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Article: The application, safety, and future of

Einloth, Katelyn R / Gayfield, Scott / McMaster, Thomas / Didier, Alexander / Dworkin, Lance / Creeden, Justin Fortune

2023 Volume 13, Issue 6, Page(s) 439–455

Language	English
Publishing date	2023-07-29
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2604624-6
ISSN	2228-5660 ; 2228-5652
ISSN (online)	2228-5660
ISSN	2228-5652
DOI	10.34172/bi.2023.27521
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Article ; Online: Addressing telemedicine challenges for surgery clinics in the Post-COVID era.

To, Henry / McMaster, Thomas / Stelmach, Wanda

ANZ journal of surgery

2021 Volume 91, Issue 9, Page(s) 1643–1644

MeSH term(s)	Ambulatory Care Facilities ; COVID-19 ; Humans ; SARS-CoV-2 ; Telemedicine
Language	English
Publishing date	2021-07-26
Publishing country	Australia
Document type	Editorial
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.17089
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Article ; Online: Innovations and Implementation of Telemedicine in Surgical Clinics Beyond COVID-19: A Narrative Review.

McMaster, Thomas / Mori, Krinal / Lee, Sharon / Manasa, Siri / Stelmach, Wanda / To, Henry

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2022 Volume 29, Issue 1, Page(s) 50–59

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; COVID-19/epidemiology ; Pandemics ; Telemedicine/methods ; Ambulatory Care Facilities ; Patient Satisfaction
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2021.0409
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Zs.A 4576: Show issues

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Article ; Online: The application of catch–effort models to estimate the efficacy of aerial shooting operations on sambar deer (<i>Cervus unicolor</i>)

Ramsey, David S. L. / McMaster, Damien / Thomas, Elaine

Wildlife Research. 2023, v. 50, no. 9 p.688-700

2023

Abstract: Context Aerial shooting from a helicopter targeting introduced sambar deer (Cervus unicolor) is a key activity being undertaken on public land in the North East and East Gippsland regions of Victoria. However, there is currently little published ... ...

Abstract	Context Aerial shooting from a helicopter targeting introduced sambar deer (Cervus unicolor) is a key activity being undertaken on public land in the North East and East Gippsland regions of Victoria. However, there is currently little published information on the efficacy of aerial shooting for reducing sambar deer populations in Australia. Aims The aims of this study were to analyse the operational data collected during an aerial shooting program in eastern Victoria, to assess the efficacy of aerial shooting at reducing sambar deer density and to inform management decisions on the required intensity of aerial shooting to achieve target densities. Methods Operational data (locations of all shot animals as well as aerial search effort) were analysed from 10 sites using a Bayesian generalised catch–effort model, which allowed for population changes between five periods of intensive control. The model allowed estimates of initial and residual abundance for each site to be made from the catch–effort data, which were used to estimate the efficacy of aerial shooting. Estimates of the detection rate of deer, which were allowed to vary with removal occasion and site, were then used to estimate the amount of aerial search effort required to reduce population densities by various proportional amounts. Key results Aerial shooting resulted in population reductions of 50–70% of sambar deer at four sites where aerial search intensities per unit area were highest. However, results at the remaining sites suggest that sambar deer densities have either remained static or increased over the five periods of aerial control. Recruitment of sambar deer between control periods, which was strongly influenced by study site elevation and season, was largely responsible for eroding reductions achieved by aerial shooting. Conclusions Catch–effort models applied to operational data collected during aerial shooting programs can be used to estimate control efficacy without the need for additional monitoring. Our analysis suggests that sufficiently high search intensities, around 1.4km of search effort per km2 of habitat in each of five removal occasions, would need to be applied to achieve at least a 50% reduction in sambar deer densities.
Keywords	Bayesian theory ; Rusa unicolor ; deer ; habitats ; models ; public lands ; wildlife ; Australia ; aerial shooting ; bushfire recovery ; catch–effort model ; culling ; dynamic N-mixture model ; invasive species ; removal models ; ungulates
Language	English
Size	p. 688-700.
Publishing place	CSIRO Publishing
Document type	Article ; Online
ZDB-ID	1070380-9
ISSN	1035-3712
ISSN	1035-3712
DOI	10.1071/WR22123
Database	NAL-Catalogue (AGRICOLA)

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Article: Current and future use of telemedicine in surgical clinics during and beyond COVID-19: A narrative review.

