LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1306

Search options

  1. Article ; Online: Comparison of proximal and minus lens autorefraction techniques to measure monocular accommodative amplitude.

    Parks, Sidney M / Kulp, Marjean T / Anderson, Heather A

    Optometry and vision science : official publication of the American Academy of Optometry

    2024  Volume 101, Issue 2, Page(s) 109–116

    Abstract: ... viewed a 0.9 mm "E" placed at 13 demands (40 to 3.3 cm = 2.5 to 30 D). The other protocols used a target ... either the "E" or a detailed picture) placed at 33 and 12.5 cm followed by 12.5 cm with a series of lenses (-2 ... 4, and -5.5 D). Adjustments were made for lens effectivity for the three lens conditions, which were ...

    Abstract Significance: This study provides a faster method for objectively measuring accommodative amplitude with an open-field autorefractor in a research setting.
    Purpose: Objective measures of accommodative amplitude with an autorefractor take time because of the numerous stimulus demands tested. This study compares protocols using different amounts and types of demands to shorten the process.
    Methods: One hundred participants were recruited for four age bins (5 to 9, 10 to 14, 15 to 19, and 20 to 24 years) and monocular amplitude measured with an autorefractor using three protocols: proximal, proximal-lens (letter), and proximal-lens (picture). For proximal, measurements were taken as participants viewed a 0.9 mm "E" placed at 13 demands (40 to 3.3 cm = 2.5 to 30 D). The other protocols used a target (either the "E" or a detailed picture) placed at 33 and 12.5 cm followed by 12.5 cm with a series of lenses (-2, -4, and -5.5 D). Adjustments were made for lens effectivity for the three lens conditions, which were thus 9.6, 11.1, and 12.0 D for individuals without additional spectacle lenses. Accommodative amplitude was defined as the greatest response measured with each technique. One-way analysis of variance was used to compare group mean amplitudes across protocols and differences between letter protocols by age bin.
    Results: Amplitudes were significantly different between protocols (p < 0.001), with proximal having higher amplitudes (mean ± standard deviation, 8.04 ± 1.70 D) compared with both proximal-lens protocols (letter, 7.48 ± 1.42 D; picture, 7.43 ± 1.42 D) by post hoc Tukey analysis. Differences in amplitude between the proximal and proximal-lens (letter) protocol were different by age group (p = 0 .003), with the youngest group having larger differences (1.14 ± 1.58 D) than the oldest groups (0.17 ± 0.58 and 0.29 ± 0.48 D, respectively) by post hoc Tukey analysis.
    Conclusions: The proximal-lens protocols took less time and identified the maximum accommodative amplitude in participants aged 15 to 24 years; however, they may underestimate true amplitude in younger children.
    MeSH term(s) Child ; Humans ; Accommodation, Ocular ; Lenses
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1001706-9
    ISSN 1538-9235 ; 1040-5488
    ISSN (online) 1538-9235
    ISSN 1040-5488
    DOI 10.1097/OPX.0000000000002103
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Surgical Intervention is Associated with Improvement in Health-Related Quality of Life Outcomes in Patients with Symptomatic Sacral Tarlov Cysts: Results from a Prospective Longitudinal Cohort Study.

    Feigenbaum, Frank / Parks, Susan E / Martin, Madelene P / Ross, Tanishu D / Kupanoff, Kristina M

    World neurosurgery

    2024  

    Abstract: Objective: The treatment of symptomatic Tarlov cysts remains a controversial topic within neurosurgery. We describe our experience with patients who underwent surgical intervention for sacral Tarlov cysts at a single institution. General and disease- ... ...

