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  1. Book ; Online: Honorary Doctorate Dr. Souha Kanj

    Kanj, Souha / Wertheim, Heiman

    2023  

    Keywords History ; Medicine ; Civil War Lebanon; Antimicrobial resistance; Infectious diseases; Honorary doctor; Honorary doctorate
    Language English
    Size 1 electronic resource (38 pages)
    Publisher Radboud University Press
    Publishing place Nijmegen
    Document type Book ; Online
    Note English
    HBZ-ID HT030377371
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Metallo-beta-lactamases: mechanisms, treatment challenges, and future prospects.

    Zakhour, Johnny / El Ayoubi, L'Emir Wassim / Kanj, Souha S

    Expert review of anti-infective therapy

    2024  Volume 22, Issue 4, Page(s) 189–201

    Abstract: Introduction: Metallo-beta-lactamases (MBLs) are responsible for resistance to almost all beta-lactam antibiotics. Found predominantly in Gram-negative bacteria, they severely limit treatment options. Understanding the epidemiology, risk factors, ... ...

    Abstract Introduction: Metallo-beta-lactamases (MBLs) are responsible for resistance to almost all beta-lactam antibiotics. Found predominantly in Gram-negative bacteria, they severely limit treatment options. Understanding the epidemiology, risk factors, treatment, and prevention of infections caused by MBL-producing organisms is essential to reduce their burden.
    Areas covered: The origins and structure of MBLs are discussed. We describe the mechanisms of action that differentiate MBLs from other beta-lactamases. We discuss the global epidemiology of MBL-producing organisms and their impact on patients' outcomes. By exposing the mechanisms of transmission of MBLs among bacterial populations, we emphasize the importance of infection prevention and control.
    Expert opinion: MBLs are spreading globally and challenging the majority of available antibacterial agents. Genotypic tests play an important role in the identification of MBL production. Phenotypic tests are less specific but may be used in low-resource settings, where MBLs are more predominant. Infection prevention and control are critical to reduce the spread of organisms producing MBL in healthcare systems. New combinations such as avibactam-aztreonam and new agents such as cefiderocol have shown promising results for the treatment of infections caused by MBL-producing organisms. New antibiotic and non-antibiotic agents are being developed and may improve the management of infections caused by MBL-producing organisms.
    MeSH term(s) Humans ; beta-Lactamases/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Aztreonam ; Gram-Negative Bacteria ; Bacteria ; Microbial Sensitivity Tests ; beta-Lactamase Inhibitors/pharmacology
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents ; Aztreonam (G2B4VE5GH8) ; beta-Lactamase Inhibitors
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2024.2311213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6106: Show issues Location:
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  3. Article ; Online: Beyond the Pandemic: The Value of Antimicrobial Stewardship.

    Kanj, Souha S / Ramirez, Paula / Rodrigues, Camilla

    Frontiers in public health

    2022  Volume 10, Page(s) 902835

    MeSH term(s) Anti-Infective Agents ; Antimicrobial Stewardship ; Pandemics
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.902835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Necrotizing fasciitis: an update on epidemiology, diagnostic methods, and treatment.

    Allaw, Fatima / Wehbe, Saliba / Kanj, Souha S

    Current opinion in infectious diseases

    2023  Volume 37, Issue 2, Page(s) 105–111

    Abstract: Purpose of review: The aim of this review is to discuss the latest evidence of epidemiology, diagnostic methods, and treatment of necrotizing soft tissue infections (NSTIs) with a particular focus on necrotizing fasciitis (NF).: Recent findings: ... ...

    Abstract Purpose of review: The aim of this review is to discuss the latest evidence of epidemiology, diagnostic methods, and treatment of necrotizing soft tissue infections (NSTIs) with a particular focus on necrotizing fasciitis (NF).
    Recent findings: NSTIs have been historically referred to as NF but encompass a broader range of infections, with variable rates ranging from 0.86 to 32.64 per 100 000 person-years, influenced by factors such as climate and seasonal variations. They have diverse microbiological profiles categorized into different types based on the involved pathogens, including polymicrobial or monomicrobial infections caused by organisms such as group A streptococcus (GAS), Staphylococcus aureus , some Gram-negative pathogens, and filamentous fungi following trauma and natural disasters. Diagnosis relies on clinical symptoms and signs, laboratory markers, and imaging. However, the gold standard for diagnosis remains intraoperative tissue culture. Treatment involves repeated surgical debridement of necrotic tissues in addition to intravenous antibiotics. Adjuvant therapies with intravenous immunoglobulin (IVIG) and hyperbaric oxygen therapy (HBOT) might have a role. Soft tissue reconstruction may be necessary following surgery.
    Summary: Prompt diagnosis and proper medical and surgical management of NSTI will improve outcomes.
    MeSH term(s) Humans ; Fasciitis, Necrotizing/diagnosis ; Fasciitis, Necrotizing/epidemiology ; Fasciitis, Necrotizing/therapy ; Soft Tissue Infections/diagnosis ; Soft Tissue Infections/epidemiology ; Soft Tissue Infections/therapy ; Anti-Bacterial Agents/therapeutic use ; Combined Modality Therapy ; Streptococcus pyogenes
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2462: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Community-acquired skin and soft-tissue infections in people who inject drugs.

