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  1. Article ; Online: Antibiotic de-escalation: finally, some action and not only words.

    Tabah, Alexis / De Bus, Liesbet / Leone, Marc

    The Lancet. Infectious diseases

    2024  Volume 24, Issue 4, Page(s) 331–333

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Sepsis/drug therapy ; Microbial Sensitivity Tests ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00749-1
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    Zs.A 5743: Show issues Location:
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  2. Article ; Online: Update on Staphylococcus aureus bacteraemia.

    Tabah, Alexis / Laupland, Kevin B

    Current opinion in critical care

    2022  Volume 28, Issue 5, Page(s) 495–504

    Abstract: Purpose of review: To review recently published evidence relevant to Staphylococcus aureus bacteremia (SAB).: Recent findings: Staphylococcus aureus is the most common pathogen causing co-infections and superinfections in patients with COVID-19. ... ...

    Abstract Purpose of review: To review recently published evidence relevant to Staphylococcus aureus bacteremia (SAB).
    Recent findings: Staphylococcus aureus is the most common pathogen causing co-infections and superinfections in patients with COVID-19. Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia ratios have sharply risen during the pandemic. SAB mortality is 18% at 1 month and 27% at 3 months but has gradually decreased over the last 30 years. Recurrences and reinfections are common (9%). Standardised items to define complicated SAB, and a new cut-off defining persisting bacteremia after 2 days with positive blood cultures have been proposed. Multiple antibiotic combinations have been trialled including vancomycin or daptomycin with β-lactams, fosfomycin, or clindamycin, without significant results. In the recently published guidelines, vancomycin remains the first line of treatment for MRSA bacteremia. For the management of methicillin-susceptible Staphylococcus aureus , cefazolin less frequently causes acute kidney injury than flucloxacillin, and when susceptibility is demonstrated, de-escalation to penicillin G is suggested.
    Summary: Our review confirms that Staphylococcus aureus represents a special aetiology among all causes of bloodstream infections. Pending results of platform and larger trials, its distinct epidemiology and determinants mandate careful integration of clinical variables and best available evidence to optimize patient outcomes.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; COVID-19 ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcus aureus ; Vancomycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000974
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    Zs.A 4999: Show issues Location:
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  3. Article ; Online: Central line associated and primary bloodstream infections.

    Stewart, Adam G / Laupland, Kevin B / Tabah, Alexis

    Current opinion in critical care

    2023  Volume 29, Issue 5, Page(s) 423–429

    Abstract: Purpose of review: Primary and intravascular catheter-associated bloodstream infections (CA-BSIs) represent an important clinical entity in the intensive care unit (ICU) being associated with significant morbidity and mortality. The purpose of this ... ...

    Abstract Purpose of review: Primary and intravascular catheter-associated bloodstream infections (CA-BSIs) represent an important clinical entity in the intensive care unit (ICU) being associated with significant morbidity and mortality. The purpose of this review was to examine the recently published data on epidemiology and management of CA-BSI and other primary BSIs specifically within the context of the ICU.
    Recent findings: In critically ill patients, the pooled prevalence of primary and CA-BSI from contemporary studies was 19.7-40.7% and 26.4-37.3% of all BSIs, respectively. Failure to achieve source control (i.e., removal of catheter in CA-BSI) is associated with higher mortality. Higher severity scores and durations of ICU stay and catheter insertion are well established risk factors for CA-BSI. The use of prevention bundles when inserting a central venous line is able to reduce CA-BSI incidence from 4 to 1.6 episodes per 1000 central venous catheter days. Differential time-to-positivity of paired blood cultures may assist in the diagnosis of CA-BSI.
    Summary: Primary BSI is frequently observed in ICU cohorts and has a poor effect on outcome. Surveillance for BSI among patients admitted to ICUs is fundamental to inform healthcare service delivery, design preventive approaches, to track resistance, and detect emerging pathogens.
    MeSH term(s) Humans ; Central Venous Catheters ; Catheter-Related Infections/epidemiology ; Hospitalization ; Intensive Care Units ; Sepsis
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001082
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    Zs.A 4999: Show issues Location:
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  4. Article ; Online: Update on prevention of intra-vascular accesses complications.

    Timsit, Jean-François / Tabah, Alexis / Mimoz, Olivier

    Intensive care medicine

    2022  Volume 48, Issue 10, Page(s) 1422–1425

    MeSH term(s) Humans ; Renal Dialysis ; Vascular Diseases
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06763-5
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  5. Article ; Online: Details and the devil within: the case of sepsis associated AKI. Author's reply.

    White, Kyle C / Laupland, Kevin B / Tabah, Alexis / Ramanan, Mahesh / Bellomo, Rinaldo

    Intensive care medicine

    2023  Volume 49, Issue 11, Page(s) 1426–1427

    MeSH term(s) Humans ; Sepsis/complications ; Acute Kidney Injury/etiology
    Language English
    Publishing date 2023-09-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07209-2
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    Zs.A 1089: Show issues Location:
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  6. Article ; Online: Clinical implications of urine output-based sepsis-associated acute kidney injury. Author's reply.

