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  1. Article ; Online: Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection.

    Kalra, Rajkumar Singh / Kandimalla, Ramesh

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 39

    MeSH term(s) COVID-19 ; Heparitin Sulfate ; Humans ; Peptidyl-Dipeptidase A/metabolism ; Protein Binding ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Heparitin Sulfate (9050-30-0) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00470-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Apoptosis, autophagy, and mitophagy dysfunction in Alzheimer's disease: Evolving emergence and mechanisms.

    Kalra, Rajkumar Singh / Kandimalla, Ramesh / Bk, Binukumar

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 1049914

    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.1049914
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  3. Article: Etiological and risk factors in recurrent febrile seizures: Insights through EEG analysis.

    Kuruva, Umesh Babu / Kompally, Vasudev / Bukkapatnam, Subhan Basha / Gudi, Prathap / Kandimalla, Ramesh

    Qatar medical journal

    2024  Volume 2023, Issue 4, Page(s) 32

    Abstract: Background: Febrile seizures, convulsive episodes in young children during febrile illnesses, are a significant concern due to their potential for recurrence and associated uncertainties. This study investigated the causes and risks associated with ... ...

    Abstract Background: Febrile seizures, convulsive episodes in young children during febrile illnesses, are a significant concern due to their potential for recurrence and associated uncertainties. This study investigated the causes and risks associated with recurrent febrile seizures and the critical role of electroencephalogram (EEG) in their accurate diagnosis.
    Methods: Following Institutional Review Board approval and going through the consenting process with parents, this study gathered the clinical features and EEG recordings of children admitted with febrile seizures in the Department of Pediatrics, Mahatma Gandhi Memorial Hospital, Kakatiya Medical College, Warangal, Telangana, India. Descriptive statistics, including mean, standard deviation (SD), frequencies, and percentages, were computed to understand the data comprehensively. The Chi-Square test was employed to analyze the association between variables, with a significance level of 0.05, ensuring reliable and trustworthy findings.
    Results: Out of 42 children studied, 28 (66.67%) presented with simple febrile seizures, with the mean time of occurrence of seizures from the onset of fever being 7.85 hours. Abnormal EEG was seen in 50% of children with complex febrile seizures and 16% with simple febrile seizures. Generalized epileptiform discharges were the most common epileptic activity observed. Low sodium levels had a significant relationship with febrile seizures in the analysis.
    Conclusions: This study emphasizes the importance of EEG in diagnosing febrile seizures, particularly in complex cases. Our findings suggest that low sodium levels may be a significant risk factor for febrile seizures. Further research is necessary to identify other preventable risk factors to reduce the burden of the medical condition.
    Language English
    Publishing date 2024-01-06
    Publishing country Qatar
    Document type Journal Article
    ZDB-ID 3031075-1
    ISSN 2227-0426 ; 0253-8253
    ISSN (online) 2227-0426
    ISSN 0253-8253
    DOI 10.5339/qmj.2023.32
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  4. Article ; Online: CRISPR-Cas9 in Alzheimer's disease: Therapeutic trends, modalities, and challenges.

    Chacko, Leena / Chaudhary, Anupama / Singh, Birbal / Dewanjee, Saikat / Kandimalla, Ramesh

    Drug discovery today

    2023  Volume 28, Issue 8, Page(s) 103652

    Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no known cure, which has prompted the exploration of novel therapeutic approaches. The clustered regularly interspaced palindromic repeats (CRISPR)-CRISPR-associated protein 9 ( ... ...

    Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no known cure, which has prompted the exploration of novel therapeutic approaches. The clustered regularly interspaced palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) tool has generated significant interest for its potential in AD therapeutics by correcting faulty genes. Our report comprehensively reviews emerging applications for CRISPR-Cas9 in developing in vitro and in vivo models for AD research and therapeutics. We further assess its ability to identify and validate genetic markers and potential therapeutic targets for AD. Moreover, we review the current challenges and delivery strategies for the in vivo application of CRISPR-Cas9 in AD therapeutics.
    MeSH term(s) Humans ; CRISPR-Cas Systems/genetics ; Gene Editing ; Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Genetic Therapy
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2023.103652
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    Zs.A 4725: Show issues Location:
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  5. Article ; Online: Advances in lipid-based carriers for cancer therapeutics: Liposomes, exosomes and hybrid exosomes.

    Moholkar, Disha N / Kandimalla, Raghuram / Gupta, Ramesh C / Aqil, Farrukh

    Cancer letters

    2023  Volume 565, Page(s) 216220

    Abstract: Cancer has recently surpassed heart disease as the leading cause of deaths worldwide for the age group 45-65 and has been the primary focus for biomedical researchers. Presently, the drugs involved in the first-line cancer therapy are raising concerns ... ...

