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  1. Article ; Online: The H

    Schaper-Gerhardt, Katrin / Köther, Brigitta / Wolff, Luca / Kabatas, Aylin / Gehring, Manuela / Nikolouli, Eirini / Mommert, Susanne / Werfel, Thomas / Gutzmer, Ralf

    Allergy

    2020  Volume 76, Issue 4, Page(s) 1261–1264

    MeSH term(s) Eosinophils ; Humans ; Interleukin-4/genetics ; Receptors, G-Protein-Coupled ; Receptors, Histamine ; Receptors, Histamine H4
    Chemical Substances Receptors, G-Protein-Coupled ; Receptors, Histamine ; Receptors, Histamine H4 ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2020-10-07
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Martian dust storm impact on atmospheric H

    Vandaele, Ann Carine / Korablev, Oleg / Daerden, Frank / Aoki, Shohei / Thomas, Ian R / Altieri, Francesca / López-Valverde, Miguel / Villanueva, Geronimo / Liuzzi, Giuliano / Smith, Michael D / Erwin, Justin T / Trompet, Loïc / Fedorova, Anna A / Montmessin, Franck / Trokhimovskiy, Alexander / Belyaev, Denis A / Ignatiev, Nikolay I / Luginin, Mikhail / Olsen, Kevin S /
    Baggio, Lucio / Alday, Juan / Bertaux, Jean-Loup / Betsis, Daria / Bolsée, David / Clancy, R Todd / Cloutis, Edward / Depiesse, Cédric / Funke, Bernd / Garcia-Comas, Maia / Gérard, Jean-Claude / Giuranna, Marco / Gonzalez-Galindo, Francisco / Grigoriev, Alexey V / Ivanov, Yuriy S / Kaminski, Jacek / Karatekin, Ozgur / Lefèvre, Franck / Lewis, Stephen / López-Puertas, Manuel / Mahieux, Arnaud / Maslov, Igor / Mason, Jon / Mumma, Michael J / Neary, Lori / Neefs, Eddy / Patrakeev, Andrey / Patsaev, Dmitry / Ristic, Bojan / Robert, Séverine / Schmidt, Frédéric / Shakun, Alexey / Teanby, Nicholas A / Viscardy, Sébastien / Willame, Yannick / Whiteway, James / Wilquet, Valérie / Wolff, Michael J / Bellucci, Giancarlo / Patel, Manish R / López-Moreno, Jose-Juan / Forget, François / Wilson, Colin F / Svedhem, Håkan / Vago, Jorge L / Rodionov, Daniel

    Nature

    2019  Volume 568, Issue 7753, Page(s) 521–525

    Abstract: Global dust storms on Mars are ... ...

    Abstract Global dust storms on Mars are rare
    Language English
    Publishing date 2019-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-019-1097-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antibiotic Exposure Does Not Impact Immune Checkpoint Blockade Response in MSI-H/dMMR Metastatic Colorectal Cancer: A Single-Center Experience.

    Serpas Higbie, Victoria / Rogers, Jane / Hwang, Hyunsoo / Qiao, Wei / Xiao, Lianchun / Dasari, Arvind / Mola-Rudd, Kerri / Morris, Van K / Wolff, Robert A / Raghav, Kanwal / Huey, Ryan / Parseghian, Christine / Willis, Jason / Kopetz, Scott / Overman, Michael J / Johnson, Benny

    The oncologist

    2022  Volume 27, Issue 11, Page(s) 952–957

    Abstract: ... with microsatellite instability high (MSI-H)/deficient mismatch repair (dMMR) tumors. However, not all MSI-H/dMMR patients ... ICB may result in poorer outcomes. We aimed to evaluate this association in patients with MSI-H/dMMR ... patients with MSI-H/dMMR mCRC that received ICB was completed. Data collected included patient demographics ...