McMaster, Thomas / Wright, Timothy / Mori, Krinal / Stelmach, Wanda / To, Henry

Annals of medicine and surgery (2012)

2021 Volume 66, Page(s) 102378

Abstract: Introduction: Telemedicine has emerged as a powerful tool in the delivery of healthcare to surgical patients and enhances clinician-patient encounters during all phases of patient care. Our study aims were: to review the current use and applicability of ...

Abstract	Introduction: Telemedicine has emerged as a powerful tool in the delivery of healthcare to surgical patients and enhances clinician-patient encounters during all phases of patient care. Our study aims were: to review the current use and applicability of telemedicine; evaluate its suitability, safety and effectiveness in a surgical outpatient setting, particularly in the era of social distancing restrictions and provide insight into future applications. Methods: Databases searched included: PubMed, OVID Medline, Embase, Scopus, Web of Science and review of reference lists. Key words used were "telemedicine"; "telehealth"; "videoconference"; "outpatient" and "surgical clinic". For inclusion, articles required to be in English, published between 2000 and 2021, were in an outpatient surgical setting and if they had a focus during the COVID-19 pandemic. Results: 335 articles were identified and screened, so that 63 articles were included in the review. Almost all articles were from Western countries (n = 60), mostly in surgical journals (n = 35) and from a range of sub-specialities, but pre-dominantly orthopaedics (n = 12) and general surgery (n = 7). The majority were original comparative studies where 31 studies directly compared telemedicine to in-person appointments and 14 papers focused on implementation during COVID-19. Discussion/conclusions: Telemedicine has been safely used across various phases of surgical outpatient care, with its effectiveness evaluated by clinical outcomes, economics and user/provider satisfaction. Telemedicine has multiple accepted benefits including time efficiency, patient/healthcare cost savings and community access, but with reported limitations of clinical uncertainty, technology infrastructure requirements, cybersecurity vulnerabilities and healthcare regulatory restraints. These limitations are being overcome by accelerated implementation during COVID-19 via fast-tracked practice development. Further work is required via development of research protocols to refine the application of emerging telemedicine technologies and their applicability to different surgical sub-specialties.
Language	English
Publishing date	2021-05-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2021.102378
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Article ; Online: Effects of metformin on wild fathead minnows (Pimephales promelas) using in-lake mesocosms in a boreal lake ecosystem.

Ussery, Erin / McMaster, Mark / Palace, Vince / Parrott, Joanne / Blandford, Nicholas C / Frank, Richard / Kidd, Karen / Birceanu, Oana / Wilson, Joanna / Alaee, Mehran / Cunningham, Jessie / Wynia, Abby / Clark, Thomas / Campbell, Sheena / Timlick, Lauren / Michaleski, Sonya / Marshall, Stephanie / Nielsen, Kristin

The Science of the total environment

2024 Volume 929, Page(s) 172457

Abstract: Due to its widespread use for the treatment of Type-2 diabetes, metformin is routinely detected in surface waters globally. Laboratory studies have shown that environmentally relevant concentrations of metformin can adversely affect the health of adult ... ...

Abstract	Due to its widespread use for the treatment of Type-2 diabetes, metformin is routinely detected in surface waters globally. Laboratory studies have shown that environmentally relevant concentrations of metformin can adversely affect the health of adult fish, with effects observed more frequently in males. However, the potential risk to wild fish populations has yet to be fully elucidated and remains a topic of debate. To explore whether environmentally relevant metformin exposure poses a risk to wild fish populations, the present study exposed wild fathead minnows (Pimephales promelas) to 5 or 50 μg/L metformin via 2 m diameter in-lake mesocosms deployed in a natural boreal lake in Northern Ontario at the International Institute for Sustainable Development - Experimental Lakes Area (IISD-ELA). Environmental monitoring was performed at regular intervals for 8-weeks, with fish length, weight (body, liver and gonad), condition factor, gonadosomatic index, liver-somatic index, body composition (water and biomolecules) and hematocrit levels evaluated at test termination. Metabolic endpoints were also evaluated using liver, brain and muscle tissue, and gonads were evaluated histologically. Results indicate that current environmental exposure scenarios may be sufficient to adversely impact the health of wild fish populations. Adult male fish exposed to metformin had significantly reduced whole body weight and condition factor and several male fish from the high-dose metformin had oocytes in their testes. Metformin-exposed fish had altered moisture and lipid (decrease) content in their tissues. Further, brain (increase) and liver (decrease) glycogen were altered in fish exposed to high-dose metformin. To our knowledge, this study constitutes the first effort to understand metformin's effects on a wild small-bodied fish population under environmentally relevant field exposure conditions.
MeSH term(s)	Animals ; Metformin ; Water Pollutants, Chemical/toxicity ; Cyprinidae/physiology ; Lakes ; Male ; Environmental Monitoring ; Ontario ; Female ; Ecosystem
Chemical Substances	Metformin (9100L32L2N) ; Water Pollutants, Chemical
Language	English
Publishing date	2024-04-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172457
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Article: Development of the "Recovery from Eating Disorders for Life" Food Guide (REAL Food Guide) - a food pyramid for adults with an eating disorder.

