Article ; Online: C
ACS omega
2023 Volume 8, Issue 23, Page(s) 20513–20523
Abstract: ... of vitamin C as an inhibitor of Rel protein activities raises the prospect of tetrone lactones to prevent ...
Abstract | Hyperphosphorylated nucleotide (p)ppGpp, synthesized by Rel protein, regulates the stringent response pathway responsible for biofilm and persister cell growth in mycobacteria. The discovery of vitamin C as an inhibitor of Rel protein activities raises the prospect of tetrone lactones to prevent such pathways. The closely related isotetrone lactone derivatives are identified herein as inhibitors of the above processes in a mycobacterium. Synthesis and biochemical evaluations show that an isotetrone possessing phenyl substituent at |
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Language | English |
Publishing date | 2023-05-31 |
Publishing country | United States |
Document type | Journal Article |
ISSN | 2470-1343 |
ISSN (online) | 2470-1343 |
DOI | 10.1021/acsomega.3c00822 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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