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Article ; Online: Alemtuzumab as rescue therapy in case of multiple sclerosis rebound following Natalizumab break: Clinical case and literature review.

Federle, Lisa / Puthenparampil, Marco / Stenta, Gianola / Paolo, Gallo / Francesco, Perini

Multiple sclerosis and related disorders

2019 Volume 30, Page(s) 262–264

Abstract: Introduction: Natalizumab break exposes multiple sclerosis (MS) patients to a high risk of disease reactivation or rebound, whose prevention and treatment constitute a clinical challenge.: Case presentation: We describe a dramatic case of MS rebound, ...

Abstract	Introduction: Natalizumab break exposes multiple sclerosis (MS) patients to a high risk of disease reactivation or rebound, whose prevention and treatment constitute a clinical challenge. Case presentation: We describe a dramatic case of MS rebound, characterized by the development of severe neurological and psychiatric symptoms, following natalizumab break. Alemtuzumab rapidly and completely suppressed brain inflammation as demonstrated by clinical and radiological findings. Conclusions: Our case further adds to the available literature evidence on Alemtuzumab as first-choice rescue therapy following Natalizumab discontinuation.
MeSH term(s)	Alemtuzumab/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; Humans ; Immunologic Factors/adverse effects ; Male ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/chemically induced ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Natalizumab/adverse effects ; Young Adult
Chemical Substances	Antineoplastic Agents, Immunological ; Immunologic Factors ; Natalizumab ; Alemtuzumab (3A189DH42V)
Language	English
Publishing date	2019-03-05
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2019.03.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hyperreflective Foci in the Retina of Active Relapse-Onset Multiple Sclerosis.

Pilotto, Elisabetta / Miante, Silvia / Torresin, Tommaso / Puthenparampil, Marco / Frizziero, Luisa / Federle, Lisa / Gallo, Paolo / Midena, Edoardo

Ophthalmology

2020 Volume 127, Issue 12, Page(s) 1774–1776

MeSH term(s)	Adult ; Ependymoglial Cells/pathology ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/diagnosis ; Retina/pathology ; Retinal Diseases/diagnosis ; Tomography, Optical Coherence ; Vision Disorders/diagnosis ; Visual Acuity/physiology ; Young Adult
Language	English
Publishing date	2020-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2020.03.024
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Ul II Zs.83: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 533: Show issues

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Article: Evidence of B-cell dysregulation in severe CNS inflammation after alemtuzumab therapy.

Rinaldi, Francesca / Federle, Lisa / Puthenparampil, Marco / Perini, Paola / Grassivaro, Francesca / Gallo, Paolo

Neurology(R) neuroimmunology & neuroinflammation

2018 Volume 5, Issue 1, Page(s) e420

Language	English
Publishing date	2018-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767740-0
ISSN	2332-7812
ISSN	2332-7812
DOI	10.1212/NXI.0000000000000420
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Article ; Online: Acute simultaneous development of brain tumour-like lesion and demyelinating polyneuropathy in a patient with chronic relapsing myelitis.

Puthenparampil, Marco / Terrin, Alberto / Federle, Lisa / Gizzi, Matteo / Perini, Paola / Gallo, Paolo

Multiple sclerosis (Houndmills, Basingstoke, England)

2017 Volume 24, Issue 4, Page(s) 546–550

Abstract: Combined central and peripheral demyelination (CCPD) is a rare chronic inflammatory disorder of the nervous system. We describe the case of a patient with a history of recurrent myelitis that acutely and simultaneously developed a brain tumour-like ... ...

Abstract	Combined central and peripheral demyelination (CCPD) is a rare chronic inflammatory disorder of the nervous system. We describe the case of a patient with a history of recurrent myelitis that acutely and simultaneously developed a brain tumour-like lesion and a sensitive-motor demyelinating polyneuropathy. The diagnosis of CCPD was supported by a detailed diagnostic workup. Up to date, no similar cases have been reported in the literature.
MeSH term(s)	Brain Neoplasms/diagnosis ; Brain Neoplasms/pathology ; Demyelinating Diseases/complications ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Middle Aged ; Myelitis/diagnosis ; Myelitis/pathology ; Neoplasm Recurrence, Local/complications ; Neoplasm Recurrence, Local/pathology ; Polyneuropathies/drug therapy ; Polyneuropathies/pathology
Language	English
Publishing date	2017-08-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/1352458517714610
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Article ; Online: B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.

