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Article ; Online: Experiences and Perceptions of Nuclear Medicine Technologists in the Assessment of Myocardial Perfusion Image Quality.

Chipeya, Lucky R / van Rensburg, Madri Jansen / Vangu, Mboyo-Di-Tamba

2021 Volume 49, Issue 3, Page(s) 226–231

Abstract: Nuclear medicine technologists (NMTs) are experts in the acquisition of myocardial perfusion (MP) images, in addition to the many other types of images acquired in nuclear medicine departments. NMTs are expected to ensure that images are of optimal ... ...

Abstract	Nuclear medicine technologists (NMTs) are experts in the acquisition of myocardial perfusion (MP) images, in addition to the many other types of images acquired in nuclear medicine departments. NMTs are expected to ensure that images are of optimal quality in order to facilitate accurate interpretation by nuclear medicine physicians (NMPs). However, ensuring optimal image quality is a shared responsibility between NMTs and NMPs. The shared responsibilities have resulted in inconsistences in the assessment of MP image quality among NMTs in different departments. Little is known about the perceptions and experiences of NMTs on the assessment of MP image quality. Therefore, the focus of this research study was NMTs. The aim of this qualitative study was to explore and describe the perceptions and experiences of NMTs on the assessment of MP image quality. The research question was, "How do NMTs perform the responsibility of ensuring MP image quality?"
MeSH term(s)	Nuclear Medicine ; Perception ; Perfusion ; Surveys and Questionnaires
Language	English
Publishing date	2021-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	189163-7
ISSN	1535-5675 ; 0091-4916
ISSN (online)	1535-5675
ISSN	0091-4916
DOI	10.2967/jnmt.120.255125
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Article ; Online: Subjective Sleep Patterns and Jet Lag Symptoms of Junior Netball Players Prior to and During an International Tournament: A Case Study.

Lever, Jonathon R / Janse van Rensburg, Dina C / Jansen van Rensburg, Audrey / Fowler, Peter / Fullagar, Hugh H K

International journal of sports physiology and performance

2021 Volume 17, Issue 1, Page(s) 137–141

Abstract: Purpose: To assess the impact of long-haul transmeridian travel on subjective sleep patterns and jet lag symptoms in youth athletes around an international tournament.: Methods: An observational descriptive design was used. Subjective sleep diaries ... ...

Abstract	Purpose: To assess the impact of long-haul transmeridian travel on subjective sleep patterns and jet lag symptoms in youth athletes around an international tournament. Methods: An observational descriptive design was used. Subjective sleep diaries and perceived responses to jet lag were collected and analyzed for a national junior netball team competing in an international tournament. Sleep diaries and questionnaires were completed daily prior to and during travel, and throughout the tournament. Results were categorized into pretravel, travel, training, and match nights. Means were compared performing a paired Student t test with significance set at P < .05. Data are presented as mean (SD) and median (minimum, maximum). Results: Athletes reported significantly greater time in bed on match days compared with training (P < .001) and travel (P = .002) days, and on pretravel days compared with travel (P < .001) and training (P = .028) days. Sleep ratings were significantly better on pretravel days compared with match (P = .013) days. Perceived jet lag was worse on match (P = .043) days compared with pretravel days. Significant differences were also observed between a number of conditions for meals, mood, bowel activity, and fatigue. Conclusion: Youth athletes experience significantly less opportunity for sleep during long-haul transmeridian travel and face disruptions to daily routines during travel which impact food intake. Young athletes also experience disturbed sleep prior to and during competition. These results highlight the need for practices to alleviate jet lag symptoms and improve the sleep of young athletes traveling for tournaments in an effort to optimize recovery and performance.
MeSH term(s)	Adolescent ; Athletes ; Athletic Performance ; Basketball ; Humans ; Jet Lag Syndrome ; Sleep ; Travel
Language	English
Publishing date	2021-09-24
Publishing country	United States
Document type	Journal Article ; Observational Study
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2021-0093
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ivermectin for COVID-19: Promising but not yet conclusive.

