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Article: Liquid biopsy for early detection of hepatocellular carcinoma.

Manea, Ioana / Iacob, Razvan / Iacob, Speranta / Cerban, Razvan / Dima, Simona / Oniscu, Gabriel / Popescu, Irinel / Gheorghe, Liliana

Frontiers in medicine

2023 Volume 10, Page(s) 1218705

Abstract: Hepatocellular carcinoma (HCC) is a highly prevalent and lethal cancer globally. Over 90% of HCC cases arise in the context of liver cirrhosis, and the severity of the underlying liver disease or advanced tumor stage at diagnosis significantly limits ... ...

Abstract	Hepatocellular carcinoma (HCC) is a highly prevalent and lethal cancer globally. Over 90% of HCC cases arise in the context of liver cirrhosis, and the severity of the underlying liver disease or advanced tumor stage at diagnosis significantly limits treatment options. Early diagnosis is crucial, and all guidelines stress the importance of screening protocols for HCC early detection as a public health objective. As serum biomarkers are not optimal for early diagnosis, liquid biopsy has emerged as a promising tool for diagnosis, prognostication, and patients' stratification for personalized therapy in various solid tumors, including HCC. While circulating tumor cells (CTCs) are better suited for personalized therapy and prognosis, cell-free DNA (cfDNA) and extracellular vesicle-based technologies show potential for early diagnosis, HCC screening, and surveillance protocols. Evaluating the added value of liquid biopsy genetic and epigenetic biomarkers for HCC screening is a key goal in translational research. Somatic mutations commonly found in HCC can be investigated in cfDNA and plasma exosomes as genetic biomarkers. Unique methylation patterns in cfDNA or cfDNA fragmentome features have been suggested as innovative tools for early HCC detection. Likewise, extracellular vesicle cargo biomarkers such as miRNAs and long non-coding RNAs may serve as potential biomarkers for early HCC detection. This review will explore recent findings on the utility of liquid biopsy for early HCC diagnosis. Combining liquid biopsy methods with traditional serological biomarkers could improve the overall diagnostic accuracy for early HCC detection.
Language	English
Publishing date	2023-09-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1218705
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Article ; Online: Zebrafish as a Potential Model for Neurodegenerative Diseases: A Focus on Toxic Metals Implications.

Paduraru, Emanuela / Iacob, Diana / Rarinca, Viorica / Plavan, Gabriel / Ureche, Dorel / Jijie, Roxana / Nicoara, Mircea

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: In the last century, industrial activities increased and caused multiple health problems for humans and animals. At this moment, heavy metals are considered the most harmful substances for their effects on organisms and humans. The impact of these toxic ... ...

Abstract	In the last century, industrial activities increased and caused multiple health problems for humans and animals. At this moment, heavy metals are considered the most harmful substances for their effects on organisms and humans. The impact of these toxic metals, which have no biological role, poses a considerable threat and is associated with several health problems. Heavy metals can interfere with metabolic processes and can sometimes act as pseudo-elements. The zebrafish is an animal model progressively used to expose the toxic effects of diverse compounds and to find treatments for different devastating diseases that human beings are currently facing. This review aims to analyse and discuss the value of zebrafish as animal models used in neurological conditions, such as Alzheimer's disease (AD), and Parkinson's disease (PD), particularly in terms of the benefits of animal models and the limitations that exist.
MeSH term(s)	Animals ; Humans ; Neurodegenerative Diseases/metabolism ; Zebrafish ; Metals, Heavy ; Heavy Metal Poisoning/complications ; Alzheimer Disease/complications
Chemical Substances	Metals, Heavy
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043428
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Article ; Online: Vitamin D Deficiency Manifested by Premature Ventricular Complexes from RVOT

Gabriel Cismaru / Cecilia Lazea / Daniela Iacob / Simona Cainap

International Journal of Biomedicine, Vol 11, Iss 2, Pp 220-

A Report on Two Twins

2021 Volume 223

Abstract: Vitamin D receptor is present in almost every cell of the body. Although some studies have suggested that values >30ng/ml would be sufficient, there is no consensus on the optimal values of serum vitamin D. Vitamin D deficiency can lead to “benign” ... ...

