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Article ; Online: Nihil novi sub sole.

Wołyniec, Wojciech / Ratkowski, Wojciech

Revista da Associacao Medica Brasileira (1992)

2018 Volume 64, Issue 1, Page(s) 9

Language	English
Publishing date	2018
Publishing country	Brazil
Document type	Letter ; Comment
ZDB-ID	2027973-5
ISSN	1806-9282 ; 0104-4230
ISSN (online)	1806-9282
ISSN	0104-4230
DOI	10.1590/1806-9282.64.01.9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Co‑occurrence of granulomatosis with polyangiitis and a lung carcinoid tumor.

Kosko, Fabian / Dębska-Ślizień, Alicja / Skonieczny, Piotr / Wołyniec, Wojciech / Lizakowski, Sławomir / Heleniak, Zbigniew

Polish archives of internal medicine

2023 Volume 133, Issue 11

MeSH term(s)	Humans ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Lung Neoplasms/diagnosis ; Lung Neoplasms/diagnostic imaging ; Lung/pathology ; Carcinoid Tumor/complications ; Carcinoid Tumor/diagnostic imaging ; Carcinoid Tumor/surgery
Language	English
Publishing date	2023-10-10
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16582
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Article ; Online: In Response to Estimating Creatinine in Ultramarathon Runners by Little et al.

Wołyniec, Wojciech / Marcin, Renke / Ratkowski, Wojciech

Wilderness & environmental medicine

2019 Volume 30, Issue 4, Page(s) 468–469

MeSH term(s)	Creatinine ; Physical Endurance ; Running
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2019-08-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1238909-2
ISSN	1545-1534 ; 1080-6032
ISSN (online)	1545-1534
ISSN	1080-6032
DOI	10.1016/j.wem.2019.05.009
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Article ; Online: Changes in Novel AKI Biomarkers after Exercise. A Systematic Review.

Wołyniec, Wojciech / Ratkowski, Wojciech / Renke, Joanna / Renke, Marcin

International journal of molecular sciences

2020 Volume 21, Issue 16

Abstract: More than 100 substances have been identified as biomarkers of acute kidney injury. These markers can help to diagnose acute kidney injury (AKI) in its early phase, when the creatinine level is not increased. The two markers most frequently studied in ... ...

Abstract	More than 100 substances have been identified as biomarkers of acute kidney injury. These markers can help to diagnose acute kidney injury (AKI) in its early phase, when the creatinine level is not increased. The two markers most frequently studied in plasma and serum are cystatin C and neutrophil gelatinase-associated lipocalin (NGAL). The former is a marker of kidney function and the latter is a marker of kidney damage. Some other promising serum markers, such as osteopontin and netrin-1, have also been proposed and studied. The list of promising urinary markers is much longer and includes cystatin C, NGAL, kidney injury molecule-1 (KIM-1), liver-type fatty-acid-binding protein (L-FABP), interleukin 18, insulin-like growth factor binding protein 7 (IGFBP-7), tissue inhibitor of metalloproteinases-2 (TIMP-2) and many others. Although these markers are increased in urine for no longer than a few hours after nephrotoxic agent action, they are not widely used in clinical practice. Only combined IGFBP-7/TIMP-2 measurement was approved in some countries as a marker of AKI. Several studies have shown that the levels of urinary AKI biomarkers are increased after physical exercise. This systematic review focuses on studies concerning changes in new AKI biomarkers in healthy adults after single exercise. Twenty-seven papers were identified and analyzed in this review. The interpretation of results from different studies was difficult because of the variety of study groups, designs and methodology. The most convincing data concern cystatin C. There is evidence that cystatin C is a better indicator of glomerular filtration rate (GFR) in athletes after exercise than creatinine and also at rest in athletes with a lean mass lower or higher than average. Serum and plasma NGAL are increased after prolonged exercise, but the level also depends on inflammation and hypoxia; therefore, it seems that in physical exercise, it is too sensitive for AKI diagnosis. It may, however, help to diagnose subclinical kidney injury, e.g., in rhabdomyolysis. Urinary biomarkers are increased after many types of exercise. Increases in NGAL, KIM-1, cystatin-C, L-FABP and interleukin 18 are common, but the levels of most urinary AKI biomarkers decrease rapidly after exercise. The importance of this short-term increase in AKI biomarkers after exercise is doubtful. It is not clear if it is a sign of mild kidney injury or physiological metabolic adaptation to exercise.
MeSH term(s)	Acute Kidney Injury/blood ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/urine ; Biomarkers/blood ; Biomarkers/urine ; Exercise/physiology ; Glomerular Filtration Rate ; Humans
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-08-07
Publishing country	Switzerland
Document type	Journal Article ; Systematic Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21165673
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Article ; Online: Changes in Novel AKI Biomarkers after Exercise. A Systematic Review

