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  1. Article ; Online: Identification of Alpha-1 Antitrypsin-Deficient Subjects with Normal Spirometry Who May Benefit from Alpha-1 Antitrypsin Replacement.

    Chan, Edward D

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 8, Page(s) 1033–1034

    MeSH term(s) Humans ; alpha 1-Antitrypsin/therapeutic use ; Spirometry ; alpha 1-Antitrypsin Deficiency/diagnosis ; alpha 1-Antitrypsin Deficiency/drug therapy ; alpha 1-Antitrypsin Deficiency/genetics ; Pulmonary Emphysema
    Chemical Substances alpha 1-Antitrypsin
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202311-2189LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
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  2. Article: Are there common threads in the susceptibility to cancer and tuberculosis?

    Chan, Edward D

    Journal of thoracic disease

    2020  Volume 12, Issue 5, Page(s) 1776–1780

    Language English
    Publishing date 2020-07-26
    Publishing country China
    Document type Editorial
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2020.03.114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial:

    Byrd, Thomas F / Chan, Edward D

    Frontiers in microbiology

    2022  Volume 13, Page(s) 943694

    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.943694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Manifestations and management of Sjögren's disease.

    Maleki-Fischbach, Mehrnaz / Kastsianok, Liudmila / Koslow, Matthew / Chan, Edward D

    Arthritis research & therapy

    2024  Volume 26, Issue 1, Page(s) 43

    Abstract: Sjögren's disease is a heterogeneous autoimmune disorder that may be associated with systemic manifestations such as pulmonary or articular involvement. Systemic complications have prognostic implications and need to be identified and managed in a timely ...

    Abstract Sjögren's disease is a heterogeneous autoimmune disorder that may be associated with systemic manifestations such as pulmonary or articular involvement. Systemic complications have prognostic implications and need to be identified and managed in a timely manner. Treatment should be tailored to the type and severity of organ involvement, ideally based on multidisciplinary evaluation.
    MeSH term(s) Humans ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/therapy ; Sjogren's Syndrome/complications ; Autoimmune Diseases/complications
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-024-03262-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5490: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Does Hypoxia Itself Beget Worsening Hypoxemia in COVID-19?

    Chan, Edward D / Sharma, Vibhu

    Mayo Clinic proceedings

    2021  Volume 96, Issue 3, Page(s) 824–825

    MeSH term(s) COVID-19 ; Humans ; Hypoxia/etiology ; SARS-CoV-2
    Language English
    Publishing date 2021-01-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.183: Show issues Location:
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  6. Article: Sarcoidosis,

    Dow, Coad Thomas / Lin, Nancy W / Chan, Edward D

    Microorganisms

    2023  Volume 11, Issue 4

    Abstract: Clinical and histological similarities between sarcoidosis and tuberculosis have driven repeated investigations looking for a mycobacterial cause of sarcoidosis. Over 50 years ago, "anonymous mycobacteria" were suggested to have a role in the etiology of ...

    Abstract Clinical and histological similarities between sarcoidosis and tuberculosis have driven repeated investigations looking for a mycobacterial cause of sarcoidosis. Over 50 years ago, "anonymous mycobacteria" were suggested to have a role in the etiology of sarcoidosis. Both tuberculosis and sarcoidosis have a predilection for lung involvement, though each can be found in any area of the body. A key histopathologic feature of both sarcoidosis and tuberculosis is the granuloma-while the tuberculous caseating granuloma has an area of caseous necrosis with a cheesy consistency; the non-caseating granuloma of sarcoidosis does not have this feature. This article reviews and reiterates the complicity of the infectious agent,
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11040829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reduced IFN-γ in Patients with Pulmonary Nontuberculous Mycobacterial Disease: Potentially Multiple Causes.

