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Article ; Online: An Outbreak Investigation of

2023 Volume 20, Issue 4, Page(s) 123–131

Abstract: ... Vibrio ... ...

Abstract	Vibrio parahaemolyticus
MeSH term(s)	Humans ; United States/epidemiology ; Vibrio parahaemolyticus ; Phylogeny ; Venezuela/epidemiology ; Foodborne Diseases/epidemiology ; Vibrio Infections/epidemiology ; Disease Outbreaks
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2148479-X
ISSN	1556-7125 ; 1535-3141
ISSN (online)	1556-7125
ISSN	1535-3141
DOI	10.1089/fpd.2022.0078
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Article ; Online: Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.

Chowdhury, Nayela N / Yang, Yi / Dutta, Ananya / Luo, Michelle / Wei, Zimu / Abrahams, Sara R / Revenko, Alexey S / Shah, Fenil / Miles, Lindsey A / Parmer, Robert J / de Laat, Bas / Wolberg, Alisa S / Luyendyk, James P / Fishel, Melissa L / Flick, Matthew J

Molecular oncology

2023 Volume 18, Issue 1, Page(s) 113–135

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. However, the potential contribution of the primary fibrinolytic protease plasminogen to PDAC ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. However, the potential contribution of the primary fibrinolytic protease plasminogen to PDAC disease progression has remained largely undefined. Mice bearing C57Bl/6-derived KPC (KRas
MeSH term(s)	Animals ; Humans ; Mice ; Adenocarcinoma ; Carcinoma, Pancreatic Ductal/pathology ; Fibrinolysin ; Pancreatic Neoplasms/pathology ; Plasminogen
Chemical Substances	Fibrinolysin (EC 3.4.21.7) ; Plasminogen (9001-91-6)
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2415106-3
ISSN	1878-0261 ; 1574-7891
ISSN (online)	1878-0261
ISSN	1574-7891
DOI	10.1002/1878-0261.13552
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Article ; Online: Disrupting nociceptive information processing flow through transcranial focused ultrasound neuromodulation of thalamic nuclei.

Mishra, Arabinda / Yang, Pai-Feng / Manuel, Thomas J / Newton, Allen T / Phipps, M Anthony / Luo, Huiwen / Sigona, Michelle K / Reed, Jamie L / Gore, John C / Grissom, William A / Caskey, Charles F / Chen, Li Min

Brain stimulation

2023 Volume 16, Issue 5, Page(s) 1430–1444

Abstract: Background: MRI-guided transcranial focused ultrasound (MRgFUS) as a next-generation neuromodulation tool can precisely target and stimulate deep brain regions with high spatial selectivity. Combined with MR-ARFI (acoustic radiation force imaging) and ... ...

Abstract	Background: MRI-guided transcranial focused ultrasound (MRgFUS) as a next-generation neuromodulation tool can precisely target and stimulate deep brain regions with high spatial selectivity. Combined with MR-ARFI (acoustic radiation force imaging) and using fMRI BOLD signal as functional readouts, our previous studies have shown that low-intensity FUS can excite or suppress neural activity in the somatosensory cortex. Objective: To investigate whether low-intensity FUS can suppress nociceptive heat stimulation-induced responses in thalamic nuclei during hand stimulation, and to determine how this suppression influences the information processing flow within nociception networks. Findings: BOLD fMRI activations evoked by 47.5 °C heat stimulation of hand were detected in 24 cortical regions, which belong to sensory, affective, and cognitive nociceptive networks. Concurrent delivery of low-intensity FUS pulses (650 kHz, 550 kPa) to the predefined heat nociceptive stimulus-responsive thalamic centromedial_parafascicular (CM_para), mediodorsal (MD), ventral_lateral (VL_ and ventral_lateral_posteroventral (VLpv) nuclei suppressed their heat responses. Off-target cortical areas exhibited reduced, enhanced, or no significant fMRI signal changes, depending on the specific areas. Differentiable thalamocortical information flow during the processing of nociceptive heat input was observed, as indicated by the time to reach 10% or 30% of the heat-evoked BOLD signal peak. Suppression of thalamic heat responses significantly altered nociceptive processing flow and direction between the thalamus and cortical areas. Modulation of contralateral versus ipsilateral areas by unilateral thalamic activity differed. Signals detected in high-order cortical areas, such as dorsal frontal (DFC) and ventrolateral prefrontal (vlPFC) cortices, exhibited faster response latencies than sensory areas. Conclusions: The concurrent delivery of FUS suppressed nociceptive heat response in thalamic nuclei and disrupted the nociceptive network. This study offers new insights into the causal functional connections within the thalamocortical networks and demonstrates the modulatory effects of low-intensity FUS on nociceptive information processing.
MeSH term(s)	Nociception ; Thalamic Nuclei/physiology ; Thalamus ; Brain ; Cognition
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2023.09.013
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Article ; Online: Loss of