    Abstract Objective: The treatment of symptomatic Tarlov cysts remains a controversial topic within neurosurgery. We describe our experience with patients who underwent surgical intervention for sacral Tarlov cysts at a single institution. General and disease-specific outcome measures were used to assess health-related quality of life.
    Methods: Patients who underwent surgical treatment for one or more sacral Tarlov cysts between 2018 and 2021 were included. The Tarlov Cyst Quality of Life (TCQoL), a validated disease-specific measure, was the primary outcome of the study. Secondary outcomes included general outcome measures: 36-Item Short Form Survey, the Oswestry Disability Index, and Visual Analog Scale. Patients were followed at 3, 6, and 12 months postoperative. Repeated measures analyses were used to assess change from preoperative to 12 months postoperative.
    Results: Data were obtained from 144 patients who underwent surgery for sacral Tarlov cysts, average age 52.3 ± 11.3 years, 90.3% female. Patients reported significant mean improvement on the TCQoL over time (preoperative 3.2±0.1; 3-months postoperative 2.1±0.1; 6-months 1.9±0.1; 12-months 1.9±0.1; P< 0.001). Patient age and duration of symptoms were not associated with outcome. 82.3% of patients reported improvement on TCQoL. There was not a significant difference in the proportion of patients reporting improvement on TCQoL by cyst size (small 90.9% vs. large 77.9%; P = 0.066).
    Conclusion: Our longitudinal series demonstrated patient-reported improvement following surgery for symptomatic sacral Tarlov cysts using a validated disease-specific health-related quality of life scale through 12 months following surgery. Patient age and preoperative duration of symptoms were not correlated with outcome.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.04.065
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface.

    Parks, Sydney E / Geng, Ting / Monsivais, Diana

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2023  Volume 90, Issue 6, Page(s) e13789

    Abstract: The endometrium is a unique and highly regenerative tissue with crucial roles during the reproductive lifespan of a woman. As the first site of contact between mother and embryo, the endometrium, and its critical processes of decidualization and immune ... ...

    Abstract The endometrium is a unique and highly regenerative tissue with crucial roles during the reproductive lifespan of a woman. As the first site of contact between mother and embryo, the endometrium, and its critical processes of decidualization and immune cell recruitment, play a leading role in the establishment of pregnancy, embryonic development, and reproductive capacity. These integral processes are achieved by the concerted actions of steroid hormones and a myriad of growth factor signaling pathways. This review focuses on the roles of the transforming growth factor β (TGFβ) pathway in the endometrium during the earliest stages of pregnancy through the lens of immune cell regulation and function. We discuss how key ligands in the TGFβ family signal through downstream SMAD transcription factors and ultimately remodel the endometrium into a state suitable for embryo implantation and development. We also focus on the key roles of the TGFβ signaling pathway in recruiting uterine natural killer cells and their collective remodeling of the decidua and spiral arteries. By providing key details about immune cell populations and TGFβ signaling within the endometrium, it is our goal to shed light on the intricate remodeling that is required to achieve a successful pregnancy.
    MeSH term(s) Pregnancy ; Female ; Humans ; Decidua/metabolism ; Transforming Growth Factor beta/metabolism ; Endometrium/metabolism ; Uterus/metabolism ; Embryo Implantation/physiology ; Signal Transduction
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2023-12-12
    Publishing country Denmark
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13789
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Pesticide use and inflammatory bowel disease in licensed pesticide applicators and spouses in the Agricultural Health Study.

    Chen, Dazhe / Parks, Christine G / Hofmann, Jonathan N / Beane Freeman, Laura E / Sandler, Dale P

    Environmental research

    2024  Volume 249, Page(s) 118464

    Abstract: Background: Pesticide exposure has been linked to some autoimmune diseases and colorectal cancer, possibly via alteration of gut microbiota or other mechanisms. While pesticides have been linked to gut dysbiosis and inflammation in animal models, few ... ...

