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  1. Book: CLINICAL MANAGEMENT OF MELANOMA

    SEIGLER, H. F.

    (DEVELOPMENTS IN ONCOLOGY ; 5)

    1982  

    Author's details ED. BY H. F. SEIGLER
    Series title DEVELOPMENTS IN ONCOLOGY ; 5
    Developments in oncology
    Collection Developments in oncology
    Keywords MELANOMA / THERAPY ; Melanom ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Malignes Melanom ; Melanocytoblastom ; Melanozytoblastom ; Melanosarkom ; Melanoma maligna
    Size X, 522 S.
    Publisher NIJHOFF
    Publishing place THE HAGUE
    Document type Book
    HBZ-ID HT002516934
    ISBN 90-247-2584-4 ; 978-90-247-2584-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1984 A 1588 order for loan Magazin

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  2. Article: A Historical Cohort in Kidney Transplantation: 55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs.

    Shaw, Brian I / Villani, Vincenzo / Kesseli, Samuel J / Nobuhara, Chloe / Samoylova, Mariya L / Moris, Dimitrios / Collins, Bradley H / McElroy, Lisa M / Poh, Melissa / Knechtle, Stuart J / Barbas, Andrew S / Seigler, Hilliard F

    Journal of clinical medicine

    2021  Volume 10, Issue 23

    Abstract: The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior survival compared ... ...

    Abstract The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior survival compared to those from deceased donors. The purpose of this study is to report our multi-decade institutional experience and outcomes for patients who received HLA-identical living donor grafts, which represent the most favorable scenario in kidney transplantation. We conducted a retrospective analysis of these graft recipients performed at a Duke University Medical Center between the years of 1965 and 2002. The recipients demonstrated excellent graft and patient survival outcomes, superior to a contemporary cohort, with median patient and graft survival of 24.2 and 30.9 years, respectively, among Duke recipients vs. 16.1 and 16.0 years in a cohort derived from national data. This study offers a broad perspective on the importance of HLA matching and graft type, and demonstrates a historical best-case-scenario in renal transplantation.
    Language English
    Publishing date 2021-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10235505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Monitoring antitumour immune response during immunotherapy of cancer: why and how?

    Dematos, P / Seigler, H F

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2007  Volume 11, Issue 4, Page(s) 239–247

    Abstract: Cancer remains one of the most important public health concerns facing us today. Despite recent therapeutic developments, conventional therapies have provided only limited success in the management of patients with advanced disease. The recent discovery ... ...

    Abstract Cancer remains one of the most important public health concerns facing us today. Despite recent therapeutic developments, conventional therapies have provided only limited success in the management of patients with advanced disease. The recent discovery of tumour-associated antigens has led to a strong interest in immunotherapy as an alternative or adjuvant cancer treatment modality. Despite the expanding volumes of literature on this form of therapy confirming its strong anti-neoplastic effects in animals, much still remains to be elucidated with respect to its clinical applicability and effectiveness in human subjects. Clinical trials evaluating a wide variety of immunotherapeutic approaches in cancer patients are currently underway throughout the world and many have yielded promising preliminary results. In order to reach a better understanding of this potentially powerful therapeutic tool in a timely fashion, a methodical, multi-institutional approach is indispensable. All patients undergoing treatment should be monitored closely in order to correlate specific therapy-induced anti-tumour responses with clinical outcomes. This article provides a brief overview of specific assays currently used to monitor immune responses in these patients. Special emphasis is placed on the theory behind these tests and specific examples from the literature are provided.
    Language English
    Publishing date 2007-10-24
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.2165/00063030-199911040-00003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Advances in the care of the patient with malignant melanoma.

    Seigler, H F

    Annals of surgery

    1997  Volume 225, Issue 1, Page(s) 15–16

    MeSH term(s) Humans ; Lymphatic Metastasis ; Melanoma/secondary ; Melanoma/surgery ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
    Language English
    Publishing date 1997-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/00000658-199701000-00002
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  5. Article: Surgical margins around primary cutaneous melanomas.

    Seigler, H F

    Annals of surgery

    1993  Volume 218, Issue 5, Page(s) 702

    MeSH term(s) Humans ; Melanoma/surgery ; Skin Neoplasms/surgery ; Surgical Procedures, Operative/methods
    Language English
    Publishing date 1993-11
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
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  6. Article: Clinicopathologic factors relating to surgical margins for cutaneous melanoma.

    Seigler, H F

    Annals of surgery

    1993  Volume 217, Issue 1, Page(s) 1

    MeSH term(s) Humans ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/surgery ; Neoplasm Recurrence, Local/prevention & control ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Surgical Procedures, Operative/methods ; Survival Rate
    Language English
    Publishing date 1993-01
    Publishing country United States
    Document type Clinical Trial ; Editorial ; Randomized Controlled Trial
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/00000658-199301000-00001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Historical Cohort in Kidney Transplantation

    Brian I. Shaw / Vincenzo Villani / Samuel J. Kesseli / Chloe Nobuhara / Mariya L. Samoylova / Dimitrios Moris / Bradley H. Collins / Lisa M. McElroy / Melissa Poh / Stuart J. Knechtle / Andrew S. Barbas / Hilliard F. Seigler

    Journal of Clinical Medicine, Vol 10, Iss 5505, p

    55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs

    2021  Volume 5505

    Abstract: The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior survival compared ... ...