Hart, Susan / Marnane, Claire / McMaster, Caitlin / Thomas, Angela

Journal of eating disorders

2018 Volume 6, Page(s) 6

Abstract: Background: There is limited evidence to inform nutrition and dietetic interventions for individuals with eating disorders even though it is recommended as an essential part of multidisciplinary management. There is minimal guidance, an absence of ... ...

Abstract	Background: There is limited evidence to inform nutrition and dietetic interventions for individuals with eating disorders even though it is recommended as an essential part of multidisciplinary management. There is minimal guidance, an absence of standardised nutrition educational material, and no research on how best to educate patients on healthy eating and how to achieve nutrition adequacy. Therefore the REAL Food Guide was developed. Methods: The REAL Food Guide is a pyramid with four layers and key nutrition messages beside each layer that was conceived to address gaps in nutrition education and intervention for individuals with eating disorders. Written and verbal consumer feedback was obtained from consumers receiving treatment regarding the acceptability and usefulness of the REAL Food Guide. A unique database was developed to reflect the types of foods and realistic portion sizes that patients are likely to select. This database was used for nutrition modelling to assess the nutrition adequacy of three meal patterns (meat containing, vegetarian and semi-vegan) for both weight maintenance and weight regain. Each meal pattern was compared to the Nutrient Reference Values for Australia and New Zealand. Results: Nutritional analysis demonstrated nutritional adequacy of meal patterns for energy, macronutrients and most micronutrients when the recommended number of serves from the REAL Food Guide were assessed. All meal patterns were adequate in micronutrients except for the semi-vegan meal pattern that was inadequate in vitamin D. Feedback from individuals with eating disorders demonstrates the nutrition education tool was acceptable to them as they felt it was more helpful for their recovery than general nutrition guidelines. Conclusion: The REAL Food Guide is a comprehensive and user-friendly guide that clinicians can use to educate patients about components of a balanced and healthy diet. The guide can educate all eating disorder clinicians, including those who are new to the field, about the basics of nutrition. Clinicians using the guide can be confident that, if followed, patient's energy and nutritional requirements will be met and important nutrition education messages are reinforced, that are tailored to the beliefs and concerns of individuals with eating disorders.
Language	English
Publishing date	2018-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2699357-0
ISSN	2050-2974
ISSN	2050-2974
DOI	10.1186/s40337-018-0192-4
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Article ; Online: TP63 isoform expression is linked with distinct clinical outcomes in cancer.

Bankhead, Armand / McMaster, Thomas / Wang, Yin / Boonstra, Philip S / Palmbos, Phillip L

EBioMedicine

2020 Volume 51, Page(s) 102561

Abstract: Background: Half of muscle-invasive bladder cancer patients will relapse with metastatic disease and molecular tests to predict relapse are needed. TP63 has been proposed as a prognostic biomarker in bladder cancer, but reports associating it with ... ...

