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  1. Article ; Online: Reviewing the journey to the clinical application of bacteriophages to treat multi-drug-resistant bacteria.

    Mboowa, Gerald

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 654

    Abstract: Antimicrobial resistance (AMR) was a leading cause of death globally in 2019. Sadly, COVID-19 has exacerbated AMR, nonetheless, the process of developing new antibiotics remains very challenging. This urgently requires the adoption of alternative ... ...

    Abstract Antimicrobial resistance (AMR) was a leading cause of death globally in 2019. Sadly, COVID-19 has exacerbated AMR, nonetheless, the process of developing new antibiotics remains very challenging. This urgently requires the adoption of alternative approaches to treat multi-drug-resistant bacterial infections. This editorial introduces the 'Bacteriophages against multi-drug resistant bacteria' collection launched at BMC Infectious Diseases which highlights progress towards using bacteriophages to tackle AMR.
    MeSH term(s) Humans ; Bacteriophages ; COVID-19 ; Drug Resistance, Multiple, Bacterial ; Bacterial Infections/drug therapy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria ; Drug Resistance, Bacterial
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Editorial
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08621-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Current and emerging diagnostic tests available for the novel COVID-19 global pandemic.

    Mboowa, Gerald

    AAS open research

    2020  Volume 3, Page(s) 8

    Abstract: On March 11, 2020 the World Health Organization (WHO) upgraded the status of the coronavirus disease 2019 (COVID-19) outbreak from epidemic to a global pandemic. This infection is caused by a novel coronavirus, SARS-CoV-2. Several rapid diagnostic tests ... ...

    Abstract On March 11, 2020 the World Health Organization (WHO) upgraded the status of the coronavirus disease 2019 (COVID-19) outbreak from epidemic to a global pandemic. This infection is caused by a novel coronavirus, SARS-CoV-2. Several rapid diagnostic tests have been developed at an astonishing pace; however, COVID-19 requires more highly specific rapid point-of-care diagnostic tests. This review describes the currently available testing approaches, as well as the available test assays including the Xpert® Xpress SARS-CoV-2 test (takes
    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country England
    Document type Journal Article
    ISSN 2515-9321
    ISSN (online) 2515-9321
    DOI 10.12688/aasopenres.13059.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Generalizability of machine learning in predicting antimicrobial resistance in E. coli: a multi-country case study in Africa.

    Nsubuga, Mike / Galiwango, Ronald / Jjingo, Daudi / Mboowa, Gerald

    BMC genomics

    2024  Volume 25, Issue 1, Page(s) 287

    Abstract: Background: Antimicrobial resistance (AMR) remains a significant global health threat particularly impacting low- and middle-income countries (LMICs). These regions often grapple with limited healthcare resources and access to advanced diagnostic tools. ...

    Abstract Background: Antimicrobial resistance (AMR) remains a significant global health threat particularly impacting low- and middle-income countries (LMICs). These regions often grapple with limited healthcare resources and access to advanced diagnostic tools. Consequently, there is a pressing need for innovative approaches that can enhance AMR surveillance and management. Machine learning (ML) though underutilized in these settings, presents a promising avenue. This study leverages ML models trained on whole-genome sequencing data from England, where such data is more readily available, to predict AMR in E. coli, targeting key antibiotics such as ciprofloxacin, ampicillin, and cefotaxime. A crucial part of our work involved the validation of these models using an independent dataset from Africa, specifically from Uganda, Nigeria, and Tanzania, to ascertain their applicability and effectiveness in LMICs.
    Results: Model performance varied across antibiotics. The Support Vector Machine excelled in predicting ciprofloxacin resistance (87% accuracy, F1 Score: 0.57), Light Gradient Boosting Machine for cefotaxime (92% accuracy, F1 Score: 0.42), and Gradient Boosting for ampicillin (58% accuracy, F1 Score: 0.66). In validation with data from Africa, Logistic Regression showed high accuracy for ampicillin (94%, F1 Score: 0.97), while Random Forest and Light Gradient Boosting Machine were effective for ciprofloxacin (50% accuracy, F1 Score: 0.56) and cefotaxime (45% accuracy, F1 Score:0.54), respectively. Key mutations associated with AMR were identified for these antibiotics.
    Conclusion: As the threat of AMR continues to rise, the successful application of these models, particularly on genomic datasets from LMICs, signals a promising avenue for improving AMR prediction to support large AMR surveillance programs. This work thus not only expands our current understanding of the genetic underpinnings of AMR but also provides a robust methodological framework that can guide future research and applications in the fight against AMR.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Escherichia coli/genetics ; Drug Resistance, Bacterial/genetics ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Ampicillin ; Cefotaxime ; Machine Learning ; Nigeria
    Chemical Substances Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) ; Ampicillin (7C782967RD) ; Cefotaxime (N2GI8B1GK7)
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-024-10214-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Current and emerging diagnostic tests available for the novel COVID-19 global pandemic [version 1; peer review

    Gerald Mboowa

    AAS Open Research, Vol

    2 approved]

    2020  Volume 3

    Abstract: On March 11, 2020 the World Health Organization (WHO) upgraded the status of the coronavirus disease 2019 (COVID-19) outbreak from epidemic to a global pandemic. This infection is caused by a novel coronavirus, SARS-CoV-2. Several rapid diagnostic tests ... ...

