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  1. Article ; Online: A Qualitative Study of the Psychological Morbidity in Paediatric Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

    Phillips, Chris / Russell, Emily / McNiven, Abigail / McPherson, Tess

    The British journal of dermatology

    2024  

    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljae154
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  2. Article ; Online: Five paediatric patients with mycosis fungoides and our approach to provide age-appropriate information and psychological support.

    Melchionda, Veronica / Ieremia, Eleni / Matin, Rubeta / McPherson, Tess

    Clinical and experimental dermatology

    2024  Volume 49, Issue 5, Page(s) 497–501

    Abstract: Cutaneous lymphoproliferative diseases in childhood are rare and they are clinically and pathologically heterogeneous, which makes their diagnosis challenging. Although there is limited long-term data and guidance on management, evidence suggests these ... ...

    Abstract Cutaneous lymphoproliferative diseases in childhood are rare and they are clinically and pathologically heterogeneous, which makes their diagnosis challenging. Although there is limited long-term data and guidance on management, evidence suggests these to be different conditions from cutaneous lymphoma in adults, highlighting the need for age-appropriate patient information. We present clinical outcomes for our paediatric cohort of five patients with mycosis fungoides, emphasizing that despite diagnostic delays, mycosis fungoides in this age group tends to yield a good prognosis. It remains uncommon to provide clinical expertise together with psychological support in a dermatology paediatric service. Here, we provide our experience in offering this combined service. In conjunction with these patients, we have co-produced an accessible patient information leaflet targeted at a younger audience for support and to clarify potential misconceptions from a diagnosis of cutaneous lymphoma.
    MeSH term(s) Adolescent ; Child ; Female ; Humans ; Male ; Age Factors ; Mycosis Fungoides/psychology ; Mycosis Fungoides/therapy ; Patient Education as Topic ; Skin Neoplasms/psychology ; Skin Neoplasms/therapy ; Young Adult
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llad457
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  3. Article ; Online: Current Understanding in Pathogenesis of Atopic Dermatitis.

    McPherson, Tess

    Indian journal of dermatology

    2016  Volume 61, Issue 6, Page(s) 649–655

    Abstract: There have been advances in our understanding of the complex pathogenesis of atopic eczema over the past few decades. This article examines the multiple factors which are implicated in this process. ...

    Abstract There have been advances in our understanding of the complex pathogenesis of atopic eczema over the past few decades. This article examines the multiple factors which are implicated in this process.
    Language English
    Publishing date 2016-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/0019-5154.193674
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  4. Article ; Online: Current understanding in pathogenesis of atopic dermatitis

    Tess McPherson

    Indian Journal of Dermatology, Vol 61, Iss 6, Pp 649-

    2016  Volume 655

    Abstract: There have been advances in our understanding of the complex pathogenesis of atopic eczema over the past few decades. This article examines the multiple factors which are implicated in this process. ...

    Abstract There have been advances in our understanding of the complex pathogenesis of atopic eczema over the past few decades. This article examines the multiple factors which are implicated in this process.
    Keywords Atopic dermatitis ; atopic march ; filaggrin ; Medicine ; R ; Dermatology ; RL1-803
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Isotretinoin and adverse neuropsychiatric outcomes: retrospective cohort study using routine data.

    Paljarvi, Tapio / McPherson, Tess / Luciano, Sierra / Herttua, Kimmo / Fazel, Seena

    The British journal of dermatology

    2022  Volume 187, Issue 1, Page(s) 64–72

    Abstract: Background: Severe neuropsychiatric outcomes have been reported in individuals exposed to isotretinoin, but the evidence is inconclusive and complicated by several methodological limitations.: Objectives: To establish and quantify the association ... ...

