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Article: Repurposing and discovery of transmembrane serine protease 2 (TMPRSS2) inhibitors as prophylactic therapies for new coronavirus disease 2019 (COVID-19).

Yang, Hao / Lin, Xinxin / Yu, Qimeng / Awadasseid, Annoor / Zhang, Wen

2024 Volume 78, Issue 11, Page(s) 217–224

Abstract: The global pandemic of COVID-19 disease is caused by the pathogenic factor called SARS-CoV-2. Meanwhile, a series of vaccines and small-molecule drugs, including the mRNA vaccines and ... ...

Abstract	The global pandemic of COVID-19 disease is caused by the pathogenic factor called SARS-CoV-2. Meanwhile, a series of vaccines and small-molecule drugs, including the mRNA vaccines and Paxlovid
MeSH term(s)	Humans ; COVID-19 ; Drug Repositioning ; Serine Endopeptidases ; Serine Proteases ; Serine Proteinase Inhibitors/therapeutic use
Chemical Substances	Serine Endopeptidases (EC 3.4.21.-) ; Serine Proteases (EC 3.4.-) ; TMPRSS2 protein, human (EC 3.4.21.-) ; Serine Proteinase Inhibitors
Language	English
Publishing date	2024-01-04
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	208793-5
ISSN	0031-7144
ISSN	0031-7144
DOI	10.1691/ph.2023.3578
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Article ; Online: A Review on the Anticancer Activity of Carbazole-based Tricyclic Compounds.

Zhang, Hua / Zhang, Wen / Zhu, Mengyu / Awadasseid, Annoor

Current medicinal chemistry

2023

Abstract: Cancers are a huge threat to human life and health. Every year, many people suffer and die from various cancers, and numerous resources have been used to combat cancer. Due to several disadvantages of anticancer agents, such as drug-induced side effects, ...

Abstract	Cancers are a huge threat to human life and health. Every year, many people suffer and die from various cancers, and numerous resources have been used to combat cancer. Due to several disadvantages of anticancer agents, such as drug-induced side effects, drug resistance, etc., there are still wide gaps in their ability to conquer cancer. Therefore, there is an urgent need to discover and develop many novel chemotypes to suppress cancer. In this review, we mainly focus on the anticancer potency of two representative sorts of carbazole-based compounds: carboline derivatives and diazacarbazole derivatives. Diazacarbazole derivatives, which have not been fully explored yet, might bring us a new vision and a valuable opportunity for overcoming the enormous hurdle we are now facing in the cancer campaign. We also provide several synthetic approaches for constructing the critical skeletons of the carbazole-based tricyclic compounds.
Language	English
Publishing date	2023-08-25
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867331666230825104254
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Article ; Online: Corrigendum to "G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy" [Biomed. Pharmacother. 139 (2021) 111550].

Awadasseid, Annoor / Ma, Xudong / Wu, Yanling / Zhang, Wen

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 148, Page(s) 112764

Language	English
Publishing date	2022-03-01
Publishing country	France
Document type	Published Erratum
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.112764
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Article ; Online: Small molecule and PROTAC molecule experiments in vitro and in vivo, focusing on mouse PD-L1 and human PD-L1 differences as targets.

Awadasseid, Annoor / Wang, Rui / Sun, Shishi / Zhang, Feng / Wu, Yanling / Zhang, Wen

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 172, Page(s) 116257

Abstract: In recent years, several monoclonal antibodies (mAbs) targeting PD-L1 have been licensed by the FDA for use in the treatment of cancer, demonstrating the effectiveness of blocking immune checkpoints, particularly the PD-1/PD-L1 pathway. Although mAb- ... ...

Abstract	In recent years, several monoclonal antibodies (mAbs) targeting PD-L1 have been licensed by the FDA for use in the treatment of cancer, demonstrating the effectiveness of blocking immune checkpoints, particularly the PD-1/PD-L1 pathway. Although mAb-based therapies have made great strides, they still have their limitations, and new small-molecule or PROTAC-molecule inhibitors that can block the PD-1/PD-L1 axis are desperately needed. Therefore, it is crucial to translate initial in vitro discoveries into appropriate in vivo animal models when creating PD-L1-blocking therapies. Due to their widespread availability and low experimental expenses, classical immunocompetent mice are appealing for research purposes. However, it is yet unclear whether the mouse (m) PD-L1 interaction with human (h) PD-1 in vivo would produce a functional immunological checkpoint. In this review, we summarize the in vitro and in vivo experimental studies of small molecules and PROTAC molecules, particularly the distinctions between mPD-L1 as a target and hPD-L1 as a target.
MeSH term(s)	Animals ; Humans ; Mice ; Antibodies, Monoclonal/pharmacology ; B7-H1 Antigen/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/metabolism ; Research Design ; Small Molecule Libraries
Chemical Substances	Antibodies, Monoclonal ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Small Molecule Libraries
Language	English
Publishing date	2024-02-13
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116257
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Article ; Online: Exploring potential bacterial populations for enhanced anthraquinone dyes biodegradation: a critical review.

