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Article ; Online: Epigenomic Reprogramming as a Driver of Malignant Glioma.

Phillips, Richard E / Soshnev, Alexey A / Allis, C David

2020 Volume 38, Issue 5, Page(s) 647–660

Abstract: Malignant gliomas are central nervous system tumors and remain among the most treatment-resistant cancers. Exome sequencing has revealed significant heterogeneity and important insights into the molecular pathogenesis of gliomas. Mutations in chromatin ... ...

Abstract	Malignant gliomas are central nervous system tumors and remain among the most treatment-resistant cancers. Exome sequencing has revealed significant heterogeneity and important insights into the molecular pathogenesis of gliomas. Mutations in chromatin modifiers-proteins that shape the epigenomic landscape through remodeling and regulation of post-translational modifications on chromatin-are very frequent and often define specific glioma subtypes. This suggests that epigenomic reprogramming may be a fundamental driver of glioma. Here, we describe the key chromatin regulatory pathways disrupted in gliomas, delineating their physiological function and our current understanding of how their dysregulation may contribute to gliomagenesis.
MeSH term(s)	Biomarkers, Tumor/genetics ; Brain Neoplasms/genetics ; Epigenesis, Genetic ; Epigenomics/methods ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Humans ; Whole Exome Sequencing
Chemical Substances	Biomarkers, Tumor
Keywords	covid19
Language	English
Publishing date	2020-09-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2020.08.008
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Article: Learning Curve of Robotic-Assisted Total Knee Arthroplasty for Non-Fellowship-Trained Orthopedic Surgeons.

Ali, Muzaffar / Phillips, David / Kamson, Anthony / Nivar, Isaac / Dahl, Raymond / Hallock, Richard

Arthroplasty today

2022 Volume 13, Page(s) 194–198

Abstract: Background: Total knee arthroplasty (TKA) serves as a reliable treatment option for patients with end-stage arthritis, but patient dissatisfaction rate remains high. With the projected increase in the volume of arthroplasty operations, surgeons have ... ...

Abstract	Background: Total knee arthroplasty (TKA) serves as a reliable treatment option for patients with end-stage arthritis, but patient dissatisfaction rate remains high. With the projected increase in the volume of arthroplasty operations, surgeons have aimed for methods in which to improve the patient outcomes. Robotic-assisted TKA has become increasingly popular. The learning curve for such technology has been investigated, but these prior studies have only been performed by fellowship-trained arthroplasty surgeons. The goal of this study was to investigate the learning curve for non-fellowship-trained orthopedic surgeons to ameliorate any concerns about increased operative time. Methods: Retrospective analysis of robotic-assisted TKAs and manual TKAs, performed by two non-fellowship-trained orthopedic surgeons, was conducted on a total of 160 patients. For each individual surgeon, the robotic-assisted TKAs were divided into 3 cohorts of 20 consecutive patients. Data from 20 consecutive manual TKAs were also gathered for each surgeon. The mean operative times were compared. Cohorts were then grouped together for both surgeons and compared in a similar fashion. Results: For surgeon 1, mean operative times were significantly increased for robotic-assisted cohorts compared with those for the manual cohort. For surgeon 2, the first robotic-assisted cohort was significantly longer. However, there were no significant differences for the second and third robotic-assisted cohorts. In the combined surgeon group, there was no significant difference between operative times for the third robotic cohort and the manual cohort. Conclusion: This study demonstrates that the general orthopedic surgeon in a community hospital may be able to adequately perform robotic-assisted surgery in a similar timeframe to their manual TKA within their first 40 robotic-arm-assisted TKA.
Language	English
Publishing date	2022-01-22
Publishing country	United States
Document type	Journal Article
ISSN	2352-3441
ISSN	2352-3441
DOI	10.1016/j.artd.2021.10.020
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Article ; Online: Time to Extubation Among ARDS Subjects With and Without COVID-19 Pneumonia.

Burns, Gregory D / Phillips, Justin S / Kallet, Richard H / Glidden, David V / Hendrickson, Carolyn M / Metcalfe, John Z

Respiratory care

2023 Volume 68, Issue 10, Page(s) 1340–1346

Abstract: Background: Pneumonia from COVID-19 that results in ARDS may require invasive mechanical ventilation. This retrospective study assessed the characteristics and outcomes of subjects with COVID-19-associated ARDS versus ARDS (non-COVID) during the first 6 ...

