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Article: Die Checkliste "Infektgefährdete Wunde" als Ergänzung zum W.A.R. (Wounds at Risk) Score. J. Dissemond, T. Eberlein, R. Strohal Und T. Wild im Namen der Autorengruppe des Originalartikels

Dissemond, J. / Eberlein, T. / Strohal, R. / Wild, T.

2011 Volume -, Issue 2, Page(s) 19

Language	German
Document type	Article
ZDB-ID	2481406-4
ISSN	1864-1121
Database	Current Contents Medicine

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Article ; Online: Predicting plant growth response under fluctuating temperature by carbon balance modelling.

Seydel, Charlotte / Biener, Julia / Brodsky, Vladimir / Eberlein, Svenja / Nägele, Thomas

Communications biology

2022 Volume 5, Issue 1, Page(s) 164

Abstract: Quantification of system dynamics is a central aim of mathematical modelling in biology. Defining experimentally supported functional relationships between molecular entities by mathematical terms enables the application of computational routines to ... ...

Abstract	Quantification of system dynamics is a central aim of mathematical modelling in biology. Defining experimentally supported functional relationships between molecular entities by mathematical terms enables the application of computational routines to simulate and analyse the underlying molecular system. In many fields of natural sciences and engineering, trigonometric functions are applied to describe oscillatory processes. As biochemical oscillations occur in many aspects of biochemistry and biophysics, Fourier analysis of metabolic functions promises to quantify, describe and analyse metabolism and its reaction towards environmental fluctuations. Here, Fourier polynomials were developed from experimental time-series data and combined with block diagram simulation of plant metabolism to study heat shock response of photosynthetic CO
MeSH term(s)	Arabidopsis Proteins/metabolism ; Carbon/metabolism ; Plant Leaves ; Sucrose/metabolism ; Temperature
Chemical Substances	Arabidopsis Proteins ; Sucrose (57-50-1) ; Carbon (7440-44-0)
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03100-w
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Article ; Online: A standardized wound infection model for antimicrobial testing of wound dressings in vitro.

Wiegand, Cornelia / Fink, Sarah / Mogrovejo, Diana C / Ruhlandt, Marina / Wiencke, Vanessa / Eberlein, Thomas / Brill, Florian H H / Tittelbach, Jörg

International wound journal

2024 Volume 21, Issue 3, Page(s) e14811

Abstract: To investigate the effectiveness of antimicrobial agents against wound infections, experiments using either 2D cultures with planktonic microorganisms or animal infection models are frequently carried out. However, the transferability of the results to ... ...

Abstract	To investigate the effectiveness of antimicrobial agents against wound infections, experiments using either 2D cultures with planktonic microorganisms or animal infection models are frequently carried out. However, the transferability of the results to human skin is limited by the lack of complexity of the 2D models or by the poor translation of the results from animal models. Hence, there is a need for wound infection models capable of assessing antimicrobial agents. In this study, an easily standardized wound infection model was established. This model consists of a mechanically wounded human skin model on a collagen matrix infected with various clinically relevant bacteria. Infection of the model led to recognition of the pathogens and induction of an inflammatory response. The untreated infection spread over time, causing significant tissue damage. By applying an antimicrobial-releasing wound dressing, the bacterial load could be reduced and the success of the treatment could be further measured by a decrease in the inflammatory reaction. In conclusion, this wound infection model can be used to evaluate new antimicrobial therapeutics as well as to study host-pathogen interactions.
MeSH term(s)	Animals ; Humans ; Anti-Infective Agents ; Bacterial Load ; Bandages ; Host-Pathogen Interactions ; Wound Infection
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14811
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Article ; Online: Capivasertib combines with docetaxel to enhance anti-tumour activity through inhibition of AKT-mediated survival mechanisms in prostate cancer.