Van Rensburg, R / Decloedt, E H / Reuter, H / Parker, A / Schrueder, N / Lahri, S

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

2021 Volume 111, Issue 3, Page(s) 13187

MeSH term(s)	COVID-19 ; Humans ; Ivermectin ; Pharmaceutical Preparations ; SARS-CoV-2 ; South Africa
Chemical Substances	Pharmaceutical Preparations ; Ivermectin (70288-86-7)
Language	English
Publishing date	2021-01-12
Publishing country	South Africa
Document type	Letter ; Comment
ZDB-ID	390968-2
ISSN	2078-5135 ; 0038-2469 ; 0256-9574
ISSN (online)	2078-5135
ISSN	0038-2469 ; 0256-9574
DOI	10.7196/SAMJ.2021.v111i3.15522
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Article: The Effect of α-Monolaurin and Butyrate Supplementation on Broiler Performance and Gut Health in the Absence and Presence of the Antibiotic Growth Promoter Zinc Bacitracin.

Letlole, Bakang R / Damen, Ellen P C W / Jansen van Rensburg, Christine

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 6

Abstract: The use of antibiotic growth promoters (AGP) is common practice to improve broiler production and performance. The use of AGP is under discussion as it can induce bacterial resistance. The purpose of this study was to determine the impact of removing AGP ...

Abstract	The use of antibiotic growth promoters (AGP) is common practice to improve broiler production and performance. The use of AGP is under discussion as it can induce bacterial resistance. The purpose of this study was to determine the impact of removing AGP from broiler feed and study the effect of feed additives. For those countries where in-feed AGP are still permitted, the effect of the products in the presence of AGP was evaluated. Half the number of male broilers received a diet free of AGP, whereas the other half received a diet supplemented with zinc bacitracin at 0.5 g/kg. Both diets were either without additional additives or combined with a coated sodium butyrate, α-monolaurin or a combination of these additives. Raised under optimal conditions, the incorporation of AGP had no effect on broiler performance, but negatively affected villi height and villi height to crypt depth (VH:CD) ratio in the duodenum. In the absence of AGP, butyric acid and α-monolaurin had a positive effect on villi height. In the presence of AGP, α-monolaurin resulted in the lowest feed conversion ratio and improved VH:CD ratio in the duodenum, jejunum and ileum. Both feed additives had minimal effect on performance parameters but showed small positive effects on gut health in the absence of AGP and could play a role in the strategy to replace AGP.
Language	English
Publishing date	2021-05-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10060651
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Article ; Online: An overview of analgesics - anticonvulsants, antidepressants, and other medications (Part 3)

R. van Rensburg / H. Reuter

South African Family Practice, Vol 61, Iss 3, Pp 59-

2019 Volume 63

Abstract: Pain is classified by various descriptions. Chronic pain has been described as being neuropathic (due to nervous system lesions), nociceptive (due to tissue damage), or mixed (a combination of neuropathic and nociceptive). The addition of the term ... ...

Abstract	Pain is classified by various descriptions. Chronic pain has been described as being neuropathic (due to nervous system lesions), nociceptive (due to tissue damage), or mixed (a combination of neuropathic and nociceptive). The addition of the term nociplastic pain is used to describe patients who experience chronic pain without tissue damage or nervous system lesions. Chronic pain is often difficult to manage, particularly neuropathic pain. Evidence-based pharmacological treatment options include anticonvulsants and antidepressants. The choice of medication will depend on various factors, including patient profile, type of pain, and associated conditions. Medications with the best evidence of efficacy for first-line use in neuropathic pain are the gabapentinoids, carbamazepine, the tricyclic antidepressants, and the serotonin-noradrenaline reuptake inhibitors duloxetine and venlafaxine. The cannabinoids and ketamine are being actively investigated for use in chronic pain. Currently the cannabinoids’ potential benefit is outweighed by the adverse effects, and recommendations for the use of ketamine is limited by its parenteral route of administration and low evidence of efficacy in chronic pain.
Keywords	neuropathic pain ; anticonvulsants ; antidepressants ; evidence-based ; cannabinoids ; Medicine ; R
Subject code	616
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An overview of analgesics

R. Van Rensburg / H. Reuter

South African Family Practice, Vol 61, Iss

NSAIDs, paracetamol, and topical analgesics

2019 Volume 1

Abstract: Pain is a complex and unique experience. It encompasses several pathways, involving nociceptive signal generation (transduction) and propagation (transmission), as well as perception and modulation of the nociceptive stimuli. Nonsteroidal anti- ... ...

