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  1. Article: Patient Parameters Associated With a Positive Blood Culture Using NeuroShell: A Retrospective Chart Review.

    Giovane, Richard / Sheppard, Robert A

    Cureus

    2022  Volume 14, Issue 8, Page(s) e28635

    Abstract: Bacteremia is a common and life-threatening condition. It has an incidence of 140 to 160 per 100,000 person-years in the United States. Since bacteremia has many presentations, it can be challenging to diagnose. Subsequently there are very few guidelines ...

    Abstract Bacteremia is a common and life-threatening condition. It has an incidence of 140 to 160 per 100,000 person-years in the United States. Since bacteremia has many presentations, it can be challenging to diagnose. Subsequently there are very few guidelines on when to order a blood culture in an emergency setting. Neural networks are a means of machine learning and are presently being used in medicine to aid in decision making. With the use of machine learning, 22 variables that have been associated with infection and bacteremia were used to build a neural network to determine which variables associated with bacteremia are most associated with a positive blood culture.
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.28635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: An Infected Dog Bite With Neisseria canis: A Case Report and Review of the Literature.

    Giovane, Richard / Pernia, Luis / Guy, Traci / Blevins, Hannah

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52712

    Abstract: ... ...

    Abstract Neisseria
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52712
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  3. Article ; Online: Knockout rates across the states as a way of predicting injury and knockout based on fighter sex, weight, or experience.

    Twohey, Eric / Velasco, George / Neidecker, John / Giovane, Richard

    The Physician and sportsmedicine

    2023  , Page(s) 1–5

    Abstract: Combat sports, such as boxing and mixed martial arts [MMA], have the unique objective to finish a bout by way of knockout [KO] or technical knockout [TKO]. There are potentially both short- and long-term neurological injuries that can happen as a result ... ...

    Abstract Combat sports, such as boxing and mixed martial arts [MMA], have the unique objective to finish a bout by way of knockout [KO] or technical knockout [TKO]. There are potentially both short- and long-term neurological injuries that can happen as a result of the repeated head trauma sustained in bouts, and thus it is imperative to identify the athletes that are at increased risk. Using an online database of professional boxing bouts [boxrec.com] over a 6-month period, KO/TKO rates were calculated across different states, weight classes, sex, and Fight Exposure Score [FES] categories. There was found to be a significant association between KO/TKO rates and weight class, sex, and FES category with heavyweights, males and FES 0 boxers having higher KO/TKO rates. KO/TKO rates were increased in winless boxers. KO/TKO rates across the states are documented in the study.
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 753046-8
    ISSN 2326-3660 ; 0091-3847
    ISSN (online) 2326-3660
    ISSN 0091-3847
    DOI 10.1080/00913847.2023.2285716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Bilateral Thalamic Stroke: A Case of COVID-19 Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) or a Coincidence Due to Underlying Risk Factors?

    Giovane, Richard / Campbell, Jessica

    Cureus

    2021  Volume 13, Issue 10, Page(s) e18977

    Abstract: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but potentially life-threatening side effect that has only been observed in adenovirus-based vaccines for coronavirus disease 2019 (COVID-19). VITT is an immune-mediated condition that ... ...

    Abstract Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but potentially life-threatening side effect that has only been observed in adenovirus-based vaccines for coronavirus disease 2019 (COVID-19). VITT is an immune-mediated condition that generally presents within five to 10 days post-vaccination with thrombosis, thrombocytopenia, and coagulation abnormalities. A diagnosis of VITT is made clinically and through laboratory testing. Although VITT is an important differential to consider, it is believed that more emphasis should be placed on vaccination due to the safety and efficacy in overcoming COVID-19.
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.18977
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  5. Article ; Online: Central Nervous System Infections.

    Giovane, Richard A / Lavender, Paul Drake

    Primary care

    2018  Volume 45, Issue 3, Page(s) 505–518

    Abstract: Infections of the nervous system are potential life-threatening and are caused by pathogens such as bacteria, viruses, and fungi. Prompt recognition and treatment of a central nervous system (CNS) infection is crucial for patient survival, as these ... ...

