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Article: Pharmacognosy of fruits of Prangos pabularia Lindl. (Komal)

Afaq, S.H / Rizwan, M

Indian journal of pharmacy Jan/Feb 1973, 35 (1)

1973

Keywords	plant physiology ; plant biochemistry
Language	English
Dates of publication	1973-01
Size	p. 28-32.
Document type	Article
ZDB-ID	412791-2
ISSN	0019-5472
ISSN	0019-5472
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Developments in advanced oxidation processes for removal of microplastics from aqueous matrices.

Rizwan, Komal / Bilal, Muhammad

Environmental science and pollution research international

2022 Volume 29, Issue 58, Page(s) 86933–86953

Abstract: Continuous incorporation of microplastics (MPs) and their fragmented residues into the ecosystem has sparked significant scientific apprehensions about persistence, a multitude of sources, and toxicity impacts on human health and aquatic entities. ... ...

Abstract	Continuous incorporation of microplastics (MPs) and their fragmented residues into the ecosystem has sparked significant scientific apprehensions about persistence, a multitude of sources, and toxicity impacts on human health and aquatic entities. Overcoming this multifaceted hazard necessitates the development of novel techniques with robust efficiencies to eliminate microplastics from the environmental compartments. Coagulation, flocculation, and membrane filtration are non-destructive techniques but necessitate extra steps for microplastic degradation, whereas biological means have been confirmed less efficient (less than 15% degradation). Recent reports have emphasized advanced oxidation processes (AOPs) as practical treatment alternatives, representing superior catalytic efficacy for microplastic degradation (≈30-95%). Nevertheless, additional investigations should be carried out to evaluate the performance of AOPs in degrading microplastics under real environmental matrices. Moreover, the detection of transformed metabolites, degradation mechanistic insights, and toxicity bioassays are required to substantiate AOP assumption as feasible remediation substitutes. This review focuses on the source, occurrence, discharge, transportation, and associated paramount health risks of microplastics. Advanced oxidation processes-assisted removal of microplastics from the aqueous matrices is thoroughly vetted with up-to-date findings. Factors affecting the degradation of MPs have been discussed in detail. In addition to the generalized mechanistic insights into photocatalytic degradation, the risk assessment of aging intermediates is also comprehended. Finally, the review was concluded by emphasizing current research gaps and incoming research tendencies to provide guidelines for efficiently addressing microplastic pollution.
MeSH term(s)	Humans ; Microplastics ; Plastics ; Ecosystem ; Environmental Monitoring ; Water Pollutants, Chemical/analysis ; Water
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical ; Water (059QF0KO0R)
Language	English
Publishing date	2022-10-24
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23545-0
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Article ; Online: Developments in advanced oxidation processes for removal of microplastics from aqueous matrices

Rizwan, Komal / Vēlāyutan̲, T. A.

Environ Sci Pollut Res. 2022 Dec., v. 29, no. 58 p.86933-86953

2022

Abstract	Continuous incorporation of microplastics (MPs) and their fragmented residues into the ecosystem has sparked significant scientific apprehensions about persistence, a multitude of sources, and toxicity impacts on human health and aquatic entities. Overcoming this multifaceted hazard necessitates the development of novel techniques with robust efficiencies to eliminate microplastics from the environmental compartments. Coagulation, flocculation, and membrane filtration are non-destructive techniques but necessitate extra steps for microplastic degradation, whereas biological means have been confirmed less efficient (less than 15% degradation). Recent reports have emphasized advanced oxidation processes (AOPs) as practical treatment alternatives, representing superior catalytic efficacy for microplastic degradation (≈30–95%). Nevertheless, additional investigations should be carried out to evaluate the performance of AOPs in degrading microplastics under real environmental matrices. Moreover, the detection of transformed metabolites, degradation mechanistic insights, and toxicity bioassays are required to substantiate AOP assumption as feasible remediation substitutes. This review focuses on the source, occurrence, discharge, transportation, and associated paramount health risks of microplastics. Advanced oxidation processes–assisted removal of microplastics from the aqueous matrices is thoroughly vetted with up-to-date findings. Factors affecting the degradation of MPs have been discussed in detail. In addition to the generalized mechanistic insights into photocatalytic degradation, the risk assessment of aging intermediates is also comprehended. Finally, the review was concluded by emphasizing current research gaps and incoming research tendencies to provide guidelines for efficiently addressing microplastic pollution.
Keywords	coagulation ; ecosystems ; flocculation ; human health ; metabolites ; microfiltration ; microplastics ; oxidation ; photocatalysis ; pollution ; remediation ; risk assessment ; toxicity ; transportation
Language	English
Dates of publication	2022-12
Size	p. 86933-86953.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
Note	Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23545-0
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Article ; Online: Metal-organic frameworks based hybrid nanocomposites as state-of-the-art analytical tools for electrochemical sensing applications.

