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Article ; Online: Author reply.

Matin, Surena F / Melquist, Jonathan / Karam, Jose A

2016 Volume 87, Page(s) 222–223

MeSH term(s)	Female ; Humans ; Laparoscopy/methods ; Lymph Node Excision/methods ; Male ; Nephrectomy/methods ; Robotics/methods ; Ureter/surgery ; Urinary Bladder/surgery ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2016-05-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2015.07.072
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

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Article ; Online: TCF21 Promotes Luminal-Like Differentiation and Suppresses Metastasis in Bladder Cancer.

Mokkapati, Sharada / Porten, Sima P / Narayan, Vikram M / Lim, Amy H / Jayaratna, Isuru S / Roth, Beat / Cheng, Tiewei / Navai, Neema / Wszolek, Matthew / Melquist, Jonathan / Manyam, Ganiraju / Choi, Woonyoung / Broom, Bradley / Pretzsch, Shanna / Czerniak, Bogdan / McConkey, David J / Dinney, Colin P N

Molecular cancer research : MCR

2020 Volume 18, Issue 6, Page(s) 811–821

Abstract: Little is known regarding the subclone evolution process in advanced bladder cancer, particularly with respect to the genomic alterations that lead to the development of metastatic lesions. In this project, we identify gene expression signatures ... ...

Abstract	Little is known regarding the subclone evolution process in advanced bladder cancer, particularly with respect to the genomic alterations that lead to the development of metastatic lesions. In this project, we identify gene expression signatures associated with metastatic bladder cancer through mRNA expression profiling of RNA isolated from 33 primary bladder cancer and corresponding lymph node (LN) metastasis samples. Gene expression profiling (GEP) was performed on RNA isolated using the Illumina DASL platform. We identified the developmental transcription factor TCF21 as being significantly higher in primary bladder cancer compared with LN metastasis samples. To elucidate its function in bladder cancer, loss- and gain-of-function experiments were conducted in bladder cancer cell lines with high and low expression of TCF21, respectively. We also performed GEP in bladder cancer cell lines following TCF21 overexpression. We identified 2,390 genes differentially expressed in primary bladder cancer and corresponding LN metastasis pairs at an FDR cutoff of 0.1 and a fold change of 1. Among those significantly altered, expression of TCF21 was higher in the primary tumor compared with LN metastasis. We validated this finding with qPCR and IHC on patient samples. Moreover, TCF21 expression was higher in luminal cell lines and knockdown of TCF21 increased invasion, tumor cell dissemination, and metastasis. In contrast, overexpression of TCF21 in highly metastatic basal bladder cancer cell lines decreased their invasive and metastatic potential. IMPLICATIONS: TCF21 is differentially overexpressed in primary bladder cancer compared with matched LN metastasis, with
MeSH term(s)	Animals ; Apoptosis ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Differentiation ; Cell Proliferation ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphatic Metastasis ; Male ; Mice ; Mice, Nude ; Middle Aged ; Neoplasm Invasiveness ; Prognosis ; Survival Rate ; Tumor Cells, Cultured ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/prevention & control ; Xenograft Model Antitumor Assays
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Biomarkers, Tumor ; TCF21 protein, human
Language	English
Publishing date	2020-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2098788-2
ISSN	1557-3125 ; 1541-7786
ISSN (online)	1557-3125
ISSN	1541-7786
DOI	10.1158/1541-7786.MCR-19-0766
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Article ; Online: Comparison of Single-docking Robotic-assisted and Traditional Laparoscopy for Retroperitoneal Lymph Node Dissection During Nephroureterectomy With Bladder Cuff Excision for Upper-tract Urothelial Carcinoma.

Melquist, Jonathan J / Redrow, Grant / Delacroix, Scott / Park, Andrew / Faria, Eliney E / Karam, Jose A / Matin, Surena F

Urology

2016 Volume 87, Page(s) 216–223

Abstract: Objective: To compare the results of traditional laparoscopy and a simple, single-docking robotic approach for retroperitoneal lymph node dissection (RPLND), nephroureterectomy, and bladder cuff excision.: Materials and methods: We evaluated 63 and ... ...

