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  1. Book ; Online: The Fungal Cell Wall

    Almeida, Fausto / Nosanchuk, Joshua D. / Alexis Niño-Vega, Gustavo / Alexis Niño-Vega, Gustavo

    2020  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; cell wall ; fungi ; pathogenic fungi ; pathogenic fungal disease ; non-pathogenic fungi ; fungal structure ; fungal metabolism
    Size 1 electronic resource (167 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231586
    ISBN 9782889661329 ; 2889661326
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Developing artificial intelligence technology for pediatric pulmonology: Lessons from COVID-19.

    Nino, Gustavo / Linguraru, Marius G

    Pediatric pulmonology

    2022  Volume 57, Issue 7, Page(s) 1588–1589

    MeSH term(s) Artificial Intelligence ; COVID-19 ; Child ; Humans ; Pulmonary Medicine ; SARS-CoV-2 ; Technology
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Letter
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Human neonatal and infant airway epithelial biology: the new frontier for developmental immunology.

    Nino, Gustavo / Gutierrez, Maria J / Rodriguez-Martinez, Carlos E

    Expert review of respiratory medicine

    2022  Volume 16, Issue 2, Page(s) 145–147

    MeSH term(s) Biology ; Humans ; Infant ; Infant, Newborn
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2022.2027757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pediatric sleep apnea and viral respiratory infections: what do clinicians need to know?

    Nino, Gustavo / Restrepo-Gualteros, Sonia M / Gutierrez, Maria J

    Expert review of respiratory medicine

    2022  Volume 16, Issue 3, Page(s) 253–255

    MeSH term(s) Child ; Humans ; Polysomnography ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive ; Virus Diseases/complications ; Virus Diseases/epidemiology
    Language English
    Publishing date 2022-03-20
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2022.2045959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: The Fungal Cell Wall.

    Almeida, Fausto / Nosanchuk, Joshua D / Niño-Vega, Gustavo Alexis

    Frontiers in microbiology

    2020  Volume 11, Page(s) 1682

    Language English
    Publishing date 2020-09-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.01682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Oxygen saturation thresholds for bronchiolitis at high altitudes: a cost-effectiveness analysis.

    Rodriguez-Martinez, Carlos E / Sossa-Briceño, Monica P / Nino, Gustavo

    Expert review of pharmacoeconomics & outcomes research

    2023  Volume 23, Issue 5, Page(s) 527–533

    Abstract: Background: There is evidence suggesting that exaggerated reliance on pulse oximetry (SpO2) and the use of arbitrary/inadequate thresholds of SpO2 might drive unnecessary hospitalizations for viral bronchiolitis, especially among high-altitude residents. ...

    Abstract Background: There is evidence suggesting that exaggerated reliance on pulse oximetry (SpO2) and the use of arbitrary/inadequate thresholds of SpO2 might drive unnecessary hospitalizations for viral bronchiolitis, especially among high-altitude residents. The aim of the present study was to compare the cost-effectiveness of two oxygen SpO2 thresholds for deciding whether infants with viral bronchiolitis living at high altitudes need hospital admission or can be discharged home.
    Methods: A cost-effectiveness study was performed to compare the cost and clinical outcomes of two oxygen SpO2 thresholds, adjusted or not, to an altitude above the sea level of Bogota, Colombia (2640 m), for deciding whether infants with viral bronchiolitis need hospitalization or can be discharged home. The principal outcome was avoidance of hospital admission.
    Results: Compared to the use of an SpO2 threshold of 90%, using an SpO2 threshold of 85% in infants with viral bronchiolitis was associated with lower overall costs (US$130.4 vs. US$194.0 average cost per patient) and a higher probability of hospitalization avoided (0.7500 vs. 0.5900), thus leading to dominance.
    Conclusions: The use of an SpO2 threshold below 90% for deciding on hospitalization in infants with viral bronchiolitis living at high altitudes appears to be logical, secure, and cost-effective.
    MeSH term(s) Infant ; Humans ; Bronchiolitis, Viral ; Oxygen Saturation ; Altitude ; Cost-Effectiveness Analysis ; Oxygen ; Bronchiolitis/therapy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2208481-2
    ISSN 1744-8379 ; 1473-7167
    ISSN (online) 1744-8379
    ISSN 1473-7167
    DOI 10.1080/14737167.2023.2192482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Phenotypical Characterization of Obstructive Sleep Apnea in Premature Infants using Polysomnography.

    Zalzal, Habib G / Newman, Daniel / Behzadpour, Hengameh / Nino, Gustavo / Lawlor, Claire M

    The Laryngoscope

    2023  Volume 134, Issue 4, Page(s) 1933–1938

    Abstract: Objective: To use objective quantification of polysomnographic (PSG) parameters in premature infants to define the severity and nature of obstructions (partial hypopnea vs. total obstruction), along with the impact on sleep fragmentation and oxygenation ...

