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  1. Article: Antimicrobial approach of abdominal post-surgical infections.

    Fiore, Marco / Corrente, Antonio / Di Franco, Sveva / Alfieri, Aniello / Pace, Maria Caterina / Martora, Francesca / Petrou, Stephen / Mauriello, Claudio / Leone, Sebastiano

    World journal of gastrointestinal surgery

    2024  Volume 15, Issue 12, Page(s) 2674–2692

    Abstract: Abdominal surgical site infections (SSIs) are infections that occur after abdominal surgery. They can be superficial, involving the skin tissue only, or more profound, involving deeper skin tissues including organs and implanted materials. Currently, ... ...

    Abstract Abdominal surgical site infections (SSIs) are infections that occur after abdominal surgery. They can be superficial, involving the skin tissue only, or more profound, involving deeper skin tissues including organs and implanted materials. Currently, SSIs are large global health problem with an incidence that varies significantly depending on the United Nations' Human Development Index. The purpose of this review is to provide a practical update on the latest available literature on SSIs, focusing on causative pathogens and treatment with an overview of the ongoing studies of new therapeutic strategies.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v15.i12.2674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Medicinal cannabis products for the treatment of acute pain.

    Fiore, Marco / Alfieri, Aniello / Di Franco, Sveva / Petrou, Stephen / Damiani, Giovanni / Pace, Maria Caterina

    World journal of clinical cases

    2023  Volume 11, Issue 12, Page(s) 2670–2676

    Abstract: For thousands of years, medicinal cannabis has been used for pain treatment, but its use for pain management is still controversial. Meta-analysis of the literature has shown contrasting results on the addition of cannabinoids to opioids compared with ... ...

    Abstract For thousands of years, medicinal cannabis has been used for pain treatment, but its use for pain management is still controversial. Meta-analysis of the literature has shown contrasting results on the addition of cannabinoids to opioids compared with placebo/other active agents to reduce pain. Clinical studies are mainly focused on medicinal cannabis use in chronic pain management, for which the analgesic effect has been proven in many studies. This review focuses on the potential use of medical cannabis for acute pain management in preclinical studies, studies on healthy subjects and the few pioneering studies in the clinical setting.
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v11.i12.2670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Literature Overview of Secondary Peritonitis Due to Carbapenem-Resistant Enterobacterales (CRE) in Intensive Care Unit (ICU) Patients.

    Di Franco, Sveva / Alfieri, Aniello / Fiore, Marco / Fittipaldi, Ciro / Pota, Vincenzo / Coppolino, Francesco / Sansone, Pasquale / Pace, Maria Caterina / Passavanti, Maria Beatrice

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: This comprehensive review of the recently published literature offers an overview of a very topical and complex healthcare problem: secondary peritonitis from multidrug-resistant pathogens, especially carbapenem- ... ...

    Abstract This comprehensive review of the recently published literature offers an overview of a very topical and complex healthcare problem: secondary peritonitis from multidrug-resistant pathogens, especially carbapenem-resistant
    Language English
    Publishing date 2022-10-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11101347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Spontaneous bacterial peritonitis due to carbapenemase-producing

    Fiore, Marco / Di Franco, Sveva / Alfieri, Aniello / Passavanti, Maria Beatrice / Pace, Maria Caterina / Petrou, Stephen / Martora, Francesca / Leone, Sebastiano

    World journal of hepatology

    2021  Volume 12, Issue 12, Page(s) 1136–1147

    Abstract: Carbapenem antibiotics were first introduced in the 1980s and have long been considered the most active agents for the treatment of multidrug-resistant gram-negative bacteria. Over the last decade, carbapenem- ... ...

    Abstract Carbapenem antibiotics were first introduced in the 1980s and have long been considered the most active agents for the treatment of multidrug-resistant gram-negative bacteria. Over the last decade, carbapenem-resistant
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v12.i12.1136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Releasing Burn-Induced Compartment Syndrome by Enzymatic Escharotomy-Debridement: A Case Study.

    Mataro, Ilaria / Lanza, Anna / Di Franco, Sveva / Di Franco, Livia / Sangiuolo, Mariella / Notaro, Maria / d'Alessio, Roberto / Villani, Romolo

    Journal of burn care & research : official publication of the American Burn Association

    2020  Volume 41, Issue 5, Page(s) 1097–1103

    Abstract: Burn-induced compartment syndrome represents a serious and acute condition in deep circumferential burns of the extremities which, if left untreated, can cause severe complications. The surgical escharotomy that releases the high subdermal pressure is ... ...