    Abstract Infections of the nervous system are potential life-threatening and are caused by pathogens such as bacteria, viruses, and fungi. Prompt recognition and treatment of a central nervous system (CNS) infection is crucial for patient survival, as these infections have a high morbidity and mortality. CNS infections include meningitis, encephalitis, and brain abscesses. This article seeks to detail the etiology, clinical course, diagnostic challenges, and treatment of CNS infections organized by infectious agent.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antifungal Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Central Nervous System Bacterial Infections/diagnosis ; Central Nervous System Bacterial Infections/drug therapy ; Central Nervous System Fungal Infections/diagnosis ; Central Nervous System Fungal Infections/drug therapy ; Central Nervous System Infections/diagnosis ; Central Nervous System Infections/therapy ; Encephalitis, Viral/diagnosis ; Encephalitis, Viral/drug therapy ; Humans ; Meningitis/diagnosis ; Meningitis/drug therapy ; Tuberculosis, Central Nervous System/diagnosis ; Tuberculosis, Central Nervous System/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Antifungal Agents ; Antiviral Agents
    Language English
    Publishing date 2018-07-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604005-6
    ISSN 1558-299X ; 0095-4543
    ISSN (online) 1558-299X
    ISSN 0095-4543
    DOI 10.1016/j.pop.2018.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1154: Show issues Location:
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  6. Article ; Online: Micronutrients for potential therapeutic use against COVID-19; a review.

    Giovane, Richard A / Di Giovanni-Kinsley, Stephanie / Keeton, Emily

    Clinical nutrition ESPEN

    2021  Volume 46, Page(s) 9–13

    Abstract: Background: SARS CoV-2 has caused a pandemic that has challenged both clinicians and researchers in finding an effective treatment option. Currently there only exists a two series vaccine that has a high efficacy in preventing infection. There is no ... ...

    Abstract Background: SARS CoV-2 has caused a pandemic that has challenged both clinicians and researchers in finding an effective treatment option. Currently there only exists a two series vaccine that has a high efficacy in preventing infection. There is no standard effective treatment against SARS CoV-2 however several nutraceuticals such as melatonin, zinc, selenium, vitamin C and vitamin D are being proposed as prevention and treatment options.
    MeSH term(s) COVID-19 ; Humans ; Micronutrients ; SARS-CoV-2 ; Vitamin D ; Vitamins
    Chemical Substances Micronutrients ; Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-10-02
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2021.09.744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prospective cohort study of long-term neurological outcomes in retired elite athletes: the Advanced BiomaRker, Advanced Imaging and Neurocognitive (BRAIN) Health Study protocol.

    Zimmerman, Karl A / Hain, Jessica A / Graham, Neil S N / Rooney, Erin Jane / Lee, Ying / Del-Giovane, Martina / Parker, Thomas D / Friedland, Daniel / Cross, Matthew J / Kemp, Simon / Wilson, Mathew G / Sylvester, Richard J / Sharp, David J

    BMJ open

    2024  Volume 14, Issue 4, Page(s) e082902

    Abstract: Introduction: Although limited, recent research suggests that contact sport participation might have an adverse long-term effect on brain health. Further work is required to determine whether this includes an increased risk of neurodegenerative disease ... ...

    Abstract Introduction: Although limited, recent research suggests that contact sport participation might have an adverse long-term effect on brain health. Further work is required to determine whether this includes an increased risk of neurodegenerative disease and/or subsequent changes in cognition and behaviour. The Advanced BiomaRker, Advanced Imaging and Neurocognitive Health Study will prospectively examine the neurological, psychiatric, psychological and general health of retired elite-level rugby union and association football/soccer players.
    Methods and analysis: 400 retired athletes will be recruited (200 rugby union and 200 association football players, male and female). Athletes will undergo a detailed clinical assessment, advanced neuroimaging, blood testing for a range of brain health outcomes and neuropsychological assessment longitudinally. Follow-up assessments will be completed at 2 and 4 years after baseline visit. 60 healthy volunteers will be recruited and undergo an aligned assessment protocol including advanced neuroimaging, blood testing and neuropsychological assessment. We will describe the previous exposure to head injuries across the cohort and investigate relationships between biomarkers of brain injury and clinical outcomes including cognitive performance, clinical diagnoses and psychiatric symptom burden.
    Ethics and dissemination: Relevant ethical approvals have been granted by the Camberwell St Giles Research Ethics Committee (Ref: 17/LO/2066). The study findings will be disseminated through manuscripts in clinical/academic journals, presentations at professional conferences and through participant and stakeholder communications.
    MeSH term(s) Humans ; Prospective Studies ; Biomarkers/blood ; Male ; Football/injuries ; Neuropsychological Tests ; Neuroimaging/methods ; Female ; Athletes/psychology ; Retirement ; Cognition ; Research Design ; Brain/diagnostic imaging ; Soccer/injuries
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-082902
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  8. Article: Micronutrients for potential therapeutic use against COVID-19; a review

    Giovane, Richard A. / Di Giovanni-Kinsley, Stephanie / Keeton, Emily

    European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2021 Dec., v. 46

    2021  

    Abstract: SARS CoV-2 has caused a pandemic that has challenged both clinicians and researchers in finding an effective treatment option. Currently there only exists a two series vaccine that has a high efficacy in preventing infection. There is no standard ... ...

