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  1. Article ; Online: Oxygen uptake during the last bouts of exercise incorporated into high-intensity intermittent cross-exercise exceeds the

    Xu, Yuzhong / Liu, Xin / Tsuji, Katsunori / Hamaoka, Takafumi / Tabata, Izumi

    Sports medicine and health science

    2024  Volume 6, Issue 1, Page(s) 63–69

    Abstract: Oxygen uptake ( ...

    Abstract Oxygen uptake (
    Language English
    Publishing date 2024-01-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-3376
    ISSN (online) 2666-3376
    DOI 10.1016/j.smhs.2024.01.002
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  2. Article: Three E2F target-related genes signature for predicting prognosis, immune features, and drug sensitivity in hepatocellular carcinoma.

    Zhang, Baozhu / Chang, Boyang / Wang, Lu / Xu, Yuzhong

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1266515

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1266515
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  3. Article ; Online: Three E2F target-related genes signature for predicting prognosis, immune features, and drug sensitivity in hepatocellular carcinoma

    Baozhu Zhang / Boyang Chang / Lu Wang / Yuzhong Xu

    Frontiers in Molecular Biosciences, Vol

    2023  Volume 10

    Abstract: Background: Hepatocellular carcinoma (HCC) is extremely malignant and difficult to treat. The adenoviral early region 2 binding factors (E2Fs) target pathway is thought to have a major role in tumor growth. This study aimed to identify a predictive E2F ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) is extremely malignant and difficult to treat. The adenoviral early region 2 binding factors (E2Fs) target pathway is thought to have a major role in tumor growth. This study aimed to identify a predictive E2F target signature and facilitate individualized treatment for HCC patients.Methods: We constructed an E2F target-related gene profile using univariate COX and LASSO regression models and proved its predictive efficacy in external cohorts. Furthermore, we characterized the role of the E2F target pathway in pathway enrichment, immune cell infiltration, and drug sensitivity of HCC.Results: Lasso Cox regression created an E2F target-related gene signature of GHR, TRIP13, and CDCA8. HCC patients with high risk were correlated with shorter survival time, immune evasion, tumor stem cell characteristics and high sensitivity to Tipifarnib and Camptothecin drugs.Conclusion: Hepatocellular carcinoma prognosis was predicted by an E2F target signature. This finding establishes the theoretical usefulness of the E2F target route in customized identification and treatment for future research.
    Keywords E2F target ; hepatocellular carcinoma ; prognosis ; immune landscape ; drug sensitivity ; Biology (General) ; QH301-705.5
    Subject code 570 ; 616
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Low levels of humoral response to monkeypox virus-specific antigens in healthy individuals.

    Zhang, Kehong / Xu, Yuzhong / Zhang, Huihua / Zheng, Huanwei / Chen, Xinchun / Lin, Dachuan

    The Journal of infection

    2023  Volume 86, Issue 6, Page(s) e156–e157

    MeSH term(s) Humans ; Monkeypox virus ; Vaccinia virus ; Antibodies, Viral
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.04.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  5. Article ; Online: Waste treats waste: Facile fabrication of porous adsorbents from recycled PET and sodium alginate for efficient dye removal.

    Yu, Jing / Bai, Lan / Feng, Zijun / Chen, Lin / Xu, Shimei / Wang, Yuzhong

    Chemosphere

    2024  Volume 355, Page(s) 141738

    Abstract: Dye-contaminated water and waste plastic both pose enormous threats to human health and the ecological environment, and simultaneously solving these two issues in a sustainable and resource-saving way is highly important. In this work, a sodium alginate- ... ...

    Abstract Dye-contaminated water and waste plastic both pose enormous threats to human health and the ecological environment, and simultaneously solving these two issues in a sustainable and resource-saving way is highly important. In this work, a sodium alginate-polyethylene terephthalate-sodium alginate (SA@PET) composite adsorbent for efficient dye removal is fabricated using wasted PET bottle and marine plant-based SA via simple and energy-efficient nonsolvent-induced phase separation (NIPS) method. Benefiting from its porous structure and the abundant binding sites, SA@PET shows an excellent methylene blue (MB) adsorption capacity of 1081 mg g
    MeSH term(s) Humans ; Alginates/chemistry ; Porosity ; Water Pollutants, Chemical/analysis ; Adsorption ; Water Purification/methods ; Methylene Blue/chemistry ; Kinetics ; Hydrogen-Ion Concentration
    Chemical Substances Alginates ; Water Pollutants, Chemical ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141738
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Exploring the ecological meanings of temperature sensitivity of ecosystem respiration from different methods.