    Abstract Background: Immune checkpoint blockade (ICB) has improved outcomes for patients with microsatellite instability high (MSI-H)/deficient mismatch repair (dMMR) tumors. However, not all MSI-H/dMMR patients will exhibit the same ICB efficacy. Previous studies suggest that concomitant antibiotic use while receiving ICB may result in poorer outcomes. We aimed to evaluate this association in patients with MSI-H/dMMR metastatic colorectal cancer (mCRC).
    Materials and methods: A single-site, retrospective review of 57 patients with MSI-H/dMMR mCRC that received ICB was completed. Data collected included patient demographics, ICB information, and antibiotic use. Antibiotic exposure was considered from 90 days prior to ICB through 6 weeks after initiation. Primary endpoint was overall response rate (ORR).
    Results: The majority of patients received pembrolizumab (27 [47%]) or nivolumab (17 [30%]) monotherapy as their ICB agent. Of the 57 patients, 19 (33.3%) had antibiotic exposure from 90 days prior to ICB initiation through 6 weeks after initiation with most (13 [68%]) having antibiotic use in the 30 days preceding ICB initiation. Similar ORRs were seen in both groups (P-value > .99). No difference was observed in OS (P-value .29) or PFS (P-value .36) between groups.
    Conclusion: Our data show no association of lower response rates or survival in those MSI-H/dMMR patients with mCRC who receive antibiotics around the initiation of ICB. This information needs to be confirmed in a larger prospective cohort.
    MeSH term(s) Humans ; DNA Mismatch Repair ; Immune Checkpoint Inhibitors ; Prospective Studies ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Microsatellite Instability ; Colonic Neoplasms
    Chemical Substances Immune Checkpoint Inhibitors ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-08-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyac162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Publisher Correction: Martian dust storm impact on atmospheric H

    Vandaele, Ann Carine / Korablev, Oleg / Daerden, Frank / Aoki, Shohei / Thomas, Ian R / Altieri, Francesca / López-Valverde, Miguel / Villanueva, Geronimo / Liuzzi, Giuliano / Smith, Michael D / Erwin, Justin T / Trompet, Loïc / Fedorova, Anna A / Montmessin, Franck / Trokhimovskiy, Alexander / Belyaev, Denis A / Ignatiev, Nikolay I / Luginin, Mikhail / Olsen, Kevin S /
    Baggio, Lucio / Alday, Juan / Bertaux, Jean-Loup / Betsis, Daria / Bolsée, David / Clancy, R Todd / Cloutis, Edward / Depiesse, Cédric / Funke, Bernd / Garcia-Comas, Maia / Gérard, Jean-Claude / Giuranna, Marco / Gonzalez-Galindo, Francisco / Grigoriev, Alexey V / Ivanov, Yuriy S / Kaminski, Jacek / Karatekin, Ozgur / Lefèvre, Franck / Lewis, Stephen / López-Puertas, Manuel / Mahieux, Arnaud / Maslov, Igor / Mason, Jon / Mumma, Michael J / Neary, Lori / Neefs, Eddy / Patrakeev, Andrey / Patsaev, Dmitry / Ristic, Bojan / Robert, Séverine / Schmidt, Frédéric / Shakun, Alexey / Teanby, Nicholas A / Viscardy, Sébastien / Willame, Yannick / Whiteway, James / Wilquet, Valérie / Wolff, Michael J / Bellucci, Giancarlo / Patel, Manish R / López-Moreno, Jose-Juan / Forget, François / Wilson, Colin F / Young, Roland / Svedhem, Håkan / Vago, Jorge L / Rodionov, Daniel

    Nature

    2019  Volume 569, Issue 7754, Page(s) E1

    Abstract: The surname of author Cathy Quantin-Nataf was misspelled 'Quantin-Nata' , authors Ehouarn Millour and Roland Young were missing from the ACS Science Team list, and minor changes have been made to the author and affiliation lists; see accompanying ... ...

    Abstract The surname of author Cathy Quantin-Nataf was misspelled 'Quantin-Nata' , authors Ehouarn Millour and Roland Young were missing from the ACS Science Team list, and minor changes have been made to the author and affiliation lists; see accompanying Amendment. These errors have been corrected online.
    Language English
    Publishing date 2019-04-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-019-1163-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Application of ¹⁵N‑Edited ¹H–¹³C Correlation NMR Spectroscopy—Toward Fragment-Based Metabolite Identification and Screening via HCN Constructs

    Lysak, Daniel H. / Wolff, William W. / Soong, Ronald / Bermel, Wolfgang / Kupče, E̅riks / Jenne, Amy / Biswas, Rajshree Ghosh / Lane, Daniel / Gasmi-Seabrook, Genevieve / Simpson, Andre