    Abstract Background: Pesticide exposure has been linked to some autoimmune diseases and colorectal cancer, possibly via alteration of gut microbiota or other mechanisms. While pesticides have been linked to gut dysbiosis and inflammation in animal models, few epidemiologic studies have examined pesticides in relation to inflammatory bowel disease (IBD).
    Objectives: We evaluated use of pesticides and incident IBD in 68,480 eligible pesticide applicators and spouses enrolled in the Agricultural Health Study.
    Methods: Self-reported IBD cases were identified from follow-up questionnaires between enrollment (1993-1997) and 2022. We evaluated IBD incidence in relation to self-reported ever use of 50 pesticides among applicators and spouses. We also explored associations with intensity-weighted lifetime days (IWLD) of pesticide use among male applicators. Covariate-adjusted hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox regression.
    Results: We identified 454 IBD cases, including 227 among male applicators. In analyses with applicators and spouses combined, associations were positive (HR > 1.2) for ever vs. never use of five organochlorine insecticides, three organophosphate insecticides, one fungicide, and five herbicides. HRs were highest for dieldrin (HR = 1.59, 95%CI: 1.03, 2.44), toxaphene (HR = 1.61, 95%CI: 1.17, 2.21), parathion (HR = 1.42, 95%CI: 1.03, 1.95), and terbufos (HR = 1.53, 95%CI: 1.19, 1.96). We had limited power in many IWLD of pesticide use analyses and did not find clear evidence of exposure-response trends; however, we observed elevated HRs in all tertiles of IWLD use of terbufos compared to never use (T1 vs. never use HR = 1.52, 95%CI: 1.03, 2.24; T2 vs. never use HR = 1.53, 95%CI: 1.04, 2.26; T3 vs. never use HR = 1.51, 95%CI: 1.03, 2.23).
    Conclusions: Exposure to specific pesticides was associated with elevated hazards of IBD. These findings may have public health importance given the widespread use of pesticides and the limited number of known modifiable environmental risk factors for IBD.
    Language English
    Publishing date 2024-02-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118464
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Tumor-Associated and Systemic Autoimmunity in Pre-Clinical Breast Cancer among Post-Menopausal Women.

    Parks, Christine G / Wilson, Lauren E / Capello, Michela / Deane, Kevin D / Hanash, Samir M

    Biomolecules

    2023  Volume 13, Issue 11

    Abstract: ... with baseline ANA data. A total of 37 ANA-positive women who developed breast cancer (i.e., cases; mean time ... who did not develop breast cancer (i.e., controls; follow-up time ~13 years [SE 3]). Baseline sera were ...

    Abstract Autoantibodies to tumor-associated antigens (anti-TAA) are potential biomarkers for breast cancer, but their relationship systemic autoimmunity as ascertained though antinuclear antibodies (ANA) is unknown and warrants consideration given the common occurrence of autoimmunity and autoimmune diseases among women. The relationship between anti-TAAs and ANA among women who were later diagnosed with breast cancer and others who remained cancer free in the Women's Health Initiative cohort. The study sample included 145 post-menopausal women with baseline ANA data. A total of 37 ANA-positive women who developed breast cancer (i.e., cases; mean time to diagnosis 6.8 years [SE 3.9]) were matched to a random sample of 36 ANA-negative cases by age and time to diagnosis. An age-matched control sample was selected including 35 ANA-positive and 37 ANA-negative women who did not develop breast cancer (i.e., controls; follow-up time ~13 years [SE 3]). Baseline sera were assessed for Immunoglobulin G (IgG) antibodies, measured by custom microarray for 171 breast and other cancer-associated TAA. We used linear regression to estimate cross-sectional associations of ANA with log-transformed anti-TAA among cases and controls. Most anti-TAA did not vary by ANA status. Two anti-TAA were elevated in ANA-positive compared to ANA-negative cases: anti-PGM3 (
    MeSH term(s) Humans ; Female ; Autoimmunity ; Breast Neoplasms ; Cross-Sectional Studies ; Postmenopause ; Autoimmune Diseases ; Antibodies, Antinuclear
    Chemical Substances Antibodies, Antinuclear
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13111566
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Touching reality: Bridging the user-researcher divide in upper-limb prosthetics.

    Brown, J D / Battaglia, E / Engdahl, S / Levay, G / Parks, A C / Skinner, E / O'Malley, M K

    Science robotics

    2023  Volume 8, Issue 83, Page(s) eadk9421

    Abstract: Realistically improving upper-limb prostheses is only possible if we listen to users' actual technological needs. ...

    Abstract Realistically improving upper-limb prostheses is only possible if we listen to users' actual technological needs.
    MeSH term(s) Artificial Limbs ; Robotics ; Upper Extremity
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ISSN 2470-9476
    ISSN (online) 2470-9476
    DOI 10.1126/scirobotics.adk9421
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Solution-phase synthesis of the chalcogenide perovskite barium zirconium sulfide as colloidal nanomaterials.