Rasheed, Tahir / Rizwan, Komal

Biosensors & bioelectronics

2021 Volume 199, Page(s) 113867

Abstract: Metal-organic frameworks (MOFs) are remarkably porous materials that have sparked a lot of interest in recent years because of their fascinating architectures and variety of potential applications. This paper systematically summarizes recent ... ...

Abstract	Metal-organic frameworks (MOFs) are remarkably porous materials that have sparked a lot of interest in recent years because of their fascinating architectures and variety of potential applications. This paper systematically summarizes recent breakthroughs in MOFs and their derivatives with different materials such as, carbon nanotubes, graphene oxides, carbon fibers, enzymes, antibodies and aptamers etc. for enhanced electrochemical sensing applications. Furthermore, an overview part is highlighted, which provides some insights into the future prospects and directions of MOFs and their derivatives in electrochemical sensing, with the goal of overcoming present limitations by pursuing more inventive ways. This overview can perhaps provide some creative ideas for future research on MOF-based materials in this rapidly expanding field.
MeSH term(s)	Biosensing Techniques ; Metal-Organic Frameworks ; Nanocomposites ; Nanotubes, Carbon ; Oligonucleotides
Chemical Substances	Metal-Organic Frameworks ; Nanotubes, Carbon ; Oligonucleotides
Language	English
Publishing date	2021-12-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2021.113867
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Article ; Online: An insights into emerging trends to control the threats of antimicrobial resistance (AMR): an address to public health risks.

Asghar, Ayesha / Khalid, Aneeza / Baqar, Zulqarnain / Hussain, Nazim / Saleem, Muhammad Zafar / Sairash / Rizwan, Komal

Archives of microbiology

2024 Volume 206, Issue 2, Page(s) 72

Abstract: Antimicrobial agents are used to treat microbial ailments, but increased use of antibiotics and exposure to infections in healthcare facilities and hospitals as well as the excessive and inappropriate use of antibiotics at the society level lead to the ... ...

Abstract	Antimicrobial agents are used to treat microbial ailments, but increased use of antibiotics and exposure to infections in healthcare facilities and hospitals as well as the excessive and inappropriate use of antibiotics at the society level lead to the emergence of multidrug-resistant (MDR) bacteria. Antimicrobial resistance (AMR) is considered a public health concern and has rendered the treatment of different infections more challenging. The bacterial strains develop resistance against antimicrobial agents by limiting intracellular drug accumulation (increasing efflux or decreasing influx of antibiotics), modification and inactivation of drugs and its targets, enzymatic inhibition, and biofilm formation. However, the driving factors of AMR include the sociocultural and economic circumstances of a country, the use of falsified and substandard medicines, the use of antibiotics in farm animals, and food processing technologies. These factors make AMR one of the major menaces faced by mankind. In order to promote reciprocal learning, this article summarizes the current AMR situation in Pakistan and how it interacts with the health issues related to the COVID-19 pandemic. The COVID-19 pandemic aids in illuminating the possible long-term impacts of AMR, which are less immediate but not less severe since their measures and effects are equivalent. Impact on other sectors, including the health industry, the economy, and trade are also discussed. We conclude by summarizing the several approaches that could be used to address this issue.
MeSH term(s)	Animals ; Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial ; Pandemics/prevention & control ; Public Health ; COVID-19
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-01-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03800-9
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Article: Metal-organic frameworks based hybrid nanocomposites as state-of–the-art analytical tools for electrochemical sensing applications

