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  1. Article: Charting the Neuroethics Landscape for Neuromodulation in Canada and Beyond.

    Lipsman, Nir / McDonald, Patrick

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2023  Volume 50, Issue s1, Page(s) s2–s3

    MeSH term(s) Humans ; Canada ; Neurosciences
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2022.294
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  2. Article ; Online: Perceptions of Invasiveness: A Moving Target for Neuromodulation.

    Lipsman, Nir / McDonald, Patrick J / Illes, Judy

    AJOB neuroscience

    2022  Volume 14, Issue 1, Page(s) 15–17

    MeSH term(s) Electric Stimulation Therapy
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2576262-X
    ISSN 2150-7759 ; 2150-7740
    ISSN (online) 2150-7759
    ISSN 2150-7740
    DOI 10.1080/21507740.2022.2150709
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  3. Article ; Online: What do we know about astrocytes and the antidepressant effects of DBS?

    Campos, Ana Carolina P / Pagano, Rosana L / Lipsman, Nir / Hamani, Clement

    Experimental neurology

    2023  Volume 368, Page(s) 114501

    Abstract: Treatment-resistant depression (TRD) is a debilitating condition that affects millions of individuals worldwide. Deep brain stimulation (DBS) has been widely used with excellent outcomes in neurological disorders such as Parkinson's disease, tremor, and ... ...

    Abstract Treatment-resistant depression (TRD) is a debilitating condition that affects millions of individuals worldwide. Deep brain stimulation (DBS) has been widely used with excellent outcomes in neurological disorders such as Parkinson's disease, tremor, and dystonia. More recently, DBS has been proposed as an adjuvant therapy for TRD. To date, the antidepressant efficacy of DBS is still controversial, and its mechanisms of action remain poorly understood. Astrocytes are the most abundant cells in the nervous system. Once believed to be a "supporting" element for neuronal function, astrocytes are now recognized to play a major role in brain homeostasis, neuroinflammation and neuroplasticity. Because of its many roles in complex multi-factorial disorders, including TRD, understanding the effect of DBS on astrocytes is pivotal to improve our knowledge about the antidepressant effects of this therapy. In depression, the number of astrocytes and the expression of astrocytic markers are decreased. One of the potential consequences of this reduced astrocytic function is the development of aberrant glutamatergic neurotransmission, which has been documented in several models of depression-like behavior. Evidence from preclinical work suggests that DBS may directly influence astrocytic activity, modulating the release of gliotransmitters, reducing neuroinflammation, and altering structural tissue organization. Compelling evidence for an involvement of astrocytes in potential mechanisms of DBS derive from studies suggesting that pharmacological lesions or the inhibition of these cells abolishes the antidepressant-like effect of DBS. In this review, we summarize preclinical data suggesting that the modulation of astrocytes may be an important mechanism for the antidepressant-like effects of DBS.
    MeSH term(s) Humans ; Deep Brain Stimulation ; Astrocytes/physiology ; Neuroinflammatory Diseases ; Brain ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2023.114501
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  4. Article ; Online: Reply: Evaluating the Scope and Safety of Bilateral MRgFUS Thalamotomy for Essential Tremor: A Critical Analysis.

    Scantlebury, Nadia / Rabin, Jennifer S / De Schlichting, Emmanuel / Hamani, Clement / Schwartz, Michael L / Lipsman, Nir / Abrahao, Agessandro

    Movement disorders clinical practice

    2024  Volume 11, Issue 3, Page(s) 320–321

    MeSH term(s) Humans ; Essential Tremor/surgery ; Thalamus/diagnostic imaging ; Magnetic Resonance Imaging ; Psychosurgery
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Letter
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13970
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  5. Article ; Online: Introduction. Education methodology and metrics in the training of neurosurgical residents.

    Jensen, Randy L / Lipsman, Nir / Amin-Hanjani, Sepideh / Haglund, Michael M

    Neurosurgical focus

    2022  Volume 53, Issue 2, Page(s) E1

    MeSH term(s) Benchmarking ; Education, Medical, Graduate ; Humans ; Internship and Residency ; Neurosurgery/education
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2022.5.FOCUS22311
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  6. Article ; Online: Author's response.

    Lipsman, Nir

    British journal of neurosurgery

    2013  Volume 27, Issue 5, Page(s) 709

    MeSH term(s) Humans ; Neurosurgery/ethics ; Physician's Role
    Language English
    Publishing date 2013-10
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
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  7. Article ; Online: Focused ultrasound as an evolving therapy for Parkinson's disease.