Abstract	Vitamin D receptor is present in almost every cell of the body. Although some studies have suggested that values >30ng/ml would be sufficient, there is no consensus on the optimal values of serum vitamin D. Vitamin D deficiency can lead to “benign” manifestations, such as back pain, joint pain, fatigue, and heavy sweating. Premature ventricular contractions (PVCs) originating from the right ventricular outflow tract (RVOT) are considered “benign,” as they occur in patients without structural heart disease and their exact cause remains unknown. We describe the case of a 10-year-old boy with frequent PVCs and vitamin D deficiency that was corrected after vitamin D supplementation. On the contrary, his twin brother had normal serum vitamin D and no PVCs. The disappearance of PVCs occurred after treatment with vitamin D 2000 IU/day.
Keywords	right ventricular outflow tract ; twins ; vitamin d ; premature ventricular contractions ; 24-hour holter ecg ; Medicine ; R
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	International Medical Research and Development Corporation
Document type	Article ; Online
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Article ; Online: Vitamin D as a Substitute of Catheter Ablation in a Paediatric Patient with High Burden Premature Ventricular Contractions

Gabriel Cismaru / Cecilia Lazea / Simona Cainap / Daniela Iacob

Journal of Clinical and Diagnostic Research, Vol 15, Iss 6, Pp SD01-SD

A Case Report

2021 Volume 03

Abstract: Catheter ablation is established as a treatment option for patients with high number Premature Ventricular Contractions (PVCs). However, complications can occur: cardiac tamponade, coronary artery injury or infectious endocarditis. Reversible causes such ...

Abstract	Catheter ablation is established as a treatment option for patients with high number Premature Ventricular Contractions (PVCs). However, complications can occur: cardiac tamponade, coronary artery injury or infectious endocarditis. Reversible causes such as hypocalcaemia, hypomagnesaemia and hypokalemia can be responsible for PVCs. Here, a case of nine years old boy, with vitamin D deficiency that presented high number PVCs which corrected using vitamin D dietary supplementation was described. A nine-year-old boy was hospitalised in the Cardiology Department for catheter ablation of PVCs. He presented short of breath during football matches and asthenia. Electrocardiography(ECG) and Holter ECG demonstrated high number PVCs with a morphology consistent of Right Ventricular Outflow Tract (RVOT) origin. Catheter ablation was postponed until Vitamin D came to normal values. Dietary supplementation was performed, together with Holter ECG monitoring. After vitamin D normalisation, PVC burden reduced significantly without the need of catheter ablation or anti-arrhythmic drugs. Catheter ablation and anti-arrhythmic drugs can be avoided in patients with frequent PVCs and vitamin D deficiency.
Keywords	cholecalciferol ; dilated cardiomyopathy ; holter electrocardiography ; right ventricular outflow tract ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Design of Ti-Mo-W Alloys and Its Correlation with Corrosion Resistance in Simulated Body Fluid (SBF).

Ghica, Ştefan-Ioan / Ghica, Valeriu-Gabriel / Petrescu, Mircea-Ionuţ / Iacob, Gheorghe / Geantă, Victor / Buzatu, Mihai / Ungureanu, Elena

Materials (Basel, Switzerland)

2023 Volume 16, Issue 6

Abstract: Titanium and its based alloys are frequently selected for designing biomedical implants and it is thus necessary to study as detailed as possible their corrosion behavior in biological solutions, such as those in the human body environment. In this paper, ...

Abstract	Titanium and its based alloys are frequently selected for designing biomedical implants and it is thus necessary to study as detailed as possible their corrosion behavior in biological solutions, such as those in the human body environment. In this paper, with the use of molecular orbital calculation, we designed and developed alloys in the Ti-19Mo-xW system (x = 7, 8, 9, and 10 wt%) and investigated the influence of different contents of tungsten on the behavior of Ti-19Mo-xW alloy samples following corrosion in simulated body fluid (SBF). The values of Bo¯ (bond order) and Md¯ (the metal-orbital energy level) were calculated for each alloy and correlations were established between Bo¯ and the content of tungsten. It was found that with the increase in tungsten content, the value of Bo¯ increases. Regarding the values of the corrosion resistance in SBF that resulted from the investigated alloys, the Ti19Mo7W alloy is distinguished by the lowest value of the corrosion current density and the lowest corrosion rate.
Language	English
Publishing date	2023-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16062453
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Article ; Online: Feasibility of a lung airway navigation system using fiber-Bragg shape sensing and artificial intelligence for early diagnosis of lung cancer.

