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Article ; Online: A pilot study of dietary fibres on pathogen growth in an

Strain, Ronan / Tran, Tam T T / Mills, Susan / Stanton, Catherine / Ross, R Paul

Microbiome research reports

2023 Volume 2, Issue 3, Page(s) 22

Abstract: ... ...

Abstract	Aim
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article
ISSN	2771-5965
ISSN (online)	2771-5965
DOI	10.20517/mrr.2022.14
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Article ; Online: Molecular characterisation of a novel sadwavirus infecting cattleya orchids in Australia.

Tran, Nga T / Campbell, Paul R / Crew, Kathleen S / Geering, Andrew D W

Archives of virology

2024 Volume 169, Issue 3, Page(s) 68

Abstract: ... each encoding a long polyprotein, with predicted cleavage sites at H/Y, E/G, Q/S, and Q/G for the RNA1 and T/G ...

Abstract	The complete genome sequence of a novel sadwavirus infecting cattleya orchids in South East Queensland is described. Isometric virions of c. 27 nm diameter were observed in sap extracts viewed under a transmission electron microscope, and the genome sequence of this virus was determined by high-throughput sequencing. The viral genome consists of two RNA components, 5,910 and 4,435 nucleotides (nt) in length, each encoding a long polyprotein, with predicted cleavage sites at H/Y, E/G, Q/S, and Q/G for the RNA1 and T/G for the RNA2 translation products, respectively. RNA2 has an additional small ORF of 684 nt near the 3' untranslated region. Phylogenetic analysis based on an amino acid sequence alignment of the Pro-Pol region suggested that this virus is most closely related to pineapple secovirus A, a member of the subgenus Cholivirus, but warrants classification as a member of a new species because it exhibited no more than 64% amino acid identity in pairwise sequence comparisons. Because of the prominent purple ringspots that were observed on the leaves of some of the plants, we propose the name "cattleya purple ringspot virus" for this virus (suggested species name: "Sadwavirus cattleyacola").
MeSH term(s)	RNA, Viral/genetics ; Phylogeny ; Amino Acid Sequence ; Secoviridae/genetics ; Virion ; Genome, Viral
Chemical Substances	RNA, Viral
Language	English
Publishing date	2024-03-07
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-024-05980-1
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Article ; Online: Mucosal and systemic immune responses after a single intranasal dose of nanoparticle and spore-based subunit vaccines in mice with pre-existing lung mycobacterial immunity.

Vergara, Emil Joseph / Tran, Andy Cano / Kim, Mi-Young / Mussá, Tufária / Paul, Matthew J / Harrison, Thomas / Reljic, Rajko

Frontiers in immunology

2023 Volume 14, Page(s) 1306449

Abstract: ... altered by intranasal administration of spore- and nanoparticle-based subunit vaccines. Analysis of lung T ... cell responses revealed an increasing trend in the frequency of important CD4 and CD8 T cell subsets ... and T effector memory cells with a Th1 cytokine (IFNγ and TNFα) signature among immunised mice ...

Abstract	Tuberculosis (TB) is a major global health threat that claims more than one million lives annually. With a quarter of the global population harbouring latent TB, post-exposure vaccination aimed at high-risk populations that could develop active TB disease would be of great public health benefit. Mucosal vaccination is an attractive approach for a predominantly lung disease like TB because it elicits both local and systemic immunity. However, the immunological consequence of mucosal immunisation in the presence of existing lung immunity remains largely unexplored. Using a mycobacterial pre-exposure mouse model, we assessed whether pre-existing mucosal and systemic immune responses can be boosted and/or qualitatively altered by intranasal administration of spore- and nanoparticle-based subunit vaccines. Analysis of lung T cell responses revealed an increasing trend in the frequency of important CD4 and CD8 T cell subsets, and T effector memory cells with a Th1 cytokine (IFNγ and TNFα) signature among immunised mice. Additionally, significantly greater antigen specific Th1, Th17 and IL-10 responses, and antigen-induced T cell proliferation were seen from the spleens of immunised mice. Measurement of antigen-specific IgG and IgA from blood and bronchoalveolar lavage fluid also revealed enhanced systemic and local humoral immune responses among immunised animals. Lastly, peripheral blood mononuclear cells (PBMCs) obtained from the TB-endemic country of Mozambique show that individuals with LTBI showed significantly greater CD4 T cell reactivity to the vaccine candidate as compared to healthy controls. These results support further testing of Spore-FP1 and Nano-FP1 as post-exposure TB vaccines.
MeSH term(s)	Animals ; Mice ; Administration, Intranasal ; Leukocytes, Mononuclear ; Lung ; Tuberculosis ; Spores ; Nanoparticles ; Vaccines, Subunit ; Immunity
Chemical Substances	Vaccines, Subunit
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1306449
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Article ; Online: Treatment Patterns of Long-Acting Somatostatin Analogs for Neuroendocrine Tumors.