    Abstract Objective: To use objective quantification of polysomnographic (PSG) parameters in premature infants to define the severity and nature of obstructions (partial hypopnea vs. total obstruction), along with the impact on sleep fragmentation and oxygenation patterns.
    Methods: Retrospective comparison of PSG features in 207 infants (<12 months) referred for sleep disordered breathing. Our study groups included term (> = 37 weeks GA, n = 162) and premature (<37 weeks GA, n = 45) infants. Groups were compared for OSA sleep-stage-specific apnea hypopnea (AHI) indexes (REM and NREM), hypopnea indexes (HI), obstructive apnea indexes (OI) and arousal indexes. Oxygenation was assessed as % of time with SpO
    Results: Overall, premature infants had greater apnea severity (AHI premature 13.9/h vs. Term 7.9/h, p = 0.018). Additional analyses showed that the primary difference between premature and term infants is seen in the group with partial obstructions (HI index) and severe OSA (OAHI> = 10/h). Premature infants also had greater arousal indexes (premature 13.8/h vs. term 10.5/h, p = 0.003). Although the percentage of time <90% at night and the median SpO
    Conclusions: Children born premature have an OSA phenotype in infancy characterized by greater severity mostly due to frequent partial obstructions (hypopneas) rather than full obstructions (obstructive apnea). Prematurity is also associated with more intermittent hypoxemia and sleep fragmentation.
    Level of evidence: 3 Laryngoscope, 134:1933-1938, 2024.
    MeSH term(s) Child ; Infant, Newborn ; Humans ; Polysomnography ; Sleep Deprivation/complications ; Retrospective Studies ; Sleep Apnea, Obstructive ; Sleep Apnea Syndromes/complications ; Infant, Premature
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30991
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  8. Article: Early Microbial-Immune Interactions and Innate Immune Training of the Respiratory System during Health and Disease.

    Nino, Gustavo / Rodriguez-Martinez, Carlos E / Gutierrez, Maria J

    Children (Basel, Switzerland)

    2021  Volume 8, Issue 5

    Abstract: Over the past two decades, several studies have positioned early-life microbial exposure as a key factor for protection or susceptibility to respiratory diseases. Birth cohorts have identified a strong link between neonatal bacterial colonization of the ... ...

    Abstract Over the past two decades, several studies have positioned early-life microbial exposure as a key factor for protection or susceptibility to respiratory diseases. Birth cohorts have identified a strong link between neonatal bacterial colonization of the nasal airway and gut with the risk for respiratory infections and childhood asthma. Translational studies have provided companion mechanistic insights on how viral and bacterial exposures in early life affect immune development at the respiratory mucosal barrier. In this review, we summarize and discuss our current understanding of how early microbial-immune interactions occur during infancy, with a particular focus on the emergent paradigm of "innate immune training". Future human-based studies including newborns and infants are needed to inform the timing and key pathways implicated in the development, maturation, and innate training of the airway immune response, and how early microbiota and virus exposures modulate these processes in the respiratory system during health and disease.
    Language English
    Publishing date 2021-05-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children8050413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Emergency department-initiated home oxygen for viral bronchiolitis: A cost-effectiveness analysis.

    Rodríguez-Martínez, Carlos E / Sossa-Briceño, Monica P / Nino, Gustavo

    Pediatric pulmonology

    2022  Volume 57, Issue 9, Page(s) 2154–2160

    Abstract: Objective: The use of emergency department (ED)-initiated outpatient oxygen therapy has been considered to be a possible alternative to hospitalization for otherwise healthy-appearing, well-hydrated infants with uncomplicated disease. However, a formal ... ...

    Abstract Objective: The use of emergency department (ED)-initiated outpatient oxygen therapy has been considered to be a possible alternative to hospitalization for otherwise healthy-appearing, well-hydrated infants with uncomplicated disease. However, a formal economic evaluation of this treatment strategy is lacking. The aim of the present study was to compare the cost-effectiveness of ED-initiated outpatient oxygen therapy versus conventional inpatient hospitalization in infants with uncomplicated hypoxic bronchiolitis living in Bogota, the high-altitude capital city of Colombia, a middle-income country (MIC).
    Methods: A decision analysis model was developed to estimate the cost-effectiveness of ED-initiated outpatient oxygen therapy versus hospitalization. The main outcome of the model was avoidance of admission to a high-dependency unit.
    Results: Compared to hospitalization, ED-initiated outpatient oxygen therapy was associated with lower total costs (US$306.7 vs. US$638.7 average cost per patient) and a higher probability of avoidance of admission to a high-dependency unit (0.9528 vs. 0.8960), thus leading to dominance. The results were robust to deterministic and probabilistic sensitivity analyses.
    Conclusions: Our study suggests that in infants attending the ED with an uncomplicated hypoxic bronchiolitis episode in the city of Bogota, a high-altitude city, ED-initiated outpatient oxygen therapy is a dominant strategy compared to conventional inpatient hospitalization, because it involves a higher probability of avoidance of admission to a high-dependency unit, at lower total treatment costs.
    MeSH term(s) Bronchiolitis/therapy ; Bronchiolitis, Viral/therapy ; Cost-Benefit Analysis ; Emergency Service, Hospital ; Hospitalization ; Humans ; Infant ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effects of COVID-19 pandemic on adherence to obstructive sleep apnea therapy: A case report.

    Naime, Samira / Weiss, Miriam / Nino, Gustavo

    Clinical case reports

    2020  Volume 9, Issue 1, Page(s) 12–14

    Abstract: Telemedicine and remote monitoring are valuable tools to address inadequate obstructive sleep apnea compliance during the current pandemic. ...

    Abstract Telemedicine and remote monitoring are valuable tools to address inadequate obstructive sleep apnea compliance during the current pandemic.
    Language English
    Publishing date 2020-12-01
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.3363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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