Abstract	Pain is a complex and unique experience. It encompasses several pathways, involving nociceptive signal generation (transduction) and propagation (transmission), as well as perception and modulation of the nociceptive stimuli. Nonsteroidal anti-inflammatory drugs (NSAIDs) primarily exert their analgesic effects through inhibition of cyclooxygenase (COX) enzymes, thereby attenuating prostaglandin synthesis. The COX-2 selective NSAIDs (coxibs) and aspirin have also been shown to reduce colorectal cancers, presumably by prostaglandin-inhibition mechanisms. Paracetamol appears to have both peripheral and central effects. The postulated mechanism for its peripheral effects is indirect COX inhibition, while the central effects are thought to be mediated by modulation of descending pain inhibition pathways. Topical analgesics are available in various formulations. The topical NSAIDs have the same mechanism of action as the systemic formulations, but with less systemic absorption and effects. The local anaesthetics provide a dense sensory block via inhibition of nerve impulse transmission, and are available in percutaneous and transdermal preparations. Capsicum is effective for neuropathic pain, and acts by stimulating and then desensitising peripheral sensory nerves.
Keywords	pain ; nociception ; nsaids ; paracetamol ; topical analgesia ; Medicine ; R
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Current evidence for directed and supportive investigational therapies against COVID-19.

van Rensburg, R / Pillay-Fuentes Lorente, V / Decloedt, E H

African journal of thoracic and critical care medicine

2020 Volume 26, Issue 2

Abstract: Coronavirus disease 2019 (COVID-19) is a global health crisis. There is currently a great need for effective and safe therapies directed at the disease, but no drugs are presently registered for use in COVID-19. Several directed therapies have been ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is a global health crisis. There is currently a great need for effective and safe therapies directed at the disease, but no drugs are presently registered for use in COVID-19. Several directed therapies have been proposed, and most are still in clinical trials. Currently available published, peer-reviewed results mostly involve small sample sizes with study limitations restricting the interpretation of the findings. Many trials currently published also do not have a control group, limiting the interpretation of the effect of the intervention. Investigational directed therapies as well as investigational supportive therapies against COVID-19 are reviewed here. Chloroquine and hydroxychloroquine show promise as directed therapies, but current trial results are conflicting. Lopinavir/ritonavir also shows potential, but was started late in the disease course in most trials. No randomised controlled evidence is currently available for remdesivir and favipiravir. Corticosteroid use is not recommended for directed therapy against COVID-19, and the role of tocilizumab is currently unclear, based on limited evidence. Early initiation of investigational directed therapies may provide benefit in selected patients. The results from larger randomised controlled trials will clarify the place of these therapies in COVID-19 treatment.
Language	English
Publishing date	2020-04-30
Publishing country	South Africa
Document type	Journal Article ; Review
ZDB-ID	2945902-3
ISSN	2617-0205 ; 2617-0191
ISSN (online)	2617-0205
ISSN	2617-0191
DOI	10.7196/AJTCCM.2020.v26i2.072
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Article ; Online: An overview of analgesics

R. van Rensburg / H. Reuter

South African Family Practice, Vol 61, Iss 2, Pp 16-

opioids, tramadol, and tapentadol (Part 2)

2019 Volume 23

Abstract: Pain can be caused by several mechanisms, and the development of chronic pain (also known as pain chronification) is a complex and often unpredictable process. Opioids, tramadol, and tapentadol provide pharmacological solutions to chronic pain of cancer ... ...