Abstract	Objective: To compare the results of traditional laparoscopy and a simple, single-docking robotic approach for retroperitoneal lymph node dissection (RPLND), nephroureterectomy, and bladder cuff excision. Materials and methods: We evaluated 63 and 37 consecutive patients who underwent laparoscopic and robotic nephrouretectomy with RPLND, respectively, for upper-tract urothelial carcinoma (UTUC). Results: Our robotic approach was associated with improved lymph node procurement (21.0 nodes [interquartile range 16.0-30.0]) when compared with laparoscopy (11.0 nodes [interquartile range 5.5-21.0]) (P < .0001). Major blood loss as defined by requiring a blood transfusion was less for the robotic group than for the laparoscopic cohort (8% vs 30%) (P = .012). In contrast, the robotic group had longer operative times (5.1 vs 3.9 hours) (P = .0001) and longer hospital stays (5.0 vs 4.0 days) (P = .0002). Conclusion: Our single-docking robotic technique for concomitant RPLND during nephrouretectomy is associated with improved lymph node yield.
MeSH term(s)	Aged ; Aged, 80 and over ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/secondary ; Carcinoma, Transitional Cell/surgery ; Female ; Follow-Up Studies ; Humans ; Laparoscopy/methods ; Lymph Node Excision/methods ; Lymphatic Metastasis ; Male ; Middle Aged ; Nephrectomy/methods ; Retroperitoneal Space ; Retrospective Studies ; Robotics/methods ; Treatment Outcome ; Ureter/surgery ; Urinary Bladder/surgery ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2015.07.070
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

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Article ; Online: The effect of concomitant carcinoma in situ on neoadjuvant chemotherapy for urothelial cell carcinoma of the bladder: inferior pathological outcomes but no effect on survival.

Parker, William P / Ho, Phillip L / Melquist, Jonathan J / Scott, Katie / Holzbeierlein, Jeffrey M / Lopez-Corona, Ernesto / Kamat, Ashish M / Lee, Eugene K

The Journal of urology

2015 Volume 193, Issue 5, Page(s) 1494–1499

Abstract: Purpose: It is generally believed that carcinoma in situ is refractory to chemotherapy but specific data are lacking to validate this. We evaluated the effect of concomitant clinical carcinoma in situ on cancer specific outcomes after neoadjuvant ... ...

Abstract	Purpose: It is generally believed that carcinoma in situ is refractory to chemotherapy but specific data are lacking to validate this. We evaluated the effect of concomitant clinical carcinoma in situ on cancer specific outcomes after neoadjuvant chemotherapy for muscle invasive bladder cancer. Materials and methods: We performed an institutional review board approved, multi-institutional, retrospective review of the records of patients treated with neoadjuvant chemotherapy followed by radical cystectomy for muscle invasive bladder cancer from 2008 to 2012. Pretreatment clinical variables were collected and patients were stratified by the presence of clinical carcinoma in situ on precystectomy transurethral bladder tumor resection specimens. Pathological outcomes, including the complete response rate (pT0N0Mx) after neoadjuvant chemotherapy, were compared between the 2 groups. Recurrence-free, cancer specific and overall survival was analyzed. Results: Of 189 patients who met study criteria 56 (29.6%) had concomitant carcinoma in situ. The condition was associated with a significant decrease in the pathological complete response rate (10.7% vs 26.3%, p = 0.02). This difference was significant on univariate and multivariable analysis (OR 0.34, 95% CI 0.13-0.85, p = 0.02 and OR 0.31, 95% CI 0.12-0.81, p = 0.02, respectively). Despite the decreased complete response rate clinical carcinoma in situ was not associated with a difference in recurrence-free, cancer specific or overall survival. Additionally, when down-staging to pathological carcinoma in situ only disease was considered a complete response, there was no significant change in recurrence-free, cancer specific or overall survival. Conclusions: Concomitant carcinoma in situ is associated with a decrease in the complete response rate but this does not appear to impact the survival outcome.
MeSH term(s)	Carcinoma in Situ/drug therapy ; Carcinoma in Situ/pathology ; Carcinoma in Situ/surgery ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/pathology ; Carcinoma, Transitional Cell/surgery ; Chemotherapy, Adjuvant ; Cystectomy ; Humans ; Neoadjuvant Therapy ; Neoplasms, Multiple Primary/drug therapy ; Neoplasms, Multiple Primary/pathology ; Neoplasms, Multiple Primary/surgery ; Remission Induction ; Retrospective Studies ; Treatment Outcome ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Evaluation Studies ; Journal Article ; Multicenter Study ; Validation Studies
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2014.11.003
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Zs.MO 331: Show issues

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Article ; Online: Partial nephrectomy for a large renal lymphatic malformation in a child presenting with hypertension.

