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  1. Article ; Online: Chronic Whipple's disease, a diagnostic challenge for the cardiologist.

    Escribano Subías, Pilar

    Revista espanola de cardiologia (English ed.)

    2023  Volume 76, Issue 12, Page(s) 954–955

    MeSH term(s) Humans ; Whipple Disease/diagnosis ; Whipple Disease/drug therapy ; Cardiologists ; Biopsy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language Spanish
    Publishing date 2023-10-19
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2023.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The importance of data in Pulmonary Arterial Hypertension: from international registries to Machine Learning.

    Becerra-Muñoz, Víctor Manuel / Gómez Sáenz, José Tomás / Escribano Subías, Pilar

    Medicina clinica

    2024  

    Abstract: Real-world registries have been critical to building the scientific knowledge of rare diseases, including Pulmonary Arterial Hypertension (PAH). In the past 4 decades, a considerable number of registries on this condition have allowed to improve the ... ...

    Title translation La importancia de los datos en la hipertensión arterial pulmonar: de los registros internacionales al machine learning.
    Abstract Real-world registries have been critical to building the scientific knowledge of rare diseases, including Pulmonary Arterial Hypertension (PAH). In the past 4 decades, a considerable number of registries on this condition have allowed to improve the pathology and its subgroupś definition, to advance in the understanding of its pathophysiology, to elaborate prognostic scales and to check the transferability of the results from clinical trials to clinical practice. However, in a moment where a huge amount of data from multiple sources is available, they are not always taken into account by the registries. For that reason, Machine Learning (ML) offer a unique opportunity to manage all these data and, finally, to obtain tools that may help to get an earlier diagnose, to help to deduce the prognosis and, in the end, to advance in Personalized Medicine. Thus, we present a narrative revision with the aims of, in one hand, summing up the aspects in which data extraction is important in rare diseases -focusing on the knowledge gained from PAH real-world registries- and, on the other hand, describing some of the achievements and the potential use of the ML techniques on PAH.
    Language Spanish
    Publishing date 2024-02-20
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.279: Show issues Location:
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  3. Article ; Online: Prognostic Stratification and Treatment for Pulmonary Arterial Hypertension. Gaps and Promising Remedies.

    Del Pozo, Roberto / Cruz-Utrilla, Alejandro / Escribano-Subias, Pilar

    Archivos de bronconeumologia

    2023  Volume 59, Issue 10, Page(s) 617–618

    MeSH term(s) Humans ; Pulmonary Arterial Hypertension/diagnosis ; Pulmonary Arterial Hypertension/drug therapy ; Prognosis ; Familial Primary Pulmonary Hypertension ; Hypertension, Pulmonary/therapy ; Risk Assessment
    Language Spanish
    Publishing date 2023-04-20
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.04.003
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  4. Article ; Online: Pulmonary arterial hypertension.

    Luna-López, Raquel / Ruiz Martín, Alicia / Escribano Subías, Pilar

    Medicina clinica

    2022  Volume 158, Issue 12, Page(s) 622–629

    Abstract: Pulmonary arterial hypertension (PAH) is a rare disease characterized by adverse remodeling of the arterial tree leading to increased vascular resistance with subsequent increase in right ventricular afterload and eventual development of heart failure. ... ...

    Title translation Hipertensión arterial pulmonar.
    Abstract Pulmonary arterial hypertension (PAH) is a rare disease characterized by adverse remodeling of the arterial tree leading to increased vascular resistance with subsequent increase in right ventricular afterload and eventual development of heart failure. The nonspecific clinical manifestations and lack of knowledge of pathology lead to a poor prognosis associated with delay in diagnosis and initiation of treatment. The most recent recommendations focus on optimizing the early differential diagnosis with other causes of pulmonary hypertension to initiate appropriate treatment based on the mortality risk estimation. In the last years, with the improvement in the diagnostic process, the emergence of new specific treatments, and the creation of specialized referral units for this pathology, the prognosis, and quality of life of patients with PAH have improved significantly.
    MeSH term(s) Heart Failure ; Heart Ventricles ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Pulmonary Arterial Hypertension/diagnosis ; Pulmonary Arterial Hypertension/etiology ; Pulmonary Arterial Hypertension/therapy ; Quality of Life
    Language Spanish
    Publishing date 2022-03-09
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2022.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Expert center and balloon pulmonary angioplasty network program in chronic thromboembolic pulmonary hypertension: safety and effectiveness of a pioneering experience.

    Velázquez Martín, Maite / Gómez Menchero, Antonio / González Ferreiro, Rocío / Andrés Morist, Abel / Maneiro Melón, Nicolas / Escribano Subias, Pilar

    Revista espanola de cardiologia (English ed.)

    2024  

    Language Spanish
    Publishing date 2024-01-26
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2023.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Simplified risk stratification based on cardiopulmonary exercise test: A Spanish two-center experience.

    Martínez-Meñaca, Amaya / Cruz-Utrilla, Alejandro / Mora-Cuesta, Víctor Manuel / Luna-López, Raquel / Segura-de la Cal, Teresa / Flox-Camacho, Ángela / Alonso-Lecue, Pilar / Escribano-Subias, Pilar / Cifrián-Martínez, José Manuel

    Pulmonary circulation

    2024  Volume 14, Issue 1, Page(s) e12342

    Abstract: A simplified 4-strata risk stratification approach based on three variables is widespread in pulmonary arterial hypertension (PAH) at follow-up. This study aimed to assess the impact of replacing the 6-min walk test (6MWT) with the peak ... ...

