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  1. Article ; Online: Spinal Muscular Atrophy: A (Now) Treatable Neurodegenerative Disease.

    Fay, Alex

    Pediatric clinics of North America

    2023  Volume 70, Issue 5, Page(s) 963–977

    Abstract: Spinal muscular atrophy (SMA) is a progressive disease of the lower motor neurons associated with recessive loss of the SMN1 gene, and which leads to worsening weakness and disability, and is fatal in its most severe forms. Over the past six years, three ...

    Abstract Spinal muscular atrophy (SMA) is a progressive disease of the lower motor neurons associated with recessive loss of the SMN1 gene, and which leads to worsening weakness and disability, and is fatal in its most severe forms. Over the past six years, three treatments have emerged, two drugs that modify exon splicing and one gene therapy, which have transformed the management of this disease. When treated pre-symptomatically, many children show normal early motor development, and the benefits extend from the newborn period to adulthood. Similar treatment approaches are now under investigation for rare types of SMA associated with genes beyond SMN1.
    MeSH term(s) Child ; Infant, Newborn ; Humans ; Neurodegenerative Diseases ; Muscular Atrophy, Spinal/diagnosis ; Muscular Atrophy, Spinal/genetics ; Muscular Atrophy, Spinal/therapy ; Genetic Therapy
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215711-1
    ISSN 1557-8240 ; 0031-3955
    ISSN (online) 1557-8240
    ISSN 0031-3955
    DOI 10.1016/j.pcl.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Modeling Running via Optimal Control for Shoe Design.

    Fay, Sarah C / Hosoi, A E

    Journal of biomechanical engineering

    2024  Volume 146, Issue 4

    Abstract: Shoe manufacturing technology is advancing faster than new shoe designs can viably be evaluated in human subject trials. To aid in the design process, this paper presents a model for estimating how new shoe properties will affect runner performance. This ...

    Abstract Shoe manufacturing technology is advancing faster than new shoe designs can viably be evaluated in human subject trials. To aid in the design process, this paper presents a model for estimating how new shoe properties will affect runner performance. This model assumes runners choose their gaits to optimize an intrinsic, unknown objective function. To learn this objective function, a simple two-dimensional mechanical model of runners was used to predict their gaits under different objectives, and the resulting gaits were compared to data from real running trials. The most realistic model gaits, i.e., the ones that best matched the data, were obtained when the model runners minimized the impulse they experience from the ground as well as the mechanical work done by their leg muscles. Using this objective function, the gait and thus performance of running under different shoe conditions can be predicted. The simple model is sufficiently sensitive to predict the difference in performance of shoes with disruptive designs but cannot distinguish between existing shoes whose properties are fairly similar. This model therefore is a viable tool for coarse-grain exploration of the design space and identifying promising behaviors of truly novel shoe materials and designs.
    MeSH term(s) Humans ; Shoes ; Biomechanical Phenomena ; Leg ; Muscle, Skeletal ; Running/physiology
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4064405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2672: Show issues Location:
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  3. Article ; Online: Editorial: Preoperative Frailty Risk Assessment Prior to Esophagectomy, Where Are We?

    Fay, K A / Hasson, R M

    Annals of surgical oncology

    2023  Volume 30, Issue 7, Page(s) 3892–3893

    MeSH term(s) Humans ; Frailty ; Esophagectomy/adverse effects ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13210-2
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Maintaining A Long-Term Practice of Daily Pelvic Floor Muscle Exercises: What Do Childbearing Women Think?

    Yount-Tavener, Susan M / Fay, Rebecca A

    Journal of midwifery & women's health

    2024  

    Abstract: Introduction: To be effective, pelvic floor muscle therapy (PFMT) exercises should be intense, be practiced consistently, and include clinical support. Many women do not adhere to a consistent PFMT program, compromising the resolution or prevention of ... ...

    Abstract Introduction: To be effective, pelvic floor muscle therapy (PFMT) exercises should be intense, be practiced consistently, and include clinical support. Many women do not adhere to a consistent PFMT program, compromising the resolution or prevention of urinary incontinence (UI). This study aimed to answer 2 key questions: What prevents women from performing PFMT long term, and what can health care providers do to support women to perform them?
    Methods: Postpartum women from 4 sites in the United States completed a questionnaire about experiences with PFMT or Kegel exercises during and after pregnancy. This study focused on one of the 7 open-ended questions: What would prevent you from performing Kegels lifelong? Thematic analysis was implemented via an inductive approach using Braun and Clarke's 6-phase process.
    Results: Three salient themes emerged that help explain factors that prevent women from adhering to a daily PFMT routine: (1) life gets in the way, (2) inadequate PFMT education and instruction, and (3) disconnect exists about long-term consequences. The sample included 368 participants.
    Discussion: The themes were congruent with the limited body of qualitative literature on experience with PFMT exercises. This study was able to identify areas of need in the US maternal health care system to help childbearing people adopt daily PFMT, such as (1) inadequate parental leave and childcare support, (2) no formalized education related to UI and PFMT and a lack of pelvic health promotion, (3) lacking prioritization of long-term PFMT, and (4) the need to dispel the acceptance that UI postbirth is normal. Health care providers should prioritize interactive education, emphasizing how to correctly perform PFMT and the importance and effectiveness of integrating clinical support. To adequately encompass pelvic floor health care and education up to one year postbirth, changes are needed to the US perinatal health care system, providing sufficient insurance reimbursement and parental social support programs.
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008180-7
    ISSN 1542-2011 ; 1526-9523
    ISSN (online) 1542-2011
    ISSN 1526-9523
    DOI 10.1111/jmwh.13626
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  5. Article ; Online: National Postpartum Permanent Contraception Practices and Perceived Barriers.