    Fishman, Paul / Lipsman, Nir

    Movement disorders : official journal of the Movement Disorder Society

    2019  Volume 34, Issue 9, Page(s) 1241–1242

    MeSH term(s) Blood-Brain Barrier/radiation effects ; Brain Diseases/therapy ; Extracorporeal Shockwave Therapy/trends ; Humans ; Parkinson Disease/therapy ; Ultrasonics
    Language English
    Publishing date 2019-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.27809
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  8. Article ; Online: The return of the lesion for localization and therapy.

    Joutsa, Juho / Lipsman, Nir / Horn, Andreas / Cosgrove, G Rees / Fox, Michael D

    Brain : a journal of neurology

    2023  Volume 146, Issue 8, Page(s) 3146–3155

    Abstract: Historically, pathological brain lesions provided the foundation for localization of symptoms and therapeutic lesions were used as a treatment for brain diseases. New medications, functional neuroimaging and deep brain stimulation have led to a decline ... ...

    Abstract Historically, pathological brain lesions provided the foundation for localization of symptoms and therapeutic lesions were used as a treatment for brain diseases. New medications, functional neuroimaging and deep brain stimulation have led to a decline in lesions in the past few decades. However, recent advances have improved our ability to localize lesion-induced symptoms, including localization to brain circuits rather than individual brain regions. Improved localization can lead to more precise treatment targets, which may mitigate traditional advantages of deep brain stimulation over lesions such as reversibility and tunability. New tools for creating therapeutic brain lesions such as high intensity focused ultrasound allow for lesions to be placed without a skin incision and are already in clinical use for tremor. Although there are limitations, and caution is warranted, improvements in lesion-based localization are refining our therapeutic targets and improved technology is providing new ways to create therapeutic lesions, which together may facilitate the return of the lesion.
    MeSH term(s) Humans ; Brain Mapping ; Brain/pathology ; Brain Diseases ; Nervous System Diseases ; Tremor
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awad123
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  9. Article ; Online: What is the role of the neurosurgeon in neuroethical discourse?

    Lipsman, Nir

    British journal of neurosurgery

    2013  Volume 27, Issue 1, Page(s) 7–8

    MeSH term(s) Biomedical Research/ethics ; Ethics, Medical ; Ethics, Research ; Humans ; Neurosurgery/ethics ; Physician's Role
    Language English
    Publishing date 2013-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.3109/02688697.2012.709558
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  10. Article ; Online: Seasonal pattern and depression outcomes from repetitive transcranial magnetic stimulation.

    Ng, Enoch / Nestor, Sean M / Rabin, Jennifer S / Hamani, Clement / Lipsman, Nir / Giacobbe, Peter

    Psychiatry research

    2023  Volume 329, Page(s) 115525

    Abstract: Individuals with major depressive disorder (MDD) may exhibit a seasonal pattern. The impact of a seasonal pattern in depressive symptoms on rTMS outcomes is unexplored. A retrospective analysis was performed on patients with MDD receiving open-label high ...

    Abstract Individuals with major depressive disorder (MDD) may exhibit a seasonal pattern. The impact of a seasonal pattern in depressive symptoms on rTMS outcomes is unexplored. A retrospective analysis was performed on patients with MDD receiving open-label high frequency rTMS to the left dorsolateral prefrontal cortex. Having a seasonal pattern was defined as scoring ≥ 12 on the Personal Inventory for Depression and Seasonal Affective Disorder (PIDS). Primary outcomes included improvement in the Hamilton Depression Rating Scale (HAMD) and remission. Secondary analyses included the use of the self-rated Quick Inventory of Depressive Symptomatology (QIDS) to assess for changes in atypical neurovegetative symptoms. Multiple linear regression, multiple logistic regression, and linear mixed effects analyses were performed. 46 % (58/127) of the sample had a seasonal pattern. Seasonal pattern did not significantly influence improvement in HAMD (PIDS < 12, 7.8, SD 5.9; PIDS ≥ 12, 10.4, SD 4.9 or remission (PIDS < 12, 30 %; PIDS ≥ 12, 34 %). There were equivalent degrees of improvement in atypical neurovegetative symptoms over time as assessed using the QIDS. Depression with seasonal pattern was found to respond to rTMS treatment similarly to depression without seasonal pattern, suggesting that this may be a viable treatment for this group.
    MeSH term(s) Humans ; Depression/therapy ; Depressive Disorder, Major/psychology ; Prefrontal Cortex/physiology ; Retrospective Studies ; Seasons ; Transcranial Magnetic Stimulation ; Treatment Outcome
    Language English
    Publishing date 2023-10-04
    Publishing country Ireland
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2023.115525
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