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Article ; Online: Surgical considerations in the management of short bowel syndrome

Mercer, David F.

Nutrition in Clinical Practice. 2023 May, v. 38 Suppl S1 p.S88-S97

2023

Abstract: Patients with short bowel syndrome (SBS) are optimally managed in centers of expertise with dedicated multidisciplinary intestinal failure (IF) teams. Over the life of a patient with SBS, many different surgical concerns may arise requiring intervention. ...

Abstract	Patients with short bowel syndrome (SBS) are optimally managed in centers of expertise with dedicated multidisciplinary intestinal failure (IF) teams. Over the life of a patient with SBS, many different surgical concerns may arise requiring intervention. These can range from reasonably simple procedures, such as the creation or maintenance of gastrostomy tube and enterostomies, to complex reconstructions of multiple enterocutaneous fistulas or the performance of intestine‐containing transplants. This review will cover the development of a surgeon's role on the IF team; common surgical issues arising in patients with SBS, with a focus on decision‐making rather than technique; and, finally, a brief overview of transplantation and some related decision‐making issues.
Keywords	decision making ; digestive system diseases ; enterostomy ; intestines ; nutrition ; patients
Language	English
Dates of publication	2023-05
Size	p. S88-S97.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	645074-x
ISSN	1941-2452 ; 0884-5336
ISSN (online)	1941-2452
ISSN	0884-5336
DOI	10.1002/ncp.10988
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Editor's Choice - Antithrombotics in Atherosclerotic Renal and Mesenteric Arterial Disease: A Systematic Review.

Ahmed, Haroon / Mercer, Ross T / Wong, Kitty H F / Hinchliffe, Robert J / Twine, Christopher P

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2023 Volume 66, Issue 1, Page(s) 138–139

Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Letter
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2023.04.024
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Outcomes of Autologous Osteochondral Transplantation With and Without Extracellular Matrix Cartilage Allograft Augmentation for Osteochondral Lesions of the Talus.

Mercer, Nathaniel P / Samsonov, Alan P / Dankert, John F / Kennedy, John G

The American journal of sports medicine

2021 Volume 50, Issue 1, Page(s) 162–169

Abstract: Background: Autologous osteochondral transplantation (AOT) using a cylindrical graft in the treatment of osteochondral lesions of the talus (OLTs) is typically indicated for patients with larger lesions. However, with lesions that are irregular in shape, ...

Abstract	Background: Autologous osteochondral transplantation (AOT) using a cylindrical graft in the treatment of osteochondral lesions of the talus (OLTs) is typically indicated for patients with larger lesions. However, with lesions that are irregular in shape, the AOT graft may not completely replace the lesion. For these lesions, we utilize extracellular matrix cartilage allograft (EMCA) augmentation in AOT to act as a physiologic grout at the host-graft interface. Purpose: To determine if the combination of EMCA with concentrated bone marrow aspirate (CBMA) would improve integration of the host-graft interface and subsequently reduce postoperative cyst formation after AOT. It was also hypothesized that EMCA in conjunction with CBMA would demonstrate improved MOCART (magnetic resonance observation of cartilage repair tissue) scores and functional outcome scores at a minimum 2 years after surgery. Study design: Cohort study; Level of evidence, 3. Methods: A retrospective analysis was performed comparing patients treated with AOT/CBMA alone and AOT with CBMA/EMCA. Clinical outcomes were evaluated with the Foot and Ankle Outcome Score. Magnetic resonance imaging appearance was evaluated with the use of the MOCART (magnetic resonance observation of cartilage repair tissue) score. Cyst formation was also evaluated on postoperative magnetic resonance imaging. Results: A total of 26 patients were included in the AOT + CBMA/EMCA group (10 male, 16 female), and 34 patients were included in the AOT/CBMA group (17 male, 17 female). The mean Foot and Ankle Outcome Score significantly improved in both groups ( Conclusion: We found that while EMCA with CBMA has benefit in regeneration and repair of OLT treated with bone marrow stimulation, there appears to be little benefit of EMCA over CBMA alone as a physiologic grout at the graft-host interface in OLT treated with AOT.
MeSH term(s)	Activities of Daily Living ; Allografts ; Bone Transplantation ; Cartilage ; Cartilage, Articular/surgery ; Cohort Studies ; Extracellular Matrix ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Quality of Life ; Retrospective Studies ; Talus/surgery ; Transplantation, Autologous ; Treatment Outcome
Language	English
Publishing date	2021-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197482-8
ISSN	1552-3365 ; 0363-5465
ISSN (online)	1552-3365
ISSN	0363-5465
DOI	10.1177/03635465211057117
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Article ; Online: Change-of-Direction and Deceleration Deficits in National-Team Female Rugby Sevens Players: Interrelationships and Associations With Speed-Related Performance.

