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  1. Book ; Thesis: Molekular- und zellbiologische Charakterisierung von ATBP - einem neuen Protein, das mit dem AT2-Rezeptor interagiert

    Menk, Mario

    2005  

    Author's details vorgelegt von Mario Menk
    Language German
    Size 95 Bl. . Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Charité Univ., Diss., 2005
    HBZ-ID HT014878954
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 MB 2175 order for loan Magazin

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  2. Book ; Online ; Thesis: Sekundärnutzung deutscher Medikationsdaten in internationalen Studien unter Wahrung der semantischen Bedeutung

    Reinecke, Ines [Verfasser] / Sedlmayr, Martin [Gutachter] / Menk, Mario [Gutachter]

    2024  

    Author's details Ines Reinecke ; Gutachter: Martin Sedlmayr, Mario Menk
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  3. Article ; Online: The authors reply.

    Graw, Jan Adriaan / Hunsicker, Oliver / Menk, Mario

    Critical care medicine

    2021  Volume 49, Issue 10, Page(s) e1044–e1045

    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; Thesis: Das akute Lungenversagen des Erwachsenen (ARDS) - klinische Risikobewertung und experimentelle Intervention

    Menk, Mario [Verfasser]

    2018  

    Author's details Mario Menk
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Hemolysis in patients with Extracorporeal Membrane Oxygenation therapy for severe Acute Respiratory Distress Syndrome - a systematic review of the literature.

    Materne, Lorenz A / Hunsicker, Oliver / Menk, Mario / Graw, Jan A

    International journal of medical sciences

    2021  Volume 18, Issue 8, Page(s) 1730–1738

    Abstract: The Acute Respiratory Distress Syndrome (ARDS) is common in patients on the Intensive Care Unit and associated with significant mortality rates. In situations of severe respiratory insufficiency and failure of all possible conservative therapeutic ... ...

    Abstract The Acute Respiratory Distress Syndrome (ARDS) is common in patients on the Intensive Care Unit and associated with significant mortality rates. In situations of severe respiratory insufficiency and failure of all possible conservative therapeutic approaches, veno-venous extracorporeal membrane oxygenation (VV ECMO) is used as a final option for temporary replacement of pulmonary function. ARDS as well as sepsis and VV ECMO treatment are all associated with intravascular hemolysis. The extent and relevance of intravascular hemolysis in the context of ARDS therapy is unclear. This systematic review aims to summarize the current evidence on the incidence and associated complications of intravascular hemolysis in adult patients with ARDS and treatment with VV ECMO. The databases MEDLINE, EMBASE and Web of Science were systematically searched and 19 publications fulfilled inclusion criteria. The incidence of hemolysis in patients with ARDS and treatment with VV ECMO ranged from 0 to 41% with survivors showing lower incidences and less severe hemolysis. A pump head thrombosis and high blood flows (≥3 l/min) as well as use of dual-lumen cannulas but not different pump models were associated with increased hemolysis. In conclusion, intravascular hemolysis in patients with ARDS and treatment with VV ECMO is a common and relevant complication that appears associated with increased mortality. Apart from ECMO hardware-settings, no additional possible causes for increased red cell breakdown such as disease severity, duration of ECMO therapy, or number and quality of red blood cell transfusions were investigated. Further research is needed to determine the origin and relevance of intravascular hemolysis in patients with ARDS and treatment with VV ECMO.
    MeSH term(s) Extracorporeal Membrane Oxygenation/adverse effects ; Hemolysis ; Humans ; Incidence ; Respiratory Distress Syndrome/blood ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/mortality ; Respiratory Distress Syndrome/therapy ; Severity of Illness Index
    Language English
    Publishing date 2021-02-18
    Publishing country Australia
    Document type Journal Article ; Systematic Review
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.50217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Air quality in Germany as a contributing factor to morbidity from COVID-19.

    Koch, Susanne / Hoffmann, Christina / Caseiro, Alexandre / Ledebur, Marie / Menk, Mario / von Schneidemesser, Erika

    Environmental research

    2022  Volume 214, Issue Pt 2, Page(s) 113896

    Abstract: Background: The SARS-CoV-2 virus has been spreading in Germany since January 2020, with regional differences in incidence, morbidity, and mortality. Long-term exposure to air pollutants as nitrogen dioxide (NO: Methods: We conducted an observational ... ...