Lee, Wai / Vemulapalli, Praneeth / Miller, Frederick / Melquist, Jonathan / Lee, Thomas K / Darras, Frank S

Journal of pediatric surgery

2012 Volume 47, Issue 1, Page(s) e23–6

Abstract: A 9-year-old girl had hypertension (systolic blood pressure of 125 mm Hg) noted at an annual well child visit. An ultrasound study demonstrated a large right renal cystic mass. A partial nephrectomy was performed. The surgical specimen was 9.7 × 9.4 × 6 ... ...

Abstract	A 9-year-old girl had hypertension (systolic blood pressure of 125 mm Hg) noted at an annual well child visit. An ultrasound study demonstrated a large right renal cystic mass. A partial nephrectomy was performed. The surgical specimen was 9.7 × 9.4 × 6.4 cm and weighed 413.2 g. The tumor stained diffusely positive for smooth muscle actin and focally positive for factor VIII. Final histologic diagnosis was primary intrarenal lymphatic malformation. The case is unusual because of the presentation, size of the mass, as well as the therapeutic approach of partial nephrectomy.
MeSH term(s)	Child ; Female ; Humans ; Hypertension/etiology ; Kidney ; Lymphatic Abnormalities/complications ; Lymphatic Abnormalities/diagnosis ; Lymphatic Abnormalities/surgery ; Nephrectomy/methods
Language	English
Publishing date	2012-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2011.10.003
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Zs.A 607: Show issues

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Article ; Online: Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis.

Roth, Beat / Jayaratna, Isuru / Sundi, Debasish / Cheng, Tiewei / Melquist, Jonathan / Choi, Woonyoung / Porten, Sima / Nitti, Giovanni / Navai, Neema / Wszolek, Matthew / Guo, Charles / Czerniak, Bogdan / McConkey, David / Dinney, Colin

Oncotarget

2017 Volume 8, Issue 21, Page(s) 34205–34222

Abstract: Epithelial-to-mesenchymal transition (EMT) has been implicated in the progression of bladder cancer. To study its contribution to bladder cancer metastasis, we established new xenograft models derived from human bladder cancer cell lines utilizing an ... ...

Abstract	Epithelial-to-mesenchymal transition (EMT) has been implicated in the progression of bladder cancer. To study its contribution to bladder cancer metastasis, we established new xenograft models derived from human bladder cancer cell lines utilizing an orthotopic "recycling" technique that allowed us to isolate and examine the primary tumor and its corresponding circulating tumor cells (CTC's) and metastatic lesions. Using whole genome mRNA expression profiling, we found that a reversible epithelial-to-mesenchymal transition (EMT) characterized by TGFβ pathway activation and SNAIL expression was associated with the accumulation of CTCs. Finally, we observed that conditional silencing of SNAIL completely blocked CTC production and regional/distant metastasis. Using this unique bladder cancer xenograft model, we conclude that metastasis is dependent on a reversible EMT mediated by SNAIL.
Language	English
Publishing date	2017-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.11009
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Article ; Online: Alemtuzumab with corticosteroid minimization for pediatric deceased donor renal transplantation: a seven-yr experience.

Supe-Markovina, Katarina / Melquist, Jonathan J / Connolly, Deirdre / DiCarlo, Heather N / Waltzer, Wayne C / Fine, Richard N / Darras, Frank S

Pediatric transplantation

2014 Volume 18, Issue 4, Page(s) 363–368

Abstract: Alemtuzumab is a monoclonal antibody targeting CD52 receptors on B and T lymphocytes and is an effective induction agent in pediatric renal transplantation. We report a seven-yr experience using alemtuzumab induction and steroid-free protocol in the ... ...