    Abstract Cancer has recently surpassed heart disease as the leading cause of deaths worldwide for the age group 45-65 and has been the primary focus for biomedical researchers. Presently, the drugs involved in the first-line cancer therapy are raising concerns due to high toxicity and lack of selectivity to cancer cells. There has been a significant increase in research with innovative nano formulations to entrap the therapeutic payload to enhance efficacy and eliminate or minimize toxic effects. Lipid-based carriers stand out due to their unique structural properties and biocompatible nature. The two main leaders of lipid-based drug carriers: long known liposomes and comparatively new exosomes have been well-researched. The similarity between the two lipid-based carriers is the vesicular structure with the core's capability to carry the payload. While liposomes utilize chemically derived and altered phospholipid components, the exosomes are naturally occurring vesicles with inherent lipids, proteins, and nucleic acids. More recently, researchers have focused on developing hybrid exosomes by fusing liposomes and exosomes. Combining these two types of vesicles may offer some advantages such as high drug loading, targeted cellular uptake, biocompatibility, controlled release, stability in harsh conditions and low immunogenicity.
    MeSH term(s) Humans ; Liposomes/chemistry ; Exosomes/metabolism ; Drug Carriers ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Phospholipids/metabolism ; Drug Delivery Systems
    Chemical Substances Liposomes ; Drug Carriers ; Phospholipids
    Language English
    Publishing date 2023-05-19
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2023.216220
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  6. Article ; Online: Engaging the spikes

    Rajkumar Singh Kalra / Ramesh Kandimalla

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection

    2021  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Label-free detection of Aβ-42: a liquid crystal droplet approach for Alzheimer's disease diagnosis.

    Pradhan, Saumya Ranjan / Pathinti, Ramadevi Suguru / Kandimalla, Ramesh / Chithari, Krishnakanth / Veeramalla N, Madhava Rao / Vallamkondu, Jayalakshmi

    RSC advances

    2024  Volume 14, Issue 17, Page(s) 12107–12118

    Abstract: This study introduces a biosensor based on liquid crystals (LC) designed to detect the Aβ-42 biomarker, commonly associated with Alzheimer's disease. The sensor utilizes LC droplets created using a PEI/Tween-20 surfactant mixture, arranged radially in an ...

    Abstract This study introduces a biosensor based on liquid crystals (LC) designed to detect the Aβ-42 biomarker, commonly associated with Alzheimer's disease. The sensor utilizes LC droplets created using a PEI/Tween-20 surfactant mixture, arranged radially in an aqueous solution. These droplets are coated with the Aβ1-16 antibody, enabling the detection of the Aβ1-42 biomarker. The key advantage of this biosensor lies in its ability to directly translate the antigen-antibody interaction into a change in the molecular orientation of the LC droplets, simplifying the detection process by removing additional procedural steps. Specifically, this immunoassay induces a transformation in the nematic droplets orientation from radial to bipolar upon successful antigen binding. When only the Aβ1-16 antibody coated the LC droplets, no change in orientation was detected, confirming the reaction's specificity. The orientation shift in the LC droplets indicates the formation of an immunocomplex between the Aβ1-16 antibody and the Aβ1-42 antigen. The LC droplet immunoassay effectively detected Aβ1-42 antigen concentrations ranging from 45 to 112.5 μM, with the Aβ1-16 antibody immobilized on the droplets at a concentration of 1 μg mL
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00615a
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  8. Article ; Online: Human olfactory neurosphere-derived cells: A unified tool for neurological disease modelling and neurotherapeutic applications.

    Ansari, Saad / Etekochay, Maudlyn O / Atanasov, Atanas G / Prasad, Vishnu P / Kandimalla, Ramesh / Mofatteh, Mohammad / V, Priyanka / Emran, Talha Bin

    International journal of surgery (London, England)

    2024  

    Abstract: As one of the leading causes of global mortality and morbidity, various neurological diseases cause social and economic burdens. Despite significant advances in the treatment of neurological diseases, establishing a proper disease model, especially for ... ...

    Abstract As one of the leading causes of global mortality and morbidity, various neurological diseases cause social and economic burdens. Despite significant advances in the treatment of neurological diseases, establishing a proper disease model, especially for degenerative and infectious diseases, remains a major challenging issue. For long, mice were the model of choice but suffered from serious drawbacks of differences in anatomical and functional aspects of the nervous system. Furthermore, the collection of post-mortem brain tissues limits their usage in cultured cell lines. Overcoming such limitations has prompted the usage of stem cells derived from the peripheral nervous system, such as the cells of the olfactory mucosa as a preferred choice. These cells can be easily cultured in vitro and retain the receptors of neuronal cells life-long. Such cells have various advantages over embryonic or induced stem cells, including homology, and ease of culture and can be conveniently obtained from diseased individuals through either biopsies or exfoliation. They have continuously helped in understanding the genetic and developmental mechanisms of degenerative diseases like Alzheimer's and Parkinson's disease. Moreover, the mode of infection of various viruses that can lead to post-viral olfactory dysfunction, such as the Zika virus can be monitored through these cells in vitro and their therapeutic development can be fastened.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001460
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    Zs.A 6502: Show issues Location:
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  9. Article ; Online: Potential of Nano-Engineered Stem Cells in the Treatment of Multiple Sclerosis: A Comprehensive Review.