Clarke, Callisia N / Cockrum, Paul / Beveridge, Thomas J R / Jerry, Michelle / McMorrow, Donna / Tran, Anh Thu / Phan, Alexandria T

Journal of health economics and outcomes research

2023 Volume 10, Issue 2, Page(s) 121–131

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2746906-2
ISSN	2327-2236 ; 2327-2236
ISSN (online)	2327-2236
ISSN	2327-2236
DOI	10.36469/001c.89300
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Article ; Online: The one-week and three-month reliability of acceleration outcomes from an insole-embedded inertial measurement unit during treadmill running.

Gaiesky, Sean K T / Fridman, Lauren / Michie, Tom / Blazey, Paul / Tran, Nicholas / Schneeberg, Amy / Napier, Christopher

Sports biomechanics

2023 , Page(s) 1–15

Abstract: Inertial measurement units (IMUs) represent an exciting opportunity for researchers to broaden our understanding of running-related injuries, and for clinicians to expand their application of running gait analysis. The primary aim of our study was to ... ...

Abstract	Inertial measurement units (IMUs) represent an exciting opportunity for researchers to broaden our understanding of running-related injuries, and for clinicians to expand their application of running gait analysis. The primary aim of our study was to investigate the 1-week (short-term) and 3-month (long-term) reliability of peak resultant, vertical, and anteroposterior accelerations derived from insole-embedded IMUs. The secondary aim was to assess the reliability of peak acceleration variability and left-right limb symmetry in all directions over the short and long term. A sample of healthy adult rearfoot runners (
Language	English
Publishing date	2023-11-09
Publishing country	England
Document type	Journal Article
ISSN	1752-6116
ISSN (online)	1752-6116
DOI	10.1080/14763141.2023.2275258
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Article ; Online: Genome Characterisation of the CGMMV Virus Population in Australia-Informing Plant Biosecurity Policy.

Mackie, Joanne / Campbell, Paul R / Kehoe, Monica A / Tran-Nguyen, Lucy T T / Rodoni, Brendan C / Constable, Fiona E

Viruses

2023 Volume 15, Issue 3

Abstract: The detection of cucumber green mottle mosaic (CGMMV) in the Northern Territory (NT), Australia, in 2014 led to the introduction of strict quarantine measures for the importation of cucurbit seeds by the Australian federal government. Further detections ... ...

Abstract	The detection of cucumber green mottle mosaic (CGMMV) in the Northern Territory (NT), Australia, in 2014 led to the introduction of strict quarantine measures for the importation of cucurbit seeds by the Australian federal government. Further detections in Queensland, Western Australia (WA), New South Wales and South Australia occurred in the period 2015-2020. To explore the diversity of the current Australian CGMMV population, 35 new coding sequence complete genomes for CGMMV isolates from Australian incursions and surveys were prepared for this study. In conjunction with published genomes from the NT and WA, sequence, phylogenetic, and genetic variation and variant analyses were performed, and the data were compared with those for international CGMMV isolates. Based on these analyses, it can be inferred that the Australian CGMMV population resulted from a single virus source via multiple introductions.
MeSH term(s)	Citrullus ; Phylogeny ; Biosecurity ; Tobamovirus/genetics ; Cucumis sativus ; Northern Territory ; Plant Diseases/prevention & control
Language	English
Publishing date	2023-03-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15030743
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Article ; Online: Putting non-communicable disease data to work in Vietnam: an investigation of community health surveillance capacity.