    Analytical Chemistry. 2023 Aug. 03, v. 95, no. 32 p.11926-11933

    2023  

    Abstract: ... Simple multidimensional nuclear magnetic resonance (NMR) experiments that correlate ¹H and ¹⁵N via single ... However, a ¹H–¹⁵N correlation spectrum of a metabolite mixture can be difficult to deconvolute, due to the lack ... of a ¹⁵N specific database. In order to bridge this gap, we present here a broadband ¹⁵N-edited ¹H–¹³C HSQC ...

    Abstract Many key building blocks of life contain nitrogen moieties. Despite the prevalence of nitrogen-containing metabolites in nature, ¹⁵N nuclei are seldom used in NMR-based metabolite assignment due to their low natural abundance and lack of comprehensive chemical shift databases. However, with advancements in isotope labeling strategies, ¹³C and ¹⁵N enriched metabolites are becoming more common in metabolomic studies. Simple multidimensional nuclear magnetic resonance (NMR) experiments that correlate ¹H and ¹⁵N via single bond ¹ J NH or multiple bond ²–³ J NH couplings using heteronuclear single quantum coherence (HSQC) or heteronuclear multiple bond coherence are well established and routinely applied for structure elucidation. However, a ¹H–¹⁵N correlation spectrum of a metabolite mixture can be difficult to deconvolute, due to the lack of a ¹⁵N specific database. In order to bridge this gap, we present here a broadband ¹⁵N-edited ¹H–¹³C HSQC NMR experiment that targets metabolites containing ¹⁵N moieties. Through this approach, nitrogen-containing metabolites, such as amino acids, nucleotide bases, and nucleosides, are identified based on their ¹³C, ¹H, and ¹⁵N chemical shift information. This approach was tested and validated using a [¹⁵N, ¹³C] enriched Daphnia magna (water flea) metabolite extract, where the number of clearly resolved ¹⁵N-containing peaks increased from only 11 in a standard HSQC to 51 in the ¹⁵N-edited HSQC, and the number of obscured peaks decreased from 59 to just 7. The approach complements the current repertoire of NMR techniques for mixture deconvolution and holds considerable potential for targeted metabolite NMR in ¹⁵N, ¹³C enriched systems.
    Keywords Daphnia magna ; analytical chemistry ; databases ; isotopes ; metabolites ; metabolomics ; nitrogen ; nuclear magnetic resonance spectroscopy ; nucleosides ; quantum mechanics
    Language English
    Dates of publication 2023-0803
    Size p. 11926-11933.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c01362
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Higher 24-h Total Movement Activity Percentile Is Associated with Better Cognitive Performance in U.S. Older Adults.

    Dooley, Erin E / Palta, Priya / Wolff-Hughes, Dana L / Martinez-Amezcua, Pablo / Staudenmayer, John / Troiano, Richard P / Pettee Gabriel, Kelley

    Medicine and science in sports and exercise

    2022  Volume 54, Issue 8, Page(s) 1317–1325

    Abstract: Purpose: This study aimed to assess the association of a wrist-worn, device-based metric of 24-h ... Examination Survey (NHANES) cycles. A wrist-worn ActiGraph GT3X+ accelerometer captured total 24-h movement ... among those that perform total 24-h movement activity at or above the 50th percentile for their age and sex. Future studies ...