    Abstract A simplified 4-strata risk stratification approach based on three variables is widespread in pulmonary arterial hypertension (PAH) at follow-up. This study aimed to assess the impact of replacing the 6-min walk test (6MWT) with the peak 0
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12342
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  7. Article ; Online: Novel Molecular Mechanisms Involved in the Medical Treatment of Pulmonary Arterial Hypertension.

    Martin de Miguel, Irene / Cruz-Utrilla, Alejandro / Oliver, Eduardo / Escribano-Subias, Pilar

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Pulmonary arterial hypertension (PAH) is a severe condition with a high mortality rate despite advances in diagnostic and therapeutic strategies. In recent years, significant scientific progress has been made in the understanding of the underlying ... ...

    Abstract Pulmonary arterial hypertension (PAH) is a severe condition with a high mortality rate despite advances in diagnostic and therapeutic strategies. In recent years, significant scientific progress has been made in the understanding of the underlying pathobiological mechanisms. Since current available treatments mainly target pulmonary vasodilation, but lack an effect on the pathological changes that develop in the pulmonary vasculature, there is need to develop novel therapeutic compounds aimed at antagonizing the pulmonary vascular remodeling. This review presents the main molecular mechanisms involved in the pathobiology of PAH, discusses the new molecular compounds currently being developed for the medical treatment of PAH and assesses their potential future role in the therapeutic algorithms of PAH.
    MeSH term(s) Humans ; Pulmonary Arterial Hypertension ; Hypertension, Pulmonary/drug therapy ; Familial Primary Pulmonary Hypertension ; Lung/pathology ; Pulmonary Artery/pathology ; Vascular Remodeling
    Language English
    Publishing date 2023-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24044147
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  8. Article ; Online: Real-World Management of Patients with Pulmonary Arterial Hypertension: Insights from EXPOSURE.

    Muller, Audrey / Escribano-Subias, Pilar / Fernandes, Catarina C / Fontana, Martina / Lange, Tobias J / Söderberg, Stefan / Gaine, Sean

    Advances in therapy

    2024  Volume 41, Issue 3, Page(s) 1103–1119

    Abstract: Introduction: Further insights into real-world management and outcomes of patients with pulmonary arterial hypertension (PAH) are needed. This interim analysis of the ongoing, multicentre, prospective EXPOSURE (EUPAS19085) observational study describes ... ...

    Abstract Introduction: Further insights into real-world management and outcomes of patients with pulmonary arterial hypertension (PAH) are needed. This interim analysis of the ongoing, multicentre, prospective EXPOSURE (EUPAS19085) observational study describes characteristics, treatment patterns and outcomes of patients with PAH initiating a new PAH-specific therapy in Europe/Canada.
    Methods and results: All analyses were descriptive. In total, 1944 patients with follow-up information were included; the majority were female, with World Health Organization functional class II/III symptoms and with idiopathic PAH or connective tissue disease-associated PAH. Most incident patients (N = 1100; diagnosed for ≤ 6 months) initiated treatment as monotherapy (48%) or double therapy (43%). Of those initiating monotherapy, 38% (199/530) escalated to double therapy (median [Q1, Q3] time to escalation 3.4 [1.9, 6.6] months), and of those initiating double therapy, 17% (78/457) escalated to triple therapy (median [Q1, Q3] time to escalation 7.0 [3.4, 12.7] months) during the observation period (median [Q1, Q3]: 17.0 [7.5, 29.9] months). The majority of the 834 prevalent patients (diagnosed > 6 months) entered the study on initiation of combination therapy and most did not change treatment regimen during the observation period (median [Q1, Q3]: 19.6 [10.2, 32.2] months). One-year survival was 88% for incident patients and 90% for prevalent patients.
    Conclusions: Results from EXPOSURE suggest a shift towards combination therapy and the alignment of real-world treatment patterns with current guideline recommendations. While survival estimates are encouraging, the extent of monotherapy use at treatment initiation and follow-up highlight an opportunity for further improvements through optimisation of treatment strategies in line with current guidelines. A graphical abstract is also available with this article.
    Trial registration number: EUPAS19085.
    MeSH term(s) Humans ; Male ; Female ; Pulmonary Arterial Hypertension/drug therapy ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/diagnosis ; Prospective Studies ; Retrospective Studies ; Familial Primary Pulmonary Hypertension
    Language English
    Publishing date 2024-01-13
    Publishing country United States
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-023-02730-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Risk Stratification in Pulmonary Veno-Occlusive Disease.

    Cruz-Utrilla, Alejandro / Pérez-Olivares, Carmen / Luna-López, Raquel / Jiménez López-Guarch, Carmen / Bedate, Pedro / Martínez Meñaca, Amaya / López Meseguer, Manuel / Escribano-Subias, Pilar

    Archivos de bronconeumologia

    2024  

    Language Spanish
    Publishing date 2024-02-24
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2024.02.011
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  10. Article ; Online: Giant pulmonary artery aneurysm in pulmonary arterial hypertension.

    Caravaca Perez, Pedro / Aurtenetxe Perez, Agueda / Escribano Subias, Pilar

    Archivos de bronconeumologia

    2021  Volume 57, Issue 8, Page(s) 541

    MeSH term(s) Aneurysm/complications ; Aneurysm/diagnostic imaging ; Humans ; Pulmonary Arterial Hypertension ; Pulmonary Artery/diagnostic imaging ; Pulmonary Circulation
    Language English
    Publishing date 2021-06-03
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbr.2021.05.014
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