    Abstract The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior survival compared to those from deceased donors. The purpose of this study is to report our multi-decade institutional experience and outcomes for patients who received HLA-identical living donor grafts, which represent the most favorable scenario in kidney transplantation. We conducted a retrospective analysis of these graft recipients performed at a Duke University Medical Center between the years of 1965 and 2002. The recipients demonstrated excellent graft and patient survival outcomes, superior to a contemporary cohort, with median patient and graft survival of 24.2 and 30.9 years, respectively, among Duke recipients vs. 16.1 and 16.0 years in a cohort derived from national data. This study offers a broad perspective on the importance of HLA matching and graft type, and demonstrates a historical best-case-scenario in renal transplantation.
    Keywords kidney transplant ; long-term outcomes ; HLA matching ; precision transplant ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article: Using a continuous transformation of the Breslow thickness for prognosis in cutaneous melanoma.

    Vollmer, R T / Seigler, H F

    American journal of clinical pathology

    2001  Volume 115, Issue 2, Page(s) 205–212

    Abstract: Although the Breslow thickness provides the most important histologic information for prognosis in cutaneous melanoma, controversies and uncertainty remain about how best to use thickness. It is unclear whether cut points should be used, or, if they are ... ...

    Abstract Although the Breslow thickness provides the most important histologic information for prognosis in cutaneous melanoma, controversies and uncertainty remain about how best to use thickness. It is unclear whether cut points should be used, or, if they are used, which are optimal. We studied new data collected from more than 1,000 patients followed up for a relatively long period. From Cox proportional hazards models of survival we learned that more cut points provide more prognostic information than using, for example, just 1 cut point at 1.7 mm. Nevertheless, a continuous transformation provides an effective alternative that captures the information that thickness provides, and it avoids the pitfalls of using multiple cut points. In a multivariate model, this transformation provided strong prognostic information, and the result produced a prognostic score for cutaneous melanoma. This score provides a practical way that Cox model results can be used, and we believe it consolidates the prognostic information provided by traditional histologic and clinical variables. When newer prognostic variables are introduced, we suggest that they be used with this continuous transformation of thickness rather than with cut points in thickness.
    MeSH term(s) Follow-Up Studies ; Humans ; Image Processing, Computer-Assisted ; Melanoma/classification ; Melanoma/mortality ; Melanoma/pathology ; Neoplasm Invasiveness/pathology ; Neoplasm Staging/methods ; Prognosis ; Proportional Hazards Models ; Skin Neoplasms/classification ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Survival Rate
    Language English
    Publishing date 2001-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1309/WAVR-560R-NU5E-4Q96
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  9. Article: A model for pretest probability of lymph node metastasis from cutaneous Melanoma.

    Vollmer, R T / Seigler, H F

    American journal of clinical pathology

    2000  Volume 114, Issue 6, Page(s) 875–879

    Abstract: Although many statistical models have been developed to predict survival in cutaneous melanoma, few predict the end point of regional lymph node metastasis shortly after the diagnosis of melanoma. We used routine clinical and histologic data from 573 ... ...

    Abstract Although many statistical models have been developed to predict survival in cutaneous melanoma, few predict the end point of regional lymph node metastasis shortly after the diagnosis of melanoma. We used routine clinical and histologic data from 573 patients referred to the Duke University Melanoma Clinic, Durham, NC, during the 1980s and 1990s who underwent lymph node resections during the first year after the diagnosis of primary cutaneous melanoma. The outcome we modeled (using the logistic regression model) was the probability of lymph node metastasis. We found that tumor thickness was the variable most significantly associated with the probability of nodal metastasis, and the presence of ulceration and tumor location also were significant, but age, sex, and mitotic rate were not. When the resulting logistic model predicted that the probability of nodal metastasis was more than .6, 93 of 115 patients had nodal metastasis. When the model predicted that the probability was less than .3, just 32 of 88 patients had positive nodes. Furthermore, after the result of the node sampling was known, Cox model analysis demonstrated that the pretest probability added significant information about subsequent survival.
    MeSH term(s) Biopsy ; Female ; Humans ; Logistic Models ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Male ; Melanoma/pathology ; Melanoma/secondary ; Mitotic Index ; Proportional Hazards Models ; Skin Neoplasms/pathology ; Survival Analysis
    Language English
    Publishing date 2000-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1309/V1XY-TKBU-HP6P-BBVL
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Investigative studies in the diagnosis and treatment of melanoma.

    Seigler, H F

    Investigative radiology

    1986  Volume 21, Issue 7, Page(s) 596–600

    Abstract: Patients with melanoma have prognostic indicators that can be accurately assessed using standard histopathologic techniques. First-order lymph node disease plays a significant role in determining both the prognosis of the patient and the therapeutic ... ...

    Abstract Patients with melanoma have prognostic indicators that can be accurately assessed using standard histopathologic techniques. First-order lymph node disease plays a significant role in determining both the prognosis of the patient and the therapeutic benefit in selected patients. The lymph nodes at risk can be determined by the technique of lymphoscintigraphy, and specificity might be possible using isotopically labeled monoclonal antibodies. Techniques utilizing immunohistology and immunocytology have been developed and applied to the clinical setting. Early diagnosis of recurrent disease is now possible using radioimmunoassays. Specific immunotherapy trials are underway and early results are encouraging.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antigens, Neoplasm/immunology ; Choroid Neoplasms/diagnosis ; Combined Modality Therapy ; Humans ; Immunotherapy ; Lymphatic Metastasis ; Melanoma/diagnosis ; Melanoma/immunology ; Melanoma/therapy ; Prognosis ; Skin Neoplasms/diagnosis ; Skin Neoplasms/immunology ; Skin Neoplasms/therapy ; Tomography, X-Ray Computed
    Chemical Substances Antibodies, Monoclonal ; Antigens, Neoplasm
    Language English
    Publishing date 1986-07
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80345-5
    ISSN 1536-0210 ; 0020-9996
    ISSN (online) 1536-0210
    ISSN 0020-9996
    DOI 10.1097/00004424-198607000-00017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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