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  1. Article: Enhancers associated with unstable RNAs are rare in plants.

    Mcdonald, Bayley R / Picard, Colette / Brabb, Ian M / Savenkova, Marina I / Schmitz, Robert J / Jacobsen, Steven E / Duttke, Sascha H

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Unstable transcripts have emerged as markers of active enhancers in vertebrates and shown to be involved in many cellular processes and medical disorders. However, their prevalence and role in plants is largely unexplored. Here, we comprehensively ... ...

    Abstract Unstable transcripts have emerged as markers of active enhancers in vertebrates and shown to be involved in many cellular processes and medical disorders. However, their prevalence and role in plants is largely unexplored. Here, we comprehensively captured all actively initiating ("nascent") transcripts across diverse crops and other plants using capped small (cs)RNA-seq. We discovered that unstable transcripts are rare, unlike in vertebrates, and often originate from promoters. Additionally, many "distal" elements in plants initiate tissue-specific stable transcripts and are likely
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.25.559415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prostate cancer in black men: Is it time for personalized screening approaches?

    Wallner, Lauren P / Jacobsen, Steven J

    Cancer

    2017  Volume 123, Issue 12, Page(s) 2203–2205

    MeSH term(s) African Americans ; African Continental Ancestry Group ; Early Detection of Cancer ; European Continental Ancestry Group ; Humans ; Male ; Mass Screening ; Prostate-Specific Antigen ; Prostatic Neoplasms
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2017-04-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.30685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rates of Biopsy-Proven Pediatric Glomerulopathies in a Large Health System, 2000-2014.

    Sim, John J / Shu, Yu-Hsiang / Hever, Aviv / O'Shaughnessy, Michelle M / Jacobsen, Steven J

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2021  Volume 79, Issue 3, Page(s) 453–455

    MeSH term(s) Biopsy ; Child ; Glomerulonephritis/epidemiology ; Humans ; Kidney Diseases
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2021.06.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Final results and overall survival data from a phase II study of acalabrutinib monotherapy in patients with relapsed/refractory mantle cell lymphoma, including those with poor prognostic factors.

    Le Gouill, Steven / Długosz-Danecka, Monika / Rule, Simon / Zinzani, Pier Luigi / Goy, Andre / Smith, Stephen D / Doorduijn, Jeanette K / Panizo, Carlos / Shah, Bijal D / Davies, Andrew J / Eek, Richard / Jacobsen, Eric / Kater, Arnon P / Robak, Tadeusz / Jain, Preetesh / Calvo, Roser / Tao, Lin / Wang, Michael

    Haematologica

    2024  Volume 109, Issue 1, Page(s) 343–350

    MeSH term(s) Adult ; Humans ; Lymphoma, Mantle-Cell/drug therapy ; Lymphoma, Mantle-Cell/pathology ; Prognosis ; Pyrazines/therapeutic use ; Clinical Trials, Phase II as Topic
    Chemical Substances acalabrutinib (I42748ELQW) ; Pyrazines
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.282469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Comparison of Death Records Between the United States Renal Data System and a Large Integrated Health Care System.

    Shaw, Sally F / Sim, John J / Zhou, Hui / Shi, Jiaxiao / Jacobsen, Steven J

    Kidney international reports

    2020  Volume 5, Issue 6, Page(s) 912–915

    Language English
    Publishing date 2020-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Secular trends in the incidence and prevalence of rheumatoid arthritis within members of an integrated health care delivery system.

    Kawatkar, Aniket A / Gabriel, Sherine E / Jacobsen, Steven J

    Rheumatology international

    2019  Volume 39, Issue 3, Page(s) 541–549

    Abstract: The study objective was to estimate secular trends in the overall incidence rate (IR) and prevalence rate (PR) of rheumatoid arthritis (RA); and subgroup-specific IR and PR by race, ethnicity, and sex in a multi-ethnic population of a large integrated ... ...