Rasheed, Tahir / Rizwan, Komal

Biosensors & bioelectronics. 2022 Mar. 01, v. 199

2022

Abstract	Metal-organic frameworks (MOFs) are remarkably porous materials that have sparked a lot of interest in recent years because of their fascinating architectures and variety of potential applications. This paper systematically summarizes recent breakthroughs in MOFs and their derivatives with different materials such as, carbon nanotubes, graphene oxides, carbon fibers, enzymes, antibodies and aptamers etc. for enhanced electrochemical sensing applications. Furthermore, an overview part is highlighted, which provides some insights into the future prospects and directions of MOFs and their derivatives in electrochemical sensing, with the goal of overcoming present limitations by pursuing more inventive ways. This overview can perhaps provide some creative ideas for future research on MOF-based materials in this rapidly expanding field.
Keywords	biosensors ; carbon nanotubes ; electrochemistry ; graphene ; nanocomposites ; oligonucleotides
Language	English
Dates of publication	2022-0301
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2021.113867
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In Vitro

Javed, Muhammad Salman / Zubair, Muhammad / Rizwan, Komal / Jamil, Muhammad

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 12

Abstract: A series of carbamothioyl-furan-2-carboxamide derivatives were synthesized using a one-pot strategy. Compounds were obtained in moderate to excellent yields (56-85%). Synthesized derivatives were evaluated for their anti-cancer (HepG2, Huh-7, and MCF-7 ... ...

Abstract	A series of carbamothioyl-furan-2-carboxamide derivatives were synthesized using a one-pot strategy. Compounds were obtained in moderate to excellent yields (56-85%). Synthesized derivatives were evaluated for their anti-cancer (HepG2, Huh-7, and MCF-7 human cancer cell lines) and anti-microbial potential. Compound p-tolylcarbamothioyl)furan-2-carboxamide showed the highest anti-cancer activity at a concentration of 20 μg/mL against hepatocellular carcinoma, with a cell viability of 33.29%. All compounds showed significant anti-cancer activity against HepG2, Huh-7, and MCF-7, while indazole and 2,4-dinitrophenyl containing carboxamide derivatives were found to be less potent against all tested cell lines. Results were compared with the standard drug doxorubicin. Carboxamide derivatives possessing 2,4-dinitrophenyl showed significant inhibition against all bacterial and fungal strains with inhibition zones (I.Z) in the range of 9-17 and MICs were found to be 150.7-295 μg/mL. All carboxamide derivatives showed significant anti-fungal activity against all tested fungal strains. Gentamicin was used as the standard drug. The results showed that carbamothioyl-furan-2-carboxamide derivatives could be a potential source of anti-cancer and anti-microbial agents.
MeSH term(s)	Humans ; Structure-Activity Relationship ; Anti-Infective Agents/pharmacology ; MCF-7 Cells ; Fungi ; Furans/pharmacology ; Antineoplastic Agents/pharmacology ; Molecular Structure ; Cell Proliferation
Chemical Substances	Anti-Infective Agents ; Furans ; Antineoplastic Agents
Language	English
Publishing date	2023-06-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28124583
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Article ; Online: In Vitro Anti-Microbial Activity and Anti-Cancer Potential of Novel Synthesized Carbamothioyl-Furan-2-Carboxamide Derivatives

Muhammad Salman Javed / Muhammad Zubair / Komal Rizwan / Muhammad Jamil

Molecules, Vol 28, Iss 4583, p

2023 Volume 4583

Abstract: A series of carbamothioyl-furan-2-carboxamide derivatives were synthesized using a one-pot strategy. Compounds were obtained in moderate to excellent yields (56–85%). Synthesized derivatives were evaluated for their anti-cancer (HepG2, Huh-7, and MCF-7 ... ...