    Abstract On March 11, 2020 the World Health Organization (WHO) upgraded the status of the coronavirus disease 2019 (COVID-19) outbreak from epidemic to a global pandemic. This infection is caused by a novel coronavirus, SARS-CoV-2. Several rapid diagnostic tests have been developed at an astonishing pace; however, COVID-19 requires more highly specific rapid point-of-care diagnostic tests. This review describes the currently available testing approaches, as well as the available test assays including the Xpert® Xpress SARS-CoV-2 test (takes ~45 min) and Abbott ID COVID-19 test (5 min) as easy to use point-of-care tests for diagnosis of novel COVID-19 that have so far received the US Food and Drug Administration emergency use authorizations clearance. This review is correct as of the date published and will be updated as more diagnostic tests come to light.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The dawn of a cure for sickle cell disease through CRISPR-based treatment: A critical test of equity in public health genomics.

    Mboowa, Gerald / Sserwadda, Ivan / Kanyerezi, Stephen / Tukwasibwe, Stephen / Kidenya, Benson

    Annals of human genetics

    2024  

    Abstract: Equity in access to genomic technologies, resources, and products remains a great challenge. This was evident especially during the coronavirus disease 2019 (COVID-19) pandemic when the majority of lower middle-income countries were unable to achieve at ... ...

    Abstract Equity in access to genomic technologies, resources, and products remains a great challenge. This was evident especially during the coronavirus disease 2019 (COVID-19) pandemic when the majority of lower middle-income countries were unable to achieve at least 10% population vaccination coverage during initial COVID-19 vaccine rollouts, despite the rapid development of those vaccines. Sickle cell disease (SCD) is an inherited monogenic red blood cell disorder that affects hemoglobin, the protein that carries oxygen through the body. Globally, the African continent carries the highest burden of SCD with at least 240,000 children born each year with the disease. SCD has evolved from a treatable to a curable disease. Recently, the UK medical regulator approved its cure through clustered regularly interspaced short palindromic repeat (CRISPR)-based treatment, whereas the US Food and Drug Administration has equally approved two SCD gene therapies. This presents a remarkable opportunity to demonstrate equity in public health genomics. This CRISPR-based treatment is expensive and therefore, a need for an ambitious action to ensure that they are affordable and accessible where they are needed most and stand to save millions of lives.
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 333-5
    ISSN 1469-1809 ; 0003-4800
    ISSN (online) 1469-1809
    ISSN 0003-4800
    DOI 10.1111/ahg.12558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.193: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Current and emerging diagnostic tests available for the novel COVID-19 global pandemic

    Mboowa, Gerald

    AAS open research

    Abstract: On March 11, 2020 the World Health Organization (WHO) upgraded the status of the coronavirus disease 2019 (COVID-19) outbreak from epidemic to a global pandemic This infection is caused by a novel coronavirus, SARS-CoV-2 Several rapid diagnostic tests ... ...

    Abstract On March 11, 2020 the World Health Organization (WHO) upgraded the status of the coronavirus disease 2019 (COVID-19) outbreak from epidemic to a global pandemic This infection is caused by a novel coronavirus, SARS-CoV-2 Several rapid diagnostic tests have been developed at an astonishing pace;however, COVID-19 requires more highly specific rapid point-of-care diagnostic tests This review describes the currently available testing approaches, as well as the available test assays including the Xpert(R) Xpress SARS-CoV-2 test (takes ~45 min) and Abbott ID COVID-19 test (5 min) as easy to use point-of-care tests for diagnosis of novel COVID-19 that have so far received the US Food and Drug Administration emergency use authorizations clearance This review is correct as of the date published and will be updated as more diagnostic tests come to light
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #601555
    Database COVID19

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  7. Article ; Online: rMAP: the Rapid Microbial Analysis Pipeline for ESKAPE bacterial group whole-genome sequence data.

    Sserwadda, Ivan / Mboowa, Gerald

    Microbial genomics

    2021  Volume 7, Issue 6

    Abstract: The recent re-emergence of multidrug-resistant pathogens has exacerbated their threat to worldwide public health. The evolution of the genomics era has led to the generation of huge volumes of sequencing data at an unprecedented rate due to the ever- ... ...