Eberlein, Cath / Williamson, Stuart C / Hopcroft, Lorna / Ros, Susana / Moss, Jennifer I / Kerr, James / van Weerden, Wytske M / de Bruin, Elza C / Dunn, Shanade / Willis, Brandon / Ross, Sarah J / Rooney, Claire / Barry, Simon T

British journal of cancer

2024 Volume 130, Issue 8, Page(s) 1377–1387

Abstract: Background/objective: To explore the anti-tumour activity of combining AKT inhibition and docetaxel in PTEN protein null and WT prostate tumours.: Methods: Mechanisms associated with docetaxel capivasertib treatment activity in prostate cancer were ... ...

Abstract	Background/objective: To explore the anti-tumour activity of combining AKT inhibition and docetaxel in PTEN protein null and WT prostate tumours. Methods: Mechanisms associated with docetaxel capivasertib treatment activity in prostate cancer were examined using a panel of in vivo tumour models and cell lines. Results: Combining docetaxel and capivasertib had increased activity in PTEN null and WT prostate tumour models in vivo. In vitro short-term docetaxel treatment caused cell cycle arrest in the majority of cells. However, a sub-population of docetaxel-persister cells did not undergo G2/M arrest but upregulated phosphorylation of PI3K/AKT pathway effectors GSK3β, p70S6K, 4E-BP1, but to a lesser extent AKT. In vivo acute docetaxel treatment induced p70S6K and 4E-BP1 phosphorylation. Treating PTEN null and WT docetaxel-persister cells with capivasertib reduced PI3K/AKT pathway activation and cell cycle progression. In vitro and in vivo it reduced proliferation and increased apoptosis or DNA damage though effects were more marked in PTEN null cells. Docetaxel-persister cells were partly reliant on GSK3β as a GSK3β inhibitor AZD2858 reversed capivasertib-induced apoptosis and DNA damage. Conclusion: Capivasertib can enhance anti-tumour effects of docetaxel by targeting residual docetaxel-persister cells, independent of PTEN status, to induce apoptosis and DNA damage in part through GSK3β.
MeSH term(s)	Male ; Humans ; Docetaxel/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/pharmacology ; Signal Transduction ; Apoptosis ; Phosphatidylinositol 3-Kinases/metabolism ; Glycogen Synthase Kinase 3 beta ; Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; PTEN Phosphohydrolase/metabolism ; Pyrimidines ; Pyrroles
Chemical Substances	Docetaxel (15H5577CQD) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; capivasertib (WFR23M21IE) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; Pyrimidines ; Pyrroles
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-024-02614-w
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Article ; Online: Do basophil activation tests help elucidate allergic reactions to the ingredients in COVID-19 vaccines?

Eberlein, Bernadette / Mathes, Sonja / Fischer, Jörg / Darsow, Ulf / Biedermann, Tilo / Brockow, Knut

Allergy

2022 Volume 77, Issue 10, Page(s) 2924–2936

Abstract: The worldwide use of COVID-19 vaccines has shown that immediate allergic reactions to the ingredients are rare but should be clarified by means of an allergological work-up. This review aims to highlight the current state of knowledge and possible ... ...

Abstract	The worldwide use of COVID-19 vaccines has shown that immediate allergic reactions to the ingredients are rare but should be clarified by means of an allergological work-up. This review aims to highlight the current state of knowledge and possible pathogenesis based on the literature published to date. In addition to recording a detailed history and performing skin tests, cellular tests (basophil activation or basophil histamine release test) by using the vaccines or modified compounds containing polyethylene glycol (PEG), rather than unmodified PEGs, have proven to be particularly helpful. Negative results with vaccines seem to indicate tolerance. Details of the performance of these cellular tests with different vaccines, PEGs of different molecular weights, other ingredients of the vaccines, as well as other PEGylated drugs, and the results in the context of COVID-19 vaccination of various working groups worldwide are summarized.
MeSH term(s)	Basophil Degranulation Test ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Humans ; Hypersensitivity ; Polyethylene Glycols
Chemical Substances	COVID-19 Vaccines ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2022-03-25
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15278
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Article: Assessment of New and Genome-Reduced

Cárdenas Espinosa, María José / Schmidgall, Tabea / Pohl, Jessica / Wagner, Georg / Wynands, Benedikt / Wierckx, Nick / Heipieper, Hermann J / Eberlein, Christian

Microorganisms

2023 Volume 11, Issue 4

Abstract: Organic olvent-tolerant strains of the Gram-negative bacterial ... ...