Wojciech Wołyniec / Wojciech Ratkowski / Joanna Renke / Marcin Renke

International Journal of Molecular Sciences, Vol 21, Iss 5673, p

2020 Volume 5673

Abstract	More than 100 substances have been identified as biomarkers of acute kidney injury. These markers can help to diagnose acute kidney injury (AKI) in its early phase, when the creatinine level is not increased. The two markers most frequently studied in plasma and serum are cystatin C and neutrophil gelatinase-associated lipocalin (NGAL). The former is a marker of kidney function and the latter is a marker of kidney damage. Some other promising serum markers, such as osteopontin and netrin-1, have also been proposed and studied. The list of promising urinary markers is much longer and includes cystatin C, NGAL, kidney injury molecule-1 (KIM-1), liver-type fatty-acid-binding protein (L-FABP), interleukin 18, insulin-like growth factor binding protein 7 (IGFBP-7), tissue inhibitor of metalloproteinases-2 (TIMP-2) and many others. Although these markers are increased in urine for no longer than a few hours after nephrotoxic agent action, they are not widely used in clinical practice. Only combined IGFBP-7/TIMP-2 measurement was approved in some countries as a marker of AKI. Several studies have shown that the levels of urinary AKI biomarkers are increased after physical exercise. This systematic review focuses on studies concerning changes in new AKI biomarkers in healthy adults after single exercise. Twenty-seven papers were identified and analyzed in this review. The interpretation of results from different studies was difficult because of the variety of study groups, designs and methodology. The most convincing data concern cystatin C. There is evidence that cystatin C is a better indicator of glomerular filtration rate (GFR) in athletes after exercise than creatinine and also at rest in athletes with a lean mass lower or higher than average. Serum and plasma NGAL are increased after prolonged exercise, but the level also depends on inflammation and hypoxia; therefore, it seems that in physical exercise, it is too sensitive for AKI diagnosis. It may, however, help to diagnose subclinical kidney injury, e.g., in ...
Keywords	urinary biomarkers ; markers of AKI ; cystatin-C ; NGAL ; KIM-1 ; exercise ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	796
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Telemedical Maritime Assistance Service at the University Center of Maritime and Tropical Medicine in Gdynia. The analysis of 6 years of activity.

Szafran-Dobrowolska, Joanna / Renke, Marcin / Wołyniec, Wojciech

Medycyna pracy

2020 Volume 71, Issue 2, Page(s) 121–125

Abstract: Background: In the 1960s, the International Labour Organization passed a convention under which all countries with national shipping were obliged to create a 24-h telemedicine center for ships. In accordance with the convention, Telemedical Assistance ... ...

Abstract	Background: In the 1960s, the International Labour Organization passed a convention under which all countries with national shipping were obliged to create a 24-h telemedicine center for ships. In accordance with the convention, Telemedical Assistance Service centers were to provide permanent access to medical advice given by qualified doctors and to create an international platform for the exchange of information and experience. In Poland, the Telemedical Maritime Assistance Service (TMAS) was established in 2012, and its duties in a 24-h system are carried out by doctors from the University Center of Maritime and Tropical Medicine (UCMTM) in Gdynia. The aim of this work was to determine the reasons for medical officers reporting for help from the TMAS doctor on duty and to create a database of the most common diagnoses and actions undertaken, and in particular evacuation. Material and methods: In the presented work, the authors analyzed TMAS telephony and e-mail advice provided by doctors of the UCMTM in Gdynia, in the period from October 2012 to the end of 2018. Results: In the 6-year period, UCMTM doctors provided TMAS advice 225 times, recommending evacuation in over 20% of these cases. Infectious diseases were the most common cause of contact in the entire period under analysis - 61 cases were recorded, accounting for as many as 27% of all applications. Injuries were the second most frequent reason for seeking help from TMAS, and 20% of TMAS applications (44 cases) were related to trauma. Conclusions: The obtained data show that TMAS doctors face various medical problems; therefore, providing proper medical assistance to patients requires a close multidisciplinary cooperation between medical officers, TMAS doctors and emergency services. Med Pr. 2020;71(2):121-5.
MeSH term(s)	Humans ; Occupational Diseases/epidemiology ; Occupational Health ; Poland ; Ships ; Telemedicine ; Tropical Medicine
Language	English
Publishing date	2020-01-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	128739-4
ISSN	2353-1339 ; 0465-5893
ISSN (online)	2353-1339
ISSN	0465-5893
DOI	10.13075/mp.5893.00897
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Article ; Online: Nefropatia mezoamerykańska – nowe wyzwanie dla lekarzy medycyny pracy.

