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Article ; Online: Wei Chang An pill regulates gastrointestinal motility in a bidirectional manner.

Jia, Sitong / Chai, Lijuan / Zhang, Jing / Zhang, Min / Li, Lin / Qi, Yaxin / Pang, Yafen / Chen, Xi / Fan, Nana / Wang, Lin / Wang, Yujing / Song, Jixiang / Sun, Yingjie / Wang, Yi / Miao, Lin / Zhang, Han

Pharmaceutical biology

2021 Volume 59, Issue 1, Page(s) 1452–1463

Abstract: Context: Wei Chang An (WCA) is a commercial prescription developed for the coordination ...

Abstract	Context: Wei Chang An (WCA) is a commercial prescription developed for the coordination of gastrointestinal movement. Objective: To investigate the role of WCA in the regulation of diarrhoea and constipation in rats. Material and methods: The diarrhoea and constipation models were prepared by gavage of Results: Data from Bristol stool form scale, diarrhoea index, visceral sensitivity, defaecation time, and intestinal propulsive rate showed that WCA protected rats against diarrhoea and constipation ( Conclusions: WCA has both antidiarrhea and anti-constipation effects, suggesting its bidirectional role in gastrointestinal modulation, and providing evidence of WCA for irritable bowel syndrome treatment.
MeSH term(s)	Animals ; Constipation/drug therapy ; Constipation/physiopathology ; Diarrhea/drug therapy ; Diarrhea/physiopathology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Gastrointestinal Motility/drug effects ; Irritable Bowel Syndrome/drug therapy ; Irritable Bowel Syndrome/physiopathology ; Male ; Myosin-Light-Chain Kinase/genetics ; Rats ; Rats, Wistar ; rho-Associated Kinases/genetics
Chemical Substances	Drugs, Chinese Herbal ; Weichang'an ; ROCK1 protein, rat (EC 2.7.11.1) ; rho-Associated Kinases (EC 2.7.11.1) ; Myosin-Light-Chain Kinase (EC 2.7.11.18)
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2021.1991383
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Article ; Online: Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice.

Zhang, Xiaolu / Sun, Yingxin / Yu, Qun / Zeng, Wenyun / Zhang, Yue / Zeng, Miao / Pang, Kexin / Yu, Yifei / Gan, Jiali / Li, Huhu / Yang, Lin / Jiang, Xijuan

Mediators of inflammation

2023 Volume 2023, Page(s) 7807302

Abstract: ... of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism ...

Abstract	Background: Alleviating mild cognitive impairment (MCI) is crucial to delay the progression of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism of JWKXS in the treatment of MCI is unclear. Thus, this study aimed to investigate the effect and mechanism of JWKXS in SAMP8 mice models of MCI. Methods: MCI models were established to examine learning and memory ability and explore the pathomechanisms in brain of SAMP8 mice at 4, 6, and 8 months. The mice were treated for 8 weeks and the effects of JWKXS on MCI were characterized through Morris water maze and HE/Nissl's/immunohistochemical staining. Its mechanism was predicted by the combination of UPLC-Q-TOF/MS and system pharmacology analysis, further verified with SAMP8 mice, BV2 microglial cells, and PC12 cells. Results: It was found that 4-month-old SAMP8 mice exhibited MCI. Two months of JWKXS treatment improved the learning and memory ability, alleviated the hippocampal tissue and neuron damage. Through network pharmacology, four key signaling pathways were found to be involved in treatment of MCI by JWKXS, including TLR4/NF- Conclusion: JWKXS treatment improved the learning and memory ability and conferred neuroprotective effects against MCI by inducing anti-inflammation and antiapoptosis.
MeSH term(s)	Rats ; Mice ; Animals ; Inflammasomes/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Toll-Like Receptor 4/metabolism ; Cognitive Dysfunction/drug therapy ; Alzheimer Disease/drug therapy ; Anti-Inflammatory Agents/therapeutic use
Chemical Substances	Kai-Xin-San ; Inflammasomes ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Toll-Like Receptor 4 ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2023/7807302
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Article ; Online: Wei Chang An pill regulates gastrointestinal motility in a bidirectional manner

Pharmaceutical Biology. 2021 Jan. 1, v. 59, no. 1 p.1450-1461

2021

Abstract: Wei Chang An (WCA) is a commercial prescription developed for the coordination of gastrointestinal ...