    Abstract SARS CoV-2 has caused a pandemic that has challenged both clinicians and researchers in finding an effective treatment option. Currently there only exists a two series vaccine that has a high efficacy in preventing infection. There is no standard effective treatment against SARS CoV-2 however several nutraceuticals such as melatonin, zinc, selenium, vitamin C and vitamin D are being proposed as prevention and treatment options.
    Keywords COVID-19 infection ; ascorbic acid ; clinical nutrition ; dietary supplements ; melatonin ; pandemic ; selenium ; therapeutics ; vaccines ; vitamin D ; zinc
    Language English
    Dates of publication 2021-12
    Size p. 9-13.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2021.09.744
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Dercum's Disease: A Case Report of a Patient Having Both Type 1 and Type 2 Dercum's Disease.

    Moattari, Cameron / Giovane, Richard A / DiGiovanni Kinsely, Stephanie

    Case reports in dermatological medicine

    2020  Volume 2020, Page(s) 6129706

    Abstract: Dercum's disease, or adiposis dolorosa, is a rare disorder which consists of multiple, painful lipomas within the subcutaneous tissue and has a distribution mainly in the abdomen and extremities. Dercum's disease can be defined as in combination with ... ...

    Abstract Dercum's disease, or adiposis dolorosa, is a rare disorder which consists of multiple, painful lipomas within the subcutaneous tissue and has a distribution mainly in the abdomen and extremities. Dercum's disease can be defined as in combination with chronic painful adipose tissue. Although the etiology of Dercum's disease is not clear, it is thought to be a combination of a neurological and endocrine disorder. Treatment for this disease is centered at managing pain. Although there is no standard of care for managing pain, there are different pain management regimes that are promising.
    Language English
    Publishing date 2020-11-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2684644-5
    ISSN 2090-6471 ; 2090-6463
    ISSN (online) 2090-6471
    ISSN 2090-6463
    DOI 10.1155/2020/6129706
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  10. Article ; Online: Current pharmacological modalities for management of novel coronavirus disease 2019 (COVID-19) and the rationale for their utilization: A review.

    Giovane, Richard A / Rezai, Shadi / Cleland, Ellen / Henderson, Cassandra E

    Reviews in medical virology

    2020  Volume 30, Issue 5, Page(s) e2136

    Abstract: SARS-CoV-2 has caused a pandemic which is putting strain on the health-care system and global economy. There is much pressure to develop both preventative and curative therapies for SARS-CoV-2 as there is no evidence to support therapies to improve ... ...

    Abstract SARS-CoV-2 has caused a pandemic which is putting strain on the health-care system and global economy. There is much pressure to develop both preventative and curative therapies for SARS-CoV-2 as there is no evidence to support therapies to improve outcomes in patients with SARS-CoV-2. Medications that inhibit certain steps of virus life cycle that are currently used to treat other illnesses such as Malaria, Ebola, HIV and Hepatitis C are being studied for use against SARS-CoV-2. To date, data is limited for medications that facilitate clinical improvement of COVID-19 infections.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Angiotensin-Converting Enzyme 2 ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Disease Progression ; Drug Combinations ; Drug Repositioning ; Esters ; Gabexate/analogs & derivatives ; Gabexate/therapeutic use ; Gene Expression Regulation ; Guanidines ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Hydroxychloroquine/therapeutic use ; Indoles/therapeutic use ; Lopinavir/therapeutic use ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/immunology ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Ritonavir/therapeutic use ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antiviral Agents ; Drug Combinations ; Esters ; Guanidines ; Indoles ; Spike Glycoprotein, Coronavirus ; lopinavir-ritonavir drug combination ; spike protein, SARS-CoV-2 ; camostat (0FD207WKDU) ; Lopinavir (2494G1JF75) ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Hydroxychloroquine (4QWG6N8QKH) ; Gabexate (4V7M9137X9) ; umifenovir (93M09WW4RU) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; tocilizumab (I031V2H011) ; Ritonavir (O3J8G9O825) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1086043-5
    ISSN 1099-1654 ; 1052-9276
    ISSN (online) 1099-1654
    ISSN 1052-9276
    DOI 10.1002/rmv.2136
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