    Abstract Purpose: This study aimed to assess the association of a wrist-worn, device-based metric of 24-h movement with cognitive function and subjective cognitive complaints among older adults, 60 yr and older.
    Methods: This is a cross-sectional analysis of the 2011-2012 and 2013-2014 National Health and Nutrition Examination Survey (NHANES) cycles. A wrist-worn ActiGraph GT3X+ accelerometer captured total 24-h movement activity, analyzed as Monitor-Independent Movement Summary units (MIMS-units), and quantified into placement based on an age- and sex-standardized percentile. Cognitive tests in the domains of memory, language/verbal fluency, and executive performance were administered. Test-specific cognitive z -scores were generated. Subjective cognitive complaints included perceived difficulty remembering and confusion/memory loss.
    Results: The analytical sample included 2708 U.S. older adults (69.5 ± 0.2 yr, 55% female, 20.9% non-White). Multivariable linear regressions revealed those in quartiles 3 (50th-74th percentile) and 4 (≥75th percentile) for their age and sex had higher cognitive function z -scores across all domains compared with those in quartile 1. Logistic regressions demonstrated those in quartiles 3 and 4 also had lower odds of reporting difficulty remembering (adjusted odds ratio [AOR] = 0.52, 95% confidence interval [CI] = 0.31-0.89; AOR = 0.57, 95% CI = 0.37-0.88) and confusion/memory loss (AOR = 0.49, 95% CI = 0.27-0.91; AOR = 0.49, 95% CI = 0.27-0.98), respectively, compared with those in quartile 1.
    Conclusions: In a representative sample of U.S. older adults, higher cognitive functioning occurs among those that perform total 24-h movement activity at or above the 50th percentile for their age and sex. Future studies should consider movement behaviors across a 24-h period on cognitive health outcomes in older adults. More research exploring prospective associations of MIMS-units and time-use behaviors across midlife and older adulthood that may affect cognitive functioning across diverse populations is needed.
    MeSH term(s) Aged ; Cognition ; Cognition Disorders ; Cross-Sectional Studies ; Female ; Humans ; Male ; Memory Disorders ; Nutrition Surveys
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000002927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial.

    Olthuis, Susanne G H / Pirson, F Anne V / Pinckaers, Florentina M E / Hinsenveld, Wouter H / Nieboer, Daan / Ceulemans, Angelique / Knapen, Robrecht R M M / Robbe, M M Quirien / Berkhemer, Olvert A / van Walderveen, Marianne A A / Lycklama À Nijeholt, Geert J / Uyttenboogaart, Maarten / Schonewille, Wouter J / van der Sluijs, P Matthijs / Wolff, Lennard / van Voorst, Henk / Postma, Alida A / Roosendaal, Stefan D / van der Hoorn, Anouk /
    Emmer, Bart J / Krietemeijer, Menno G M / van Doormaal, Pieter-Jan / Roozenbeek, Bob / Goldhoorn, Robert-Jan B / Staals, Julie / de Ridder, Inger R / van der Leij, Christiaan / Coutinho, Jonathan M / van der Worp, H Bart / Lo, Rob T H / Bokkers, Reinoud P H / van Dijk, Ewoud I / Boogaarts, Hieronymus D / Wermer, Marieke J H / van Es, Adriaan C G M / van Tuijl, Julia H / Kortman, Hans G J / Gons, Rob A R / Yo, Lonneke S F / Vos, Jan-Albert / de Laat, Karlijn F / van Dijk, Lukas C / van den Wijngaard, Ido R / Hofmeijer, Jeannette / Martens, Jasper M / Brouwers, Paul J A M / Bulut, Tomas / Remmers, Michel J M / de Jong, Thijs E A M / den Hertog, Heleen M / van Hasselt, Boudewijn A A M / Rozeman, Anouk D / Elgersma, Otto E H / van der Veen, Bas / Sudiono, Davy R / Lingsma, Hester F / Roos, Yvo B W E M / Majoie, Charles B L M / van der Lugt, Aad / Dippel, Diederik W J / van Zwam, Wim H / van Oostenbrugge, Robert J

    Lancet (London, England)

    2023  Volume 401, Issue 10385, Page(s) 1371–1380

    Abstract: ... within a 6 h window. MR CLEAN-LATE aimed to assess efficacy and safety of endovascular treatment for patients ... treated in the late window (6-24 h from symptom onset or last seen well) selected on the basis ... by an anterior circulation large-vessel occlusion who presented 6-24 h from onset or last seen well, and who were ...

