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  1. Article ; Online: Older breast cancer patients: challenges facing oncologists.

    Vinh-Hung, Vincent / Nguyen, Nam P

    Translational cancer research

    2022  Volume 9, Issue Suppl 1, Page(s) S1–S2

    Language English
    Publishing date 2022-01-18
    Publishing country China
    Document type Editorial
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2020.01.05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Twenty-five Years Overall Survival Prognostic Value of the Lymph Node Ratio in

    Gorobets, Olena / Keam, Bhumsuk / Vinh-Hung, Vincent / Nguyen, Nam P

    Anticancer research

    2024  Volume 44, Issue 5, Page(s) 1995–2002

    Abstract: Background/aim: The lymph node ratio (LNR) indicates the number of involved lymph nodes divided by the number of lymph nodes found during axillary exploration. This study investigated the prognostic value of the LNR in de novo metastatic breast cancer ( ... ...

    Abstract Background/aim: The lymph node ratio (LNR) indicates the number of involved lymph nodes divided by the number of lymph nodes found during axillary exploration. This study investigated the prognostic value of the LNR in de novo metastatic breast cancer (dnMBC). We hypothesized that LNR might predict long-term survival even in cases where the disease has already disseminated beyond the regional stage.
    Patients and methods: Patients with dnMBC were selected from the Surveillance, Epidemiology, and End Results (SEER) 9-registries database 1988-2012. Positive lymph nodes (npos) were categorized as pN0 (npos=0), pN1 (npos=1 to 3), pN2 (npos=4 to 9), and pN3 (npos≥10). The LNR was categorized as Lnr0 (LNR=0), Lnr1 (LNR=0.01 to 0.20), Lnr2 (LNR=0.21 to 0.65), and Lnr3 (LNR≥0.65). The prognostic values were compared using Gini's mean difference Δ of the restricted mean overall survival time (RMST) according to npos versus LNR groups.
    Results: A total of 12,085 patients with dnMBC had LNR data. At 25 years follow-up, the npos RMSTs were 10.4, 5.1, 5.8, and 5.0 years, for pN0 to pN3, respectively. The npos Gini's Δ was 2.8 years (standard error ±0.2). The LNR RMSTs were 10.4, 9.9, 7.6, and 4.0 years for Lnr0 to Lnr3, respectively. Δ for LNR was 3.6 (±0.2) years. Among node positive cases, the LNR low-risk group had an RMST of 9.9 years, approaching node-negative cases, while the high-risk group had an RMST of 4.0 years.
    Conclusion: LNR identified different prognostic groups, suggesting a possible role of lymph node involvement as a marker of lymphangiogenesis or lymphatic changes in the immune microenvironment, which warrants further investigation in dnMBC.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Breast Neoplasms/mortality ; Prognosis ; Middle Aged ; Lymphatic Metastasis ; Lymph Node Ratio ; Lymph Nodes/pathology ; SEER Program ; Aged ; Adult
    Language English
    Publishing date 2024-04-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.17002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Rationale for Combing Stereotactic Body Radiation Therapy with Immune Checkpoint Inhibitors in Medically Inoperable Early-Stage Non-Small Cell Lung Cancer.

    Chi, Alexander / Nguyen, Nam P

    Cancers

    2022  Volume 14, Issue 13

    Abstract: Stereotactic body radiation therapy (SBRT) has been widely adopted as an alternative to lobar resection in medically inoperable patients with lymph-node negative (N0) early-stage (ES) non-small cell lung cancer (NSCLC). Excellent in-field local control ... ...

    Abstract Stereotactic body radiation therapy (SBRT) has been widely adopted as an alternative to lobar resection in medically inoperable patients with lymph-node negative (N0) early-stage (ES) non-small cell lung cancer (NSCLC). Excellent in-field local control has been consistently achieved with SBRT in ES NSCLC ≤ 3 cm in size. However, the out-of-field control following SBRT remains suboptimal. The rate of recurrence, especially distant recurrence remains high for larger tumors. Additional systemic therapy is warranted in N0 ES NSCLC that is larger in size. Radiation has been shown to have immunomodulatory effects on cancer, which is most prominent with higher fractional doses. Strong synergistic effects are observed when immune checkpoint inhibitors (ICIs) are combined with radiation doses in SBRT's dose range. Unlike chemotherapy, ICIs can potentiate a strong systemic response outside of the irradiated field when combined with SBRT. Together with their less toxic nature, ICIs represent a very suitable class of systemic agents to be combined with SBRT when treating ES NSCLC with high-risk features, such as larger tumor size. In this review, we describe the rationale and emerging evidence, as well as ongoing investigations in this area.
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14133144
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  4. Article ; Online: Current Advancements and Future Perspectives of Immunotherapy in Breast Cancer Treatment