Abstract	Alemtuzumab is a monoclonal antibody targeting CD52 receptors on B and T lymphocytes and is an effective induction agent in pediatric renal transplantation. We report a seven-yr experience using alemtuzumab induction and steroid-free protocol in the pediatric population as safe and effective. Twenty-one pediatric deceased donor renal transplants were performed at a single academic institution. All received induction with single-dose alemtuzumab and were maintained on a steroid-free protocol using TAC and MMF immunosuppression. There were 15 males and six females in the study whose ages ranged from one to 19 yr. The average follow-up was 32 months (range from 12 to 78.2 months and median 33.7 ± 23.7 months). All patients had immediate graft function. Graft survival was 95%, and patient survival was 100%. Mean 12 and 36 months eGFR were 63.33 ± 21.01 and 59.90 ± 15.27 mL/min/1.73m(2), respectively. Three patients developed acute T-cell-mediated rejection due to non-adherence while no recipients developed cytomegalovirus infection, PTLD, or polyoma BK viral nephropathy. Steroid avoidance with single-dose alemtuzumab induction provides adequate and safe immunosuppression in pediatric deceased donor renal transplant recipients receiving TAC and low-dose MMF maintenance therapy.
MeSH term(s)	Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Alemtuzumab ; Antibodies, Monoclonal, Humanized/therapeutic use ; Child ; Child, Preschool ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Graft Rejection/prevention & control ; Graft Survival ; Humans ; Immunosuppressive Agents/therapeutic use ; Induction Chemotherapy ; Kaplan-Meier Estimate ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/mortality ; Maintenance Chemotherapy ; Male ; Mycophenolic Acid/analogs & derivatives ; Mycophenolic Acid/therapeutic use ; Retrospective Studies ; Survival Rate ; Tacrolimus/therapeutic use ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones ; Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents ; Alemtuzumab (3A189DH42V) ; Mycophenolic Acid (HU9DX48N0T) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2014-06
Publishing country	Denmark
Document type	Evaluation Studies ; Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.12253
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Zs.A 4947: Show issues

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Article ; Online: Current diagnosis and management of syringocele: a review.

Melquist, Jonathan / Sharma, Vidit / Sciullo, Daniella / McCaffrey, Heather / Khan, S Ali

International braz j urol : official journal of the Brazilian Society of Urology

2010 Volume 36, Issue 1, Page(s) 3–9

Abstract: Cowper's syringocele is a rare but an under-diagnosed cystic dilation of the Cowper's ducts and is increasingly being recognized in the adult population. Recent literature suggests that syringoceles be classified based on the configuration of the duct's ... ...

Abstract	Cowper's syringocele is a rare but an under-diagnosed cystic dilation of the Cowper's ducts and is increasingly being recognized in the adult population. Recent literature suggests that syringoceles be classified based on the configuration of the duct's orifice to the urethra, either open or closed, as this also allows the clinical presentations of 2 syringoceles to be divided, albeit with some overlap. Usually post-void dribbling, hematuria, or urethral discharge indicates open syringocele, while obstructive symptoms are associated with closed syringoceles. As these symptoms are shared by many serious conditions, a working differential diagnosis is critical. Ultrasonography coupled with retro and ante grade urethrography usually suffices to diagnose syringocele, but supplementary procedures - such as cystourethroscopy, computed tomography scan, and magnetic resonance imaging - can prove useful. Conservative observation is first recommended, but persistent symptoms are usually treated with endoscopic marsupialization unless contraindicated. Upon reviewing the literature, this paper addresses the clinical anatomy, classification, presentation, diagnosis, and treatment of syringoceles in further detail.
MeSH term(s)	Adult ; Bulbourethral Glands ; Child ; Cysts/diagnosis ; Cysts/therapy ; Dilatation, Pathologic/classification ; Dilatation, Pathologic/diagnosis ; Dilatation, Pathologic/therapy ; Genital Diseases, Male/diagnosis ; Genital Diseases, Male/therapy ; Humans ; Male
Language	English
Publishing date	2010-03-03
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2206649-4
ISSN	1677-6119 ; 1677-5538
ISSN (online)	1677-6119
ISSN	1677-5538
DOI	10.1590/s1677-55382010000100002
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Article ; Online: The importance of clinical stage among patients with a complete pathologic response at radical cystectomy after neoadjuvant chemotherapy.

Parker, William P / Ho, Philip L / Boorjian, Stephen A / Melquist, Jonathan J / Thapa, Prabin / Holzbeierlein, Jeffrey M / Frank, Igor / Kamat, Ashish M / Lee, Eugene K

World journal of urology

2016 Volume 34, Issue 11, Page(s) 1561–1566

Abstract: Purpose: Patients without evidence of disease at radical cystectomy (RC) following neoadjuvant chemotherapy (NAC) have the greatest potential for survival in muscle-invasive bladder cancer. Historically, 15 % of such patients will experience disease ... ...