Gruionu, Lucian Gheorghe / Udriștoiu, Anca Loredana / Iacob, Andreea Valentina / Constantinescu, Cătălin / Stan, Răzvan / Gruionu, Gabriel

PloS one

2022 Volume 17, Issue 12, Page(s) e0277938

Abstract: Currently early diagnosis of malignant lesions at the periphery of lung parenchyma requires guidance of the biopsy needle catheter from the bronchoscope into the smaller peripheral airways via harmful X-ray radiation. Previously, we developed an image- ... ...

Abstract	Currently early diagnosis of malignant lesions at the periphery of lung parenchyma requires guidance of the biopsy needle catheter from the bronchoscope into the smaller peripheral airways via harmful X-ray radiation. Previously, we developed an image-guided system, iMTECH which uses electromagnetic tracking and although it increases the precision of biopsy collection and minimizes the use of harmful X-ray radiation during the interventional procedures, it only traces the tip of the biopsy catheter leaving the remaining catheter untraceable in real time and therefore increasing image registration error. To address this issue, we developed a shape sensing guidance system containing a fiber-Bragg grating (FBG) catheter and an artificial intelligence (AI) software, AIrShape to track and guide the entire biopsy instrument inside the lung airways, without radiation or electromagnetic navigation. We used a FBG fiber with one central and three peripheral cores positioned at 120° from each other, an array of 25 draw tower gratings with 1cm/3nm spacing, 2 mm grating length, Ormocer-T coating, and a total outer diameter of 0.2 mm. The FBG fiber was placed in the working channel of a custom made three-lumen catheter with a tip bending mechanism (FBG catheter). The AIrShape software determines the position of the FBG catheter by superimposing its position to the lung airway center lines using an AI algorithm. The feasibility of the FBG system was tested in an anatomically accurate lung airway model and validated visually and with the iMTECH platform. The results prove a viable shape-sensing hardware and software navigation solution for flexible medical instruments to reach the peripheral airways. During future studies, the feasibility of FBG catheter will be tested in pre-clinical animal models.
MeSH term(s)	Humans ; Artificial Intelligence ; Lung/diagnostic imaging ; Lung Neoplasms/diagnostic imaging ; Early Diagnosis
Language	English
Publishing date	2022-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0277938
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Article ; Online: Prognostic Value of Circulating Cell-Free DNA Concentration and Neutrophil-to-Lymphocyte Ratio in Patients with Pancreatic Ductal Adenocarcinoma: A Prospective Cohort Study.

Varzaru, Bianca / Iacob, Razvan Andrei / Bunduc, Stefania / Manea, Ioana / Sorop, Andrei / Spiridon, Andreea / Chelaru, Raluca / Croitoru, Adina / Topala, Mihaela / Becheanu, Gabriel / Dumbrava, Mona / Dima, Simona / Popescu, Irinel / Gheorghe, Cristian

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: Circulating cell-free DNA (ccfDNA) quantity correlates with the clinical characteristics and prognosis of various cancer types. We investigated whether ccfDNA levels and the neutrophil-to-lymphocyte ratio (NLR) have prognostic value in patients with ... ...

Abstract	Circulating cell-free DNA (ccfDNA) quantity correlates with the clinical characteristics and prognosis of various cancer types. We investigated whether ccfDNA levels and the neutrophil-to-lymphocyte ratio (NLR) have prognostic value in patients with pancreatic ductal adenocarcinoma (PDAC). Peripheral blood was collected from 82 patients with PDAC prior to any diagnostic procedure or the administration of chemotherapy. Plasma DNA was isolated, and ccfDNA concentration and NLR were determined. We found that ccfDNA levels were correlated with age and tumor burden. Moreover, higher values of NLR (≥3.31) were linked with worse overall survival (OS) (4 vs. 10 months; log rank
MeSH term(s)	Humans ; Neutrophils/pathology ; Prognosis ; Prospective Studies ; Lymphocyte Count ; Lymphocytes/pathology ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/pathology ; Cell-Free Nucleic Acids ; Retrospective Studies
Chemical Substances	Cell-Free Nucleic Acids
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052854
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Article: Splenectomy Does Not Increase Early Morbidity in Patients Undergoing Total Gastrectomy: A Case-Control Study with Propensity Score Analysis.