Afzali, Ali Maisam / Nirschl, Lucy / Sie, Christopher / Pfaller, Monika / Ulianov, Oleksii / Hassler, Tobias / Federle, Christine / Petrozziello, Elisabetta / Kalluri, Sudhakar Reddy / Chen, Hsin Hsiang / Tyystjärvi, Sofia / Muschaweckh, Andreas / Lammens, Katja / Delbridge, Claire / Büttner, Andreas / Steiger, Katja / Seyhan, Gönül / Ottersen, Ole Petter / Öllinger, Rupert /

Rad, Roland / Jarosch, Sebastian / Straub, Adrian / Mühlbauer, Anton / Grassmann, Simon / Hemmer, Bernhard / Böttcher, Jan P / Wagner, Ingrid / Kreutzfeldt, Mario / Merkler, Doron / Pardàs, Irene Bonafonte / Schmidt Supprian, Marc / Buchholz, Veit R / Heink, Sylvia / Busch, Dirk H / Klein, Ludger / Korn, Thomas

Nature

2024 Volume 627, Issue 8003, Page(s) 407–415

Abstract: Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target ... ...

Abstract	Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen
MeSH term(s)	Animals ; Humans ; Mice ; AIRE Protein ; Aquaporin 4/deficiency ; Aquaporin 4/genetics ; Aquaporin 4/immunology ; Aquaporin 4/metabolism ; Autoantibodies/immunology ; Autoantigens/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD40 Antigens/immunology ; Germinal Center/cytology ; Germinal Center/immunology ; Immune Tolerance ; Neuromyelitis Optica/immunology ; Neuromyelitis Optica/metabolism ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/immunology ; Thymus Gland/cytology ; Thymus Gland/immunology ; Thyroid Epithelial Cells/immunology ; Thyroid Epithelial Cells/metabolism ; Transcriptome
Chemical Substances	AIRE Protein ; AQP4 protein, human ; Aqp4 protein, mouse ; Aquaporin 4 ; Autoantibodies ; Autoantigens ; CD40 Antigens ; interleukin-21 (MKM3CA6LT1) ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07079-8
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Decreased platelet number in multiple sclerosis during alemtuzumab infusion: a common, transient and clinically silent phenomenon.

Puthenparampil, Marco / Rinaldi, Francesca / Federle, Lisa / Cazzola, Chiara / Perini, Paola / Gallo, Paolo

Therapeutic advances in neurological disorders

2017 Volume 11, Page(s) 1756285617741056

Abstract: Background: The cause and clinical significance of the transient decrease in platelet (PLT) count observed in relapsing remitting multiple sclerosis (RRMS) during alemtuzumab administration remain undefined. The aim of this study was to analyse the ... ...

Abstract	Background: The cause and clinical significance of the transient decrease in platelet (PLT) count observed in relapsing remitting multiple sclerosis (RRMS) during alemtuzumab administration remain undefined. The aim of this study was to analyse the kinetics and clinical relevance of early onset thrombocytopaenia in alemtuzumab-treated RRMS. Methods: A total of 26 patients with RRMS were included in a longitudinal study. Blood samples were collected immediately before the first alemtuzumab infusion (D0), and after 3 days (D3), 28 days (D28) and 49 days (D49). PLT, red blood cell (RC), leucocyte and lymphocyte counts, haemoglobin (Hb) concentration and haematocrit (Htc) were measured. Patients with MS were clinically evaluated every day of drug infusion and then at D28 and D49 to verify the presence of signs or symptoms suggestive of thrombocytopaenia. Results: PLT number significantly decreased at D3 ( Conclusions: The early PLT decrease in alemtuzumab-treated patients is transient, mild, not associated with clinically relevant events and is probably related to the cytokine-released syndrome. Notwithstanding this, our findings suggest the opportunity for PLT monitoring during infusion and in the following 2 months, since a decrease in PLT count may occur.
Language	English
Publishing date	2017-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2442245-9
ISSN	1756-2864 ; 1756-2856
ISSN (online)	1756-2864
ISSN	1756-2856
DOI	10.1177/1756285617741056
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Article ; Online: Contrast media for fluoroscopic examinations of the GI and GU tracts: current challenges and recommendations.