    Zhang, Yang / Zhu, Gaofeng / Zhang, Kun / Huang, Heng / He, Liyang / Xu, Cong / Chen, Huiling / Su, Yonghong / Zhang, Yuzhong / Fan, Haochen / Wang, Boyuan

    The Science of the total environment

    2024  Volume 923, Page(s) 171403

    Abstract: Temperature sensitivity ( ... ...

    Abstract Temperature sensitivity (Q
    Language English
    Publishing date 2024-03-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171403
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Construction and verification of a histone deacetylases-related prognostic signature model for colon cancer.

    Hao, Lei / Lu, Weiqi / Wu, Jianyu / Chen, Yuzhong / Xu, Dongni / Wang, Peizong

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8983

    Abstract: Histone deacetylases (HDACs) contribute significantly to the initiation, progression, and prognosis of colorectal adenocarcinoma (COAD). Additionally, HDACs regulate the tumor microenvironment, immune escape, and tumor stem cells, and are closely linked ... ...

    Abstract Histone deacetylases (HDACs) contribute significantly to the initiation, progression, and prognosis of colorectal adenocarcinoma (COAD). Additionally, HDACs regulate the tumor microenvironment, immune escape, and tumor stem cells, and are closely linked to COAD prognosis. We developed a prognostic model for COAD that incorporates HDACs to evaluate their specific roles. The COAD dataset containing clinical and mutation data was collected using the TCGA and GEO databases to obtain genes associated with HDAC. LASSO analysis and univariate and multivariate Cox regression analysis were used to determine the presence of prognostic genes. Multivariate Cox analysis was also used to determine risk scores for HDAC-related features. Furthermore, genomic alterations, immune infiltration, and drug response were compared between high- and low-risk groups. Cellular experiments validated the potential regulatory role of BRD3 on COAD proliferation, migration, and apoptosis. The median risk scores, calculated based on the characteristics, demonstrated a more significant prognostic improvement in patients in the low-risk group. Furthermore, HDAC-related features were identified as important independent prognostic factors for patients with COAD. Additionally, genomic mutation status, immune infiltration, and function, as well as response to immunotherapy and chemotherapy, were found to be associated with risk scores. Subgroup analyses indicate that anti-PD-1 therapy may be beneficial for patients in the low-risk group. Additionally, a decrease in risk score was associated with a decrease in immune infiltration. Finally, HCT116 and HT29 cells exhibited inhibition of BRD3 gene proliferation and migration, as well as promotion of apoptosis. In patients with COAD, HDAC-related characteristics may be useful in predicting survival and selecting treatment.
    MeSH term(s) Humans ; Prognosis ; Colonic Neoplasms/genetics ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Genes, Regulator ; Adenocarcinoma ; Histone Deacetylases/genetics ; Tumor Microenvironment/genetics
    Chemical Substances Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59724-x
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  8. Article ; Online: Study on Sustainability of Shelter Forest Construction and Protection Behavior of Farmers in the Sandstorm Area of Hexi Corridor, China

    Yuzhong Zhang / Xianying Xu / Hujun Liu / Li Wang / Danni Niu

    Sustainability, Vol 15, Iss 5242, p

    2023  Volume 5242

    Abstract: An accurate assessment of farmers’ participation in shelter forest construction and protection behavior is of great practical significance for the renewal and restoration of degraded shelter forests, improvements in the ecological environment, and the ... ...

    Abstract An accurate assessment of farmers’ participation in shelter forest construction and protection behavior is of great practical significance for the renewal and restoration of degraded shelter forests, improvements in the ecological environment, and the sustainable development of agroforestry. This study was based on the theory of planned behavior and structural equation modeling. The cognition and behavior of farmers in typical wind and sand areas of the Hexi Corridor were constructed to measure their participation in the construction and protection of shelter forests from the “cognition-behavior” dimension. The results showed that all three dimensions of farmers’ perceptions had a significant positive effect on farmers’ participation in the construction and protection of shelter forests. The combined path coefficients of the three dimensions were behavioral attitudes (0.337), subjective norms (0.216), and perceived behavioral control (0.170), with farmers’ behavioral attitudes having a more pronounced effect on forest construction and protection behaviors. In the behavioral response to the construction and protection of shelter forests, farmers have a positive attitude toward compensation, management, and pest control, while the response to adjustment pattern, willingness to pay, and tree species replacement is relatively insignificant. It is suggested that the government should increase the publicity of shelter forest protection, improve the ecological compensation and reward and punishment mechanism, improve the management system, and strengthen the training of farmers’ professional knowledge and skills. These measures could increase farmers’ awareness of forest construction and protection to ensure that farmers actively participate in the construction and management of shelter forests.
    Keywords Hexi Corridor ; shelter forest ; farmers’ cognition ; construction and protection ; wind and sand area ; theory of planned behavior ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 910
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Long Non-coding RNAs in Tuberculosis: From Immunity to Biomarkers.