    Abstract Background: Endovascular treatment for anterior circulation ischaemic stroke is effective and safe within a 6 h window. MR CLEAN-LATE aimed to assess efficacy and safety of endovascular treatment for patients treated in the late window (6-24 h from symptom onset or last seen well) selected on the basis of the presence of collateral flow on CT angiography (CTA).
    Methods: MR CLEAN-LATE was a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial done in 18 stroke intervention centres in the Netherlands. Patients aged 18 years or older with ischaemic stroke, presenting in the late window with an anterior circulation large-vessel occlusion and collateral flow on CTA, and a neurological deficit score of at least 2 on the National Institutes of Health Stroke Scale were included. Patients who were eligible for late-window endovascular treatment were treated according to national guidelines (based on clinical and perfusion imaging criteria derived from the DAWN and DEFUSE-3 trials) and excluded from MR CLEAN-LATE enrolment. Patients were randomly assigned (1:1) to receive endovascular treatment or no endovascular treatment (control), in addition to best medical treatment. Randomisation was web based, with block sizes ranging from eight to 20, and stratified by centre. The primary outcome was the modified Rankin Scale (mRS) score at 90 days after randomisation. Safety outcomes included all-cause mortality at 90 days after randomisation and symptomatic intracranial haemorrhage. All randomly assigned patients who provided deferred consent or died before consent could be obtained comprised the modified intention-to-treat population, in which the primary and safety outcomes were assessed. Analyses were adjusted for predefined confounders. Treatment effect was estimated with ordinal logistic regression and reported as an adjusted common odds ratio (OR) with a 95% CI. This trial was registered with the ISRCTN, ISRCTN19922220.
    Findings: Between Feb 2, 2018, and Jan 27, 2022, 535 patients were randomly assigned, and 502 (94%) patients provided deferred consent or died before consent was obtained (255 in the endovascular treatment group and 247 in the control group; 261 [52%] females). The median mRS score at 90 days was lower in the endovascular treatment group than in the control group (3 [IQR 2-5] vs 4 [2-6]), and we observed a shift towards better outcomes on the mRS for the endovascular treatment group (adjusted common OR 1·67 [95% CI 1·20-2·32]). All-cause mortality did not differ significantly between groups (62 [24%] of 255 patients vs 74 [30%] of 247 patients; adjusted OR 0·72 [95% CI 0·44-1·18]). Symptomatic intracranial haemorrhage occurred more often in the endovascular treatment group than in the control group (17 [7%] vs four [2%]; adjusted OR 4·59 [95% CI 1·49-14·10]).
    Interpretation: In this study, endovascular treatment was efficacious and safe for patients with ischaemic stroke caused by an anterior circulation large-vessel occlusion who presented 6-24 h from onset or last seen well, and who were selected on the basis of the presence of collateral flow on CTA. Selection of patients for endovascular treatment in the late window could be primarily based on the presence of collateral flow.
    Funding: Collaboration for New Treatments of Acute Stroke consortium, Dutch Heart Foundation, Stryker, Medtronic, Cerenovus, Top Sector Life Sciences & Health, and the Netherlands Brain Foundation.
    MeSH term(s) Female ; Humans ; Male ; Stroke/therapy ; Stroke/drug therapy ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/surgery ; Computed Tomography Angiography ; Netherlands ; Intracranial Hemorrhages/etiology ; Ischemic Stroke/complications ; Treatment Outcome
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00575-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Synthesis, Structure and Cytotoxicity Testing of Novel 7-(4,5-dihydro-1 H -imidazol-2-yl)-2-aryl-6,7-dihydro-2 H -imidazo[2,1- c ][1,2,4]triazol-3(5 H )-Imine Derivatives

    Łukasz Balewski / Franciszek Sączewski / Patrick J. Bednarski / Lisa Wolff / Anna Nadworska / Maria Gdaniec / Anita Kornicka

    Molecules, Vol 25, Iss 5924, p

    2020  Volume 5924

    Abstract: ... dihydro-1 H -imidazole ( 2 ), yielding 7-(4,5-dihydro-1 H -imidazol-2-yl)-2-aryl-6,7-dihydro-2 H -imidazo ... 2,1- c ][ 1 , 2 ,4]triazol-3(5 H )-imines 3a–c , which are subsequently converted ... chlorophenyl)-7-(4,5-dihydro-1 H -imidazol-2-yl)-6,7-dihydro-2 H -imidazo[2,1- c ][1, 2 ,4]triazol-3(5 H ...