Abstract	Wei Chang An (WCA) is a commercial prescription developed for the coordination of gastrointestinal movement. To investigate the role of WCA in the regulation of diarrhoea and constipation in rats. The diarrhoea and constipation models were prepared by gavage of Folium senna and diphenoxylate hydrochloride. Rats were randomized equally (n = 6) into the normal group given saline daily, the positive group given Pinaverium Bromide (13.5 mg/kg) or Sennoside A (0.1 mg/kg) and three WCA-treated groups (22, 44, and 88 mg/kg) by gavage daily for 7 consecutive days. The effects of WCA were assessed by a series of faecal symptoms and histopathology. Gastrointestinal parameters were determined by ELISA. The effect of WCA on gastrointestinal tissues was evaluated by strip assay. Expression of ROCK-1 and MLCK was measured by RT-PCR and Western blotting. Data from Bristol stool form scale, diarrhoea index, visceral sensitivity, defaecation time, and intestinal propulsive rate showed that WCA protected rats against diarrhoea and constipation (p < 0.01). The up-regulation of Substance P and 5-hydroxytryptamine in diarrhoea rats and down-regulation of Substance P and vasoactive intestinal polypeptide in constipation rats were inhibited by WCA (p < 0.05). WCA stimulated the gastrointestinal strip contractions but inhibited ACh-induced contractions (p < 0.01). The decreased ROCK-1 and MLCK expression in diarrhoea rats and increased in constipation rats were suppressed by WCA (p < 0.01). WCA has both antidiarrhea and anti-constipation effects, suggesting its bidirectional role in gastrointestinal modulation, and providing evidence of WCA for irritable bowel syndrome treatment.
Keywords	constipation ; defecation ; diarrhea ; gastrointestinal motility ; histopathology ; intestines ; irritable bowel syndrome ; sennosides ; serotonin ; substance P ; vasoactive intestinal peptide ; Diarrhoea ; Rho-associated coiled-coil forming protein kinase-1 (ROCK-1) ; myosin light chain kinase (MLCK) ; irritable bowel syndrome (IBS)
Language	English
Dates of publication	2021-0101
Size	p. 1450-1461.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2021.1991383
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comprehensive chemical profiling of Jia-Wei-Qi-Fu-Yin and its network pharmacology-based analysis on Alzheimer's disease.

An, Hai-Ming / Huang, Da-Rong / Yang, Hua / Liu, Xin-Guang / Du, Jing / Li, Yi / Li, Chao-Ran / Pang, Han-Qing / Liu, Run-Zhou / Peng, Chao / Li, Ping / Gao, Wen

Journal of pharmaceutical and biomedical analysis

2020 Volume 189, Page(s) 113467

Abstract: Jia-Wei-Qi-Fu-Yin (JWQFY) is a newly developed anti-Alzheimer's disease (AD) prescription modified ...

Abstract	Jia-Wei-Qi-Fu-Yin (JWQFY) is a newly developed anti-Alzheimer's disease (AD) prescription modified from a classical traditional Chinese medicine formula, Qi-Fu-Yin (QFY). However, a systematic understanding of its chemical constituents and molecular mechanisms is still elusive. To address this problem, comprehensive chemical profiling followed by network pharmacology-based analysis of JWQFY was performed. Firstly, a total of 136 compounds were characterized by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-QTOF MS), 17 of them were specifically identified in JWQFY comparing with QFY. Seventy compounds were further quantified via a validated HPLC coupled with triple quadrupole tandem mass spectrometry (QQQ MS) method. Then the protein targets of the seventy compounds were gathered from public databases for network construction. As a result, fifty-seven compounds were filtered, which interacted with 655 targets. Thirty-four of them were mapped into the KEGG pathway of AD, indicating JWQFY might exert anti-AD effects by anti-inflammation, neuronal apoptosis intervening, Aβ production inhibition and phosphorylating tau protein moderating. Furthermore, in the compound-target-AD network, a list of hub compounds and hub targets was identified based on their topological features, including the degree, node betweenness and closeness. Four of the hub compounds were specifically originated from JWQFY, supporting the modification rationality of this formula. This study provided a scientific basis for understanding the bioactive compounds and the multi-target mechanism of JWQFY.
MeSH term(s)	Alzheimer Disease/drug therapy ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Humans ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal ; qi-fu-yin
Language	English
Publishing date	2020-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2020.113467
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Article: Pollution characteristics and risk assessment of polycyclic aromatic hydrocarbons in the sediment of Wei River