Jamal, Mayada / Awadasseid, Annoor / Su, Xiaomei

Biotechnology letters

2022 Volume 44, Issue 9, Page(s) 1011–1025

Abstract: Anthraquinone dyes, which include an anthraquinone chromophore group, are the second-largest among dye classes, which is often employed in textile manufacturing. A significant number of anthraquinone dyes get into the environment, creating severe ... ...

Abstract	Anthraquinone dyes, which include an anthraquinone chromophore group, are the second-largest among dye classes, which is often employed in textile manufacturing. A significant number of anthraquinone dyes get into the environment, creating severe pollution since many of these dyes have intricate and stable structures. Currently, microbiological treatment of wastewater is an economically and feasibly viable solution for treating printing and dyeing wastewater, and there are growing reports of biodegradation of anthraquinone dyes. In this review, we outline the current advances in the biodegradation of anthraquinone dyes, summarizes dyes biodegradation by bacterial, fungal, and algae strains, factors influencing dyes biodegradation, current methods in enhancing dyes biodegradation, resuscitation of viable but non-culturable (VBNC) bacteria for better microbial performance, and potentials of VBNC bacteria in degrading dyes. Finally, future directions and important areas for study are given, and such efforts are anticipated to improve the anaerobic degradation process.
MeSH term(s)	Anthraquinones/metabolism ; Bacteria/metabolism ; Biodegradation, Environmental ; Coloring Agents/metabolism ; Waste Water
Chemical Substances	Anthraquinones ; Coloring Agents ; Waste Water
Language	English
Publishing date	2022-07-24
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-022-03279-2
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Article ; Online: Recent advances and mechanisms of action of PD-L1 degraders as potential therapeutic agents.

Zhang, Feng / Jiang, Ruiya / Sun, Shishi / Wu, Caiyun / Yu, Qimeng / Awadasseid, Annoor / Wang, Jianwei / Zhang, Wen

European journal of medicinal chemistry

2024 Volume 268, Page(s) 116267

Abstract: PD-L1 is an important immune checkpoint protein that can bind to T cells' PD-1 receptor, thereby promoting immune escape from tumors. In recent years, many researchers have developed strategies to degrade PD-L1 to improve the effect of immunotherapy. The ...

Abstract	PD-L1 is an important immune checkpoint protein that can bind to T cells' PD-1 receptor, thereby promoting immune escape from tumors. In recent years, many researchers have developed strategies to degrade PD-L1 to improve the effect of immunotherapy. The study of degrading PD-L1 provides new opportunities for immunotherapy. Here, we mainly summarize and review the current active molecules and mechanisms that mediate the degradation of immature and mature PD-L1 during the post-translational modification stages, involving PD-L1 phosphorylation, glycosylation, palmitoylation, ubiquitination, and the autophagy-lysosomal process. This review expects that by degrading PD-L1 protein, we will not only gain a better understanding of oncogenic mechanisms involving tumor PD-L1 protein but also provide a new way to improve immunotherapy.
MeSH term(s)	Humans ; B7-H1 Antigen/metabolism ; Neoplasms/metabolism ; Protein Processing, Post-Translational ; Immunotherapy ; T-Lymphocytes
Chemical Substances	B7-H1 Antigen
Language	English
Publishing date	2024-02-23
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2024.116267
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Article ; Online: Extracellular Vesicles (Exosomes) as Immunosuppressive Mediating Variables in Tumor and Chronic Inflammatory Microenvironments.

Awadasseid, Annoor / Wu, Yanling / Zhang, Wen

Cells

2021 Volume 10, Issue 10

Abstract: Exosomes are extracellular vesicles released by most of the eukaryotic cells. Exosomes' components include proteins, lipids, microRNA, circular RNA, long noncoding RNA, DNA, etc. Exosomes may carry both pro and anti-inflammatory cargos; however, exosomes ...

Abstract	Exosomes are extracellular vesicles released by most of the eukaryotic cells. Exosomes' components include proteins, lipids, microRNA, circular RNA, long noncoding RNA, DNA, etc. Exosomes may carry both pro and anti-inflammatory cargos; however, exosomes are predominantly filled with immunosuppressive cargos such as enzymes and microRNAs in chronic inflammation. Exosomes have surfaced as essential participants in physiological and pathological intercellular communication. Exosomes may prevent or promote the formation of an aggressive tumor and chronic inflammatory microenvironments, thus influencing tumor and chronic inflammatory progression as well as clinical prognosis. Exosomes, which transmit many signals that may either enhance or constrain immunosuppression of lymphoid and myeloid cell populations in tumors, are increasingly becoming recognized as significant mediators of immune regulation in cancer. In this review, we outline the function of exosomes as mediators of immunosuppression in tumor and chronic inflammatory microenvironments, with the aim to improve cancer therapy.
MeSH term(s)	Exosomes/metabolism ; Extracellular Vesicles/immunology ; Extracellular Vesicles/metabolism ; Humans ; Immunosuppression Therapy/adverse effects ; Inflammation/genetics ; Inflammation/immunology ; Neoplasms/genetics ; Neoplasms/immunology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Language	English
Publishing date	2021-09-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10102533
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy.