    Abstract The appropriate 1-arylhydrazinecarbonitriles 1a–c are subjected to the reaction with 2-chloro-4,5-dihydro-1 H -imidazole ( 2 ), yielding 7-(4,5-dihydro-1 H -imidazol-2-yl)-2-aryl-6,7-dihydro-2 H -imidazo[2,1- c ][ 1 , 2 ,4]triazol-3(5 H )-imines 3a–c , which are subsequently converted into the corresponding amides 4a – e , 8a – c , sulfonamides 5a – n , 9 , ureas 6a – I , and thioureas 7a – d . The structures of the newly prepared derivatives 3a – c , 4a – e , 5a – n , 6a – i , 7a – d , 8a – c , and 9 are confirmed by IR, NMR spectroscopic data, as well as single-crystal X-ray analyses of 5e and 8c . The in vitro cytotoxic potency of these compounds is determined on a panel of human cancer cell lines, and the relationships between structure and antitumor activity are discussed. The most active 4-chloro- N -(2-(4-chlorophenyl)-7-(4,5-dihydro-1 H -imidazol-2-yl)-6,7-dihydro-2 H -imidazo[2,1- c ][1, 2 ,4]triazol-3(5 H )-ylidene)benzamide ( 4e ) and N -(7-(4,5-dihydro-1 H -imidazol-2-yl)-2-( p -tolyl)-6,7-dihydro-2 H -imidazo[2,1- c ][ 1 , 2 ,4]triazol-3(5 H )-ylidene)-[1,1′-biphenyl]-4-sulfonamide ( 5l ) inhibits the growth of the cervical cancer SISO and bladder cancer RT-112 cell lines with IC 50 values in the range of 2.38–3.77 μM. Moreover, N -(7-(4,5-dihydro-1 H -imidazol-2-yl)-2-phenyl-6,7-dihydro-2 H -imidazo[2,1- c ][1, 2 ,4]triazol-3(5 H )-ylidene)-4-phenoxybenzenesulfonamide ( 5m ) has the best selectivity towards the SISO cell line and induces apoptosis in this cell line.
    Keywords imidazo[2,1- c ][1,2,4]triazol-3(5 H )-imines ; amides ; sulfonamides ; ureas ; thioureas ; X-ray analysis ; Organic chemistry ; QD241-441
    Subject code 333
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Search for Heavy Higgs Bosons A/H Decaying to a Top Quark Pair in pp Collisions at sqrt[s]=8  TeV with the ATLAS Detector.