Kanclerz, Katarzyna / Wołyniec, Wojciech / Rutkowski, Przemysław / Renke, Marcin

Medycyna pracy

2020 Volume 71, Issue 3, Page(s) 353–361

Abstract: Mesoamerican nephropathy (MeN) is an endemic form of chronic kidney disease (CKD) that is not related to risk factors for CKD, such as diabetes and hypertension. It primarily affects men, rural and agricultural laborers, who work in an extremely hot and ... ...

Title translation	Mesoamerican nephropathy - a new challenge for occupational physicians.
Abstract	Mesoamerican nephropathy (MeN) is an endemic form of chronic kidney disease (CKD) that is not related to risk factors for CKD, such as diabetes and hypertension. It primarily affects men, rural and agricultural laborers, who work in an extremely hot and dry environment. The greatest increase in the prevalence of CKD, particularly since the late 1990s, has been reported in Central America and Southern Mexico, where the prevalence is almost 9 times higher than in the USA. The highest mortality associated with CKD is reported in El Salvador where a 10-fold increase was recorded in 1984-2005. In histological examination, MeN patients manifest tubulointerstitial lesions and, in some cases, also lesions in the glomeruli. The cause of MeN remains unclear. Repeated episodes of occupational heat stress, and sweating accompanied by water loss, have a significant impact on the disease development. The disease is a significant social and economic problem, and a challenge in the field of diagnostics, therapy and prevention for physicians of many specialties, especially for occupational physicians. Med Pr. 2020;71(3):353-61.
MeSH term(s)	Adult ; Central America/epidemiology ; Comorbidity ; Female ; Heat Stress Disorders/classification ; Heat Stress Disorders/epidemiology ; Humans ; Kidney/physiopathology ; Male ; Occupational Exposure/adverse effects ; Prevalence ; Renal Insufficiency, Chronic/classification ; Renal Insufficiency, Chronic/epidemiology ; Rural Population/statistics & numerical data ; Terminology as Topic
Language	Polish
Publishing date	2020-04-03
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	128739-4
ISSN	2353-1339 ; 0465-5893
ISSN (online)	2353-1339
ISSN	0465-5893
DOI	10.13075/mp.5893.00889
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Article: Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise.

Wołyniec, Wojciech / Szwarc, Andrzej / Kasprowicz, Katarzyna / Zorena, Katarzyna / Jaskulak, Marta / Renke, Marcin / Naczyk, Marta / Ratkowski, Wojciech

Frontiers in physiology

2022 Volume 13, Page(s) 841056

Abstract: The proper fluid and carbohydrates intake is essential before and during physical exercise, and for this reason most athletes drink beverages containing a high amount of free sugars. Sweetened soft drinks are also commonly consumed by those not doing any ...

Abstract	The proper fluid and carbohydrates intake is essential before and during physical exercise, and for this reason most athletes drink beverages containing a high amount of free sugars. Sweetened soft drinks are also commonly consumed by those not doing any sport, and this habit seems to be both unhealthy and also the cause of metabolic problems. Recently, several sweeteners have been proposed to replace sugars in popular beverages. To examine the impact of free sugars and the popular sweetener xylitol on metabolic profile and the markers of kidney function and injury after exercise the present study was conducted with semi-professional football players. All participants were healthy, with a mean age of 21.91 years. Their sports skills were on the level of the 4th-5th division of the league. The subjects took part in four football training sessions. During each session they drank a 7% solution of sugar (sucrose, fructose, glucose) or xylitol. The tolerability of these beverages and well-being during exercise was monitored. Before and after each training session, blood and urine were collected. The markers of kidney function and injury, uric acid, electrolytes, complete blood count, CRP, serum albumin, serum glucose and the lipid profile were analyzed. The main finding of this study was that the xylitol beverage is the least tolerated during exercise and 38.89% of participants experienced diarrhea after training and xylitol intake. Xylitol also led to unfavorable metabolic changes and a large increase in uric acid and creatinine levels. A mean increase of 1.8 mg/dl in the uric acid level was observed after xylitol intake. Increases in acute kidney injury markers were observed after all experiments, but changes in urine albumin and cystatin C were highest after xylitol. The other three beverages (containing "free sugars" - glucose, fructose and sucrose) had a similar impact on the variables studied, although the glucose solution seems to have some advantages over other beverages. The conclusion is that sweeteners are not a good alternative to sugars, especially during exercise. Pure water without sweeteners should be drunk by those who need to limit their calorie consumption.
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.841056
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Article ; Online: Telemedical Maritime Assistance Service at the University Center of Maritime and Tropical Medicine in Gdynia. The analysis of 6 years of activity

