. The precision of the filter varied considerably, ranging from 0.36 to 17%. The NNR (number needed to read) value varied largely from 6 to 278. The time saved by using the filter ranged from 13-70%. Conclusions: We developed a search filter for OVID-Medline with acceptable performance that could be used in systematic reviews of PF studies. Using this filter could save as much as 40% of the title and abstract screening task. The specificity of the filter could be improved by defining additional terms to be included, although it is important to evaluate any modification to guarantee the filter is still highly sensitive.
MeSH term(s)	Data Collection ; Humans ; MEDLINE ; Prognosis ; Research ; Systematic Reviews as Topic
Language	English
Publishing date	2022-04-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041362-2
ISSN	1471-2288 ; 1471-2288
ISSN (online)	1471-2288
ISSN	1471-2288
DOI	10.1186/s12874-022-01595-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Corrigendum: CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis.

Ron, Raquel / Martínez-Sanz, Javier / Herrera, Sabina / Ramos-Ruperto, Luis / Díez-Vidal, Alejandro / Sainz, Talía / Álvarez-Díaz, Noelia / Correa-Pérez, Andrea / Muriel, Alfonso / López-Alcalde, Jesús / Pérez-Molina, José A / Moreno, Santiago / Serrano-Villar, Sergio

Frontiers in immunology

2024 Volume 15, Page(s) 1383117

Abstract: This corrects the article DOI: 10.3389/fimmu.2024.1343124.]. ...

Abstract	[This corrects the article DOI: 10.3389/fimmu.2024.1343124.].
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1383117
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Article ; Online: CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis.

Ron, Raquel / Martínez-Sanz, Javier / Herrera, Sabina / Ramos-Ruperto, Luis / Díez, Alejandro / Sainz, Talía / Álvarez-Díaz, Noelia / Correa-Pérez, Andrea / Muriel, Alfonso / López-Alcalde, Jesús / Pérez-Molina, José A / Moreno, Santiago / Serrano-Villar, Sergio

Frontiers in immunology

2024 Volume 15, Page(s) 1343124

Abstract: Background: In people living with HIV (PLHIV), the CD4/CD8 ratio has been proposed as a useful marker for non-AIDS events. However, its predictive ability on mortality over CD4 counts, and the role of CD8+ T-cell counts remain controversial.: Methods!# ...

Abstract	Background: In people living with HIV (PLHIV), the CD4/CD8 ratio has been proposed as a useful marker for non-AIDS events. However, its predictive ability on mortality over CD4 counts, and the role of CD8+ T-cell counts remain controversial. Methods: We conducted a systematic review and meta-analysis of published studies from 1996 to 2023, including PLHIV on antiretroviral treatment, and reporting CD4/CD8 ratio or CD8+ counts. The primary outcome was non-AIDS mortality or all-cause mortality. We performed a standard random-effects pairwise meta-analysis comparing low versus high CD4/CD8 ratio with a predefined cut-off point of 0.5. (CRD42020170931). Findings: We identified 2,479 studies for screening. 20 studies were included in the systematic review. Seven studies found an association between low CD4/CD8 ratio categories and increased mortality risk, with variable cut-off points between 0.4-1. Four studies were selected for meta-analysis, including 12,893 participants and 618 reported deaths. Patients with values of CD4/CD8 ratio below 0.5 showed a higher mortality risk (OR 3.65; 95% CI 3.04 - 4.35; I2 = 0.00%) compared to those with higher values. While the meta-analysis of CD8+ T-cell counts was not feasible due to methodological differences between studies, the systematic review suggests a negative prognostic impact of higher values (>1,138 to 1,500 cells/uL) in the long term. Conclusions: Our results support the use of the CD4/CD8 ratio as a prognostic marker in clinical practice, especially in patients with values below 0.5, but consensus criteria on ratio timing measurement, cut-off values, and time to event are needed in future studies to get more robust conclusions. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020170931, identifier CRD42020170931.
MeSH term(s)	Humans ; Prognosis ; HIV Infections/drug therapy ; CD4-CD8 Ratio ; CD8-Positive T-Lymphocytes ; CD4 Lymphocyte Count
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1343124
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Article ; Online: Sex as a Prognostic Factor in Systematic Reviews

Elena Stallings / Alba Antequera / Jesús López-Alcalde / Miguel García-Martín / Gerard Urrútia / Javier Zamora

Journal of Personalized Medicine, Vol 11, Iss 441, p

Challenges and Lessons Learned

2021 Volume 441

Abstract	Sex is a common baseline factor collected in studies that has the potential to be a prognostic factor (PF) in several clinical areas. In recent years, research on sex as a PF has increased; however, this influx of new studies frequently shows conflicting results across the same treatment or disease state. Thus, systematic reviews (SRs) addressing sex as a PF may help us to better understand diseases and further personalize healthcare. We wrote this article to offer insights into the challenges we encountered when conducting SRs on sex as a PF and suggestions on how to overcome these obstacles, regardless of the clinical domain. When carrying out a PF SR with sex as the index factor, it is important to keep in mind the modifications that must be made in various SR stages, such as modifying the PF section of CHARMS-PF, adjusting certain sections of QUIPS and extracting data on the sex and gender terms used throughout the studies. In this paper, we provide an overview of the lessons learned from carrying out our reviews on sex as a PF in different disciplines and now call on researchers, funding agencies and journals to realize the importance of studying sex as a PF.
Keywords	sex ; gender ; prognosis ; prognostic factor ; systematic review ; methods ; Medicine ; R
Subject code	306
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Current State of Research About Chinese Herbal Medicines (CHM) for the Treatment of Coronavirus Disease 2019 (COVID-19)

López-Alcalde, Jesús / Yan, Yuqian / Witt, Claudia M. / Barth, Jürgen

The Journal of Alternative and Complementary Medicine

A Scoping Review

2020 Volume 26, Issue 7, Page(s) 557–570

Keywords	Complementary and alternative medicine ; covid19
Language	English
Publisher	Mary Ann Liebert Inc
Publishing country	us
Document type	Article ; Online
ZDB-ID	1237383-7
ISSN	1075-5535
ISSN	1075-5535
DOI	10.1089/acm.2020.0189
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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