    Maria Vasileiou / Savvas Papageorgiou / Nam P. Nguyen

    Immuno, Vol 3, Iss 13, Pp 195-

    2023  Volume 216

    Abstract: Breast cancer is the most commonly diagnosed cancer in women and is a leading cause of cancer death in women worldwide. Despite the available treatment options, such as surgery, chemotherapy, radiotherapy, endocrine therapy and molecular targeted therapy, ...

    Abstract Breast cancer is the most commonly diagnosed cancer in women and is a leading cause of cancer death in women worldwide. Despite the available treatment options, such as surgery, chemotherapy, radiotherapy, endocrine therapy and molecular targeted therapy, breast cancer treatment remains a challenge. The advent of immunotherapy has revolutionized the treatment of breast cancer as it utilizes the host’s immune system to directly target tumor cells. In this literature review, we aim to summarize the recent advancements made in using immunotherapy for treating breast cancer patients. We discuss the different types of existing immunotherapies for breast cancer, including targeted therapy using monoclonal antibodies against breast cancer specific antigens and the use of immune checkpoint inhibitors to elicit an immune response against cancer cells. Finally, we consider the development of breast cancer vaccines that train the immune system to specifically recognize cancer cells and the future perspectives of immunotherapy for breast cancer.
    Keywords breast cancer ; immunotherapy ; monoclonal antibodies ; immune checkpoint inhibitors ; vaccines ; cytokines ; Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Effects of farrowing induction using cloprostenol on sow farrowing characteristics.

    Nam, Nguyen Hoai / Dao, Bui Tran Anh / Sukon, Peerapol

    Veterinary world

    2022  Volume 15, Issue 6, Page(s) 1535–1540

    Abstract: ... induction led to an increase in birth interval, dystocia rate, dystocia per farrow (p < 0.05) and ... in addition to the percentage of sows that farrowed on the day following induction (60% vs. 27.8%; p < 0.05 ...

    Abstract Background and aim: Previous findings regarding the effects of farrowing induction on the farrowing characteristics of sows are controversial. This study aimed to investigate the effects of farrowing induction on the following characteristics: (1) Proportion of sows that farrowed during working hours, (2) stillbirth rate, (3) number of stillbirths per farrow, (4) dystocia rate per farrow, (5) dystocia rate (the proportion of farrowings that had at least one dystocia event), (6) number of dystocia events per farrow, (6) farrowing duration, (7) birth interval, and (8) birth weight.
    Materials and methods: Thirty-eight Landrace x Yorkshire sows were randomly allocated into two groups; the control group and the treatment group. In the control group (n = 18), sows farrowed spontaneously. In the treatment group (n = 20), farrowing was induced approximately 2 days earlier than the herd's average length of gestation (7:00 am on day 114) by injecting cloprostenol into the perivulval region. All sows were supervised throughout their farrowing. We recorded the interval between induction and farrowing; total number of births; number of live, stillborn, and mummified piglet births; number of dystocia events; birth interval; farrowing duration; and birth weight. A generalized linear mixed model, a linear mixed-effects model, the Chi-squared test, and Student's t-test were used to compare outcomes between the two groups.
    Results: Farrowing induction did not influence the percentage of sows that farrowed during working hours (7 am-5 pm), stillbirth rate, birth weight, and number of dystocia events per farrow. Farrowing induction led to an increase in birth interval, dystocia rate, dystocia per farrow (p < 0.05) and in addition to the percentage of sows that farrowed on the day following induction (60% vs. 27.8%; p < 0.05).
    Conclusion: Farrowing induction using a single dose of cloprostenol 2 days before the expected farrowing date can be performed with care to concentrate farrowing into a short interval. This can enhance the optimization of cross-fostering and the practice of an all-in-all-out strategy in the swine breeding industry.
    Language English
    Publishing date 2022-06-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2456277-4
    ISSN 2231-0916 ; 0972-8988
    ISSN (online) 2231-0916
    ISSN 0972-8988
    DOI 10.14202/vetworld.2022.1535-1540
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  6. Article ; Online: Nitrogen and carbon removal from anaerobic digester effluents with low carbon to nitrogen ratios under feammox conditions.