Abstract	Background: Half of muscle-invasive bladder cancer patients will relapse with metastatic disease and molecular tests to predict relapse are needed. TP63 has been proposed as a prognostic biomarker in bladder cancer, but reports associating it with clinical outcomes are conflicting. Since TP63 is expressed as multiple isoforms, we hypothesized that these conflicting associations with clinical outcome may be explained by distinct opposing effects of differential TP63 isoform expression. Methods: Using RNA-Seq data from The Cancer Genome Atlas (TCGA), TP63 isoform-level expression was quantified and associated with clinical covariates (e.g. survival, stage) across 8,519 patients from 29 diseases. A comprehensive catalog of TP63 isoforms was assembled using gene annotation databases and de novo discovery in bladder cancer patients. Quantifications and un-annotated TP63 isoforms were validated using quantitative RT-PCR and a separate bladder cancer cohort. Findings: DNp63 isoform expression was associated with improved bladder cancer patient survival in patients with a luminal subtype (HR = 0.89, CI 0.80-0.99, Cox p = 0.034). Conversely, TAp63 isoform expression was associated with reduced bladder cancer patient survival in patients with a basal subtype (HR = 2.35, CI 1.64-3.37, Cox p < 0.0001). These associations were observed in multiple TCGA disease cohorts and correlated with epidermal differentiation (DNp63) and immune-related (TAp63) gene signatures. Interpretation: These results comprehensively define TP63 isoform expression in human cancer and suggest that TP63 isoforms are involved in distinct transcriptional programs with opposing effects on clinical outcome.
MeSH term(s)	Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Proportional Hazards Models ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Signal Transduction ; Survival Analysis ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Treatment Outcome ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Urinary Bladder Neoplasms/classification ; Urinary Bladder Neoplasms/genetics
Chemical Substances	Protein Isoforms ; TP63 protein, human ; Transcription Factors ; Tumor Suppressor Proteins
Language	English
Publishing date	2020-01-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2019.11.022
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Article ; Online: Evaporation and propagation of liquid drop streams at vacuum pressures: Experiments and modeling.

Guildenbecher, Daniel R / Barnard, John J / Grasser, Thomas W / McMaster, Anthony M / Campbell, Robert B / Grote, David P / Nandy, Prabal / Light, Max

Physical review. E

2021 Volume 103, Issue 4-1, Page(s) 43105

Abstract: Evaporation of streams of liquid droplets in environments at vacuum pressures below the vapor pressure has not been widely studied. Here, experiments and simulations are reported that quantify the change in droplet diameter when a steady stream of ≈100 ... ...

Abstract	Evaporation of streams of liquid droplets in environments at vacuum pressures below the vapor pressure has not been widely studied. Here, experiments and simulations are reported that quantify the change in droplet diameter when a steady stream of ≈100 μm diameter drops is injected into a chamber initially evacuated to <10^{-8}bar. In experiments, droplets fall through the center of a 0.8 m long liquid nitrogen cooled shroud, simulating infinity radiation and vapor mass flux boundary conditions. Experimentally measured changes in drop diameters vary from ≈0 to 6 μm when the initial vapor pressure is increased from 10^{-6} to 10^{-3} bar by heating the liquid. Measured diameter changes are predicted by a model based on the Hertz-Knudsen equation. One uncertainty in the calculation is the "sticking coefficient" β. Assuming a constant β for all conditions studied here, predicted diameter changes best match measurements with β≈0.3. This value falls within the range of β reported in the literature for organic liquids. Finally, at the higher vapor pressure conditions considered here, the drop stream disperses transverse to the main flow direction. This spread is attributed to forces imparted by an absolute pressure gradient produced by the evaporating stream.
Language	English
Publishing date	2021-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.103.043105
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Article ; Online: Advancing diagnosis and research for rare genetic diseases in Indigenous peoples.

Baynam, Gareth / Julkowska, Daria / Bowdin, Sarah / Hermes, Azure / McMaster, Christopher R / Prichep, Elissa / Richer, Étienne / van der Westhuizen, Francois H / Repetto, Gabriela M / Malherbe, Helen / Reichardt, Juergen K V / Arbour, Laura / Hudson, Maui / du Plessis, Kelly / Haendel, Melissa / Wilcox, Phillip / Lynch, Sally Ann / Rind, Shamir / Easteal, Simon /

Estivill, Xavier / Caron, Nadine / Chongo, Meck / Thomas, Yarlalu / Letinturier, Mary Catherine V / Vorster, Barend Christiaan

Nature genetics

2024 Volume 56, Issue 2, Page(s) 189–193

MeSH term(s)	Humans ; Indigenous Peoples ; Rare Diseases/diagnosis ; Rare Diseases/genetics
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/s41588-023-01642-1
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