    Abstract The study objective was to estimate secular trends in the overall incidence rate (IR) and prevalence rate (PR) of rheumatoid arthritis (RA); and subgroup-specific IR and PR by race, ethnicity, and sex in a multi-ethnic population of a large integrated health care delivery system. An ecological study was conducted within the adult population of Kaiser Permanente Southern California health plan. From January 1995 up to and including December 2014, annual IR and PR were calculated separately by race, ethnicity, sex and pooled overall. Depending on the stationarity of each ecological series, annual percentage change in IR and PR was evaluated using auto-regressive integrated moving average models. Average overall IR was 53 [95% confidence interval (CI) 46, 61] per 100,000 person-years. The overall as well as subgroup-specific annual IR of RA were unchanged from 1995 to 2014. In 1995, the overall PR of RA was 59 (44, 74) per 100,000 person-years which increased by 14% (7%, 21%) annually thereafter. The increase in PR in Caucasians was lower as compared to African American, Asian and other race (13% vs 15%, 15%, and 18%, respectively). Compared to non-Hispanic ethnicity, the increase in PR among Hispanic was higher (17% vs 14%). Over the past 2 decades, while the incidence of RA was unchanged, the prevalence had increased significantly overall as well as within every subgroup of race, ethnicity, and sex.
    MeSH term(s) Adult ; African Americans ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/ethnology ; Asian Americans ; Delivery of Health Care, Integrated ; European Continental Ancestry Group ; Female ; Hispanic Americans ; Humans ; Incidence ; Male ; Middle Aged ; Prevalence
    Language English
    Publishing date 2019-01-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-018-04235-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Physician Compliance to Choosing Wisely® Initiative in Radiographic Imaging of Low Risk Prostate Cancer in an Integrated Health Care System.

    Artenstein, Daniel / Kern, Tyler / Chen, Michael C / Chung, Joanie J / Jacobsen, Steven J / Chien, Gary W

    Urology practice

    2021  Volume 8, Issue 3, Page(s) 355–359

    Abstract: Introduction: We evaluated the adherence of urologists within an integrated health care system to Choosing Wisely®, an initiative aimed at avoiding unnecessary medical tests. In urology, 2 of the guidelines state bone scans and pelvic computerized ... ...

    Abstract Introduction: We evaluated the adherence of urologists within an integrated health care system to Choosing Wisely®, an initiative aimed at avoiding unnecessary medical tests. In urology, 2 of the guidelines state bone scans and pelvic computerized tomography scans are unnecessary in low risk prostate cancer.
    Methods: We performed a retrospective study on patients diagnosed with low risk prostate cancer between January 1, 2010 and December 31, 2017 at Kaiser Permanente Southern California. All demographics and imaging data were obtained. Patients with symptoms concerning for metastatic disease or with other malignancies were excluded by chart review. Statistical analysis was employed to compare the use of bone scans and computerized tomography scans in this population before and after the Choosing Wisely guidelines were published.
    Results: Of the 6,996 patients, 121 (1.7%) and 96 (1.4%) underwent a bone scan and computerized tomography scan, respectively. A Cochran-Armitage test showed no change after implementation of the statements. Logistic regression analysis revealed that for every point increase in prostate specific antigen, the odds ratio was 1.09 for ordering both a bone scan and computerized tomography scan. When compared to Whites, the odds ratio of having a bone scan and computerized tomography scan were 0.35 and 0.37 for Blacks, 0.30 and 0.38 for Hispanics, and 0.47 and 0.61 for Asians, respectively.
    Conclusions: Over the study period, there were low rates of inappropriate imaging for low risk prostate cancer. There was no change in trend after publication of the Choosing Wisely. Higher prostate specific antigen levels and White ethnicity were predictors for ordering inappropriate imaging.
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2352-0787
    ISSN (online) 2352-0787
    DOI 10.1097/UPJ.0000000000000219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Causes of Death in End-Stage Kidney Disease: Comparison between the United States Renal Data System and a Large Integrated Health Care System.

    Bhandari, Simran K / Zhou, Hui / Shaw, Sally F / Shi, Jiaxiao / Tilluckdharry, Natasha S / Rhee, Connie M / Jacobsen, Steven J / Sim, John J

    American journal of nephrology

    2022  Volume 53, Issue 1, Page(s) 32–40

    Abstract: Introduction: Using a large diverse population of incident end-stage kidney disease (ESKD) patients from an integrated health system, we sought to evaluate the concordance of causes of death (CODs) between the underlying COD from the United States Renal ...