Federle, Michael P / Jaffe, Tracy A / Davis, Peter L / Al-Hawary, Mahmoud M / Levine, Marc S

Abdominal radiology (New York)

2016 Volume 42, Issue 1, Page(s) 90–100

Abstract: One of the significant challenges facing radiologists who perform and interpret studies of the gastrointestinal and genitourinary systems have been periodic interruptions in the availability of barium and iodinated contrast media specially formulated for ...

Abstract	One of the significant challenges facing radiologists who perform and interpret studies of the gastrointestinal and genitourinary systems have been periodic interruptions in the availability of barium and iodinated contrast media specially formulated for gastrointestinal (GI) and genitourinary (GU) studies. These interruptions are due to the US Food and Drug Administration's recent requirement for more stringent documentation of the safety and efficacy of contrast media and the consolidation among contrast manufacturers. Therefore, radiologists may be required to recommend an alternative means of evaluation, such as computed tomography, magnetic resonance, or endoscopy, or they may need to substitute a different formulation of a contrast agent not specifically developed for GI or GU use, for example the utilization of an agent designed and marketed for vascular use. This article reviews the current status of fluoroscopic contrast media, and provides suggestions and recommendations for the optimal and alternative use of contrast media formulations.
MeSH term(s)	Contrast Media/administration & dosage ; Female ; Female Urogenital Diseases/diagnostic imaging ; Fluoroscopy ; Gastrointestinal Diseases/diagnostic imaging ; Humans ; Male ; Male Urogenital Diseases/diagnostic imaging
Chemical Substances	Contrast Media
Language	English
Publishing date	2016-08-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-016-0861-1
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Zs.A 1262: Show issues

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Article ; Online: PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.

Rush, Jeffrey S / Parajuli, Prakash / Ruda, Alessandro / Li, Jian / Pohane, Amol Arunrao / Zamakhaeva, Svetlana / Rahman, Mohammad M / Chang, Jennifer C / Gogos, Artemis / Kenner, Cameron W / Lambeau, Gérard / Federle, Michael J / Korotkov, Konstantin V / Widmalm, Göran / Korotkova, Natalia

Nature communications

2022 Volume 13, Issue 1, Page(s) 590

Abstract: The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC). GAC is a promising target for the development of GAS vaccines. In this study, employing chemical, ...

Abstract	The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC). GAC is a promising target for the development of GAS vaccines. In this study, employing chemical, compositional, and NMR methods, we show that GAC is attached to peptidoglycan via glucosamine 1-phosphate. This structural feature makes the GAC-peptidoglycan linkage highly sensitive to cleavage by nitrous acid and resistant to mild acid conditions. Using this characteristic of the GAS cell wall, we identify PplD as a protein required for deacetylation of linkage N-acetylglucosamine (GlcNAc). X-ray structural analysis indicates that PplD performs catalysis via a modified acid/base mechanism. Genetic surveys in silico together with functional analysis indicate that PplD homologs deacetylate the polysaccharide linkage in many streptococcal species. We further demonstrate that introduction of positive charges to the cell wall by GlcNAc deacetylation protects GAS against host cationic antimicrobial proteins.
MeSH term(s)	Acetylesterase/metabolism ; Acetylglucosamine/metabolism ; Bacterial Proteins/metabolism ; Cell Wall/metabolism ; Crystallography, X-Ray ; Glucosamine/analogs & derivatives ; Glucosephosphates ; Histones ; Humans ; Nitrous Acid ; Peptidoglycan/chemistry ; Peptidoglycan/metabolism ; Polysaccharides, Bacterial/metabolism ; Streptococcal Infections/microbiology ; Streptococcus/metabolism ; Streptococcus mutans
Chemical Substances	Bacterial Proteins ; Glucosephosphates ; Histones ; Peptidoglycan ; Polysaccharides, Bacterial ; glucosamine 1-phosphate (2152-75-2) ; Acetylesterase (EC 3.1.1.6) ; Glucosamine (N08U5BOQ1K) ; Nitrous Acid (T2I5UM75DN) ; Acetylglucosamine (V956696549)
Language	English
Publishing date	2022-02-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-28257-0
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Article ; Online: Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography.