Pang, Lin / Zhang, Shengwei / Wang, Lijun / Yang, Tao / Wang, Shuo

Environmental earth sciences. 2021 Mar., v. 80, no. 5

2021

Abstract: ... were collected in Wei River, and 16 priority PAHs were analyzed for pollution features as well ... of Wei River ranged from 60.5 to 10,241.1 ng g⁻¹ dw, with an average of 2250.4 ng g⁻¹ dw. The total ... Σ16PAHs and ΣCPAHs were observed in the lower reach of Wei River. PAHs in the sediment were dominated by 3 ...

Abstract	Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous organic pollutants which can be accumulated in river sediment, posing potential threats to ecosystem and human health. A total of 20 surface sediment samples were collected in Wei River, and 16 priority PAHs were analyzed for pollution features as well as ecological and human health risk. The results showed that the sum of the 16 PAHs (Σ16PAHs) in the sediment of Wei River ranged from 60.5 to 10,241.1 ng g⁻¹ dw, with an average of 2250.4 ng g⁻¹ dw. The total of seven carcinogenic PAHs (ΣCPAHs) was in the range of 5.8–7232.7 ng g⁻¹ dw, with a mean of 1276.5 ng g⁻¹ dw, accounting for 56.7% of the Σ16PAHs and presenting a high carcinogenic potential. Elevated Σ16PAHs and ΣCPAHs were observed in the lower reach of Wei River. PAHs in the sediment were dominated by 3- and 5-ring PAHs, and mainly related to various combustion processes. The ecological risk of individual PAHs (except for Chy) in the sediment was not to be neglected, with the highest risk of Acy and Flu. The total ecological risk of PAHs in the sediment was a moderate to high level. The non-carcinogenic risk of exposure to PAHs for children, adolescences and adults was insignificant. The carcinogenic risk of exposure to PAHs was in the range of 10–⁶—10–⁴ for children, adolescences and adults, indicating an acceptable carcinogenic risk.
Keywords	carcinogenicity ; combustion ; ecosystems ; human health ; pollution ; risk ; risk assessment ; rivers ; sediments
Language	English
Dates of publication	2021-03
Size	p. 203.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2493699-6
ISSN	1866-6299 ; 1866-6280
ISSN (online)	1866-6299
ISSN	1866-6280
DOI	10.1007/s12665-021-09483-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A validated UHPLC-MS/MS method for pharmacokinetic and brain distribution studies of twenty constituents in rat after oral administration of Jia-Wei-Qi-Fu-Yin.

An, Hai-Ming / Li, Meng-Ning / Yang, Hua / Pang, Han-Qing / Qu, Cheng / Xu, Yi / Liu, Run-Zhou / Peng, Chao / Li, Ping / Gao, Wen

Journal of pharmaceutical and biomedical analysis

2021 Volume 202, Page(s) 114140

Abstract: ... phenolic acid, in rat plasma and brain, which was administrated intragastrically with Jia-Wei-Qi-Fu-Yin (JWQFY ...

Abstract	A rapid ultra-high performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UHPLC-QqQ MS/MS) approach with high sensitivity and selectivity was developed for the quantification of twenty compounds, including 9 saponins, 8 flavonoids, 2 oligosaccharide esters and 1 phenolic acid, in rat plasma and brain, which was administrated intragastrically with Jia-Wei-Qi-Fu-Yin (JWQFY), Mass spectrometric detection was operated under multiple reaction monitoring (MRM) mode. All calibration curves possessed good linearity with correlation coefficients ( r
MeSH term(s)	Administration, Oral ; Animals ; Brain ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Rats ; Reproducibility of Results ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal ; qi-fu-yin
Language	English
Publishing date	2021-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2021.114140
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Article: Vegetation change and its influence on runoff and sediment in different landform units of China, Wei River, China

Gao, Haidong / Jia, Lianlian / Pang, Guowei / Wu, Zhao

Ecological engineering. 2019 Sept. 20,

2019

Abstract: ... the spatial variation of vegetation varies greatly. We selected the Wei River basin in the transition zone ...