    Murphy, Ellen / Pelletier, Andrea / Fay, Kathryn / Bartz, Deborah

    Obstetrics and gynecology

    2024  

    Abstract: Single institution-level studies have demonstrated low postpartum permanent contraception fulfillment rates after vaginal birth. To explore the national scope of the problem, we collected cross-sectional survey data from faculty at 109 U.S. academic ... ...

    Abstract Single institution-level studies have demonstrated low postpartum permanent contraception fulfillment rates after vaginal birth. To explore the national scope of the problem, we collected cross-sectional survey data from faculty at 109 U.S. academic medical centers to elicit perceptions about postpartum permanent contraception practices after vaginal birth, including barriers to and changes in practice after the Dobbs v Jackson Women's Health Organization decision, a decision that eliminated the U.S. federal protection of the right to abortion. Of 68 respondent institutions, 65 (95.6%) offered postpartum permanent contraception. A large majority (87.3%) perceived there to be a problem with postpartum permanent contraception fulfillment at their institution. Respondents at institutions with postpartum permanent contraception fulfillment rates in the bottom quartile used main operating rooms (66.7% vs 25.0% respectively, P=.032) and reported institutional culture barriers (86.7% vs 50.0%, respectively, P=.054) more frequently than respondents in the top quartile. Our national data indicate that health care culture changes and the use of labor and delivery operating rooms could increase postpartum permanent contraception fulfillment.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000005584
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  6. Book ; Online ; E-Book: The mammalian auditory pathways

    Oliver, Douglas L. / Cant, Nell B. / Fay, Richard R. / Popper, Arthur N.

    synaptic organization and microcircuits

    (Springer handbook of auditory research ; 65)

    2018  

    Author's details Douglas L. Oliver, Nell B. Cant, Richard R. Fay, Arthur N. Popper editors
    Series title Springer handbook of auditory research ; 65
    Collection
    Language English
    Size 1 Online-Ressource (xviii, 267 Seiten)), Illustrationen
    Publisher ASA Press ; Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019718933
    ISBN 978-3-319-71798-2 ; 9783319717968 ; 3-319-71798-7 ; 3319717960
    DOI 10.1007/978-3-319-71798-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book ; Thesis: Veränderungen der Wahrnehmung des Selbst und der Paarbeziehung durch intensive Paargruppenanalyse

    Fay, Annette

    2003  

    Author's details vorgelegt von Annette Fay
    Language German ; English
    Size 190, 1, 28 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2004
    Note Zsfassung in engl. Sprache
    HBZ-ID HT014673380
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 D 2899 order for loan Magazin

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  8. Book ; Online ; E-Book: Understanding the cochlea

    Manley, Geoffrey A. / Gummer, Anthony W. / Popper, Arthur N. / Fay, Richard R.

    (Springer handbook of auditory research ; 62)

    2017  

    Author's details Geoffrey A. Manley, Anthony W. Gummer, Arthut N. Popper, Richard R. Fay editors
    Series title Springer handbook of auditory research ; 62
    Collection
    Language English
    Size 1 Online-Ressource (xviii, 351 Seiten)), Illustrationen
    Publisher ASA Press ; Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019718972
    ISBN 978-3-319-52073-5 ; 9783319520711 ; 3-319-52073-3 ; 3319520717
    DOI 10.1007/978-3-319-52073-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article ; Online: LED PEDD Discharge Photometry: Effects of Software Driven Measurements for Sensing Applications.

    Fay, Cormac D / Nattestad, Andrew

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 4

    Abstract: This work explores the effects of embedded software-driven measurements on a sensory target when using a LED as a photodetector. Water turbidity is used as the sensory target in this study to explore these effects using a practical and important water ... ...

    Abstract This work explores the effects of embedded software-driven measurements on a sensory target when using a LED as a photodetector. Water turbidity is used as the sensory target in this study to explore these effects using a practical and important water quality parameter. Impacts on turbidity measurements are examined by adopting the Paired Emitter Detector Diode (PEDD) capacitive discharge technique and comparing common embedded software/firmware implementations. The findings show that the chosen software method can (a) affect the detection performance by up to 67%, (b) result in a variable sampling frequency/period, and (c) lead to an disagreement of the photo capacitance by up to 23%. Optimized code is offered to correct for these issues and its effectiveness is shown through comparative analyses, with the disagreement reduced significantly from 23% to 0.18%. Overall, this work demonstrates that the embedded software is a key and critical factor for PEDD capacitive discharge measurements and must be considered carefully for future measurements in sensor related studies.
    MeSH term(s) Body Fluids ; Humans ; Patient Discharge ; Photometry ; Software
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22041526
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  10. Article ; Online: Natural Product Synthesis: The Endless Quest for Unreachable Perfection.

    Fay, Nicolas / Kouklovsky, Cyrille / de la Torre, Aurélien

    ACS organic & inorganic Au

    2023  Volume 3, Issue 6, Page(s) 350–363

    Abstract: Total synthesis is a field in constant progress. Its practitioners aim to develop ideal synthetic strategies to build complex molecules. As such, they are both a driving force and a showcase of the progress of organic synthesis. In this Perspective, we ... ...

    Abstract Total synthesis is a field in constant progress. Its practitioners aim to develop ideal synthetic strategies to build complex molecules. As such, they are both a driving force and a showcase of the progress of organic synthesis. In this Perspective, we discuss recent notable total syntheses. The syntheses selected herein are classified according to the key strategic considerations for each approach.
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2694-247X
    ISSN (online) 2694-247X
    DOI 10.1021/acsorginorgau.3c00040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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