Tascilar, Koray / Fagni, Filippo / Kleyer, Arnd / Bayat, Sara / Heidemann, Robert / Steiger, Florian / Krönke, Gerhard / Bohr, Daniela / Ramming, Andreas / Hartmann, Fabian / Klett, Daniel / Federle, Anna / Regensburger, Adrian P / Wagner, Alexandra L / Knieling, Ferdinand / Neurath, Markus F / Schett, Georg / Waldner, Maximilian / Simon, David

Rheumatology (Oxford, England)

2022 Volume 62, Issue 2, Page(s) 841–849

Abstract: Objective: To explore the metabolic characteristics of arthritis and enthesitis using multispectral opto-acoustic tomography (MSOT), a technology using near-infrared multispectral laser to stimulate tissues and detect the emitted acoustic energy, ... ...

Abstract	Objective: To explore the metabolic characteristics of arthritis and enthesitis using multispectral opto-acoustic tomography (MSOT), a technology using near-infrared multispectral laser to stimulate tissues and detect the emitted acoustic energy, enabling non-invasive quantification of tissue components in vivo based on differential absorbance at multiple wavelengths. Methods: We performed a cross-sectional study in patients with RA or PsA and healthy controls (HCs). Participants underwent clinical, ultrasonographic and MSOT examination of MCP and wrist joints as well as the entheses of the common extensor tendon at the lateral humeral epicondyles and of the patellar, quadriceps and Achilles tendon. MSOT-measured haemoglobin (Hb), oxygen saturation, collagen and lipid levels were quantified and scaled mean differences between affected and unaffected joints and entheses were calculated as defined by clinical examination or ultrasonography using linear mixed effects models. Results: We obtained 1535 MSOT and 982 ultrasonography scans from 87 participants (34 PsA, 17 RA, 36 HCs). Entheseal tenderness was not associated with significant metabolic changes, whereas enthesitis-related sonographic changes were associated with increased total Hb, oxygen saturation and collagen content. In contrast, the presence of arthritis-related clinical and sonographic findings showed increased Hb levels, reduced oxygen saturation and reduced collagen content. Synovial hypertrophy was associated with increased lipid content in the joints. Conclusion: MSOT allows determination of distinct metabolic differences between arthritis and enthesitis in a non-invasive setting in humans in vivo.
MeSH term(s)	Humans ; Arthritis, Psoriatic/diagnostic imaging ; Cross-Sectional Studies ; Inflammation/diagnostic imaging ; Ultrasonography ; Enthesopathy/diagnostic imaging ; Tomography, X-Ray Computed ; Lipids
Chemical Substances	Lipids
Language	English
Publishing date	2022-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keac346
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

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Article: Diagnosis of intestinal injuries by computed tomography and the use of oral contrast medium.

Federle, M P

Annals of emergency medicine

1998 Volume 31, Issue 6, Page(s) 769–771

MeSH term(s)	Abdominal Injuries/diagnostic imaging ; Contrast Media/administration & dosage ; Humans ; Intestines/injuries ; Selection Bias ; Tomography, X-Ray Computed ; Wounds, Nonpenetrating/diagnostic imaging
Chemical Substances	Contrast Media
Language	English
Publishing date	1998-06
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	603080-4
ISSN	1097-6760 ; 0196-0644
ISSN (online)	1097-6760
ISSN	0196-0644
DOI	10.1016/s0196-0644(98)70238-0
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