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  1. Book ; Thesis: In-vitro-Untersuchungen zum Einfluß der extrazellulären Lebermatrix auf Wachstum und Differenzierung kultivierter humaner Hepatozyten

    Kronenberger, Bernd

    1998  

    Author's details vorgelegt von Bernd Kronenberger
    Language German
    Size 128 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 1998
    HBZ-ID HT011159753
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Chronische Hepatitis C – Langzeittherapie mit Peginterferon erfolglos

    Kronenberger, Bernd

    Gastroenterologie up2date

    2009  Volume 5, Issue 03, Page(s) 168–169

    Language German
    Publishing date 2009-09-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2203033-5
    ISSN 1616-9727 ; 1616-9670
    ISSN (online) 1616-9727
    ISSN 1616-9670
    DOI 10.1055/s-0029-1214987
    Database Thieme publisher's database

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  3. Article ; Online: FIBER SEGMENTATION IN CRACK REGIONS OF STEEL FIBER REINFORCED CONCRETE USING PRINCIPAL CURVATURE

    Markus Kronenberger / Katja Schladitz / Bernd Hamann / Hans Hagen

    Image Analysis and Stereology, Vol 37, Iss 2, Pp 127-

    2018  Volume 137

    Abstract: This paper tackles the non-trivial image-processing task to segment hook-ended fibers in three-dimensional images. For this purpose, a novel segmentation method is presented that relies on the following observation: For a single fiber the configurations ... ...

    Abstract This paper tackles the non-trivial image-processing task to segment hook-ended fibers in three-dimensional images. For this purpose, a novel segmentation method is presented that relies on the following observation: For a single fiber the configurations of principal curvatures that can occur on its surface are limited. Deviations from these configurations indicate potential overlaps of fibers. The method that was developed based on this observation is used to separate several simulated clusters of touching fibers as a proof-of-concept. Further, it is applied to two images of cracked steel fiber reinforced concrete specimens arising from a 4-point bending test. The method's performance is compared to manual separation. Overall, we can state that the proposed method yields satisfying results when data meets the following criteria: Low fiber volume density, circular fiber cross section and sufficient spatial resolution of fiber-fiber contacts.
    Keywords fiber reinforced concrete ; fiber segmentation ; image analysis ; X-ray micro-computed tomography ; Medicine (General) ; R5-920 ; Mathematics ; QA1-939
    Subject code 621
    Language English
    Publishing date 2018-07-01T00:00:00Z
    Publisher Slovenian Society for Stereology and Quantitative Image Analysis
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Correction: Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells.

    Piiper, Albrecht / Dikic, Ivan / Lutz, Manfred P / Leser, Jürgen / Kronenberger, Bernd / Elez, Robert / Cramer, Henning / Müller-Esterl, Werner / Zeuzem, Stefan

    The Journal of biological chemistry

    2020  Volume 295, Issue 43, Page(s) 14792

    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.AAC120.016177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fiber segmentation in crack regions of steel fiber reinforced concrete using principal curvature

    Kronenberger, Markus / Schladitz, Katja / Hamann, Bernd / Hagen, Hans

    2018  

    Abstract: S.127-137 ... This paper tackles the non-trivial image-processing task to segment hook-ended fibers in three-dimensional images. For this purpose, a novel segmentation method is presented that relies on the following observation: For a single fiber the ... ...

    Abstract S.127-137

    This paper tackles the non-trivial image-processing task to segment hook-ended fibers in three-dimensional images. For this purpose, a novel segmentation method is presented that relies on the following observation: For a single fiber the configurations of principal curvatures that can occur on its surface are limited. Deviations from these configurations indicate potential overlaps of fibers. The method that was developed based on this observation is used to separate several simulated clusters of touching fibers as a proof-of-concept. Further, it is applied to two images of cracked steel fiber reinforced concrete specimens arising from a 4-point bending test. The method's performance is compared to manual separation. Overall, we can state that the proposed method yields satisfying results when data meets the following criteria: Low fiber volume density, circular fiber cross section and sufficient spatial resolution of fiber-fiber contacts.

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    Keywords 003 ; 570 ; 006 ; 519
    Subject code 621
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Occludin a new HCV entry factor: is the list of essential hepatitis C virus receptors complete?