    Abstract Background: The SARS-CoV-2 virus has been spreading in Germany since January 2020, with regional differences in incidence, morbidity, and mortality. Long-term exposure to air pollutants as nitrogen dioxide (NO
    Methods: We conducted an observational study in Germany on county-level, investigating the association between long-term (2010-2019) air pollutant exposure (European Environment Agency, AirBase data set) and COVID-19 incidence, morbidity, and mortality rate during the first outbreak of SARS-CoV-2 (open source data Robert Koch Institute). We used negative binominal models, including adjustment for risk factors (age, sex, days since first COVID-19 case, population density, socio-economic and health parameters).
    Results: After adjustment for risk factors in the tri-pollutant model (NO
    Conclusions: Our results indicate that long-term NO
    MeSH term(s) Air Pollutants/analysis ; Air Pollutants/toxicity ; Air Pollution/adverse effects ; Air Pollution/analysis ; COVID-19/epidemiology ; Environmental Exposure/analysis ; Germany/epidemiology ; Humans ; Incidence ; Nitrogen Dioxide/analysis ; Nitrogen Dioxide/toxicity ; Particulate Matter/analysis ; Particulate Matter/toxicity ; SARS-CoV-2
    Chemical Substances Air Pollutants ; Particulate Matter ; Nitrogen Dioxide (S7G510RUBH)
    Language English
    Publishing date 2022-07-13
    Publishing country Netherlands
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.113896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Conference proceedings: Die Gebrauchstauglichkeit des Patientendatenmanagement-Systems COPRA 6 – qualitative Interviewstudie zu Hürden bei der Benutzung

    Thissen, Alica / Fürstenau, Daniel / Menk, Mario / Salgado, Eduardo / Balzer, Felix

    2022  , Page(s) Abstr. 57

    Event/congress 67. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS), 13. Jahreskongress der Technologie- und Methodenplattform für die vernetzte medizinische Forschung e.V. (TMF); sine loco [digital]; Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie; 2022
    Keywords Medizin, Gesundheit ; Patientendatenmanagementsysteme ; COPRA 6 ; usability ; user experience ; Intensivmedizin
    Publishing date 2022-08-19
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22gmds038
    Database German Medical Science

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  8. Article ; Online: Haptoglobin depletion during the first seven days of veno-venous ECMO therapy is associated with increased mortality and adverse outcomes in patients with ARDS.

    Bünger, Victoria / Hunsicker, Oliver / Krannich, Alexander / Balzer, Felix / Spies, Claudia D / Kuebler, Wolfgang M / Weber-Carstens, Steffen / Menk, Mario / Graw, Jan A

    Shock (Augusta, Ga.)

    2024  

    Abstract: Background: Hemolysis is a frequent complication in patients with sepsis, ARDS, or extracorporeal membrane oxygenation (ECMO). Haptoglobin (Hp) can scavenge released cell-free hemoglobin (CFH). Hemolysis and low plasma concentrations of Hp may be ... ...

    Abstract Background: Hemolysis is a frequent complication in patients with sepsis, ARDS, or extracorporeal membrane oxygenation (ECMO). Haptoglobin (Hp) can scavenge released cell-free hemoglobin (CFH). Hemolysis and low plasma concentrations of Hp may be independently associated with mortality in critically ill patients.
    Methods: Retrospective analysis of 435 patients with ARDS and veno-venous ECMO therapy, admitted to a tertiary ARDS referral center (01/2007-12/2018). Hp-depletion was defined as decrease in plasma Hp concentration < 0.39 g/l within the first week after ECMO initiation. Patients with Hp depletion were compared to patients without Hp depletion. The primary endpoint was 28-day mortality. Secondary endpoints included organ dysfunction-free, renal replacement therapy (RRT)-free, vasopressor-free, and ECMO-free composites.
    Results: Patients with Hp-depletion (n = 269) had a significantly higher mortality 28 days after ECMO initiation compared to patients without Hp-depletion (43.5%, [95% CI: 37.52-49.66] vs. 25.3%, [19.03-32.74], p < 0.001). Furthermore, patients with Hp depletion had fewer organ dysfunction-free days (subdistribution hazard ratio, [SHR] 0.35, [95% CI 0.25-0.50], p < 0.001), lower chances for successful weaning from renal replacement therapy (SHR 0.50, [0.32-0.79], p < 0.001), vasopressor therapy (SHR 0.39, [0.28-0.54], p < 0.001), and ECMO therapy (SHR 0.41, [0.30-0.57], p < 0.001) within 28 days after ECMO initiation. Patients with initial Hp <0.66 g/l had higher risks for Hp-depletion than patients with initial Hp ≥ 0.66 g/l.
    Conclusion: Patients with Hp-depletion within the first week of ECMO therapy might benefit from close monitoring of hemolysis with early detection and elimination of the underlying cause. They might be potential candidates for future Hp supplementation therapy to prevent overload of the CFH-scavenger system.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000002352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3985: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Post-encoding modulation of spatial memory consolidation by propofol.