Abstract	Purpose: Patients without evidence of disease at radical cystectomy (RC) following neoadjuvant chemotherapy (NAC) have the greatest potential for survival in muscle-invasive bladder cancer. Historically, 15 % of such patients will experience disease recurrence and cancer-specific mortality. We sought to evaluate the effect of pre-treatment clinical factors on the risk of recurrence in patients who were ypT0N0 at RC. Methods: We performed a multi-institutional review of patients treated with NAC + RC for muscle-invasive bladder cancer (≥cT2) without pathologic evidence of disease at surgery (ypT0N0). The association of pre-treatment clinicopathologic features with recurrence was evaluated using Cox proportional hazards. Results: A total of 78 patients were identified with ypT0 disease at RC after NAC. Median postoperative follow-up was 32.4 months (IQR 16.8, 60.0), during which time 17 patients recurred at a median of 6.4 months after RC. Estimated 3-year recurrence-free survival (RFS) of this cohort was 74.8 %. In univariate analysis, cT4 disease (HR 3.12; p = 0.04) and time to RC (HR 1.17 for each month increase; p < 0.01) were associated with inferior RFS. Conclusion: Patients without evidence of disease at the time of RC are still at risk of recurrence and death from bladder cancer. Higher clinical stage and increased time to RC were associated with an increased risk of recurrence and subsequent death. These data highlight the importance of timely RC and the continued risk of recurrence in higher clinically staged patients-underscoring the need for close monitoring and patient counseling.
MeSH term(s)	Aged ; Antineoplastic Agents/therapeutic use ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/mortality ; Carcinoma, Transitional Cell/therapy ; Cystectomy/methods ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Survival Rate/trends ; United States/epidemiology ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/mortality ; Urinary Bladder Neoplasms/therapy
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2016-11
Publishing country	Germany
Document type	Journal Article ; Multicenter Study
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-016-1801-y
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Article ; Online: Outcome of patients with clinically node-positive bladder cancer undergoing consolidative surgery after preoperative chemotherapy: The M.D. Anderson Cancer Center Experience.

Ho, Philip L / Willis, Daniel L / Patil, Jeevitha / Xiao, Lianchun / Williams, Stephen B / Melquist, Jonathan J / Tart, Karen / Parikh, Sahil / Shah, Jay B / Delacroix, Scott E / Navai, Neema / Siefker-Radtke, Arlene / Dinney, Colin P / Pisters, Louis L / Kamat, Ashish M

Urologic oncology

2016 Volume 34, Issue 2, Page(s) 59.e1–8

Abstract: Purpose: Patients with urothelial cancer with nodal metastasis have a poor prognosis, with many deemed incurable. We report outcomes of a prospective clinical protocol of patients with clinically node-positive disease treated via a multimodality ... ...

Abstract	Purpose: Patients with urothelial cancer with nodal metastasis have a poor prognosis, with many deemed incurable. We report outcomes of a prospective clinical protocol of patients with clinically node-positive disease treated via a multimodality treatment approach. Patients and methods: A total of 55 patients with bladder urothelial carcinoma with concurrent node-positive disease including pelvic nodal and retroperitoneal lymph node (RPLN) involvement underwent preoperative chemotherapy followed by consolidative surgery between 1995 and 2010. Associations between clinicopathologic factors and outcomes were analyzed using log-rank test and Cox regression analysis. Results: Median cancer-specific survival (CSS) was 26 months (95% CI: 12.9-not applicable) for all patients. A total of 30 (55%) patients had pN0 category disease at the time of surgical extirpation. Despite radiologic complete response after chemotherapy, 6 of 21 patients (29%) had pN+category disease. The 5-year CSS rate was 66% for pN0 category disease vs. 12% for pN+category disease (P<0.001). Radiologic complete response to chemotherapy was associated with a 5-year CSS rate of 60% vs. 33% for a partial response (P = 0.038). Although no recurrences occurred within the lymphadenectomy template, 2 (14%) patients with cM1 RPLN disease who did not undergo RPLN dissection had recurrences in the RPLN basin and died within 6 months. Conclusion: Multimodality treatment approach with upfront chemotherapy followed by surgery can result in a 66% 5-year CSS rate for patients rendered as having pN0 category disease despite initially presenting with node-positive disease. However, as those with residual disease do so poorly, further efforts in refining selection of patients for surgical consolidation are needed.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Drug Therapy ; Female ; Humans ; Male ; Middle Aged ; Preoperative Period ; Prognosis ; Survival Rate ; Treatment Outcome ; United States ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2015.08.012
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