Awadasseid, Annoor / Ma, Xudong / Wu, Yanling / Zhang, Wen

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 139, Page(s) 111550

Abstract: G-quadruplexes (G4) are secondary four-stranded DNA helical structures consisting of guanine-rich nucleic acids, which can be formed in the promoter regions of several genes under proper conditions. Several cancer cells have been shown to emerge from ... ...

Abstract	G-quadruplexes (G4) are secondary four-stranded DNA helical structures consisting of guanine-rich nucleic acids, which can be formed in the promoter regions of several genes under proper conditions. Several cancer cells have been shown to emerge from genomic changes in the expression of crucial growth-regulating genes that allow cells to develop and begin to propagate in an undifferentiated state. Recent attempts have focused on producing treatments targeted at particular protein products of genes that are abnormally expressed. Many of the proteins found are hard to target and considered undruggable due to structural challenges, protein overexpression, or mutations that affect treatment resistance. The utilization of small molecules that stabilize secondary DNA structures existing in several possible oncogenes' promoters and modulate their transcription is a new strategy that avoids some of these problems. In this review, we outline the function of G-quadruplex stabilization in cancer by small-molecules with the aim to improve cancer therapy.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; G-Quadruplexes/drug effects ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Promoter Regions, Genetic ; Small Molecule Libraries
Chemical Substances	Antineoplastic Agents ; Small Molecule Libraries
Language	English
Publishing date	2021-04-05
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.111550
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Article: Exploring potential bacterial populations for enhanced anthraquinone dyes biodegradation: a critical review

Jamal, Mayada / Awadasseid, Annoor / Su, Xiaomei

Biotechnology letters. 2022 Sept., v. 44, no. 9

2022

Abstract	Anthraquinone dyes, which include an anthraquinone chromophore group, are the second-largest among dye classes, which is often employed in textile manufacturing. A significant number of anthraquinone dyes get into the environment, creating severe pollution since many of these dyes have intricate and stable structures. Currently, microbiological treatment of wastewater is an economically and feasibly viable solution for treating printing and dyeing wastewater, and there are growing reports of biodegradation of anthraquinone dyes. In this review, we outline the current advances in the biodegradation of anthraquinone dyes, summarizes dyes biodegradation by bacterial, fungal, and algae strains, factors influencing dyes biodegradation, current methods in enhancing dyes biodegradation, resuscitation of viable but non-culturable (VBNC) bacteria for better microbial performance, and potentials of VBNC bacteria in degrading dyes. Finally, future directions and important areas for study are given, and such efforts are anticipated to improve the anaerobic degradation process.
Keywords	anthraquinones ; biodegradation ; biotechnology ; dyes ; fabrics ; fungi ; pollution ; wastewater ; wastewater treatment
Language	English
Dates of publication	2022-09
Size	p. 1011-1025.
Publishing place	Springer Netherlands
Document type	Article
Note	Review
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-022-03279-2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: SARS-CoV-2 variants evolved during the early stage of the pandemic and effects of mutations on adaptation in Wuhan populations.

Awadasseid, Annoor / Wu, Yanling / Tanaka, Yoshimasa / Zhang, Wen

International journal of biological sciences

2021 Volume 17, Issue 1, Page(s) 97–106

Abstract: The outbreak of the coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic apparently started in December 2019 in Wuhan, China, and has since affected many countries worldwide, turning ... ...

Abstract	The outbreak of the coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pandemic apparently started in December 2019 in Wuhan, China, and has since affected many countries worldwide, turning into a major global threat. Chinese researchers reported that SARS-CoV-2 could be classified into two major variants. They suggest that investigating the variations and characteristics of these variants might help assess risks and develop better treatment and prevention strategies. The two variants were named L-type and S-type, in which L-type was prevailed in an initial outbreak in Wuhan, Central China's Hubei Province, and S-type was phylogenetically older than L-type and less prevalent at an early stage, but with a later increase in frequency in Wuhan. There were 149 mutations in 103 sequenced SARS-CoV-2 genomes, 83 of which were nonsynonymous, leading to alteration in the amino acid sequence of proteins. Much effort is currently being devoted to elucidate whether or not these mutations affect viral transmissibility and virulence. In this review, we summarize the mutations in SARS-CoV-2 during the early phase of virus evolution and discuss the significance of the gene alterations in infections.
MeSH term(s)	Adaptation, Physiological ; COVID-19/epidemiology ; COVID-19/virology ; China/epidemiology ; Disease Outbreaks ; Genome, Viral ; Humans ; Mutation ; Pandemics ; Phylogeny ; Recombination, Genetic ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology
Language	English
Publishing date	2021-01-01
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.47827
Database	MEDical Literature Analysis and Retrieval System OnLINE

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