    Abstract The recent re-emergence of multidrug-resistant pathogens has exacerbated their threat to worldwide public health. The evolution of the genomics era has led to the generation of huge volumes of sequencing data at an unprecedented rate due to the ever-reducing costs of whole-genome sequencing (WGS). We have developed the Rapid Microbial Analysis Pipeline (rMAP), a user-friendly pipeline capable of profiling the resistomes of ESKAPE pathogens (
    MeSH term(s) Acinetobacter baumannii/genetics ; Animals ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial/genetics ; Enterobacter/genetics ; Enterococcus faecium/genetics ; Genome, Bacterial ; Genomics ; Humans ; Klebsiella pneumoniae/genetics ; Multilocus Sequence Typing ; Phylogeny ; Plasmids ; Staphylococcus aureus/genetics ; Whole Genome Sequencing/methods
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-06-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000583
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  8. Article ; Online: Knowledge and attitude of secondary school students in Nakaseke, Uganda towards HIV transmission and treatment.

    Nabisubi, Patricia / Kanyerezi, Stephen / Kebirungi, Grace / Mboowa, Gerald

    AAS open research

    2021  Volume 4, Page(s) 23

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-07-12
    Publishing country England
    Document type Journal Article
    ISSN 2515-9321
    ISSN (online) 2515-9321
    DOI 10.12688/aasopenres.13210.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Genetics of Sub-Saharan African Human Population: Implications for HIV/AIDS, Tuberculosis, and Malaria.

    Mboowa, Gerald

    International journal of evolutionary biology

    2014  Volume 2014, Page(s) 108291

    Abstract: Sub-Saharan Africa has continued leading in prevalence and incidence of major infectious disease killers such as HIV/AIDS, tuberculosis, and malaria. Epidemiological triad of infectious diseases includes susceptible host, pathogen, and environment. It is ...

    Abstract Sub-Saharan Africa has continued leading in prevalence and incidence of major infectious disease killers such as HIV/AIDS, tuberculosis, and malaria. Epidemiological triad of infectious diseases includes susceptible host, pathogen, and environment. It is imperative that all aspects of vertices of the infectious disease triad are analysed to better understand why this is so. Studies done to address this intriguing reality though have mainly addressed pathogen and environmental components of the triad. Africa is the most genetically diverse region of the world as well as being the origin of modern humans. Malaria is relatively an ancient infection in this region as compared to TB and HIV/AIDS; from the evolutionary perspective, we would draw lessons that this ancestrally unique population now under three important infectious diseases both ancient and exotic will be skewed into increased genetic diversity; moreover, other evolutionary forces are also still at play. Host genetic diversity resulting from many years of malaria infection has been well documented in this population; we are yet to account for genetic diversity from the trio of these infections. Effect of host genetics on treatment outcome has been documented. Host genetics of sub-Saharan African population and its implication to infectious diseases are an important aspect that this review seeks to address.
    Language English
    Publishing date 2014-08-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2090-8032
    ISSN 2090-8032
    DOI 10.1155/2014/108291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genomics and bioinformatics capacity in Africa: no continent is left behind.

    Mboowa, Gerald / Sserwadda, Ivan / Aruhomukama, Dickson

    Genome

    2021  Volume 64, Issue 5, Page(s) 503–513

    Abstract: Despite the poor genomics research capacity in Africa, efforts have been made to empower African scientists to get involved in genomics research, particularly that involving African populations. As part of the Human Heredity and Health in Africa ( ... ...

    Abstract Despite the poor genomics research capacity in Africa, efforts have been made to empower African scientists to get involved in genomics research, particularly that involving African populations. As part of the Human Heredity and Health in Africa (H3Africa) Consortium, an initiative was set to make genomics research in Africa an African endeavor and was developed through funding from the United States' National Institutes of Health Common Fund and the Wellcome Trust. H3Africa is intended to encourage a contemporary research approach by African investigators and to stimulate the study of genomic and environmental determinants of common diseases. The goal of these endeavors is to improve the health of African populations. To build capacity for bioinformatics and genomics research, organizations such as the African Society for Bioinformatics and Computational Biology have been established. In this article, we discuss the current status of the bioinformatics infrastructure in Africa as well as the training challenges and opportunities.
    MeSH term(s) Africa ; Computational Biology ; Education ; Education, Distance ; Genome ; Genomics/education ; Humans ; Internet ; Research ; Uganda ; Whole Genome Sequencing
    Language English
    Publishing date 2021-01-12
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 639031-6
    ISSN 1480-3321 ; 0831-2796
    ISSN (online) 1480-3321
    ISSN 0831-2796
    DOI 10.1139/gen-2020-0013
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1266: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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