Abstract	Background: Pneumonia from COVID-19 that results in ARDS may require invasive mechanical ventilation. This retrospective study assessed the characteristics and outcomes of subjects with COVID-19-associated ARDS versus ARDS (non-COVID) during the first 6 months of the COVID-19 pandemic in 2020. The primary objective was to determine whether mechanical ventilation duration differed between these cohorts and identify other potential contributory factors. Methods: We retrospectively identified 73 subjects admitted between March 1 and August 12, 2020, with either COVID-19-associated ARDS (37) or ARDS (36) who were managed with the lung protective ventilator protocol and required >48 h of mechanical ventilation. Exclusion criteria were the following: <18 years old or the patient required tracheostomy or interfacility transfer. Demographic and baseline clinical data were collected at ARDS onset (ARDS day 0), with subsequent data collected on ARDS days 1-3, 5, 7, 10, 14, and 21. Comparisons were made by using the Wilcoxon rank-sum test (continuous variables) and chi-square test (categorical variables) stratified by COVID-19 status. A Cox proportional hazards model assessed the cause-specific hazard ratio for extubation. Results: The median (interquartile range) mechanical ventilation duration among the subjects who survived to extubation was longer in those with COVID-19-ARDS versus the subjects with non-COVID ARDS: 10 (6-20) d versus 4 (2-8) d; Conclusions: Mechanical ventilation duration was longer in subjects with COVID-19-associated ARDS compared with the subjects with non-COVID ARDS, which may be explained by a lower rate of improvement in oxygenation status.
MeSH term(s)	Humans ; Adolescent ; COVID-19/complications ; Retrospective Studies ; Airway Extubation ; Pandemics ; Respiration, Artificial/methods ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.09876
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Article ; Online: Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation.

Bartlett, Richard D / Phillips, James B / Choi, David

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2019 Volume 191, Issue 43, Page(s) E1199

MeSH term(s)	Autografts ; Cell Transplantation ; Olfactory Mucosa ; Stem Cell Transplantation ; Transplantation, Autologous
Language	English
Publishing date	2019-10-28
Publishing country	Canada
Document type	Letter ; Comment
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.73255
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Article ; Online: System-Level Factors and Time Spent on Electronic Health Records by Primary Care Physicians.

Rotenstein, Lisa S / Holmgren, A Jay / Horn, Daniel M / Lipsitz, Stuart / Phillips, Russell / Gitomer, Richard / Bates, David W

JAMA network open

2023 Volume 6, Issue 11, Page(s) e2344713

Abstract: Importance: Primary care physicians (PCPs) spend the most time on the electronic health record (EHR) of any specialty. Thus, it is critical to understand what factors contribute to varying levels of PCP time spent on EHRs.: Objective: To characterize ...

Abstract	Importance: Primary care physicians (PCPs) spend the most time on the electronic health record (EHR) of any specialty. Thus, it is critical to understand what factors contribute to varying levels of PCP time spent on EHRs. Objective: To characterize variation in EHR time across PCPs and primary care clinics, and to describe how specific PCP, patient panel, clinic, and team collaboration factors are associated with PCPs' time spent on EHRs. Design, setting, and participants: This cross-sectional study included 307 PCPs practicing across 31 primary care clinics at Massachusetts General Hospital and Brigham and Women's Hospital during 2021. Data were analyzed from October 2022 to October 2023. Main outcomes and measures: Total per-visit EHR time, total per-visit pajama time (ie, time spent on the EHR between 5:30 pm to 7:00 am and on weekends), and total per-visit time on the electronic inbox as measured by activity log data derived from an EHR database. Results: The sample included 307 PCPs (183 [59.6%] female). On a per-visit basis, PCPs spent a median (IQR) of 36.2 (28.9-45.7) total minutes on the EHR, 6.2 (3.1-11.5) minutes of pajama time, and 7.8 (5.5-10.7) minutes on the electronic inbox. When comparing PCP time expenditure by clinic, median (IQR) total EHR time, median (IQR) pajama time, and median (IQR) electronic inbox time ranged from 23.5 (20.7-53.1) to 47.9 (30.6-70.7) minutes per visit, 1.7 (0.7-10.5) to 13.1 (7.7-28.2) minutes per visit, and 4.7 (4.1-5.2) to 10.8 (8.9-15.2) minutes per visit, respectively. In a multivariable model with an outcome of total per-visit EHR time per visit, an above median percentage of teamwork on orders was associated with 3.81 (95% CI, 0.49-7.13) minutes per visit fewer and having a clinic pharmacy technician was associated with 7.87 (95% CI, 2.03-13.72) minutes per visit fewer. Practicing in a community health center was associated with fewer minutes of total EHR time per visit (5.40 [95% CI, 0.06-10.74] minutes). Conclusions and relevance: There is substantial variation in EHR time among individual PCPs and PCPs within clinics. Organization-level factors, such as team collaboration on orders, support for medication refill functions, and practicing in a community health center, are associated with lower EHR time for PCPs. These findings highlight the importance of addressing EHR burden at a systems level.
MeSH term(s)	Humans ; Female ; Male ; Cross-Sectional Studies ; Electronic Health Records ; Physicians, Primary Care ; Ambulatory Care Facilities ; Hospitals, General
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.44713
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Article ; Online: Contrasting responses of woody and grassland ecosystems to increased CO