    Abstract Background: Severe neuropsychiatric outcomes have been reported in individuals exposed to isotretinoin, but the evidence is inconclusive and complicated by several methodological limitations.
    Objectives: To establish and quantify the association between isotretinoin use for acne and 1-year incident neuropsychiatric adverse outcomes.
    Methods: A propensity score-matched cohort study of electronic medical records between the years 2013 and 2019 with patients followed up for 1 year after their index dispensed prescription was conducted. The database included over 12 million patients aged 12-27 years. We analysed data for individuals with acne in this age range with a dispensed prescription for isotretinoin or a control prescription. Outcomes included diagnoses of any incident sleep or mental health disorder, or nonfatal self-harm within 1 year of the index prescription.
    Results: We included 30 866 patients prescribed isotretinoin for their acne, 44 748 prescribed oral antibiotics, 108 367 prescribed topical anti-acne agents and 78 666 patients with acne but without an anti-acne prescription. After propensity score matching for baseline confounders, the odds ratio (OR) for any incident neuropsychiatric outcomes in patients with acne exposed to isotretinoin was 0·80 [95% confidence interval (CI) 0·74-0·87] compared with those on oral antibiotics; 0·94 (95% CI 0·87-1·02) compared with those using topical anti-acne medicines; and 1·06 (95% CI 0·97-1·16) compared with those without a prescription for anti-acne medicines. Patients exposed to isotretinoin experienced significantly more incident physical symptoms than patients in any of the three comparison cohorts.
    Conclusions: Isotretinoin was not independently associated with excess adverse neuropsychiatric outcomes at the population level. When monitoring potential adverse outcomes during isotretinoin treatment, clinicians should also consider the high mental health burden associated with treatment-resistant acne and the potential contribution of physical side-effects of prescribed medication on mental health.
    MeSH term(s) Acne Vulgaris/epidemiology ; Anti-Bacterial Agents/therapeutic use ; Cohort Studies ; Dermatologic Agents/adverse effects ; Humans ; Isotretinoin/adverse effects ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents ; Dermatologic Agents ; Isotretinoin (EH28UP18IF)
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21049
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  6. Article ; Online: The case for neutrality on assisted dying - a personal view.

    McPherson, Tess

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2013  Volume 63, Issue 607, Page(s) 68

    MeSH term(s) Humans ; Suicide, Assisted/ethics
    Language English
    Publishing date 2013-04-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp13X661048
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  7. Article ; Online: Paraneoplastic subacute cutaneous lupus erythematosus associated with cholangiocarcinoma.

    Jenkins, David / McPherson, Tess

    The Australasian journal of dermatology

    2016  Volume 57, Issue 1, Page(s) e5–7

    Abstract: Subacute cutaneous lupus erythematosus (SCLE) is a dermatosis that occurs in genetically predisposed individuals. The exogenous stimulus that triggers this condition is usually unknown; however, medication is often implicated. Malignancy is a rare cause. ...

    Abstract Subacute cutaneous lupus erythematosus (SCLE) is a dermatosis that occurs in genetically predisposed individuals. The exogenous stimulus that triggers this condition is usually unknown; however, medication is often implicated. Malignancy is a rare cause. We present a case of paraneoplastic SCLE to cholangiocarcinoma and briefly review the features of this interesting entity.
    MeSH term(s) Adult ; Bile Duct Neoplasms/complications ; Cholangiocarcinoma/complications ; Female ; Humans ; Lupus Erythematosus, Cutaneous/etiology ; Paraneoplastic Syndromes/etiology
    Language English
    Publishing date 2016-02
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.12251
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    Zs.A 236: Show issues Location:
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  8. Article ; Online: My mum wanted assisted dying but we watched her die slowly and in pain.

    McPherson, Tess

    BMJ (Clinical research ed.)

    2012  Volume 344, Page(s) e4007

    MeSH term(s) Anecdotes as Topic ; Chronic Pain/etiology ; Female ; Humans ; Pancreatic Neoplasms/psychology ; Right to Die ; Suicide, Assisted/psychology
    Language English
    Publishing date 2012-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.e4007
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  9. Article ; Online: A case of severe refractory Darier's disease of the feet in which management with carbon dioxide (CO

    Dunnigan, Anna V / Salence, Brogan / McPherson, Tess / Walker, Neil P J

    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

    2020  Volume 22, Issue 4-5, Page(s) 174–176

    Abstract: Darier's disease is a rare genodermatosis typically characterized by scaly or crusted papules. Usual management comprises topical and oral treatments, however medical therapy may be inadequate in cases of severe disease. For these patients, further ... ...