    Allaw, Fatima / Zakhour, Johnny / Kanj, Souha S

    Current opinion in infectious diseases

    2023  Volume 36, Issue 2, Page(s) 67–73

    Abstract: Purpose of review: The aim of this review is to discuss the latest evidence of the epidemiology, microbiology, risk factors, diagnosis and management of community-acquired skin and soft tissue infections (SSTIs) in people who inject drug (PWID).: ... ...

    Abstract Purpose of review: The aim of this review is to discuss the latest evidence of the epidemiology, microbiology, risk factors, diagnosis and management of community-acquired skin and soft tissue infections (SSTIs) in people who inject drug (PWID).
    Recent findings: SSTIs are common complications in PWID and a major cause of morbidity and mortality. Infections can range from uncomplicated cellulitis, to abscesses, deep tissue necrosis and necrotizing fasciitis. They are predominantly caused by Gram-positive pathogens in particular Staphylococcus aureus and Streptococcus species; however, toxin-producing organisms such as Clostridium botulism or Clostridium tetani should be considered. The pathogenesis of SSTI in the setting of intravenous drug use (IDU) is different from non-IDU related SSTI, and management often requires surgical interventions in addition to adjunctive antibiotics. Harm reduction strategies and education about safe practices should be implemented to prevent morbidity and mortality as well as healthcare burden of SSTI in PWID.
    Summary: Prompt diagnosis and proper medical and surgical management of SSTI will improve outcomes in PWID.
    MeSH term(s) Humans ; Soft Tissue Infections/etiology ; Soft Tissue Infections/complications ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/epidemiology ; Drug Users ; Skin ; Skin Diseases, Infectious/epidemiology ; Skin Diseases, Infectious/etiology ; Community-Acquired Infections/etiology ; Community-Acquired Infections/complications ; Methicillin-Resistant Staphylococcus aureus
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2462: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Accelerating antibiotic access and stewardship: a new model to safeguard public health.

    Cohn, Jennifer / Mendelson, Marc / Kanj, Souha S / Shafiq, Nusrat / Boszczowski, Icaro / Laxminarayan, Ramanan

    The Lancet. Infectious diseases

    2024  

    Abstract: This Personal View discusses the challenges faced, especially by low-income and middle-income countries (LMICs), in responding to the growing burden of bacterial antimicrobial resistance. Many patients in LMICs lack access to effective and affordable ... ...

    Abstract This Personal View discusses the challenges faced, especially by low-income and middle-income countries (LMICs), in responding to the growing burden of bacterial antimicrobial resistance. Many patients in LMICs lack access to effective and affordable treatments needed to successfully treat patients. Meanwhile, traditional antimicrobial stewardship models face implementation challenges due to financial, health system, and human resource constraints. These constraints call for a paradigm shift from traditional high-income country-style antimicrobial stewardship, which is often resource intensive and aimed at cost containment, to a broader concept of sustainable access. We suggest a model of context-adapted stewardship that continues to emphasise providing the right antibiotic, at the right time, for the right duration, and at an affordable price. Taking lessons from other disease areas, including tuberculosis, we identify interventions such as task shifting to various health-care workers and the implementation of a hub-and-spoke model to support appropriate use of antibiotics, to enable optimal access and maximisation of scarce resources.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(24)00070-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Correction: Human monkeypox: A review of the literature.

    El Eid, Rozana / Allaw, Fatima / Haddad, Sara F / Kanj, Souha S

    PLoS pathogens

    2022  Volume 18, Issue 12, Page(s) e1011008

    Abstract: This corrects the article DOI: 10.1371/journal.ppat.1010768.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.ppat.1010768.].
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Recent advances in the treatment of Ebola disease: A brief overview.

    El Ayoubi, L'Emir Wassim / Mahmoud, Omar / Zakhour, Johnny / Kanj, Souha S

    PLoS pathogens

    2024  Volume 20, Issue 3, Page(s) e1012038

    Abstract: Ebola disease (EBOD) remains a significant and ongoing threat to African countries, characterized by a mortality rate of 25% to 90% in patients with high viral load and significant transmissibility. The most recent outbreak, reported in Uganda in ... ...