    White, Kyle C / Laupland, Kevin B / Tabah, Alexis / Ramanan, Mahesh / Bellomo, Rinaldo

    Intensive care medicine

    2023  Volume 49, Issue 10, Page(s) 1266–1267

    MeSH term(s) Humans ; Acute Kidney Injury/etiology ; Sepsis/complications
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07205-6
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    Zs.A 1089: Show issues Location:
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  7. Article ; Online: Double the risk of death and other 'inconvenient truths' about oliguria. Author's reply.

    White, Kyle C / Laupland, Kevin B / Tabah, Alexis / Ramanan, Mahesh / Bellomo, Rinaldo

    Intensive care medicine

    2023  Volume 49, Issue 11, Page(s) 1422–1423

    MeSH term(s) Humans ; Oliguria/etiology
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07218-1
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    Zs.A 1089: Show issues Location:
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  8. Article ; Online: Mandated nursing ratios decrease mortality and costs in the hospital, and what about the ICU?

    Reynolds, Hannah Victoria / Von Dohren, Gary / Tabah, Alexis

    Anaesthesia, critical care & pain medicine

    2021  Volume 40, Issue 6, Page(s) 100977

    MeSH term(s) Hospitals ; Humans ; Intensive Care Units ; Personnel Staffing and Scheduling
    Language English
    Publishing date 2021-11-05
    Publishing country France
    Document type Editorial ; Comment
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2021.100977
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  9. Article ; Online: Time in ICU and post-intensive care syndrome: how long is long enough?

    Flaws, Dylan / Fraser, John F / Laupland, Kevin / Lavana, Jayshree / Patterson, Sue / Tabah, Alexis / Tronstad, Oystein / Ramanan, Mahesh

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 34

    Abstract: Background: Our understanding of post-ICU recovery is influenced by which patients are selected to study and treat. Many studies currently list an ICU length of stay of at least 24, 48, or 72 h as an inclusion criterion. This may be driven by ... ...

    Abstract Background: Our understanding of post-ICU recovery is influenced by which patients are selected to study and treat. Many studies currently list an ICU length of stay of at least 24, 48, or 72 h as an inclusion criterion. This may be driven by established evidence that prolonged time in an ICU bed and prolonged ventilation can complicate post-ICU rehabilitation. However, recovery after short ICU stays still needs to be explored.
    Methods: This is a secondary analysis from the tracking outcomes post-intensive care (TOPIC) study. One hundred and thirty-two participants were assessed 6-months post-ICU discharge using standardised and validated self-report tools for physical function, cognitive function, anxiety, depression and post-traumatic stress disorder (with clinically significant impairment on any tool being considered a complicated recovery). Routinely collected data relating to the ICU stay were retrospectively accessed, including length of stay and duration of mechanical ventilation. Patients with short ICU stays were intentionally included, with 77 (58%) participants having an ICU length of stay < 72 h.
    Results: Of 132 participants, 40 (30%) had at least one identified post-ICU impairment 6 months after leaving ICU, 22 (17%) of whom had an ICU length of stay < 72 h.
    Conclusion: Many patients with an ICU length of stay < 72 h are reporting post-ICU impairment 6 months after leaving ICU. This is a population often excluded from studies and interventions. Future research should further explore post-ICU impairment among shorter stays.
    MeSH term(s) Humans ; Retrospective Studies ; Critical Illness ; Anxiety ; Intensive Care Units
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04812-7
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    Zs.A 5517: Show issues Location:
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  10. Article ; Online: Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series.

    Reynolds, Hannah V / Pollock, Hamish H G / Apte, Yogesh V / Tabah, Alexis

    A&A practice

    2022  Volume 16, Issue 1, Page(s) e01561

    Abstract: Severe and life-threatening cases of metformin-associated lactic acidosis (MALA) are treated with renal replacement therapy. Intermittent hemodialysis is recommended, as it achieves rapid more elimination of metformin compared to continuous renal ... ...

    Abstract Severe and life-threatening cases of metformin-associated lactic acidosis (MALA) are treated with renal replacement therapy. Intermittent hemodialysis is recommended, as it achieves rapid more elimination of metformin compared to continuous renal replacement therapy (CRRT). This case series describes 4 patients, 2 with acute metformin intoxications and 2 with insidious metformin toxicity. All were treated using a novel approach with dual CRRT to achieve rapid elimination of metformin. Three of the 4 patients survived to hospital discharge. Dual CRRT may be an effective alternative when dialysis is not readily available.
    MeSH term(s) Acidosis, Lactic/chemically induced ; Acidosis, Lactic/therapy ; Continuous Renal Replacement Therapy ; Humans ; Hypoglycemic Agents/adverse effects ; Metformin/adverse effects ; Renal Dialysis
    Chemical Substances Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2575-3126
    ISSN (online) 2575-3126
    DOI 10.1213/XAA.0000000000001561
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