    Ghosh, Sushruta / Bhatti, Gurjit Kaur / Sharma, Pushpender Kumar / Kandimalla, Ramesh / Mastana, Sarabjit Singh / Bhatti, Jasvinder Singh

    Cellular and molecular neurobiology

    2023  Volume 44, Issue 1, Page(s) 6

    Abstract: Multiple sclerosis (MS) is a chronic and degrading autoimmune disorder mainly targeting the central nervous system, leading to progressive neurodegeneration, demyelination, and axonal damage. Current treatment options for MS are limited in efficacy, ... ...

    Abstract Multiple sclerosis (MS) is a chronic and degrading autoimmune disorder mainly targeting the central nervous system, leading to progressive neurodegeneration, demyelination, and axonal damage. Current treatment options for MS are limited in efficacy, generally linked to adverse side effects, and do not offer a cure. Stem cell therapies have emerged as a promising therapeutic strategy for MS, potentially promoting remyelination, exerting immunomodulatory effects and protecting against neurodegeneration. Therefore, this review article focussed on the potential of nano-engineering in stem cells as a therapeutic approach for MS, focusing on the synergistic effects of combining stem cell biology with nanotechnology to stimulate the proliferation of oligodendrocytes (OLs) from neural stem cells and OL precursor cells, by manipulating neural signalling pathways-PDGF, BMP, Wnt, Notch and their essential genes such as Sox, bHLH, Nkx. Here we discuss the pathophysiology of MS, the use of various types of stem cells in MS treatment and their mechanisms of action. In the context of nanotechnology, we present an overview of its applications in the medical and research field and discuss different methods and materials used to nano-engineer stem cells, including surface modification, biomaterials and scaffolds, and nanoparticle-based delivery systems. We further elaborate on nano-engineered stem cell techniques, such as nano script, nano-exosome hybrid, nano-topography and their potentials in MS. The article also highlights enhanced homing, engraftment, and survival of nano-engineered stem cells, targeted and controlled release of therapeutic agents, and immunomodulatory and tissue repair effects with their challenges and limitations. This visual illustration depicts the process of utilizing nano-engineering in stem cells and exosomes for the purpose of delivering more accurate and improved treatments for Multiple Sclerosis (MS). This approach targets specifically the creation of oligodendrocytes, the breakdown of which is the primary pathological factor in MS.
    MeSH term(s) Humans ; Multiple Sclerosis/pathology ; Neural Stem Cells ; Oligodendroglia/metabolism ; Central Nervous System/pathology ; Axons/pathology ; Myelin Sheath/pathology
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 283404-2
    ISSN 1573-6830 ; 0272-4340
    ISSN (online) 1573-6830
    ISSN 0272-4340
    DOI 10.1007/s10571-023-01434-5
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    Zs.A 1727: Show issues Location:
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  10. Article ; Online: Milk exosomes: A biogenic nanocarrier for small molecules and macromolecules to combat cancer.

    Kandimalla, Raghuram / Aqil, Farrukh / Tyagi, Neha / Gupta, Ramesh

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2020  Volume 85, Issue 2, Page(s) e13349

    Abstract: Exosomes are unique biogenic nanocarriers of endocytic origin that are generated from most of the cells and found in biofluids like milk, plasma, saliva, and urine. Bovine milk represents the largest and an economic source for the production of exosomes. ...

    Abstract Exosomes are unique biogenic nanocarriers of endocytic origin that are generated from most of the cells and found in biofluids like milk, plasma, saliva, and urine. Bovine milk represents the largest and an economic source for the production of exosomes. In recent past, the utility of the milk exosomes as drug carriers is intensified. Exosomes are emerging for delivery of both small and large therapeutics due to their biocompatibility. In this article, we highlighted the various exosomal isolation techniques, physicochemical properties, their biodistribution, and utility of milk exosomes in delivering the small drug molecules and siRNA to combat cancer.
    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Biological Therapy/methods ; Drug Delivery Systems/methods ; Exosomes/metabolism ; Humans ; Milk/metabolism ; Nanostructures ; Neoplasms/therapy ; RNA, Small Interfering/therapeutic use
    Chemical Substances Antineoplastic Agents ; RNA, Small Interfering
    Language English
    Publishing date 2020-10-06
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13349
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1653: Show issues Location:
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