Joanna Szafran-Dobrowolska / Marcin Renke / Wojciech Wołyniec

Medycyna Pracy, Vol 71, Iss 2, Pp 121-

2020 Volume 125

Abstract: Background In the 1960s, the International Labour Organization passed a convention under which all countries with national shipping were obliged to create a 24-h telemedicine center for ships. In accordance with the convention, Telemedical Assistance ... ...

Abstract	Background In the 1960s, the International Labour Organization passed a convention under which all countries with national shipping were obliged to create a 24-h telemedicine center for ships. In accordance with the convention, Telemedical Assistance Service centers were to provide permanent access to medical advice given by qualified doctors and to create an international platform for the exchange of information and experience. In Poland, the Telemedical Maritime Assistance Service (TMAS) was established in 2012, and its duties in a 24-h system are carried out by doctors from the University Center of Maritime and Tropical Medicine (UCMTM) in Gdynia. The aim of this work was to determine the reasons for medical officers reporting for help from the TMAS doctor on duty and to create a database of the most common diagnoses and actions undertaken, and in particular evacuation. Material and Methods In the presented work, the authors analyzed TMAS telephony and e-mail advice provided by doctors of the UCMTM in Gdynia, in the period from October 2012 to the end of 2018. Results In the 6-year period, UCMTM doctors provided TMAS advice 225 times, recommending evacuation in over 20% of these cases. Infectious diseases were the most common cause of contact in the entire period under analysis – 61 cases were recorded, accounting for as many as 27% of all applications. Injuries were the second most frequent reason for seeking help from TMAS, and 20% of TMAS applications (44 cases) were related to trauma. Conclusions The obtained data show that TMAS doctors face various medical problems; therefore, providing proper medical assistance to patients requires a close multidisciplinary cooperation between medical officers, TMAS doctors and emergency services. Med Pr. 2020;71(2):121–5
Keywords	occupational exposure ; telemedicine ; emergency responders ; naval medicine ; ships ; maritime rescue system ; Public aspects of medicine ; RA1-1270
Subject code	600
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Nofer Institute of Occupational Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mesoamerican nephropathy – a new challenge for occupational physicians

Katarzyna Kanclerz / Wojciech Wołyniec / Przemysław Rutkowski / Marcin Renke

Medycyna Pracy, Vol 71, Iss 3, Pp 353-

2020 Volume 361

Abstract	Mesoamerican nephropathy (MeN) is an endemic form of chronic kidney disease (CKD) that is not related to risk factors for CKD, such as diabetes and hypertension. It primarily affects men, rural and agricultural laborers, who work in an extremely hot and dry environment. The greatest increase in the prevalence of CKD, particularly since the late 1990s, has been reported in Central America and Southern Mexico, where the prevalence is almost 9 times higher than in the USA. The highest mortality associated with CKD is reported in El Salvador where a 10-fold increase was recorded in 1984–2005. In histological examination, MeN patients manifest tubulointerstitial lesions and, in some cases, also lesions in the glomeruli. The cause of MeN remains unclear. Repeated episodes of occupational heat stress, and sweating accompanied by water loss, have a significant impact on the disease development. The disease is a significant social and economic problem, and a challenge in the field of diagnostics, therapy and prevention for physicians of many specialties, especially for occupational physicians. Med Pr. 2020;71(3):353–61
Keywords	mesoamerican nephropathy ; endemic nephropathy ; chronic kidney disease ; evaluation of fitness for work ; albuminuria ; preventive care over employees ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Nofer Institute of Occupational Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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