Abstract	Organic olvent-tolerant strains of the Gram-negative bacterial genus
Language	English
Publishing date	2023-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11040837
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Article ; Online: Quantification of skin sensitivity to ultraviolet radiation using ultrawideband optoacoustic mesoscopy.

Hindelang, B / Aguirre, J / Berezhnoi, A / Biedermann, T / Darsow, U / Eberlein, B / Ntziachristos, V

The British journal of dermatology

2020 Volume 184, Issue 2, Page(s) 352–354

MeSH term(s)	Humans ; Photoacoustic Techniques ; Skin Physiological Phenomena ; Ultraviolet Rays/adverse effects
Language	English
Publishing date	2020-11-29
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.19463
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Article ; Online: Mucosal immunization with a low-energy electron inactivated respiratory syncytial virus vaccine protects mice without Th2 immune bias.

Eberlein, Valentina / Rosencrantz, Sophia / Finkensieper, Julia / Besecke, Joana Kira / Mansuroglu, Yaser / Kamp, Jan-Christopher / Lange, Franziska / Dressman, Jennifer / Schopf, Simone / Hesse, Christina / Thoma, Martin / Fertey, Jasmin / Ulbert, Sebastian / Grunwald, Thomas

Frontiers in immunology

2024 Volume 15, Page(s) 1382318

Abstract: The respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections associated with numerous hospitalizations. Recently, intramuscular (i.m.) vaccines against RSV have been approved for elderly and pregnant women. ... ...

Abstract	The respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections associated with numerous hospitalizations. Recently, intramuscular (i.m.) vaccines against RSV have been approved for elderly and pregnant women. Noninvasive mucosal vaccination, e.g., by inhalation, offers an alternative against respiratory pathogens like RSV. Effective mucosal vaccines induce local immune responses, potentially resulting in the efficient and fast elimination of respiratory viruses after natural infection. To investigate this immune response to an RSV challenge, low-energy electron inactivated RSV (LEEI-RSV) was formulated with phosphatidylcholine-liposomes (PC-LEEI-RSV) or 1,2-dioleoyl-3-trimethylammonium-propane and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DD-LEEI-RSV) for vaccination of mice intranasally. As controls, LEEI-RSV and formalin-inactivated-RSV (FI-RSV) were used
MeSH term(s)	Animals ; Respiratory Syncytial Virus Vaccines/immunology ; Respiratory Syncytial Virus Vaccines/administration & dosage ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Infections/immunology ; Mice ; Vaccines, Inactivated/immunology ; Vaccines, Inactivated/administration & dosage ; Female ; Th2 Cells/immunology ; Antibodies, Viral/immunology ; Antibodies, Viral/blood ; Immunity, Mucosal ; Mice, Inbred BALB C ; Immunization ; Respiratory Syncytial Virus, Human/immunology ; Vaccination/methods ; Respiratory Syncytial Viruses/immunology ; Viral Load ; Immunoglobulin A/immunology
Chemical Substances	Respiratory Syncytial Virus Vaccines ; Vaccines, Inactivated ; Antibodies, Viral ; Immunoglobulin A
Language	English
Publishing date	2024-04-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1382318
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Article ; Online: Barriers and facilitators to ask for lower urinary tract symptoms in people with low back pain and pelvic girdle pain. A qualitative study.

Vredeveld, T / Eberlein, A / Ramaekers, S P J / Coppieters, M W / Pool-Goudzwaard, A L

Musculoskeletal science & practice

2020 Volume 48, Page(s) 102155

Abstract: Background: Lower urinary tract symptoms (LUTS) may be a relevant comorbidity when managing people with low back or pelvic girdle pain. It is unknown how often physiotherapists inquire about LUTS, and what the potential barriers and facilitators are to ... ...