Nguyen, Thu Nam T / Nguyen, Thi Tho T / Tran, Bao Quoc / Pham, Cong Tuan / Perry, Kelly E / Haregu, Tilahun / Oldenburg, Brian / Kowal, Paul

BMC public health

2023 Volume 23, Issue 1, Page(s) 321

Abstract: Introduction: Despite the public health system's critical role in non-communicable disease (NCD) surveillance in Vietnam, limited evidence exists on the implementation of NCD surveillance activities within these systems and the need for capacity ... ...

Abstract	Introduction: Despite the public health system's critical role in non-communicable disease (NCD) surveillance in Vietnam, limited evidence exists on the implementation of NCD surveillance activities within these systems and the need for capacity building across different system levels to meet expected NCD surveillance goals. This study aimed to evaluate the status of and describe factors affecting the implementation of NCD surveillance activities and to identify the NCD surveillance capacity building needs of the public health system in Vietnam. Methods: We used a mixed-methods approach in four provinces, conducting self-completed surveys of staff from six Preventive Medicine Institutes (PHI), 53 Centres for Disease Control (CDC) and 148 commune health stations (CHS), as well as 14 in-depth interviews and 22 focus group discussions at four PHI, four CDC, and eight district health centres and CHS. Results: Study findings highlighted that although Vietnam has a well-functioning NCD surveillance system, a number of quality issues related to NCD surveillance data were salient. Multifactorial reasons were identified for incomplete, unconfirmed, and inaccurate mortality data and current disease surveillance data. Data on NCD management and treatment were reported to be of better quality than data for screening, targeted treatment, and counselling communication. Main factors affected the effective implementation of NCD surveillance, namely lack of complete and specific guidelines for NCD surveillance, limitations in human resource capacity within NCD departments, and shortage of funding for NCD surveillance activities. Conclusion: Study findings provide practical strategies for strengthening health system capacity for NCD surveillance through developing policies, guidelines, and standardised tools to guide NCD surveillance and a road map for integrated NCD surveillance, developing training packages and manuals for all levels of the health system, and conducting utilisation-focused surveillance training programs.
MeSH term(s)	Humans ; Public Health ; Noncommunicable Diseases/epidemiology ; Noncommunicable Diseases/prevention & control ; Vietnam/epidemiology ; Workforce ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-14986-4
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Article ; Online: Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants.

Liu, Shi / Daley, Eileen J / Tran, Lauren My-Linh / Yu, Zhen / Reyes, Monica / Dean, Thomas / Khatri, Ashok / Levine, Paul M / Balana, Aaron T / Pratt, Matthew R / Jüppner, Harald / Gellman, Samuel H / Gardella, Thomas J

Journal of the American Chemical Society

2024 Volume 146, Issue 10, Page(s) 6522–6529

Abstract: Parathyroid hormone 1 receptor (PTH1R) plays a key role in mediating calcium homeostasis and bone development, and aberrant PTH1R activity underlies several human diseases. Peptidic PTH1R antagonists and inverse agonists have therapeutic potential in ... ...

Abstract	Parathyroid hormone 1 receptor (PTH1R) plays a key role in mediating calcium homeostasis and bone development, and aberrant PTH1R activity underlies several human diseases. Peptidic PTH1R antagonists and inverse agonists have therapeutic potential in treating these diseases, but their poor pharmacokinetics and pharmacodynamics undermine their in vivo efficacy. Herein, we report the use of a backbone-modification strategy to design a peptidic PTH1R inhibitor that displays prolonged activity as an antagonist of wild-type PTH1R and an inverse agonist of the constitutively active PTH1R-H223R mutant both in vitro and in vivo. This peptide may be of interest for the future development of therapeutic agents that ameliorate PTH1R malfunction.
MeSH term(s)	Humans ; Drug Inverse Agonism ; Receptor, Parathyroid Hormone, Type 1 ; Peptides ; Parathyroid Hormone/pharmacology
Chemical Substances	Receptor, Parathyroid Hormone, Type 1 ; Peptides ; Parathyroid Hormone ; PTH1R protein, human
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c09694
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Article ; Online: Eyelid and orbital trauma for the primary care physician.