Abstract	China has been ranked first in its contribution to the newly increased green areas in the world since 2000. Because of the significant differences in natural and geographical conditions in China, the spatial variation of vegetation varies greatly. We selected the Wei River basin in the transition zone between the Qinling Mountains and the Loess Plateau as the research object. Based on MOD13Q1 normalized difference vegetation index (NDVI) data, the characteristics of and factors influencing vegetation restoration, and their effects on the process of runoff-sediment under various landform units (Loess Plateau, Guanzhong Plain and Qinling Mountain areas) were studied using statistical and trend analyses. Our results indicated that the NDVI in 68.02% of the total research area had significantly increased (p < 0.05), with the fastest vegetation restoration in the loess area. The Theil Sen slopes in the loess, mountain and plain areas were 0.0095/year, 0.0049/year and 0.0013/year, respectively, with significant differences among them (p < 0.05). In the loess area, vegetation restoration rate was slightly higher in the zone with an elevation of 1000–2500 m than 500–1000 m. The fastest vegetation restoration in the mountains was in mountainous areas at low altitude, and the rate tended to decrease with greater elevation. In addition, the fastest vegetation restoration in the loess and mountain regions was in areas with gentle slopes of 5–15°. The relationship between vegetation and precipitation was stronger in the mountains than in the loess area. The results also revealed that improvement in vegetation coverage of cultivated and grassland was the leading cause of vegetation restoration in loess and mountain areas, but urbanization was the main factor affecting vegetation degradation in the plain. In the context of vegetation restoration, change in precipitation was still the dominant factor affecting variation in runoff and sediment load. In the loess area, vegetation restoration has a greater impact on sediment load, while in the Qinling Mountains, vegetation restoration mainly affects runoff.
Keywords	altitude ; ecological restoration ; grasslands ; loess ; mountains ; normalized difference vegetation index ; pollution load ; rivers ; runoff ; sediment yield ; urbanization ; watersheds ; China
Language	English
Dates of publication	2019-0920
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	1127407-4
ISSN	0925-8574
ISSN	0925-8574
DOI	10.1016/j.ecoleng.2019.105609
Database	NAL-Catalogue (AGRICOLA)

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Z 5865: Show issues

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Book: Ying yang ji shi pin wei sheng

Pang, Wenzhen

(Hu shi jin sheng zi xue cong shu ; 9)

1990

Title translation	Nutrition and food hygiene.
Author's details	Pang Wenzhen zhu bian
Series title	Hu shi jin sheng zi xue cong shu ; 9
MeSH term(s)	Diet Therapy ; Foodborne Diseases ; Nutritional Physiological Phenomena
Language	Chinese
Size	5, 9, 254 p., [1] folded leaf.
Edition	Di 1 ban.
Publisher	Ren min wei sheng chu ban she
Publishing place	Beijing Shi
Document type	Book
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Chinese phonology of the Wei-Chin period

Ding, Pang-hsin

reconstruction of the finals as reflected in poetry

(Special Publications. Institute of History and Philology. Academia Sinica ; 65)

1975

Author's details	Pang-hsin Ting
Series title	Special Publications. Institute of History and Philology. Academia Sinica ; 65
Language	English
Size	III, 296 S
Publisher	Inst., Acad
Publishing place	Taipei, Republic of China
Document type	Book
Note	Bearb. Diss. - [Schriftart: Ant. u. Chines.]
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Conference proceedings: K'ang Yu-wei

Lo, Jung-pang

a biography and a symposium

(Monographs and papers (Association for Asian Studies) ; 23)

1967

Author's details	edited with translation by Jung-pang Lo
Series title	Monographs and papers (Association for Asian Studies) ; 23
Language	English
Size	541 S., Ill., Kt., 24 cm
Publisher	University of Arizona Press
Publishing place	Tucson
Document type	Book ; Conference proceedings
Note	Bibliography S. 410 - 480
Database	Former special subject collection: coastal and deep sea fishing

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