Chang, Ya-Ting / Kowalczyk, Max / Fogerson, P Michelle / Lee, Yu-Ju / Haque, Minza / Adams, Eliza L / Wang, David C / DeNardo, Laura A / Tessier-Lavigne, Marc / Huguenard, John R / Luo, Liqun / Huang, Wei-Hsiang

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 43, Page(s) e2210122119

Abstract: Hyperexcitability of brain circuits is a common feature of autism spectrum disorders (ASDs). Genetic deletion of a chromatin-binding protein, ...

Abstract	Hyperexcitability of brain circuits is a common feature of autism spectrum disorders (ASDs). Genetic deletion of a chromatin-binding protein,
MeSH term(s)	Mice ; Animals ; Smith-Magenis Syndrome/genetics ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Phenotype ; Disease Models, Animal ; Chromatin ; Hippocampus/metabolism ; Seizures/genetics ; Tretinoin
Chemical Substances	Trans-Activators ; Chromatin ; Tretinoin (5688UTC01R) ; Rai1 protein, mouse
Language	English
Publishing date	2022-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2210122119
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Article ; Online: PET Imaging of Innate Immune Activation Using

JACS Au

2023 Volume 3, Issue 12, Page(s) 3297–3310

Abstract: Chronic innate immune activation is a key hallmark of many neurological diseases and is known to result in the upregulation of GPR84 in myeloid cells (macrophages, microglia, and monocytes). As such, GPR84 can potentially serve as a sensor of ... ...

Abstract	Chronic innate immune activation is a key hallmark of many neurological diseases and is known to result in the upregulation of GPR84 in myeloid cells (macrophages, microglia, and monocytes). As such, GPR84 can potentially serve as a sensor of proinflammatory innate immune responses. To assess the utility of GPR84 as an imaging biomarker, we synthesized
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ISSN	2691-3704
ISSN (online)	2691-3704
DOI	10.1021/jacsau.3c00435
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Article ; Online: Low physical function Post-Cancer diagnosis is associated with higher mortality risk in postmenopausal women.

Gonzalo-Encabo, Paola / Vasbinder, Alexi / Bea, Jennifer W / Reding, Kerryn W / Laddu, Deepika / LaMonte, Michael J / Stefanick, Marcia L / Kroenke, Candyce H / Jung, Su Yon / Shadyab, Aladdin H / Naughton, Michelle J / Patel, Manali I / Luo, Juhua / Banack, Hailey R / Sun, Yangbo / Simon, Michael S / Dieli-Conwright, Christina M

Journal of the National Cancer Institute

2024

Abstract: Background: Postmenopausal women with cancer experience an accelerated physical dysfunction beyond that expected through aging alone due to cancer and its treatments. The aim of this study is to determine whether declines in physical function after ... ...

Abstract	Background: Postmenopausal women with cancer experience an accelerated physical dysfunction beyond that expected through aging alone due to cancer and its treatments. The aim of this study is to determine whether declines in physical function after cancer diagnosis are associated with all-cause mortality and cancer-specific mortality. Methods: This prospective cohort study included 8,068 postmenopausal women enrolled in the Women's Health Initiative (WHI) who were diagnosed with cancer and had physical function assessed within 1-year of cancer diagnosis. Self-reported physical function was measured using the 10-item physical function subscale of the RAND 36-Item Health Survey. Cause of death was determined by medical record review with central adjudication and linkage to the National Death Index. Death was adjudicated through February 2022. Results: Over a median follow-up of 7.7 years from cancer diagnosis 3,316 (41.1%) women died. Our results showed that for every 10% decline in the physical function score after cancer diagnosis, all-cause mortality and cancer-specific mortality were significantly reduced by 12% (HR, 0.88; 95% CI, 0.87 to 0.89) and (HR, 0.88; 95%CI, 0.86 to 0.91), respectively. Further categorical analyses showed a significant dose-response relationship between post-diagnosis physical function categories and mortality outcomes (trend test P < .001), where the median survival time for women in the lowest physical function quartile was 9.1 (8.6, 10.6) years compared to 18.4 (15.8, 22.0) years for women in the highest physical function quartile. Conclusion: Postmenopausal women with low physical function after cancer diagnosis may be at higher risk of mortality from all causes and cancer-related mortality.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djae055
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Article ; Online: Current and future prospects for CRISPR-based tools in bacteria.