Freitas, Tomás T / Pereira, Lucas A / Zabaloy, Santiago / Alcaraz, Pedro E / Arruda, Ademir F S / Mercer, Valter P / Bishop, Chris / Loturco, Irineu

International journal of sports physiology and performance

2023 Volume 18, Issue 9, Page(s) 1079–1084

Abstract: ... 505 COD velocities were not significantly associated (P > .05). Large to very large significant ... associations (r values ranging from .54 to .78; P < .05) were detected between linear sprint velocity ... significant correlation with CODD and DD (r = -.77 and -.79 respectively; P < .05). A large and significant ...

Abstract	Purpose: To investigate the relationships between a series of direct and indirect measures of linear and multidirectional speed performance in elite female rugby sevens players. Methods: Nineteen players from the Brazilian national team performed 40-m linear sprint and 505 change-of-direction (COD) tests on the same day. Based on the linear sprint and COD test performances, the COD deficit (CODD) and deceleration deficit (DD) were also obtained. A Pearson product-moment correlation analysis was used to determine the relationships between linear sprint and COD-derived variables. Results: Linear sprint and 505 COD velocities were not significantly associated (P > .05). Large to very large significant associations (r values ranging from .54 to .78; P < .05) were detected between linear sprint velocity for the different distances tested (10, 15, 30, and 40 m) and CODD. The COD velocity presented a very large inverse significant correlation with CODD and DD (r = -.77 and -.79 respectively; P < .05). A large and significant correlation was identified between CODD and DD (r = .79; P < .05). Conclusions: Significant associations were observed between linear sprint and CODD, suggesting that faster players are less efficient at changing direction. No relationship was found between sprint velocity and DD, highlighting the independent nature of linear sprints and deceleration capabilities. A comprehensive and detailed analysis of multidirectional speed performance should consider not only linear sprint and COD performances but also complementary COD-derived variables such as the CODD and DD.
MeSH term(s)	Humans ; Female ; Athletic Performance ; Rugby ; Deceleration ; Running ; Brazil
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2023-0150
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Article ; Online: Inducing Energetic Switching Using Klotho Improves Vascular Smooth Muscle Cell Phenotype.

Docherty, Craig K / Strembitska, Anastasiya / Baker, Christa P / Schmidt, Fiona F / Reay, Kieran / Mercer, John R

International journal of molecular sciences

2021 Volume 23, Issue 1

Abstract: The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM), and ...

Abstract	The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM), and defects in mitochondrial oxidative metabolism as significant observations. The antiageing protein Klotho could prolong VSMC survival in the atherosclerotic plaque and delay the consequences of plaque rupture by improving VSMC phenotype to delay heart attacks and stroke. Comparing wild-type VSMCs from an ApoE model of atherosclerosis with a flox'd Pink1 knockout of inducible mitochondrial dysfunction we show WT Pink1 is essential for normal cell viability, while Klotho mediates energetic switching which may preserve cell survival. Methods: Wild-type ApoE VSMCs were screened to identify potential drug candidates that could improve longevity without inducing cytotoxicity. The central regulator of cell metabolism AMP Kinase was used as a readout of energy homeostasis. Functional energetic switching between oxidative and glycolytic metabolism was assessed using XF24 technology. Live cell imaging was then used as a functional readout for the WT drug response, compared with Pink1 (phosphatase-and-tensin-homolog (PTEN)-induced kinase-1) knockout cells. Results: Candidate drugs were assessed to induce pACC, pAMPK, and pLKB1 before selecting Klotho for its improved ability to perform energetic switching. Klotho mediated an inverse dose-dependent effect and was able to switch between oxidative and glycolytic metabolism. Klotho mediated improved glycolytic energetics in wild-type cells which were not present in Pink1 knockout cells that model mitochondrial dysfunction. Klotho improved WT cell survival and migration, increasing proliferation and decreasing necrosis independent of effects on apoptosis. Conclusions: Klotho plays an important role in VSMC energetics which requires Pink1 to mediate energetic switching between oxidative and glycolytic metabolism. Klotho improved VSMC phenotype and, if targeted to the plaque early in the disease, could be a useful strategy to delay the effects of plaque ageing and improve VSMC survival.
MeSH term(s)	Animals ; Apolipoproteins E/metabolism ; Apoptosis/physiology ; Atherosclerosis/metabolism ; Cell Proliferation/physiology ; Cell Survival/physiology ; Cells, Cultured ; Glycolysis/physiology ; Klotho Proteins/metabolism ; Mice ; Mitochondria/metabolism ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Oxidative Stress/physiology ; Phenotype ; Plaque, Atherosclerotic/metabolism ; Protein Kinases/metabolism
Chemical Substances	Apolipoproteins E ; Protein Kinases (EC 2.7.-) ; Klotho Proteins (EC 3.2.1.31)
Language	English
Publishing date	2021-12-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23010217
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Article ; Online: Ongoing military evolution of Trauma Life Support.