    Nguyen, Hai T / Nguyen, Luu D / Le, Chung P / Hoang, Nam D / Dinh, Hang T

    Bioresource technology

    2023  Volume 371, Page(s) 128585

    Abstract: Removal of nitrogen and carbon from anaerobic digester (AD) effluents is challenging for currently available technologies. Herein, effective treatment for real AD effluents was achieved via the feammox process by using a Multistage Feammox Bioreactor ( ... ...

    Abstract Removal of nitrogen and carbon from anaerobic digester (AD) effluents is challenging for currently available technologies. Herein, effective treatment for real AD effluents was achieved via the feammox process by using a Multistage Feammox Bioreactor (MSFB). The reactor achieved the best performance with AD effluent of a low carbon to nitrogen (C/N) ratio of 2.5. A 6-day retention time reached removal efficiencies for NH
    MeSH term(s) Nitrogen ; Anaerobiosis ; Oxidation-Reduction ; Nitrogen Cycle ; Bioreactors/microbiology ; Iron ; Ammonium Compounds ; Carbon
    Chemical Substances Nitrogen (N762921K75) ; Iron (E1UOL152H7) ; Ammonium Compounds ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2023.128585
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    In stock of ZB MED Bonn / Germany

    Z 3258: Show issues

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  7. Article ; Online: Retraction: New synthesis of 2-aroylbenzothiazoles

    Huynh, Tien V / Doan, Khang V / Luong, Ngoc T K / Nguyen, Duyen T P / Doan, Son H / Nguyen, Tung T / Phan, Nam T S

    RSC advances

    2023  Volume 13, Issue 14, Page(s) 9502

    Abstract: This retracts the article DOI: 10.1039/D0RA01750G.]. ...

    Abstract [This retracts the article DOI: 10.1039/D0RA01750G.].
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Retraction of Publication
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra90023a
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  8. Article ; Online: Sensitive MnFe

    Nha, T T N / Nam, P H / Phuc, N X / Nguyen, V Q / Nam, N H / Manh, D H / Tam, L T / Linh, N T N / Khanh, B T V / Lu, L T / Nguyen, L H / Phong, P T

    RSC advances

    2021  Volume 11, Issue 48, Page(s) 30054–30068

    Abstract: In this study, we present an experiment showing that designing multifunctional ... ...

    Abstract In this study, we present an experiment showing that designing multifunctional MnFe
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra03216j
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  9. Article ; Online: Correction: Sensitive MnFe

    Nha, T T N / Nam, P H / Phuc, N X / Nguyen, V Q / Nam, N H / Manh, D H / Tam, L T / Linh, N T N / Khanh, B T V / Lu, L T / Nguyen, L H / Phong, P T

    RSC advances

    2021  Volume 11, Issue 53, Page(s) 33372

    Abstract: This corrects the article DOI: 10.1039/D1RA03216J.]. ...

    Abstract [This corrects the article DOI: 10.1039/D1RA03216J.].
    Language English
    Publishing date 2021-10-12
    Publishing country England
    Document type Published Erratum
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra90155a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Metallic Metastable Hybrid 1T'/1T Phase Triggered Co,PSnS

    Singh, Manjinder / Nguyen, Thanh Tuan / P, Muthu Austeria / Ngo, Quynh Phuong / Kim, Do Hwan / Kim, Nam Hoon / Lee, Joong Hee

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 11, Page(s) e2206726

    Abstract: ... metastable hybrid-phase induced 1T'/1T Co,PSnS ...

    Abstract The development of trifunctional electrocatalyst for oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER) with deeply understanding the mechanism to enhance the electrochemical performance is still a challenging task. In this work, the distorted metastable hybrid-phase induced 1T'/1T Co,PSnS
    Language English
    Publishing date 2023-01-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202206726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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