    Abstract Burn-induced compartment syndrome represents a serious and acute condition in deep circumferential burns of the extremities which, if left untreated, can cause severe complications. The surgical escharotomy that releases the high subdermal pressure is the therapeutic treatment of choice for burn-induced compartment syndrome. Guidelines for escharotomy indications and timing include pressure greater than 30 mm Hg and 6 Ps (Pain, Pallor, Paresthesia, Paralysis, Pulseless, and Poikilothermia). Nevertheless, despite the need for an early as possible pressure release, escharotomy is often delayed when a capable surgeon is not available, or if the indication is not completely clear to justify potential risks associated with surgical escharotomy. Early treatment of circumferential burns of the extremities with a Bromelain-based enzymatic agent NexoBrid® may represent a less traumatic and invasive procedure to reduce intra-compartmental pressure, replacing surgical escharotomy. This case study of 23 patients describes the variation of compartmental pressure in patients with circumferential burns of the extremities treated with NexoBrid® enzymatic escharotomy-debridement. All the patients were treated with NexoBrid® within 2 to 22 hours post-injury in our Burn Intensive Care Center. The excessive pressure recorded before treatment returned to normal below 30 mm Hg and an approximately 60% reduction of the compartmental pressure was observed in most cases within 1 hour from NXB application. On NexoBrid® removal after 4 hours complete debridement-escharotomy of the burns was achieved. Enzymatic escharotomy-debridement appears to be a useful and safe method to reduce postburn compartmental pressure. Additional randomized, well-controlled powered studies are needed to further support these results.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bromelains/therapeutic use ; Burns/complications ; Burns/therapy ; Cicatrix/complications ; Cicatrix/pathology ; Cicatrix/therapy ; Compartment Syndromes/etiology ; Compartment Syndromes/pathology ; Compartment Syndromes/therapy ; Debridement ; Female ; Hand Injuries/complications ; Hand Injuries/therapy ; Humans ; Male ; Middle Aged ; Prospective Studies ; Young Adult
    Chemical Substances Bromelains (9001-00-7)
    Language English
    Publishing date 2020-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2224246-6
    ISSN 1559-0488 ; 1559-047X
    ISSN (online) 1559-0488
    ISSN 1559-047X
    DOI 10.1093/jbcr/iraa055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6223: Show issues Location:
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  6. Article: Blood Stream Infections from MDR Bacteria.

    Di Franco, Sveva / Alfieri, Aniello / Pace, Maria Caterina / Sansone, Pasquale / Pota, Vincenzo / Fittipaldi, Ciro / Fiore, Marco / Passavanti, Maria Beatrice

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 6

    Abstract: Background: Bloodstream infections (BSIs) constitute a growing public health concern, are among the most severe nosocomial pathologies, and are considered a worldwide cause of unfaithful outcomes, increasing treatment costs and diagnostic uncertainties. ...

    Abstract Background: Bloodstream infections (BSIs) constitute a growing public health concern, are among the most severe nosocomial pathologies, and are considered a worldwide cause of unfaithful outcomes, increasing treatment costs and diagnostic uncertainties. BSIs are one of the most frequent lethal conditions that are managed in intensive care units (ICUs). In the case of septic shock, immune deficiency, and delayed treatment, even with adequate antimicrobial therapy and/or source control, the outcomes are often unfavorable.
    Methods: this review article summarizes the epidemiological and microbiological characteristics of BSIs with a particular focus on ICU acquired BSIs (ICU-BSIs), which are usually caused by multidrug-resistant (MDR) pathogens. For this reason, their antimicrobial resistance patterns and therapeutic options have also been compiled.
    Results: ICU-acquired BSIs prevail in 5-7% of ICU patients.
    Conclusions: Considering that prevention and treatment of sepsis is nowadays considered a global health priority by the World Health Organization, it is our obligation to invest more resources into solving or reducing the spread of these unfaithful infections. It is relevant to identify patients with risk factors that make them more susceptible to BSIs, to guarantee earlier molecular or microbiological diagnoses, and more rapidly appropriate treatment by using de-escalation strategies where possible.
    Language English
    Publishing date 2021-06-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11060575
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  7. Article: Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review.

    Alfieri, Aniello / Di Franco, Sveva / Donatiello, Valerio / Maffei, Vincenzo / Fittipaldi, Ciro / Fiore, Marco / Coppolino, Francesco / Sansone, Pasquale / Pace, Maria Caterina / Passavanti, Maria Beatrice

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 12

    Abstract: Plazomicin is a next-generation semisynthetic aminoglycoside antibiotic that can be used to treat infections by multi-resistant bacteria. It is effective against many bacteria-producing carbapenemases or other specific hydrolases. This scoping review ... ...

    Abstract Plazomicin is a next-generation semisynthetic aminoglycoside antibiotic that can be used to treat infections by multi-resistant bacteria. It is effective against many bacteria-producing carbapenemases or other specific hydrolases. This scoping review aims to define the role acquired by plazomicin from its approval by the FDA (US Food and Drug Administration) in 2018 to the present day. Furthermore, we aim to provide a base for a future meta-analysis. This project was conducted following the recommendations presented in the PRISMA extension for scoping reviews and the JBI Manual for Evidence Synthesis. Among 901 potentially engaging citations, 345 duplicates were removed, and only 81 articles were selected for the analysis. According to the data analysis, plazomicin has been used to treat urinary tract infections, bloodstream infections, and ventilation-associated pneumonia. The pathogens killed included multi-resistant
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12121949
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  8. Article ; Online: Blood Stream Infections from MDR Bacteria

    Sveva Di Franco / Aniello Alfieri / Maria Caterina Pace / Pasquale Sansone / Vincenzo Pota / Ciro Fittipaldi / Marco Fiore / Maria Beatrice Passavanti

    Life, Vol 11, Iss 575, p

    2021  Volume 575

    Abstract: Background: Bloodstream infections (BSIs) constitute a growing public health concern, are among the most severe nosocomial pathologies, and are considered a worldwide cause of unfaithful outcomes, increasing treatment costs and diagnostic uncertainties. ... ...