    Kronenberger, Bernd / Zeuzem, Stefan

    Gastroenterology

    2009  Volume 137, Issue 2, Page(s) 727–728

    Language English
    Publishing date 2009-08
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2009.06.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Endpoint Detection of Partially Overlapping Straight Fibers using High Positive Gaussian Curvature in 3D images

    Markus Kronenberger / Katja Schladitz / Oliver Wirjadi / Christopher Weber / Bernd Hamann / Hans Hagen

    Image Analysis and Stereology, Vol 38, Iss 3, Pp 245-

    2019  Volume 253

    Abstract: This paper introduces a method for detecting endpoints of partially overlapping straight fibers in three-dimensional voxel image data. The novel approach directly determines fiber endpoints without the need for more expansive single-fiber segmentation. ... ...

    Abstract This paper introduces a method for detecting endpoints of partially overlapping straight fibers in three-dimensional voxel image data. The novel approach directly determines fiber endpoints without the need for more expansive single-fiber segmentation. In the context of fiber-reinforced polymers, endpoint information is of practical significance as it can indicate potential damage in endless fiber systems, or can serve as input for estimating statistical fiber length distribution. We tackle this challenge by exploiting Gaussian curvature of the surface of the fibers. Fiber endpoints have high positive curvature, allowing one to distinguish them from the rest of a structure. Accuracy data of the proposed method are presented for various data sets. For simulated fiber systems with fiber volume fractions of less than 20 %, true positive rates above 94 % and false positive rates below 5 % are observed. Two well-resolved real data sets show a reduction of the first rate to 90.3 % and an increase of the second rate to 13.1 %.
    Keywords endpoint segmentation ; image processing ; x-ray micro-computed tomography ; fiber reinforced polymer ; Medicine (General) ; R5-920 ; Mathematics ; QA1-939
    Subject code 519
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Slovenian Society for Stereology and Quantitative Image Analysis
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Low 25-Hydroxyvitamin D Levels Are Associated with Infections and Mortality in Patients with Cirrhosis.

    Finkelmeier, Fabian / Kronenberger, Bernd / Zeuzem, Stefan / Piiper, Albrecht / Waidmann, Oliver

    PloS one

    2015  Volume 10, Issue 6, Page(s) e0132119

    Abstract: Background & aims: Vitamin D, best known to regulate bone mineralization, has numerous additional roles including regulation inflammatory pathways. Recently, an increased incidence of 25-hydroxyvitamin D3 (25(OH)D3) deficiency has been found in subjects ...

    Abstract Background & aims: Vitamin D, best known to regulate bone mineralization, has numerous additional roles including regulation inflammatory pathways. Recently, an increased incidence of 25-hydroxyvitamin D3 (25(OH)D3) deficiency has been found in subjects suffering from liver diseases. We here investigated if low vitamin D levels might be associated with prognosis, inflammation and infectious complications in patients with cirrhosis.
    Methods: We performed a prospective cohort study investigating the relation between 25(OH)D3 levels and stages of cirrhosis, mortality and complications of cirrhosis, including infections.
    Results: 251 patients with cirrhosis were enrolled into the present prospective cohort study. 25(OH)D3 levels were quantified by radioimmunoassay from serum samples obtained at study inclusion. The mean follow-up time was 411 ± 397 days with a range of 1-1382 days. 30 (12.0%) patients underwent liver transplantation and 85 (33.8%) individuals died within the study. The mean serum 25(OH)D3 concentration was 8.93 ± 7.1 ng/ml with a range of 1.0 to 46.0 ng/ml. 25(OH)D3 levels differed significantly between Child Pugh scores and showed a negative correlation with the model of end stage liver disease (MELD) score. Patients with decompensated cirrhosis and infectious complications, had significantly lower 25(OH)D3 levels compared to subjects without complications. Low 25(OH)D3 was associated with mortality in uni- as well as multivariate Cox regression models.
    Conclusions: 25(OH)D3 deficiency is associated with advanced liver disease and low 25(OH)D3 levels are an indicator for a poor outcome and are associated with infectious complications.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Liver Cirrhosis/blood ; Liver Cirrhosis/immunology ; Liver Cirrhosis/mortality ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/complications
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2015-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0132119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Current and future treatment options for HCV.

    Kronenberger, Bernd / Zeuzem, Stefan

    Annals of hepatology

    2009  Volume 8, Issue 2, Page(s) 103–112

    Abstract: Aim of antiviral therapy of patients with chronic hepatitis C is the sustained elimination of the hepatitis C virus (HCV). The standard of care (SOC) is peginterferon alfa-2a/-2b with ribavirin for 48 weeks or 24 weeks in patients infected with HCV ... ...