    Iggena, Deetje / Maier, Patrizia M / Häußler, Sophia M / Menk, Mario / Olze, Heidi / Larkum, Matthew E / Finke, Carsten / Ploner, Christoph J

    Cortex; a journal devoted to the study of the nervous system and behavior

    2022  Volume 156, Page(s) 1–12

    Abstract: Memory consolidation is a continuous transformative process between encoding and retrieval of mental representations. Recent research has shown that neural activity immediately after encoding is particularly associated with later successful retrieval. It ...

    Abstract Memory consolidation is a continuous transformative process between encoding and retrieval of mental representations. Recent research has shown that neural activity immediately after encoding is particularly associated with later successful retrieval. It is currently unclear whether post-encoding neural activity makes a distinct and causal contribution to memory consolidation. Here, we investigated the role of the post-encoding period for consolidation of spatial memory in neurologically normal human subjects. We used the GABA
    MeSH term(s) Humans ; Animals ; Spatial Memory ; Memory Consolidation ; Propofol/pharmacology ; gamma-Aminobutyric Acid
    Chemical Substances Propofol (YI7VU623SF) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-09-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 280622-8
    ISSN 1973-8102 ; 0010-9452
    ISSN (online) 1973-8102
    ISSN 0010-9452
    DOI 10.1016/j.cortex.2022.08.004
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    Zs.A 687: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Dynamic thromboembolic left ventricular outflow tract obstruction after aggressive procoagulant treatment in hemorrhagic shock: a case report.

    Skrypnikov, Vladimir / Rosenthal, Christoph / Weber-Carstens, Steffen / Menk, Mario / Russ, Martin

    Journal of medical case reports

    2021  Volume 15, Issue 1, Page(s) 269

    Abstract: Background: In cases of hypertrophic obstructive cardiomyopathy (HOCM), the systolic anterior motion of the mitral valve apparatus results in an obstruction of the left ventricular outflow tract (LVOT), which is known as the SAM [systolic anterior ... ...

    Abstract Background: In cases of hypertrophic obstructive cardiomyopathy (HOCM), the systolic anterior motion of the mitral valve apparatus results in an obstruction of the left ventricular outflow tract (LVOT), which is known as the SAM [systolic anterior motion] phenomenon. Hypothetically, a pathological obstruction of the LVOT of a different etiology would result in a comparable hemodynamic instability, which would be refractory to inotrope therapy, and may be detectable through echocardiography.
    Case presentation: We observed a severely impaired left ventricular function due to a combination of a thrombotic LVOT obstruction and distinctive mitral regurgitation in a 56-year-old Caucasian, female patient after massive transfusion with aggressive procoagulant therapy. Initially, the patient had to be resuscitated due to cardiac arrest after a long-distance flight. The resuscitation attempts in combination with lysis therapy due to suspected pulmonary artery embolism were initially successful but resulted in traumatic liver injury, hemorrhagic shock and subsequent acute respiratory distress syndrome (ARDS). Oxygenation was stabilized with veno-venous extracorporeal membrane oxygenation (ECMO), but the hemodynamic situation deteriorated further. Transesophageal echocardiography (TEE) showed a massive, dynamic LVOT obstruction. Two thrombi were attached to the anterior leaflet of the mitral valve, resulting in a predominantly systolic obstruction. Unfortunately, the patient died of multiple-organ failure despite another round of lysis therapy and escalation of the ECMO circuit to a veno-venoarterial cannulation for hemodynamic support.
    Conclusion: Massive transfusion with aggressive procoagulant therapy resulted in mitral valve leaflet thrombosis with dynamic, predominantly systolic LVOT obstruction, comparable to the SAM phenomenon. The pathology was only detectable with a TEE investigation.
    MeSH term(s) Cardiomyopathy, Hypertrophic ; Female ; Humans ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve Insufficiency/diagnostic imaging ; Shock, Hemorrhagic/etiology ; Shock, Hemorrhagic/therapy ; Ventricular Outflow Obstruction/diagnostic imaging ; Ventricular Outflow Obstruction/etiology ; Ventricular Outflow Obstruction/therapy
    Language English
    Publishing date 2021-05-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-021-02840-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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