Abstract	Background: Lower urinary tract symptoms (LUTS) may be a relevant comorbidity when managing people with low back or pelvic girdle pain. It is unknown how often physiotherapists inquire about LUTS, and what the potential barriers and facilitators are to inquire about LUTS in this patient population. Objective: To explore the frequency of inquiring about LUTS, and to identify the barriers and facilitators among physiotherapists with and without additional pelvic health training to ask for LUTS in people with low back or pelvic girdle pain. Design: A qualitative study using thematic analysis. Methods: Through purposeful sampling, 29 primary care physiotherapists were interviewed (16 physiotherapists and 13 physiotherapists with additional pelvic health training). Thematic analysis was performed to identify themes regarding facilitators and barriers. Findings: The frequency of inquiring about LUTS was: 'never': 10%, 'sometimes': 38%, and 'always': 52%. Four barriers were identified: (1) lack of knowledge of the physiotherapist, (2) a standardised assessment approach which did not include LUTS, (3) patient expectations assumed by the physiotherapist, and (4) social, cultural and personal barriers. Three facilitators were identified: (1) communication skills and experience of the physiotherapist, (2) education and knowledge, and (3) interprofessional consultation and referral. Conclusion: The majority of physiotherapists surveyed in this study regularly asked for LUTS in people with low back or pelvic pain. For when not asked, the identified barriers seem modifiable with adequate training, knowledge and skill acquisition, and sound clinical reasoning.
MeSH term(s)	Attitude of Health Personnel ; Humans ; Low Back Pain ; Lower Urinary Tract Symptoms ; Pelvic Girdle Pain ; Physical Therapists
Language	English
Publishing date	2020-05-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2888772-4
ISSN	2468-7812
ISSN (online)	2468-7812
DOI	10.1016/j.msksp.2020.102155
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Article ; Online: Gelatin-Containing Vaccines for Varicella, Zoster, Measles, Mumps, and Rubella Induce Basophil Activation in Patients with Alpha-Gal Syndrome.

Schmidle, Paul / Mehlich, Jana / Brockow, Knut / Darsow, Ulf / Biedermann, Tilo / Eberlein, Bernadette

International archives of allergy and immunology

2021 Volume 182, Issue 8, Page(s) 716–722

Abstract: Background: The alpha-gal syndrome (AGS) describes a new type I allergy entity to the carbohydrate epitope galactose-α-1,3-galactose (alpha-gal), which is mainly found in mammalian food products (e.g., beef, pork, and venison). Apart from meat products, ...

Abstract	Background: The alpha-gal syndrome (AGS) describes a new type I allergy entity to the carbohydrate epitope galactose-α-1,3-galactose (alpha-gal), which is mainly found in mammalian food products (e.g., beef, pork, and venison). Apart from meat products, alpha-gal can also be found in products containing gelatin of bovine or porcine origin. Recent case reports pointed to severe anaphylaxis in patients suffering from AGS after vaccination with vaccines containing hydrolyzed gelatin. It was the objective of this study to evaluate if basophil activation tests (BATs) performed with such vaccines were positive in patients with AGS. Methods: BAT was performed with different dilutions of a gelatin-containing measles, mumps, and rubella (MMR) live vaccine; an attenuated varicella (V) vaccine; an attenuated V-zoster (VZ) vaccine; a MMR live vaccine not containing gelatin (non-gelatin MMR vaccine) in 2 patients with confirmed AGS, 2 patients highly suspicious for AGS, and 2 healthy individuals without any previous medical history for allergies. Results: All patients showed strongly positive results for all gelatin-containing vaccines (MMR vaccine, V vaccine, and VZ vaccine). Non-gelatin MMR vaccine was negative. The 2 healthy controls did not show any basophil activation. Conclusions: Gelatin-containing vaccines should be administered with caution or avoided in patients with AGS because of their high potential to activate basophils indicating a risk for anaphylaxis. Also, BAT is a useful additional tool when it comes to screening for potentially high-risk alpha-gal-containing drugs.
Language	English
Publishing date	2021-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000514263
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