    Abstract Introduction: Using a large diverse population of incident end-stage kidney disease (ESKD) patients from an integrated health system, we sought to evaluate the concordance of causes of death (CODs) between the underlying COD from the United States Renal Data System (USRDS) registry and CODs obtained from Kaiser Permanente Southern California (KPSC).
    Methods: A retrospective cohort study was performed among incident ESKD patients who had mortality records and CODs reported in both KPSC and USRDS databases between January 1, 2007, and December 31, 2016. Underlying CODs reported by the KPSC were compared to the CODs reported by USRDS. Overall and subcategory-specific COD agreements were assessed using Cohen's weighted kappa statistic (95% CI). Proportions of positive and negative agreement were also determined.
    Results: Among 4,188 ESKD patient deaths, 4,118 patients had CODs recorded in both KPSC and USRDS. The most common KPSC CODs were circulatory system diseases (35.7%), endocrine/nutritional/metabolic diseases (24.2%), genitourinary diseases (12.9%), and neoplasms (9.6%). Most common USRDS CODs were cardiac disease (46.9%), withdrawal from dialysis (12.6%), and infection (10.1%). Of 2,593 records with causes listed NOT as "Other," 453 (17.4%) had no agreement in CODs between the USRDS and the underlying, secondary, tertiary, or quaternary causes recorded by KPSC. In comparing CODs recorded within KPSC to the USRDS, Cohen's weighted kappa (95% CI) was 0.20 (0.18-0.22) with overall agreement of 36.4%.
    Conclusion: Among an incident ESKD population with mortality records, we found that there was only fair or slight agreement between CODs reported between the USRDS registry and KPSC, a large integrated health care system.
    MeSH term(s) Cause of Death ; Delivery of Health Care, Integrated ; Female ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Male ; Renal Dialysis ; Retrospective Studies ; United States/epidemiology
    Language English
    Publishing date 2022-01-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000520466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure.

    Yan, Chunsheng / Han, Wenyu / Zhou, Qingyang / Niwa, Kanji / Tang, Melody J / Burch, Jessica E / Zhang, Yalong / Delgadillo, David A / Sun, Zuodong / Wu, Zhongshou / Jacobsen, Steven E / Nelson, Hosea / Houk, K N / Tang, Yi

    Journal of the American Chemical Society

    2023  Volume 145, Issue 46, Page(s) 25080–25085

    Abstract: Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome mining identified the associated metabolite to be treconorin, which has a terpene- ... ...

    Abstract Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome mining identified the associated metabolite to be treconorin, which has a terpene-like,
    MeSH term(s) Terpenes ; Polyketides ; Multigene Family ; Fungi/genetics
    Chemical Substances Terpenes ; Polyketides
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c10179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: CRISPR-Cas-mediated transcriptional control and epi-mutagenesis.

    Gardiner, Jason / Ghoshal, Basudev / Wang, Ming / Jacobsen, Steven E

    Plant physiology

    2022  Volume 188, Issue 4, Page(s) 1811–1824

    Abstract: Tools for sequence-specific DNA binding have opened the door to new approaches in investigating fundamental questions in biology and crop development. While there are several platforms to choose from, many of the recent advances in sequence-specific ... ...

    Abstract Tools for sequence-specific DNA binding have opened the door to new approaches in investigating fundamental questions in biology and crop development. While there are several platforms to choose from, many of the recent advances in sequence-specific targeting tools are focused on developing Clustered Regularly Interspaced Short Palindromic Repeats- CRISPR Associated (CRISPR-Cas)-based systems. Using a catalytically inactive Cas protein (dCas), this system can act as a vector for different modular catalytic domains (effector domains) to control a gene's expression or alter epigenetic marks such as DNA methylation. Recent trends in developing CRISPR-dCas systems include creating versions that can target multiple copies of effector domains to a single site, targeting epigenetic changes that, in some cases, can be inherited to the next generation in the absence of the targeting construct, and combining effector domains and targeting strategies to create synergies that increase the functionality or efficiency of the system. This review summarizes and compares DNA targeting technologies, the effector domains used to target transcriptional control and epi-mutagenesis, and the different CRISPR-dCas systems used in plants.
    MeSH term(s) CRISPR-Cas Systems/genetics ; Mutagenesis
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiac033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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