Mercer, S J / Mahoney, P F

Anaesthesia

2015 Volume 70, Issue 11, Page(s) 1332–1333

MeSH term(s)	Advanced Trauma Life Support Care/methods ; Humans ; Practice Guidelines as Topic
Language	English
Publishing date	2015-11
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	80033-8
ISSN	1365-2044 ; 0003-2409
ISSN (online)	1365-2044
ISSN	0003-2409
DOI	10.1111/anae.13243
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Article ; Online: Variations in Physical and Competitive Performance of Highly Trained Sprinters Across an Annual Training Season.

Loturco, Irineu / Fernandes, Victor / Bishop, Chris / Mercer, Valter P / Siqueira, Felipe / Nakaya, Katsuhico / Pereira, Lucas A / Haugen, Thomas

Journal of strength and conditioning research

2022 Volume 37, Issue 5, Page(s) 1104–1110

Abstract: Abstract: Loturco, I, Fernandes, V, Bishop, C, Mercer, VP, Siqueira, F, Nakaya, K, Pereira, LA ...

Abstract	Abstract: Loturco, I, Fernandes, V, Bishop, C, Mercer, VP, Siqueira, F, Nakaya, K, Pereira, LA, and Haugen, T. Variations in physical and competitive performance of highly trained sprinters across an annual training season. J Strength Cond Res 37(5): 1104-1110, 2023-We assessed the changes in sprint, jump, and power parameters across the annual training cycle and tested the longitudinal correlations among these variables in top-level sprinters. Thirteen sprinters training with 4 different Olympic sprint coaches were sequentially assessed over 14 months, from January 2019 to March 2020, within 4 consecutive training camps. Performance tests were conducted as follows: standing long jump, squat and countermovement jumps, 10-m and 60-m sprint time, and maximum power output in the half-squat, jump-squat, and hip-thrust exercises. The competitive results of the sprinters throughout the study period were also recorded and analyzed. A repeated measures analysis of variance was used to compare the physical measurements between different testing sessions. A Pearson product-moment correlation was applied to examine the longitudinal relationships between changes in speed-related and power-related parameters. Percentage change was computed and compared with coefficient of variation values to determine whether changes in performance metrics were higher than the test variance, thus providing an indication of whether true changes occurred on an individual basis. Overall, sprinters did not exhibit significant changes in sprint speed, jumping ability, and power output. In addition, variations in competitive times (i.e., 100 m races) followed a similar pattern, within an average range of ±1.36%, for both male and female sprinters. As expected, top-level sprinters presented only small variations in physical and competitive performance over time. Nevertheless, the use of an individual statistical technique (i.e., true changes calculation) revealed that these nonsignificant increases or decreases may represent meaningful changes in their competitive potential.
MeSH term(s)	Humans ; Male ; Female ; Running ; Athletic Performance ; Exercise Test ; Seasons ; Muscle Strength
Language	English
Publishing date	2022-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0000000000004380
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Article: Transcriptomics of a Greenlandic Snailfish Reveals Exceptionally High Expression of Antifreeze Protein Transcripts.

Burns, John A / Gruber, David F / Gaffney, Jean P / Sparks, John S / Brugler, Mercer R

Evolutionary bioinformatics online

2022 Volume 18, Page(s) 11769343221118347

Abstract: Polar fishes have evolved antifreeze proteins (AFPs) that allow them to survive in subzero temperatures. We performed deep transcriptomic sequencing on a postlarval/juvenile variegated snailfish, ...