    Zhang, Xianyi / Chen, Chan / Xu, Yuzhong

    Frontiers in microbiology

    2022  Volume 13, Page(s) 883513

    Abstract: Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the leading lethal infectious disease with 1.3 million deaths in 2020. Despite significant advances have been made in detection techniques and therapeutic approaches for tuberculosis, no ... ...

    Abstract Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the leading lethal infectious disease with 1.3 million deaths in 2020. Despite significant advances have been made in detection techniques and therapeutic approaches for tuberculosis, no suitable diagnostic tools are available for early and precise screening. Many studies have reported that Long non-coding RNAs (lncRNAs) play a regulatory role in gene expression in the host immune response against Mtb. Dysregulation of lncRNAs expression patterns associated with immunoregulatory pathways arose in mycobacterial infection. Meanwhile, host-induced lncRNAs regulate antibacterial processes such as apoptosis and autophagy to limit bacterial proliferation. In this review, we try to summarize the latest reports on how dysregulated expressed lncRNAs influence host immune response in tuberculosis infection. We also discuss their potential clinical prospects for tuberculosis diagnosis and development as molecular biomarkers.
    Language English
    Publishing date 2022-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.883513
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  10. Article ; Online: SIAP: an intelligent algorithm for multiple prescription pattern recognition based on weighted similarity distances.

    Wang, Yifei / Xu, Julia / Zhang, Jie / Xu, Hong / Sun, Yuzhong / Miao, Yuan / Wen, Tiancai

    BMC medical informatics and decision making

    2023  Volume 23, Issue 1, Page(s) 79

    Abstract: Background: Clinical practices have demonstrated that disease treatment can be very complex. Patients with chronic diseases often suffer from more than one disease. Complex diseases are often treated with a variety of drugs, including both primary and ... ...

    Abstract Background: Clinical practices have demonstrated that disease treatment can be very complex. Patients with chronic diseases often suffer from more than one disease. Complex diseases are often treated with a variety of drugs, including both primary and auxiliary treatments. This complexity and multidimensionality increase the difficulty of extracting knowledge from clinical data.
    Methods: In this study, we proposed a subgroup identification algorithm for complex prescriptions (SIAP). We applied the SIAP algorithm to identify the importance level of each drug in complex prescriptions. The algorithm quickly classified and determined valid prescription combinations for patients. The algorithm was validated through classification matching of classical prescriptions in traditional Chinese medicine. We collected 376 formulas and their compositions from a formulary to construct a database of standard prescriptions. We also collected 1438 herbal prescriptions from clinical data for automated prescription identification. The prescriptions were divided into training and test sets. Finally, the parameters of the two sub-algorithms of SIAP and SIAP-All, as well as those of the combination algorithm SIAP + All, were optimized on the training set. A comparison analysis was performed against the baseline intersection set rate (ISR) algorithm. The algorithm for this study was implemented with Python 3.6.
    Results: The SIAP-All and SIAP + All algorithms outperformed the benchmark ISR algorithm in terms of accuracy, recall, and F1 value. The F1 values were 0.7568 for SIAP-All and 0.7799 for SIAP + All, showing improvements of 8.73% and 11.04% over the existing ISR algorithm, respectively.
    Conclusion: We developed an algorithm, SIAP, to automatically match sub-prescriptions of complex drugs with corresponding standard or classic prescriptions. The matching algorithm weights the drugs in the prescription according to their importance level. The results of this study can help to classify and analyse the drug compositions of complex prescriptions.
    MeSH term(s) Humans ; Medicine, Chinese Traditional ; Databases, Factual ; Drug Prescriptions ; Algorithms
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2046490-3
    ISSN 1472-6947 ; 1472-6947
    ISSN (online) 1472-6947
    ISSN 1472-6947
    DOI 10.1186/s12911-023-02141-3
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