    Abstract Aim of antiviral therapy of patients with chronic hepatitis C is the sustained elimination of the hepatitis C virus (HCV). The standard of care (SOC) is peginterferon alfa-2a/-2b with ribavirin for 48 weeks or 24 weeks in patients infected with HCV genotype 1 or 2/3, respectively. Overall, approximately half of the patients can be cured by SOC. Based on baseline viral load and the speed of virologic response during treatment, individualization of treatment duration is possible. However, this approach is not sufficient to substantially improve the sustained virologic response (SVR) rates. This goal can be achieved with new HCV specific inhibitors against the NS3/4A polymerase and the NS5B polymerase. Recent trials reported SVR rates in the order of 67-69% and 67-75% for the combination of SOC with the protease inhibitors telaprevir and boceprevir, respectively, in patients with HCV genotype 1 infection. Several new HCV specific inhibitors such as protease inhibitors, nucleoside and non-nucleoside polymerase inhibitors as well as non HCV specific compounds with anti-HCV activity such as cyclophilin inhibitors, silibinin, and nitazoxanide are currently in clinical evaluation. The review describes recent developments and discusses limitations posed by resistance development and drug toxicity.
    MeSH term(s) Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Drug Resistance, Viral ; Drug Therapy, Combination ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/drug therapy ; Humans ; Treatment Outcome ; Viral Load
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2009-06-03
    Publishing country Mexico
    Document type Journal Article ; Review
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Treatment of chronic hepatitis C: anticipated impact of resistance in patients treated with protease inhibitors.

    Kronenberger, Bernd / Zeuzem, Stefan

    Current gastroenterology reports

    2009  Volume 11, Issue 1, Page(s) 15–21

    Abstract: A main target of specifically targeted antiviral therapy for hepatitis C (STAT-C) is the NS3-protease, which has key functions in the hepatitis C virus (HCV) replication cycle. HCV/NS3-protease inhibitors have shown high antiviral activity in vitro and ... ...

    Abstract A main target of specifically targeted antiviral therapy for hepatitis C (STAT-C) is the NS3-protease, which has key functions in the hepatitis C virus (HCV) replication cycle. HCV/NS3-protease inhibitors have shown high antiviral activity in vitro and in patients with chronic hepatitis C. Protease-resistant HCV variants occurred rapidly in patients receiving protease-inhibitor monotherapy. The development of resistance can be best explained by selection of preexisting resistant variants, which grow out under selective pressure. Numerous mutations associated with resistance were identified. Clinical trials showed that protease-resistant strains are sensitive to interferon and that a triple combination of protease inhibitors, peginterferon, and ribavirin may improve the sustained virologic response rate compared with standard peginterferon/ribavirin combination therapy. Overall, it can be anticipated that successful treatment with protease inhibitors will require either combination therapy with peginterferon/ribavirin or a combination of STAT-C compounds with distinct modes of action and resistance patterns.
    MeSH term(s) Antiviral Agents/therapeutic use ; Drug Resistance, Viral/genetics ; Drug Therapy, Combination ; Genotype ; Hepacivirus/drug effects ; Hepacivirus/physiology ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/virology ; Humans ; Interferons/genetics ; Interferons/therapeutic use ; Mutation/drug effects ; Oligopeptides/therapeutic use ; Phenotype ; Proline/analogs & derivatives ; Proline/therapeutic use ; Protease Inhibitors/therapeutic use ; Ribavirin/therapeutic use ; Viral Nonstructural Proteins/antagonists & inhibitors ; Virus Replication/drug effects ; Virus Replication/genetics
    Chemical Substances Antiviral Agents ; NS3 protein, hepatitis C virus ; Oligopeptides ; Protease Inhibitors ; Viral Nonstructural Proteins ; Ribavirin (49717AWG6K) ; telaprevir (655M5O3W0U) ; N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide (89BT58KELH) ; Interferons (9008-11-1) ; Proline (9DLQ4CIU6V)
    Language English
    Publishing date 2009-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2041376-2
    ISSN 1534-312X ; 1522-8037
    ISSN (online) 1534-312X
    ISSN 1522-8037
    DOI 10.1007/s11894-009-0003-9
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