    Chan, Edward D

    American journal of respiratory cell and molecular biology

    2018  Volume 59, Issue 1, Page(s) 130–131

    MeSH term(s) Gene Expression ; Humans ; Interferon-gamma ; Mycobacterium Infections, Nontuberculous
    Chemical Substances Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2018-06-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2018-0012LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Thin body habitus is a risk factor for active pulmonary tuberculosis, but not for infection.

    Chan, Edward D

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2018  Volume 22, Issue 8, Page(s) 967–968

    MeSH term(s) Body Mass Index ; Humans ; Risk Factors ; Tuberculosis ; Tuberculosis, Pulmonary ; Weight Loss
    Language English
    Publishing date 2018-07-09
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.18.0272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4776: Show issues Location:
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    Zs.MO 261: Show issues

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  9. Article ; Online: What is the evidence that mycobacteria are associated with the pathogenesis of Sjogren's syndrome?

    Dow, Coad Thomas / Chan, Edward D

    Journal of translational autoimmunity

    2021  Volume 4, Page(s) 100085

    Abstract: Sjogren's syndrome (SS) is a common, systemic autoimmune disorder primarily affecting the exocrine glands resulting in xerostomia and xerophthalmia. SS may also manifest with polyarthralgia, polyarthritis, polymyalgia, cutaneous/other organ vasculitis, ... ...

    Abstract Sjogren's syndrome (SS) is a common, systemic autoimmune disorder primarily affecting the exocrine glands resulting in xerostomia and xerophthalmia. SS may also manifest with polyarthralgia, polyarthritis, polymyalgia, cutaneous/other organ vasculitis, interstitial lung disease, and/or various other disorders. The primary autoantibodies associated with SS and used as adjuncts to diagnosis are anti-Ro (SSA) and anti-La (SSB). The pathogenesis of SS is considered to involve genetic susceptibility and environmental triggers. An identified genetic susceptibility for SS lies in variants of the tumor necrosis factor alpha inducible protein 3 (
    Language English
    Publishing date 2021-02-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2021.100085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A narrative review of the controversy on the risk of mycobacterial infections with immune checkpoint inhibitor use: does Goldilocks have the answer?

    Vaddi, Akshara / Hulsebus, Holly J / O'Neill, Emily L / Knight, Vijaya / Chan, Edward D

    Journal of thoracic disease

    2024  Volume 16, Issue 2, Page(s) 1601–1624

    Abstract: Background and objective: Immune checkpoint inhibitors (ICIs) have revolutionized oncologic treatment. Whether ICIs increase susceptibility to or provide protection against mycobacterial infections remains controversial. The objective of this narrative ... ...

    Abstract Background and objective: Immune checkpoint inhibitors (ICIs) have revolutionized oncologic treatment. Whether ICIs increase susceptibility to or provide protection against mycobacterial infections remains controversial. The objective of this narrative review is to summarize the literature on the link between ICI use and mycobacterial infections-tuberculosis and non-tuberculous mycobacterial (NTM) infections-and to critically discuss evidence linking ICIs with mycobacterial infections, the possible confounders, and, if indeed the ICIs predispose to such infections, the potential mechanisms of how this may occur.
    Methods: We conducted a literature search on PubMed for relevant articles published from 2011 to current time [2024] utilizing specific keywords of "immune checkpoint inhibitors", "programmed cell death protein-1", "PD-1", "programmed death-ligand 1", "PD-L1", "cytotoxic T-lymphocyte-associated protein-4", or "CTLA-4" with that of "non-tuberculous mycobacterial lung disease", "tuberculosis", or "mycobacteria". The bibliographies of identified papers were perused for additional relevant articles.
    Key content and findings: Ex vivo
    Conclusions: Studies are needed to test the hypothesis that ICIs may either protect or predispose to mycobacterial infections, depending on the baseline host immune status. Prospective studies are required of patients on ICIs that control for potential confounders as anecdotal case reports are insufficient to provide a causal link. Murine studies with ICIs are also required to corroborate or refute studies of mice with genetic disruption of an immune checkpoint.
    Language English
    Publishing date 2024-02-27
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-1395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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