Luo, Michelle L / Leenay, Ryan T / Beisel, Chase L

Biotechnology and bioengineering

2016 Volume 113, Issue 5, Page(s) 930–943

Abstract: CRISPR-Cas systems have rapidly transitioned from intriguing prokaryotic defense systems to powerful and versatile biomolecular tools. This article reviews how these systems have been translated into technologies to manipulate bacterial genetics, ... ...

Abstract	CRISPR-Cas systems have rapidly transitioned from intriguing prokaryotic defense systems to powerful and versatile biomolecular tools. This article reviews how these systems have been translated into technologies to manipulate bacterial genetics, physiology, and communities. Recent applications in bacteria have centered on multiplexed genome editing, programmable gene regulation, and sequence-specific antimicrobials, while future applications can build on advances in eukaryotes, the rich natural diversity of CRISPR-Cas systems, and the untapped potential of CRISPR-based DNA acquisition. Overall, these systems have formed the basis of an ever-expanding genetic toolbox and hold tremendous potential for our future understanding and engineering of the bacterial world.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/genetics ; Bacterial Infections/drug therapy ; CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Drug Discovery ; Drug Resistance, Bacterial ; Gene Editing/methods ; Gene Expression Regulation, Bacterial ; Genetic Engineering/methods ; Genome, Bacterial ; Humans
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	280318-5
ISSN	1097-0290 ; 0006-3592
ISSN (online)	1097-0290
ISSN	0006-3592
DOI	10.1002/bit.25851
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Article ; Online: Changes in physical function in older women with endometrial cancer with or without adjuvant therapy.

Quick, Allison M / McLaughlin, Eric / Krok Schoen, Jessica L / Felix, Ashley S / Presley, Carolyn J / Cespedes Feliciano, Elizabeth M / Shadyab, Aladdin H / Jung, Su Yon / Luo, Juhua / King, Jennifer J / Rapp, Stephen R / Werts, Samantha / Chlebowski, Rowan T / Naughton, Michelle / Paskett, Electra

Journal of cancer survivorship : research and practice

2023

Abstract: Objective: To evaluate changes in physical function (PF) for older women with endometrial cancer (EC) + / - adjuvant therapy in the Women's Health Initiative Life and Longevity after Cancer cohort.: Materials and methods: This study examined women ≥ ... ...

Abstract	Objective: To evaluate changes in physical function (PF) for older women with endometrial cancer (EC) + / - adjuvant therapy in the Women's Health Initiative Life and Longevity after Cancer cohort. Materials and methods: This study examined women ≥ 70 years of age with EC with available treatment records. Change in PF was measured using the RAND-36 and compared between groups using Wilcoxon rank-sum tests. Multivariable median regression was used to compare the changes in scores while adjusting for confounding variables. Results: Included in the study were 287 women, 150 (52.3%) women who did not receive adjuvant therapy and 137 (47.7%) who received adjuvant therapy. When comparing PF scores, there was a statistically significant difference in the median percent change in functional decline, with a greater decline in those who received adjuvant therapy (- 5.9% [- 23.5 to 0%]) compared to those who did not (0 [- 18.8 to + 6.7%]), p = 0.02). Results were not statistically significant after multivariable adjustment, but women who underwent chemotherapy had a greater percent change (median ∆ - 13.8% [- 35.5 to 0%]) compared to those who received radiation alone (median ∆ - 5.9% [- 31.3 to 0%]) or chemotherapy and radiation (median ∆ - 6.5% [- 25.8 to + 5.7%]. Conclusions: Older women with EC who received adjuvant therapy experienced greater change in PF than those who did not receive adjuvant therapy, particularly women who received chemotherapy. These results were not statistically significant on multivariate analysis. Implications for cancer survivors: EC survivors may experience changes in PF because of chemotherapy and/or radiation therapy. Additional supportive care may need to be provided to older women to mitigate functional decline.
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388888-X
ISSN	1932-2267 ; 1932-2259
ISSN (online)	1932-2267
ISSN	1932-2259
DOI	10.1007/s11764-023-01460-8
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Article: The impact of the low-income housing tax credit on children's health and wellbeing in Georgia.