    Zilevu, Daniel / Parks, Omri O / Creutz, Sidney E

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 75, Page(s) 10512–10515

    Abstract: Chalcogenide perovskites such as ... ...

    Abstract Chalcogenide perovskites such as BaZrS
    Language English
    Publishing date 2022-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc03494h
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Safety, tolerability, and acceptability of

    Bayar, E / MacIntyre, D A / Sykes, L / Mountain, K / Parks, T P / Lee, P P / Bennett, P R

    Beneficial microbes

    2023  Volume 14, Issue 1, Page(s) 45–56

    Abstract: The vaginal microbiota is a determinant for the risk of preterm birth (PTB). Dominance of the vaginal niche ... ...

    Abstract The vaginal microbiota is a determinant for the risk of preterm birth (PTB). Dominance of the vaginal niche by
    MeSH term(s) Infant, Newborn ; Female ; Pregnancy ; Humans ; Lactobacillus crispatus ; Premature Birth ; Pregnant Women ; Probiotics/adverse effects ; Vagina
    Language English
    Publishing date 2023-02-23
    Publishing country Netherlands
    Document type Observational Study ; Journal Article
    ZDB-ID 2561259-1
    ISSN 1876-2891 ; 1876-2883
    ISSN (online) 1876-2891
    ISSN 1876-2883
    DOI 10.3920/BM2022.0084
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Harnessing the active site triad: merging hemilability, proton responsivity, and ligand-based redox-activity.

    Baumgardner, Douglas F / Parks, Wyatt E / Gilbertson, John D

    Dalton transactions (Cambridge, England : 2003)

    2020  Volume 49, Issue 4, Page(s) 960–965

    Abstract: Metalloenzymes catalyze many important reactions by managing the proton and electron flux at the enzyme active site. The motifs utilized to facilitate these transformations include hemilabile, redox-active, and so called proton responsive sites. Given ... ...

    Abstract Metalloenzymes catalyze many important reactions by managing the proton and electron flux at the enzyme active site. The motifs utilized to facilitate these transformations include hemilabile, redox-active, and so called proton responsive sites. Given the importance of incorporating and understanding these motifs in the area of coordination chemistry and catalysis, we highlight recent milestones in the field. Work incorporating the triad of hemilability, redox-activity, and proton responsivity into single ligand scaffolds will be described.
    MeSH term(s) Catalytic Domain ; Galactose Oxidase/chemistry ; Galactose Oxidase/metabolism ; Ligands ; Models, Molecular ; Oxidation-Reduction ; Protein Conformation ; Protons
    Chemical Substances Ligands ; Protons ; Galactose Oxidase (EC 1.1.3.9)
    Language English
    Publishing date 2020-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c9dt04470a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Effect of reciprocity-breaking on fine-track tip/tilt systems.

    Isaacs, J / Parks, D / DiComo, G / Helle, M

    Applied optics

    2023  Volume 62, Issue 17, Page(s) 4699–4705

    Abstract: ... that in the absence of image noise (i.e., when the beacon power is arbitrarily high, and the signal-to-noise ratio is ...

    Abstract We analyze here a candidate system for correcting the wander of a self-channeled laser pulse using a fast-steering mirror along with a cooperative beacon imaged with a telescope. For our model system, the imaging telescope is coaxial with the propagation of the outgoing pulse. In the ideal case, any incoming light gathered from the beacon would be collimated, such that taking a centroid beacon image would yield the precise tip and tilt required for the self-channeled pulse to propagate back to the beacon on the reciprocal path. The degree to which reality differs from this ideal case determines the effectiveness of the wander correction. We simulate our system for a range of propagation and imaging conditions. We also show that in the absence of image noise (i.e., when the beacon power is arbitrarily high, and the signal-to-noise ratio is not an important consideration), the system exhibits its best performance when the receiving aperture diameter of the imaging system is close to the transverse size of the outgoing pulse, maximizing reciprocity. When realistic noise and finite beacon power are included in the simulation, however, we find that this reciprocity advantage may not be sufficient to compensate for the reduced photon count and resolving power of a small receiving aperture. In this case, the optimal aperture diameter will be the smallest possible, which allows for an acceptable signal-to-noise ratio.
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.491531
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top