Iacob, Stefan / Morarasu, Stefan / Roata, Cristian Ene / Musina, Ana-Maria / Bargaoanu, Roxana / Ong, Wee Liam / Baboi, Bogdan / Lunca, Sorinel / Dimofte, Gabriel Mihail

Chirurgia (Bucharest, Romania : 1990)

2023 Volume 118, Issue 5, Page(s) 464–469

Abstract: Aim: In gastric cancer (GC), D2 lymph node dissection is, alongside negative-margins gastrectomy, of paramount importance. There is a debate between Western and Eastern scientific communities concerning the risk-benefit balance with respect to ... ...

Abstract	Aim: In gastric cancer (GC), D2 lymph node dissection is, alongside negative-margins gastrectomy, of paramount importance. There is a debate between Western and Eastern scientific communities concerning the risk-benefit balance with respect to splenectomy, as Western countries are inclined to perform spleen-preserving gastrectomy due to an increased risk for postoperative complications. In Eastern countries (such as Japan) this is not the case. Our study aimed to determine whether or not spleen-sacrificing total gastrectomy for GC was associated with a higher rate of early postoperative morbidity or mortality. Method: We performed a retrospective case-control study in which we included patients who underwent total gastrectomy with D2 lymphadenectomy for GC (stages I-III) with curative intent, in a single high-volume tertiary oncologic centre. We divided the cases into two groups: spleenpreserving (SP) and spleen-sacrificing (SS) and evaluated the early complications rate following surgery. Afterwards, we performed propensity score matching (PSM) and analysis of the two groups.
MeSH term(s)	Humans ; Splenectomy/adverse effects ; Case-Control Studies ; Retrospective Studies ; Propensity Score ; Treatment Outcome ; Gastrectomy/methods ; Lymph Node Excision/methods ; Stomach Neoplasms/pathology ; Morbidity ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
Language	English
Publishing date	2023-10-26
Publishing country	Romania
Document type	Journal Article
ZDB-ID	419244-8
ISSN	1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
ISSN (online)	1842-368X
ISSN	1221-9118 ; 0009-4730 ; 0377-5003
DOI	10.21614/chirurgia.2023.v.118.i.5.p.464
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Article: Relationship between the Formation of Magnetic Clusters and Hexagonal Phase of Gold Matrix in Au

Locovei, Claudiu / Radu, Cristian / Kuncser, Andrei / Iacob, Nicusor / Schinteie, Gabriel / Stanciu, Anda / Iftimie, Sorina / Kuncser, Victor

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 7

Abstract: ... ...

Abstract	Au
Language	English
Publishing date	2022-04-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12071176
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Article: Host and immunosuppression-related factors influencing fibrosis occurrence post liver transplantation.

Iacob, Speranta / Iacob, Razvan / Manea, Ioana / Uta, Mihaela / Chiosa, Andrei / Dumbrava, Mona / Becheanu, Gabriel / Stoica, Luminita / Popa, Codruta / Brasoveanu, Vlad / Hrehoret, Doina / Gheorghe, Cristian / Gheorghe, Liana / Dima, Simona / Popescu, Irinel

Frontiers in pharmacology

2022 Volume 13, Page(s) 1042664

Abstract: Post liver transplantation (LT) fibrosis has a negative impact on graft function. Cytokine production in the host immune response after LT may contribute to the variable CYP3A-dependent immunosuppressive drug disposition, with subsequent impact on liver ... ...

Abstract	Post liver transplantation (LT) fibrosis has a negative impact on graft function. Cytokine production in the host immune response after LT may contribute to the variable CYP3A-dependent immunosuppressive drug disposition, with subsequent impact on liver fibrogenesis, together with host-related factors. We aimed to investigate whether the cytochrome P4503A53 (CYP3A53) or TBX21 genotypes impact post-LT liver fibrogenesis. Furthermore, the impact of immunosuppressants on cellular apoptosis has been evaluated using human hepatocytes harvested from cirrhotic explanted livers. We have enrolled 98 LT recipients that were followed for occurrence of liver fibrosis for at least 12 months. There was a statistically significant higher trough level of TAC in patients with homozygous CC-TBX21 genotype (7.83 ± 2.84 ng/ml) vs. 5.66 ± 2.16 ng/ml in patients without this genotype (
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1042664
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