    Aaboud, M / Aad, G / Abbott, B / Abdinov, O / Abeloos, B / Abidi, S H / AbouZeid, O S / Abraham, N L / Abramowicz, H / Abreu, H / Abreu, R / Abulaiti, Y / Acharya, B S / Adachi, S / Adamczyk, L / Adelman, J / Adersberger, M / Adye, T / Affolder, A A /
    Agatonovic-Jovin, T / Agheorghiesei, C / Aguilar-Saavedra, J A / Ahlen, S P / Ahmadov, F / Aielli, G / Akatsuka, S / Akerstedt, H / Åkesson, T P A / Akilli, E / Akimov, A V / Alberghi, G L / Albert, J / Albicocco, P / Alconada Verzini, M J / Alderweireldt, S C / Aleksa, M / Aleksandrov, I N / Alexa, C / Alexander, G / Alexopoulos, T / Alhroob, M / Ali, B / Aliev, M / Alimonti, G / Alison, J / Alkire, S P / Allbrooke, B M M / Allen, B W / Allport, P P / Aloisio, A / Alonso, A / Alonso, F / Alpigiani, C / Alshehri, A A / Alstaty, M I / Alvarez Gonzalez, B / Álvarez Piqueras, D / Alviggi, M G / Amadio, B T / Amaral Coutinho, Y / Amelung, C / Amidei, D / Amor Dos Santos, S P / Amoroso, S / Amundsen, G / Anastopoulos, C / Ancu, L S / Andari, N / Andeen, T / Anders, C F / Anders, J K / Anderson, K J / Andreazza, A / Andrei, V / Angelidakis, S / Angelozzi, I / Angerami, A / Anisenkov, A V / Anjos, N / Annovi, A / Antel, C / Antonelli, M / Antonov, A / Antrim, D J / Anulli, F / Aoki, M / Aperio Bella, L / Arabidze, G / Arai, Y / Araque, J P / Araujo Ferraz, V / Arce, A T H / Ardell, R E / Arduh, F A / Arguin, J-F / Argyropoulos, S / Arik, M / Armbruster, A J / Armitage, L J / Arnaez, O / Arnold, H / Arratia, M / Arslan, O / Artamonov, A / Artoni, G / Artz, S / Asai, S / Asbah, N / Ashkenazi, A / Asquith, L / Assamagan, K / Astalos, R / Atkinson, M / Atlay, N B / Augsten, K / Avolio, G / Axen, B / Ayoub, M K / Azuelos, G / Baas, A E / Baca, M J / Bachacou, H / Bachas, K / Backes, M / Backhaus, M / Bagnaia, P / Bahmani, M / Bahrasemani, H / Baines, J T / Bajic, M / Baker, O K / Baldin, E M / Balek, P / Balli, F / Balunas, W K / Banas, E / Bandyopadhyay, A / Banerjee, Sw / Bannoura, A A E / Barak, L / Barberio, E L / Barberis, D / Barbero, M / Barillari, T / Barisits, M-S / Barkeloo, J T / Barklow, T / Barlow, N / Barnes, S L / Barnett, B M / Barnett, R M / Barnovska-Blenessy, Z / Baroncelli, A / Barone, G / Barr, A J / Barranco Navarro, L / Barreiro, F / Barreiro 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Tanioka, R / Tannenwald, B B / Tapia Araya, S / Tapprogge, S / Tarem, S / Tartarelli, G F / Tas, P / Tasevsky, M / Tashiro, T / Tassi, E / Tavares Delgado, A / Tayalati, Y / Taylor, A C / Taylor, G N / Taylor, P T E / Taylor, W / Teixeira-Dias, P / Temple, D / Ten Kate, H / Teng, P K / Teoh, J J / Tepel, F / Terada, S / Terashi, K / Terron, J / Terzo, S / Testa, M / Teuscher, R J / Theveneaux-Pelzer, T / Thiele, F / Thomas, J P / Thomas-Wilsker, J / Thompson, P D / Thompson, A S / Thomsen, L A / Thomson, E / Tibbetts, M J / Ticse Torres, R E / Tikhomirov, V O / Tikhonov, Yu A / Timoshenko, S / Tipton, P / Tisserant, S / Todome, K / Todorova-Nova, S / Todt, S / Tojo, J / Tokár, S / Tokushuku, K / Tolley, E / Tomlinson, L / Tomoto, M / Tompkins, L / Toms, K / Tong, B / Tornambe, P / Torrence, E / Torres, H / Torró Pastor, E / Toth, J / Touchard, F / Tovey, D R / Treado, C J / Trefzger, T / Tresoldi, F / Tricoli, A / Trigger, I M / Trincaz-Duvoid, S / Tripiana, M F / Trischuk, W / Trocmé, B / Trofymov, A / Troncon, C / Trottier-McDonald, M / Trovatelli, M / Truong, L / Trzebinski, M / Trzupek, A / Tsang, K W / Tseng, J C-L / Tsiareshka, P V / Tsipolitis, G / Tsirintanis, N / Tsiskaridze, S / Tsiskaridze, V / Tskhadadze, E G / Tsui, K M / Tsukerman, I I / Tsulaia, V / Tsuno, S / Tsybychev, D / Tu, Y / Tudorache, A / Tudorache, V / Tulbure, T T / Tuna, A N / Tupputi, S A / Turchikhin, S / Turgeman, D / Turk Cakir, I / Turra, R / Tuts, P M / Ucchielli, G / Ueda, I / Ughetto, M / Ukegawa, F / Unal, G / Undrus, A / Unel, G / Ungaro, F C / Unno, Y / Unverdorben, C / Urban, J / Urquijo, P / Urrejola, P / Usai, G / Usui, J / Vacavant, L / Vacek, V / Vachon, B / Vadla, K O H / Vaidya, A / Valderanis, C / Valdes Santurio, E / Valente, M / Valentinetti, S / Valero, A / Valéry, L / Valkar, S / Vallier, A / Valls Ferrer, J A / Van Den Wollenberg, W / van der Graaf, H / van Gemmeren, P / Van Nieuwkoop, J / van Vulpen, I / van Woerden, M C / Vanadia, M / Vandelli, W / Vaniachine, A / 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Wolter, M W / Wolters, H / Wong, V W S / Worm, S D / Wosiek, B K / Wotschack, J / Wozniak, K W / Wu, M / Wu, S L / Wu, X / Wu, Y / Wyatt, T R / Wynne, B M / Xella, S / Xi, Z / Xia, L / Xu, D / Xu, L / Xu, T / Yabsley, B / Yacoob, S / Yamaguchi, D / Yamaguchi, Y / Yamamoto, A / Yamamoto, S / Yamanaka, T / Yamatani, M / Yamauchi, K / Yamazaki, Y / Yan, Z / Yang, H / Yang, Y / Yang, Z / Yao, W-M / Yap, Y C / Yasu, Y / Yatsenko, E / Yau Wong, K H / Ye, J / Ye, S / Yeletskikh, I / Yigitbasi, E / Yildirim, E / Yorita, K / Yoshihara, K / Young, C / Young, C J S / Yu, J / Yuen, S P Y / Yusuff, I / Zabinski, B / Zacharis, G / Zaidan, R / Zaitsev, A M / Zakharchuk, N / Zalieckas, J / Zaman, A / Zambito, S / Zanzi, D / Zeitnitz, C / Zemaityte, G / Zemla, A / Zeng, J C / Zeng, Q / Zenin, O / Ženiš, T / Zerwas, D / Zhang, D / Zhang, F / Zhang, G / Zhang, H / Zhang, J / Zhang, L / Zhang, M / Zhang, P / Zhang, R / Zhang, X / Zhang, Y / Zhang, Z / Zhao, X / Zhao, Y / Zhao, Z / Zhemchugov, A / Zhou, B / Zhou, C / Zhou, L / Zhou, M / Zhou, N / Zhu, C G / Zhu, H / Zhu, J / Zhu, Y / Zhuang, X / Zhukov, K / Zibell, A / Zieminska, D / Zimine, N I / Zimmermann, C / Zimmermann, S / Zinonos, Z / Zinser, M / Ziolkowski, M / Živković, L / Zobernig, G / Zoccoli, A / Zou, R / Zur Nedden, M / Zwalinski, L