Abstract	Polar fishes have evolved antifreeze proteins (AFPs) that allow them to survive in subzero temperatures. We performed deep transcriptomic sequencing on a postlarval/juvenile variegated snailfish,
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2227610-5
ISSN	1176-9343
ISSN	1176-9343
DOI	10.1177/11769343221118347
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Article ; Online: Variations in Power Performance and Perceptual Responses to Training in Olympic Boxers Over a 7-Month Training Period.

Pereira, Lucas A / Romano, Felipe / Alves, Mateus / Mercer, Valter P / Bishop, Chris / Franchini, Emerson / Loturco, Irineu

International journal of sports physiology and performance

2023 Volume 18, Issue 4, Page(s) 414–419

Abstract: ... No significant differences (P > .05) were observed between Olympic and non-Olympic groups ... significant changes (P > .05) were detected throughout the study for countermovement jump height and bench ...

Abstract	Purpose: To assess the variations in power performance and perceptual training responses and compare the physical performance of national boxing athletes qualified or not qualified for the Tokyo Olympic Games over a 7-month training period. Methods: Twelve amateur boxers from the Brazilian national team were tested 6 times across 7 months. In the first assessment, boxers performed squat and countermovement jumps and bench press, prone bench pull, half squat, and jump squat power tests. In the following testing sessions, only countermovement jump and bench press power were assessed. In addition, the rating of perceived exertion and total quality recovery status were assessed in 106 training sessions across the study. Independent t test and repeated-measures analysis of variance were used for data analysis purposes. Results: No significant differences (P > .05) were observed between Olympic and non-Olympic groups for any test variables (effect size [95% CI] ranging from 0.01 [-1.13 to 1.13] to 0.69 [-0.53 to 1.79]). No significant changes (P > .05) were detected throughout the study for countermovement jump height and bench press power in either group (effect size [95% CI] ranging from 0.01 [-1.13 to 1.13] to 1.03 [-0.25 to 2.14]). Overall, both groups exhibited similar variations in both rating of perceived exertion and total quality recovery over the 7-month period. Conclusions: Within the same national team, power-related performance was similar between Olympic and non-Olympic boxers. The maintenance of power abilities and optimization of technical and tactical skills seem to be key issues to consider during the final stages of preparation for international boxing competitions.
MeSH term(s)	Humans ; Athletic Performance/physiology ; Athletes ; Boxing/physiology ; Posture ; Brazil ; Muscle Strength/physiology
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2022-0229
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Article: Resistance Training Practices of Brazilian Olympic Sprint and Jump Coaches: Toward a Deeper Understanding of Their Choices and Insights (Part III).

Loturco, Irineu / Zabaloy, Santiago / Pereira, Lucas A / Moura, Túlio B M A / Mercer, Valter P / Victor, Fernandes / Zając, Adam / Matusinski, Aleksander / Freitas, Tomás T / Bishop, Chris

Journal of human kinetics

2024 Volume 90, Page(s) 183–214

Abstract: In the final part of this three-article collection on the training strategies of Brazilian Olympic sprint and jump coaches, we provide a detailed description of the resistance training methods and exercises most commonly employed by these speed experts. ... ...

Abstract	In the final part of this three-article collection on the training strategies of Brazilian Olympic sprint and jump coaches, we provide a detailed description of the resistance training methods and exercises most commonly employed by these speed experts. Always with the objective of maximizing the sprint and jump capabilities of their athletes, these experienced coaches primarily utilize variable, eccentric, concentric, machine-based, isometric, complex, and isoinertial resistance training methods in their daily practices. Squats (in their different forms), Olympic weightlifting, ballistics, hip thrusts, lunges, calf raises, core exercises, leg curls, stiff-leg deadlifts, and leg extension are the most commonly prescribed exercises in their training programs, during both the preparatory and competitive periods. Therefore, the current manuscript comprehensively describes and examines these methods, with the additional aim of extrapolating their application to other sports, especially those where sprint speed is a key performance factor.
Language	English
Publishing date	2024-02-02
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2503989-1
ISSN	1899-7562 ; 1640-5544
ISSN (online)	1899-7562
ISSN	1640-5544
DOI	10.5114/jhk/182888
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