    Abstract Background: Bloodstream infections (BSIs) constitute a growing public health concern, are among the most severe nosocomial pathologies, and are considered a worldwide cause of unfaithful outcomes, increasing treatment costs and diagnostic uncertainties. BSIs are one of the most frequent lethal conditions that are managed in intensive care units (ICUs). In the case of septic shock, immune deficiency, and delayed treatment, even with adequate antimicrobial therapy and/or source control, the outcomes are often unfavorable. Methods: this review article summarizes the epidemiological and microbiological characteristics of BSIs with a particular focus on ICU acquired BSIs (ICU-BSIs), which are usually caused by multidrug-resistant (MDR) pathogens. For this reason, their antimicrobial resistance patterns and therapeutic options have also been compiled. Results: ICU-acquired BSIs prevail in 5–7% of ICU patients. Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii , and Pseudomonas aeruginosae are the pathogens most often responsible for MDR infections. MDR Enterobacteriaceae have seen their prevalence increase from 6.2% (1997–2000) to 15.8% (2013–2016) in recent years. Conclusions: Considering that prevention and treatment of sepsis is nowadays considered a global health priority by the World Health Organization, it is our obligation to invest more resources into solving or reducing the spread of these unfaithful infections. It is relevant to identify patients with risk factors that make them more susceptible to BSIs, to guarantee earlier molecular or microbiological diagnoses, and more rapidly appropriate treatment by using de-escalation strategies where possible.
    Keywords bloodstream infections ; intensive care unit ; multidrug-resistant pathogens ; septic shock ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Spontaneous bacterial peritonitis caused by Gram-negative bacteria: an update of epidemiology and antimicrobial treatments.

    Fiore, Marco / Di Franco, Sveva / Alfieri, Aniello / Passavanti, Maria Beatrice / Pace, Maria Caterina / Kelly, Molly E / Damiani, Giovanni / Leone, Sebastiano

    Expert review of gastroenterology & hepatology

    2019  Volume 13, Issue 7, Page(s) 683–692

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Microbial ; End Stage Liver Disease/complications ; Gram-Negative Bacteria ; Humans ; Peritonitis/drug therapy ; Peritonitis/epidemiology ; Peritonitis/microbiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-05-29
    Publishing country England
    Document type Journal Article ; Review ; Video-Audio Media
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2019.1621167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6978: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Ceftazidime-Avibactam Combination Therapy Compared to Ceftazidime-Avibactam Monotherapy for the Treatment of Severe Infections Due to Carbapenem-Resistant Pathogens: A Systematic Review and Network Meta-Analysis.

    Fiore, Marco / Alfieri, Aniello / Di Franco, Sveva / Pace, Maria Caterina / Simeon, Vittorio / Ingoglia, Giulia / Cortegiani, Andrea

    Antibiotics (Basel, Switzerland)

    2020  Volume 9, Issue 7

    Abstract: Ceftazidime-avibactam (CZA) is a novel beta-lactam beta-lactamase inhibitor combination approved for the treatment of complicated urinary tract infections, complicated intra-abdominal infections, and for hospital-acquired/ventilator-associated pneumonia. ...

    Abstract Ceftazidime-avibactam (CZA) is a novel beta-lactam beta-lactamase inhibitor combination approved for the treatment of complicated urinary tract infections, complicated intra-abdominal infections, and for hospital-acquired/ventilator-associated pneumonia. The aim of this systematic review (PROSPERO registration number: CRD42019128927) was to evaluate the effectiveness of CZA combination therapy versus CZA monotherapy in the treatment of severe infections. The databases included in the search, until February 12th, 2020, were MEDLINE by PubMed, EMBASE, and The Cochrane Central Register of Controlled Trials. We included both randomized controlled trials (RCTs) and non-randomized studies published in peer-reviewed journals and in the English language. The primary outcome was all-cause mortality (longest follow-up) evaluated in patients with the diagnosis of infection with at least one pathogen; secondary outcomes were clinical and microbiological improvement/cure. Thirteen studies were included in the qualitative synthesis: 7 RCTs and 6 retrospective studies All the six retrospective studies identified carbapenamase-producing Enterobacteriaceae (CRE) as the cause of infection and for this reason were included in the network meta-analysis (NMA); the quality of the studies, assessed using the New Castle-Ottawa Scale, was moderate-high. In all the six retrospective studies included in the NMA, CZA was used in large part for off-label indications (mostly blood stream infections: 80-100% of patients included). No difference in mortality rate was observed in patients undergoing CZA combination therapy compared to CZA monotherapy [
    Language English
    Publishing date 2020-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics9070388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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