    Physical review letters

    2017  Volume 119, Issue 19, Page(s) 191803

    Abstract: A search for heavy pseudoscalar (A) and scalar (H) Higgs bosons decaying into a top quark pair (tt ... as a function of the mass m_{A/H} and the ratio of the vacuum expectation values of the two Higgs fields, tanβ ... for m_{A/H}>500  GeV. ...

    Abstract A search for heavy pseudoscalar (A) and scalar (H) Higgs bosons decaying into a top quark pair (tt[over ¯]) has been performed with 20.3  fb^{-1} of proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider at a center-of-mass energy sqrt[s]=8  TeV. Interference effects between the signal process and standard model tt[over ¯] production, which are expected to distort the signal shape from a single peak to a peak-dip structure, are taken into account. No significant deviation from the standard model prediction is observed in the tt[over ¯] invariant mass spectrum in final states with an electron or muon, large missing transverse momentum, and at least four jets. The results are interpreted within the context of a type-II two-Higgs-doublet model. Exclusion limits on the signal strength are derived as a function of the mass m_{A/H} and the ratio of the vacuum expectation values of the two Higgs fields, tanβ, for m_{A/H}>500  GeV.
    Language English
    Publishing date 2017-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.119.191803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Zur Geschichte der Krankenhausstadt Berlin-Buch

    Wolff, Horst-Peter / Kalinich, Arno

    2022  

    Title translation Zur Geschichte der Krankenanstalten in Berlin-Buch
    Author's details Horst-Peter Wolff, Arno Kalinich
    Keywords Hospitals / history ; Berlin ; Klinikum Buch ; Geschichte 1896-2004
    Language German
    Size 377 Seiten, Illustrationen, Pläne, 21 cm
    Edition 5. Auflage
    Publisher Mabuse-Verlag
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book
    HBZ-ID HT021324672
    ISBN 978-3-938304-42-6 ; 3-938304-42-1
    Database Catalogue ZB MED Medicine, Health

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