Abstract	A series of carbamothioyl-furan-2-carboxamide derivatives were synthesized using a one-pot strategy. Compounds were obtained in moderate to excellent yields (56–85%). Synthesized derivatives were evaluated for their anti-cancer (HepG2, Huh-7, and MCF-7 human cancer cell lines) and anti-microbial potential. Compound p-tolylcarbamothioyl)furan-2-carboxamide showed the highest anti-cancer activity at a concentration of 20 μg/mL against hepatocellular carcinoma, with a cell viability of 33.29%. All compounds showed significant anti-cancer activity against HepG2, Huh-7, and MCF-7, while indazole and 2,4-dinitrophenyl containing carboxamide derivatives were found to be less potent against all tested cell lines. Results were compared with the standard drug doxorubicin. Carboxamide derivatives possessing 2,4-dinitrophenyl showed significant inhibition against all bacterial and fungal strains with inhibition zones (I.Z) in the range of 9–17 and MICs were found to be 150.7–295 μg/mL. All carboxamide derivatives showed significant anti-fungal activity against all tested fungal strains. Gentamicin was used as the standard drug. The results showed that carbamothioyl-furan-2-carboxamide derivatives could be a potential source of anti-cancer and anti-microbial agents.
Keywords	carbamothioyl ; carboxamide ; furan ; anti-cancer ; anti-microbial ; Organic chemistry ; QD241-441
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phytochemistry and Diverse Pharmacology of Genus

Rizwan, Komal / Majeed, Ismat / Bilal, Muhammad / Rasheed, Tahir / Shakeel, Ahmad / Iqbal, Shahid

Biomolecules

2022 Volume 12, Issue 1

Abstract: ... The ... ...

Abstract	The genus
MeSH term(s)	Ethnopharmacology ; Mimosa ; Phytochemicals/chemistry ; Plant Extracts/chemistry ; Prospective Studies
Chemical Substances	Phytochemicals ; Plant Extracts
Language	English
Publishing date	2022-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12010083
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Article ; Online: Recent advancements in fusion protein technologies in oncotherapy: A review.

Mahmood, Tehreem / Shahbaz, Areej / Hussain, Nazim / Ali, Rahat / Bashir, Hamid / Rizwan, Komal

International journal of biological macromolecules

2023 Volume 230, Page(s) 123161

Abstract: Cancer is a complicated, adaptable, and heterogeneous disease caused by a wide variety of genetic changes that might impair ability of cells to function normally. The majority of the tumors can only be shrunk using conventional oncology therapies like ... ...

Abstract	Cancer is a complicated, adaptable, and heterogeneous disease caused by a wide variety of genetic changes that might impair ability of cells to function normally. The majority of the tumors can only be shrunk using conventional oncology therapies like chemotherapy, radiation, and surgical resection, and the tumor often recurs. The inability of conventional cancer therapies to completely destroy the Cancer Stem Cells (CSCs) that otherwise lead to therapy resistance is thus addressed by therapeutic approaches that concentrate on targeting CSCs and their micro-environmental niche. In this review, we summarize approaches that are used for the development of fusion proteins and their therapeutic applications for treating cancer. The main purpose of making advancements towards the fusion technology instead of using conventional treatment methods is to achieve a prolonged half-life of the therapeutic drugs. The fusion of drugs to the immune response enhancing cytokines or the fusion of antibody and cytokines not only increases half-life but also increase the stability of the anti-tumor drug. Several molecules including different fragments of antibodies, cytokines, Human Serum Albumin, transferrin, XTEN polymers, Elastin-like polypeptides (ELPs) can be employed as a fusion partner and the resulting fusion proteins are reported to show enhanced anti-tumor response.
MeSH term(s)	Humans ; Peptides/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/chemistry ; Polymers/chemistry ; Neoplasms/drug therapy ; Technology ; Cytokines
Chemical Substances	Peptides ; Antineoplastic Agents ; Polymers ; Cytokines
Language	English
Publishing date	2023-01-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123161
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