Ports, Katie A / Rostad, Whitney L / Luo, Feijun / Putnam, Michelle / Zurick, Elizabeth

Children and youth services review

2019 Volume 93, Page(s) 390–396

Abstract: Housing instability is a risk factor for child abuse and neglect (CAN). Thus, policies that increase availability of affordable housing may reduce CAN rates. The Low Income Housing Tax Credit (LIHTC) program is the largest affordable housing policy ... ...

Abstract	Housing instability is a risk factor for child abuse and neglect (CAN). Thus, policies that increase availability of affordable housing may reduce CAN rates. The Low Income Housing Tax Credit (LIHTC) program is the largest affordable housing policy initiative in the country. This study used fixed-effects models to estimate the relationship between LIHTC units and county-level CAN reports in Georgia from 2005 to 2015, controlling for county demographic characteristics. One-way fixed-effects models (including only county fixed-effects) demonstrated significant negative associations between number of LIHTC units and substantiated cases of CAN and total reports of sexual abuse. In two-way fixed-effects models (including county and year fixed-effects), LIHTC units were not associated with any of the outcomes. The findings are subject to limitations, including voluntary provision of CAN data, suppressed data for counties with < 10 CAN cases, and no assessment of the quality of LIHTC neighborhood. LIHTC may be a promising prevention strategy, but more research is needed.
Language	English
Publishing date	2019-01-05
Publishing country	United States
Document type	Journal Article
ISSN	0190-7409
ISSN	0190-7409
DOI	10.1016/j.childyouth.2018.08.012
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Article ; Online: Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease.

Sakaue, Saori / Gurajala, Saisriram / Curtis, Michelle / Luo, Yang / Choi, Wanson / Ishigaki, Kazuyoshi / Kang, Joyce B / Rumker, Laurie / Deutsch, Aaron J / Schönherr, Sebastian / Forer, Lukas / LeFaive, Jonathon / Fuchsberger, Christian / Han, Buhm / Lenz, Tobias L / de Bakker, Paul I W / Okada, Yukinori / Smith, Albert V / Raychaudhuri, Soumya

Nature protocols

2023 Volume 18, Issue 9, Page(s) 2625–2641

Abstract: The human leukocyte antigen (HLA) locus is associated with more complex diseases than any other locus in the human genome. In many diseases, HLA explains more heritability than all other known loci combined. In silico HLA imputation methods enable rapid ... ...

Abstract	The human leukocyte antigen (HLA) locus is associated with more complex diseases than any other locus in the human genome. In many diseases, HLA explains more heritability than all other known loci combined. In silico HLA imputation methods enable rapid and accurate estimation of HLA alleles in the millions of individuals that are already genotyped on microarrays. HLA imputation has been used to define causal variation in autoimmune diseases, such as type I diabetes, and in human immunodeficiency virus infection control. However, there are few guidelines on performing HLA imputation, association testing, and fine mapping. Here, we present a comprehensive tutorial to impute HLA alleles from genotype data. We provide detailed guidance on performing standard quality control measures for input genotyping data and describe options to impute HLA alleles and amino acids either locally or using the web-based Michigan Imputation Server, which hosts a multi-ancestry HLA imputation reference panel. We also offer best practice recommendations to conduct association tests to define the alleles, amino acids, and haplotypes that affect human traits. Along with the pipeline, we provide a step-by-step online guide with scripts and available software ( https://github.com/immunogenomics/HLA_analyses_tutorial ). This tutorial will be broadly applicable to large-scale genotyping data and will contribute to defining the role of HLA in human diseases across global populations.
MeSH term(s)	Humans ; Alleles ; HLA Antigens/genetics ; Genotype ; Histocompatibility Antigens Class I ; Haplotypes ; Amino Acids/genetics ; Polymorphism, Single Nucleotide ; Genome-Wide Association Study
Chemical Substances	HLA Antigens ; Histocompatibility Antigens Class I ; Amino Acids
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2244966-8
ISSN	1750-2799 ; 1754-2189
ISSN (online)	1750-2799
ISSN	1754-2189
DOI	10.1038/s41596-023-00853-4
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