Gordon, Abigail A / Tran, Lillian T / Phelps, Paul O

Disease-a-month : DM

2020 Volume 66, Issue 10, Page(s) 101045

Abstract: Patients who experience trauma to the eyelid or the orbit may present to their primary care providers or directly to the emergency room for evaluation of their injuries. These patients will often be in pain and may have bleeding around the eye, which can ...

Abstract	Patients who experience trauma to the eyelid or the orbit may present to their primary care providers or directly to the emergency room for evaluation of their injuries. These patients will often be in pain and may have bleeding around the eye, which can make evaluation of these patients difficult. Many traumatic injuries to the eye require quick and immediate intervention. In this article, we will review the background, anatomy, exam and management of some of the most common eye traumas including eyelid lacerations, orbital hemorrhages, intraorbital foreign bodies, and orbital fractures.
MeSH term(s)	Decompression, Surgical ; Eyelids/injuries ; Facial Injuries/diagnosis ; Facial Injuries/therapy ; Foreign Bodies/diagnosis ; Foreign Bodies/therapy ; Hemorrhage/diagnosis ; Hemorrhage/therapy ; Humans ; Lacerations/diagnosis ; Lacerations/therapy ; Ophthalmologic Surgical Procedures ; Orbit ; Orbital Diseases/diagnosis ; Orbital Diseases/therapy ; Orbital Fractures/diagnosis ; Orbital Fractures/therapy ; Physicians, Primary Care ; Primary Health Care ; Reconstructive Surgical Procedures ; Retrobulbar Hemorrhage/diagnosis ; Retrobulbar Hemorrhage/therapy ; Suture Techniques ; Tetanus/prevention & control ; Tetanus Toxoid/therapeutic use ; Therapeutic Irrigation ; Tomography, X-Ray Computed
Chemical Substances	Tetanus Toxoid
Language	English
Publishing date	2020-07-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	390545-7
ISSN	1557-8194 ; 0011-5029
ISSN (online)	1557-8194
ISSN	0011-5029
DOI	10.1016/j.disamonth.2020.101045
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Article ; Online: Pharmacologic Interventions to Prevent Delirium in Trauma Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Zitikyte, Gabriele / Roy, Danielle C / Tran, Alexandre / Fernando, Shannon M / Rosenberg, Erin / Kanji, Salmaan / Engels, Paul T / Wells, George A / Vaillancourt, Christian

Critical care explorations

2023 Volume 5, Issue 3, Page(s) e0875

Abstract: To compare the relative efficacy of pharmacologic interventions in the prevention of delirium in ICU trauma patients.: Data sources: We searched Medical Literature Analysis and Retrieval System Online, Embase, and Cochrane Registry of Clinical Trials ... ...

Abstract	To compare the relative efficacy of pharmacologic interventions in the prevention of delirium in ICU trauma patients. Data sources: We searched Medical Literature Analysis and Retrieval System Online, Embase, and Cochrane Registry of Clinical Trials from database inception until June 7, 2022. We included randomized controlled trials comparing pharmacologic interventions in critically ill trauma patients. Study selection: Two reviewers independently screened studies for eligibility, extracted data, and assessed risk of bias. Data extraction: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines for network analysis were followed. Random-effects models were fit using a Bayesian approach to network meta-analysis. Between-group comparisons were estimated using hazard ratios (HRs) for dichotomous outcomes and mean differences for continuous outcomes, each with 95% credible intervals. Treatment rankings were estimated for each outcome in the form of surface under the cumulative ranking curve values. Data synthesis: A total 3,541 citations were screened; six randomized clinical trials ( Conclusions: The results of this network meta-analysis suggest that there is no difference found between pharmacologic interventions on delirium occurrence, length of ICU stay, length of hospital stay, or mortality, in trauma ICU patients.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000875
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