    Abstract Ebola disease (EBOD) remains a significant and ongoing threat to African countries, characterized by a mortality rate of 25% to 90% in patients with high viral load and significant transmissibility. The most recent outbreak, reported in Uganda in September 2022, was declared officially over in January 2023. However, it was caused by the Sudan Ebola virus (SUDV), a culprit species not previously reported for a decade. Since its discovery in 1976, the management of EBOD has primarily relied on supportive care. Following the devastating outbreak in West Africa from 2014 to 2016 secondary to the Zaire Ebola virus (EBOV), where over 28,000 lives were lost, dedicated efforts to find effective therapeutic agents have resulted in considerable progress in treating and preventing disease secondary to EBOV. Notably, 2 monoclonal antibodies-Ebanga and a cocktail of monoclonal antibodies, called Inmazeb-received Food and Drug Administration (FDA) approval in 2020. Additionally, multiple vaccines have been approved for EBOD prevention by various regulatory bodies, with Ervebo, a recombinant vesicular stomatitis virus-vectored vaccine against EBOV being the first vaccine to receive approval by the FDA in 2019. This review covers the key signs and symptoms of EBOD, its modes of transmission, and the principles guiding supportive care. Furthermore, it explores recent advancements in treating and preventing EBOD, highlighting the unique properties of each therapeutic agent and the ongoing progress in discovering new treatments.
    MeSH term(s) Humans ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/prevention & control ; Antibodies, Viral ; Ebola Vaccines ; Ebolavirus/genetics ; Viral Vaccines ; Antibodies, Monoclonal/therapeutic use ; Uganda/epidemiology
    Chemical Substances Antibodies, Viral ; Ebola Vaccines ; Viral Vaccines ; Antibodies, Monoclonal
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1012038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Beyond the Pandemic

    Souha S. Kanj / Paula Ramirez / Camilla Rodrigues

    Frontiers in Public Health, Vol

    The Value of Antimicrobial Stewardship

    2022  Volume 10

    Keywords COVID-19 ; stewardship ; antimicrobial resistance ; infection prevention and control ; One Health ; lessons learned ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Epidemiology and microbiology of catheter-associated urinary tract infections: A 14-year surveillance study at a tertiary care center in Lebanon.

    Shmoury, Abdel Hadi / Hanna, Wael / Zakhour, Johnny / Zahreddine, Nada Kara / Kanj, Souha S

    Journal of infection and public health

    2024  Volume 17, Issue 5, Page(s) 825–832

    Abstract: Background: Catheter-associated urinary tract infections (CAUTIs) are the most common device-associated healthcare-acquired infections and pose a significant burden on patients and healthcare systems worldwide. However, there is a paucity of data on ... ...

    Abstract Background: Catheter-associated urinary tract infections (CAUTIs) are the most common device-associated healthcare-acquired infections and pose a significant burden on patients and healthcare systems worldwide. However, there is a paucity of data on CAUTI epidemiology and microbiology in the Middle East and North Africa (MENA) region, including Lebanon.
    Methods: This 14-year retrospective cohort study was conducted at a tertiary care center in Lebanon. It analyzed data on all adult patients diagnosed with CAUTI between January 2009 and December 2022 in intensive care units (ICUs) and between June 2011 and December 2022 in regular units. Incidence rates, urinary catheter utilization ratios, and microbiological profiles were collected and analyzed.
    Results: A total of 620 CAUTI cases were identified during the study period. The overall CAUTI rate was 2.4 per 1000 catheter-days, with higher rates in ICUs (3.2 per 1000 catheter-days) compared to regular units (1.4 per 1000 catheter-days). No significant changes in the rates were noted despite implementing many interventions. The most common pathogens were Gram-negative bacteria, with Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae being predominant. Multidrug-resistant organisms represented 48% of all isolates. Enterobacterales were largely extended-spectrum β-lactamase (ESBL) producing, and most Acinetobacter baumannii isolates showed multidrug resistance.
    Conclusions: This study provides important insights into CAUTI epidemiology and microbiology in a tertiary care center in Lebanon, addressing the knowledge gap in this area in the MENA region. Despite implementing prevention measures, CAUTI rates remained stable over the 14-year period. The findings highlight the need for continuous improvement in infection prevention practices, diagnostic stewardship, and antimicrobial stewardship, especially given the rising threat of antimicrobial resistance. These results can serve as a guide for the development of targeted preventive strategies to reduce the burden of CAUTIs, particularly in low- and middle-income countries where antimicrobial resistance is a major issue.
    MeSH term(s) Adult ; Humans ; Catheter-Related Infections/prevention & control ; Tertiary Care Centers ; Retrospective Studies ; Lebanon/epidemiology ; Urinary Tract Infections/microbiology ; Intensive Care Units ; Catheters/adverse effects ; Anti-Infective Agents ; Cross Infection/microbiology
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2467587-8
    ISSN 1876-035X ; 1876-0341
    ISSN (online) 1876-035X
    ISSN 1876-0341
    DOI 10.1016/j.jiph.2024.03.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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