Pan, Yude / Jackson, Robert B / Hollinger, David Y / Phillips, Oliver L / Nowak, Robert S / Norby, Richard J / Oren, Ram / Reich, Peter B / Lüscher, Andreas / Mueller, Kevin E / Owensby, Clenton / Birdsey, Richard / Hom, John / Luo, Yiqi

Nature ecology & evolution

2022 Volume 6, Issue 3, Page(s) 315–323

Abstract: Experiments show that elevated atmospheric ... ...

Abstract	Experiments show that elevated atmospheric CO
MeSH term(s)	Carbon Dioxide ; Ecosystem ; Grassland ; Photosynthesis ; Water Supply
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2397-334X
ISSN (online)	2397-334X
DOI	10.1038/s41559-021-01642-6
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Article ; Online: Renal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people with HIV.

Hunt, Matthew / Phillips, Richard / Hardy, Yasmine / Owusu, Dorcas O / Mitchelmore, Rosa / Durrani, Mehrab / Payne, Brendan A I / Chadwick, David R

AIDS (London, England)

2022 Volume 36, Issue 7, Page(s) 1049–1051

Abstract: We investigated the contributions of thymidine analogue and tenofovir disoproxil fumarate (TDF) antiretroviral therapy on renal mitochondrial toxicity in Ghanaian people with HIV (PWH). Similar levels of renal biochemical and mitochondrial dysfunction ... ...

Abstract	We investigated the contributions of thymidine analogue and tenofovir disoproxil fumarate (TDF) antiretroviral therapy on renal mitochondrial toxicity in Ghanaian people with HIV (PWH). Similar levels of renal biochemical and mitochondrial dysfunction were seen, and there was no increased risk in PWH who had sequenced from thymidine analogue to TDF. However, mild renal impairment was associated with mitochondrial DNA damage in TDF but not thymidine analogue-treated PWH. These data support the continued use of TDF in resource-limited settings.
MeSH term(s)	Anti-HIV Agents/adverse effects ; Ghana ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Mitochondria ; Renal Insufficiency/chemically induced ; Tenofovir/adverse effects ; Thymidine/adverse effects
Chemical Substances	Anti-HIV Agents ; Tenofovir (99YXE507IL) ; Thymidine (VC2W18DGKR)
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003209
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Article: Decision Considerations and Strategies for Lip Surgery in Patients with Cleft lip/Palate: A Qualitative Study.

Trotman, Carroll Ann / Faraway, Julian / Bennett, M Elizabeth / Garson, G David / Phillips, Ceib / Bruun, Richard / Daniel, Renie / David, Lisa Renee / Ganske, Ingrid / Leeper, Lauren K / Rogers-Vizena, Carolyn R / Runyan, Christopher / Scott, Andrew R / Wood, Jeyhan

medRxiv : the preprint server for health sciences

2023

Abstract: ... statistical analyses using the Grounded Theory Method.: Results: Rich narratives/themes emerged that included timing ...

Abstract	Objective: To qualitatively assess surgeons decision making for lip surgery in patients with cleft lip/palate (CL/P). Design: Prospective, non-randomized, clinical trial. Setting: Clinical data institutional laboratory setting. Patients participants: The study included both patient and surgeon participants recruited from four craniofacial centers. The patient participants were babies with a CL/P requiring primary lip repair surgery (n=16) and adolescents with repaired CL/P who may require secondary lip revision surgery (n=32). The surgeon participants (n=8) were experienced in cleft care. Facial imaging data that included 2D images, 3D images, videos, and objective 3D visual modelling of facial movements were collected from each patient, and compiled as a collage termed the Standardized Assessment for Facial Surgery (SAFS) for systematic viewing by the surgeons. Interventions: The SAFS served as the intervention. Each surgeon viewed the SAFS for six distinct patients (two babies and four adolescents) and provided a list of surgical problems and goals. Then an in-depth-interview (IDI) was conducted with each surgeon to explore their decision-making processes. IDIs were conducted either in person or virtually, recorded, and then transcribed for qualitative statistical analyses using the Grounded Theory Method. Results: Rich narratives/themes emerged that included timing of the surgery; risks/limitations and benefits of surgery; patient/family goals; planning for muscle repair and scarring; multiplicity of surgeries and their impact; and availability of resources. For diagnoses/treatments, surgeons agreed, and level of surgical experience was not a factor. Conclusions: The themes provided important information to populate a checklist of considerations to serve as a guide for clinicians.
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.04.20.23287416
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Article ; Online: Mental distress and health-related quality of life in gambiense human African trypanosomiasis: a case-control study in the Democratic Republic of Congo.