Abstract	Pain can be caused by several mechanisms, and the development of chronic pain (also known as pain chronification) is a complex and often unpredictable process. Opioids, tramadol, and tapentadol provide pharmacological solutions to chronic pain of cancer or non-cancer origins, particularly if central sensitization is present. It may also be indicated for short-term use in acute pain. Despite large studies and meta-analyses of opioids for a variety of pain conditions, the evidence for its clinical effectiveness is still unclear. This is, however, mostly due to significant heterogeneity and bias between studies assessed. The dual analgesic mechanisms of tramadol and tapentadol appear to be effective options for pain relief, with an overall lower incidence of opioid-related adverse effects. Tapentadol has an analgesic effect comparable to the strong opioids, which appears to be mediated by its greater mu opioid receptor activity and more selective noradrenaline reuptake inhibition. Tramadol produces less analgesia than tapentadol, but it is also associated with reduced opioid-related adverse effects and dependence. The opioids and tramadol may be significantly affected by polymorphisms of CYP2D6, while this effect is lessened with tapentadol.
Keywords	Medicine ; R
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Personal and occupational experiences of COVID-19 and their effects on South African health workers' wellbeing.

Curran, R / Bachmann, M / Van Rensburg, A J / Murdoch, J / Awotiwon, A / Ras, C-J / Petersen, I / Fairall, L

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

2021 Volume 111, Issue 7, Page(s) 607–608

MeSH term(s)	COVID-19/psychology ; Health Personnel/psychology ; Humans ; Middle Aged ; Occupational Health ; South Africa ; Surveys and Questionnaires
Language	English
Publishing date	2021-05-10
Publishing country	South Africa
Document type	Letter
ZDB-ID	390968-2
ISSN	2078-5135 ; 0038-2469 ; 0256-9574
ISSN (online)	2078-5135
ISSN	0038-2469 ; 0256-9574
DOI	10.7196/SAMJ.2021.v111i7.15733
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Article ; Online: A tailored phase I-specific patient-reported outcome (PRO) survey to capture the patient experience of symptomatic adverse events.

Janse van Rensburg, Helena J / Liu, Zhihui / Watson, Geoffrey A / Veitch, Zachary W / Shepshelovich, Daniel / Spreafico, Anna / Abdul Razak, Albiruni R / Bedard, Philippe L / Siu, Lillian L / Minasian, Lori / Hansen, Aaron R

British journal of cancer

2023 Volume 129, Issue 4, Page(s) 612–619

Abstract: Background: Patient perspectives are fundamental to defining tolerability of investigational anti-neoplastic therapies in clinical trials. Phase I trials present a unique challenge in designing tools for efficiently collecting patient-reported outcomes ( ...

Abstract	Background: Patient perspectives are fundamental to defining tolerability of investigational anti-neoplastic therapies in clinical trials. Phase I trials present a unique challenge in designing tools for efficiently collecting patient-reported outcomes (PROs) given the difficulty of anticipating adverse events of relevance. However, phase I trials also offer an opportunity for investigators to optimize drug dosing based on tolerability for future larger-scale trials and in eventual clinical practice. Existing tools for comprehensively capturing PROs are generally cumbersome and are not routinely used in phase I trials. Methods: Here, we describe the creation of a tailored survey based on the National Cancer Institute's PRO-CTCAE for collecting patients' perspectives on symptomatic adverse events in phase I trials in oncology. Results: We describe our stepwise approach to condensing the original 78-symptom library into a modified 30 term core list of symptoms which can be efficiently applied. We further show that our tailored survey aligns with phase I trialists' perspectives on symptoms of relevance. Conclusions: This tailored survey represents the first PRO tool developed specifically for assessing tolerability in the phase I oncology population. We provide recommendations for future work aimed at integrating this survey into clinical practice.
MeSH term(s)	Humans ; Antineoplastic Agents/adverse effects ; Medical Oncology ; Neoplasms/epidemiology ; Patient Reported Outcome Measures ; Surveys and Questionnaires ; Clinical Trials, Phase I as Topic
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-023-02307-w
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