    Abstract Darier's disease is a rare genodermatosis typically characterized by scaly or crusted papules. Usual management comprises topical and oral treatments, however medical therapy may be inadequate in cases of severe disease. For these patients, further treatment options may include the use of carbon dioxide (CO
    MeSH term(s) Carbon Dioxide/therapeutic use ; Darier Disease/therapy ; Foot/pathology ; Humans ; Laser Therapy ; Lasers, Gas/therapeutic use ; Skin/pathology
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2146360-8
    ISSN 1476-4180 ; 1476-4172
    ISSN (online) 1476-4180
    ISSN 1476-4172
    DOI 10.1080/14764172.2020.1783453
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    Zs.A 5905: Show issues Location:
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  10. Article ; Online: A real-world retrospective observational study exploring NHS resource use in England for the management of moderate-to-severe atopic dermatitis in secondary care for children and adolescents.

    McPherson, Tess / Cork, Michael J / Goodhead, Charlotte / Michaelis, Louise J / Flohr, Carsten / Petrovic, Milos / Hennessy, Liz / Rajkovic, Ivana / Hudson, Richard

    Pediatric dermatology

    2022  Volume 40, Issue 1, Page(s) 50–63

    Abstract: Purpose: To describe secondary care health care resource utilization (HCRU) for children and adolescents with atopic dermatitis (AD).: Patients and methods: This UK chart review of patients with moderate-to-severe AD was conducted in four National ... ...

    Abstract Purpose: To describe secondary care health care resource utilization (HCRU) for children and adolescents with atopic dermatitis (AD).
    Patients and methods: This UK chart review of patients with moderate-to-severe AD was conducted in four National Health Service hospitals. Cohorts were defined by age (children 6-11 years, adolescents 12-17) at first consultation. Eligible patients were selected consecutively, starting with the most recently consulting patient. At least 12 months' data were abstracted from medical records. Data were collected on HCRU, demographics/clinical characteristics, treatment, and patient-reported outcomes.
    Results: Data were abstracted for 55 patients. Most patients (80%) had severe AD at first referral, a mean (SD) of 3.2 (10.7) patient-reported flare episodes/patient/year-of-observation, and 18.5 (16.7) tests/scans/procedures/patient/year. Mean (SD) observation duration was 3.6 (1.8) years. Patients had tried mean (SD) 7.9 (5.3) treatments/patient/year of observation. Topical corticosteroids (TCS; 24.5% of prescriptions) were most frequently prescribed. Mean (SD) use of emollients/moisturizers, TCS, systemic corticosteroids, and systemic immunosuppressants was 30.9 (21.3), 21.1 (23.4), 1.7 (8.3), and 7.8 (8.2) months. There was a mean (SD) of 5.3 (2.9) consultations/patient/year-of-observation; 116 (10.7%) for flare. Most hospitalizations (87.5%) were for children; the 8/55 (15%) hospitalized patients (mean 2.0 hospitalizations/patient during observation period) spent 6.2 (SD: 5.1) nights in hospital/hospitalization. Earliest mean (SD) Children's Dermatology Life Quality Index score was 15.3 (7.2); latest was 12.9 (7.5).
    Conclusion: Children and adolescents with moderate-to-severe AD had a high HCRU burden and small changes in quality of life, indicating that current treatments may provide suboptimal AD control in most cases.
    MeSH term(s) Child ; Humans ; Adolescent ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/epidemiology ; State Medicine ; Quality of Life ; Secondary Care ; Adrenal Cortex Hormones/therapeutic use ; England/epidemiology ; Severity of Illness Index
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15134
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