Mudji, Junior / Ackam, Nancy / Amoako, Yaw Ampem / Madinga, Blaise / Mumbere, Pépé / Agbanyo, Abigail / Blum, Johannes / Phillips, Richard Odame / Molyneux, David Hurst

Transactions of the Royal Society of Tropical Medicine and Hygiene

2022 Volume 116, Issue 11, Page(s) 1022–1031

Abstract: Background: The extent to which neuropsychiatric sequelae affects the mental health status and quality of life of former gambiense human African trypanosomiasis (gHAT) patients is not known.: Methods: We assessed anxiety, depression and health- ... ...

Abstract	Background: The extent to which neuropsychiatric sequelae affects the mental health status and quality of life of former gambiense human African trypanosomiasis (gHAT) patients is not known. Methods: We assessed anxiety, depression and health-related quality of life (HRQoL) in 93 patients and their age- and sex-matched controls using the Hospital Anxiety and Depression Scale, Becks Depression Inventory and the 36-item Short Form Health Survey in structured interviews in the Vanga health zone in the Democratic Republic of Congo. Data were analysed using Stata version 14.0. The degree of association between neurologic sequelae and mental distress was evaluated using the Student's t-test and χ2 or Fisher's exact tests, where appropriate, with a p-value <0.05 deemed to be statistically significant. Results: We found that neurological sequelae persisted in former patients at least 15 y after treatment. Depression (p<0.001) and anxiety (p=0.001) were significantly higher in former patients with neurologic sequelae. The mean quality-of-life (QoL) scores were significantly lower for patients than in controls in the physical, emotional and mental health domains. Conclusions: The presence of neurological sequelae leads to mental distress and a diminished QoL in former gHAT patients. Minimising neurologic sequelae and incorporating psychosocial interventions should be essential management goals for gHAT.
MeSH term(s)	Animals ; Humans ; Trypanosomiasis, African/complications ; Trypanosomiasis, African/epidemiology ; Quality of Life ; Case-Control Studies ; Democratic Republic of the Congo/epidemiology ; Anxiety/etiology
Language	English
Publishing date	2022-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/trac035
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Article ; Online: Suicide among emergency service workers: a retrospective mortality study of national coronial data, 2001-2017.

Petrie, Katherine / Spittal, Matthew / Zeritis, Stephanie / Phillips, Matthew / Deady, Mark / Forbes, David / Bryant, Richard / Shand, Fiona / Harvey, Samuel B

Psychological medicine

2022 Volume 53, Issue 12, Page(s) 5470–5477

Abstract: Background: Emergency service workers (ESW) are known to be at increased risk of mental disorders but population-level and longitudinal data regarding their risk of suicide are lacking.: Method: Suicide data for 2001-2017 were extracted from the ... ...

Abstract	Background: Emergency service workers (ESW) are known to be at increased risk of mental disorders but population-level and longitudinal data regarding their risk of suicide are lacking. Method: Suicide data for 2001-2017 were extracted from the Australian National Coronial Information Service (NCIS) for two occupational groups: ESW (ambulance personnel, fire-fighters and emergency workers, police officers) and individuals employed in all other occupations. Age-standardised suicide rates were calculated and risk of suicide compared using negative binomial regression modelling. Results: 13 800 suicide cases were identified among employed adults (20-69 years) over the study period. The age-standardised suicide rate across all ESW was 14.3 per 100 000 (95% CI 11.0-17.7) compared to 9.8 per 100 000 (95% CI 9.6-9.9) for other occupations. Significant occupational differences in the method of suicide were identified ( Conclusion: Whilst age-standardised suicide rates among ESW are higher than other occupations, emergency service work was not independently associated with an increased risk of suicide, with the exception of an observed trend in ambulance personnel. Despite an increased focus on ESW mental health and wellbeing over the last two decades, there was no evidence that rates of suicide among ESW are changing over time.
MeSH term(s)	Adult ; Humans ; Retrospective Studies ; Australia/epidemiology ; Suicide ; Occupations ; Emergency Medical Services
Language	English
Publishing date	2022-09-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291722002653
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