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  1. Article ; Online: Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Cases.

    Brizuela, Claudia / Meza, Gastón / Khoury, Maroun

    Journal of endodontics

    2024  

    Abstract: Introduction: Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth.: Methods: Here, we report two cases in which cell-based RET (CB-RET) using ... ...

    Abstract Introduction: Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth.
    Methods: Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis.
    Results: After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization.
    Conclusions: This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752412-2
    ISSN 1878-3554 ; 0099-2399
    ISSN (online) 1878-3554
    ISSN 0099-2399
    DOI 10.1016/j.joen.2024.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1920: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Impact of platelet-derived mitochondria transfer in the metabolic profiling and progression of metastatic MDA-MB-231 human triple-negative breast cancer cells.

    Cereceda, Lucas / Cardenas, J Cesar / Khoury, Maroun / Silva-Pavez, Eduardo / Hidalgo, Yessia

    Frontiers in cell and developmental biology

    2024  Volume 11, Page(s) 1324158

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1324158
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  3. Article ; Online: Musculoskeletal Progenitor/Stromal Cell-Derived Mitochondria Modulate Cell Differentiation and Therapeutical Function.

    Jorgensen, Christian / Khoury, Maroun

    Frontiers in immunology

    2021  Volume 12, Page(s) 606781

    Abstract: Musculoskeletal stromal cells' (MSCs') metabolism impacts cell differentiation as well as immune function. During osteogenic and adipogenic differentiation, BM-MSCs show a preference for glycolysis during proliferation but shift to an oxidative ... ...

    Abstract Musculoskeletal stromal cells' (MSCs') metabolism impacts cell differentiation as well as immune function. During osteogenic and adipogenic differentiation, BM-MSCs show a preference for glycolysis during proliferation but shift to an oxidative phosphorylation (OxPhos)-dependent metabolism. The MSC immunoregulatory fate is achieved with cell polarization, and the result is sustained production of immunoregulatory molecules (including PGE2, HGF, IL1RA, IL6, IL8, IDO activity) in response to inflammatory stimuli. MSCs adapt their energetic metabolism when acquiring immunomodulatory property and shift to aerobic glycolysis. This can be achieved
    MeSH term(s) Animals ; Biomarkers ; Cell Culture Techniques ; Cell Differentiation ; Cell- and Tissue-Based Therapy/methods ; Cellular Reprogramming ; Energy Metabolism ; Humans ; Immunomodulation ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Myoblasts, Skeletal/cytology ; Myoblasts, Skeletal/metabolism ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism ; Signal Transduction
    Chemical Substances Biomarkers ; Reactive Oxygen Species
    Language English
    Publishing date 2021-03-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.606781
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  4. Article ; Online: Predictors of high trust and the role of confidence levels in seeking cancer-related information.

    Sacca, Lea / Maroun, Veronica / Khoury, Milad

    Informatics for health & social care

    2021  Volume 47, Issue 1, Page(s) 53–61

    Abstract: One of the most commonly searched topics on the internet in the United States is cancer. Our study aims to provide a general overview of the predictors of trust for two health information sources, doctors and the internet, when seeking cancer-related ... ...

    Abstract One of the most commonly searched topics on the internet in the United States is cancer. Our study aims to provide a general overview of the predictors of trust for two health information sources, doctors and the internet, when seeking cancer-related information. The data were obtained from the 2018 HINTS 5 Cycle 2 survey, which was administered from January through May to a total of 3,504 respondents. We carried out next a series of ordinal logistic regression models to identify predictors of high trust in doctors and the internet separately for cancer-seeking information. Demographic predictor variables varied as predictors of high trust for cancer knowledge across both sources. Respondents who reported less confidence in their ability to seek cancer information had significantly higher odds of high trust in both doctors (OR = 8.43, CI: 5.58-12.73) and the internet (OR = 2.93, CI: 1.97-4.35) as compared to those who reported being "completely confident" in their ability to obtain cancer information. Understanding the key predictors of trust in doctors and the internet is crucial to the enhancement of health. The role of confidence as a predictor of trust in seeking cancer information has been shown to consistently influence the levels of trust attributed to each topic.
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2431238-1
    ISSN 1753-8165 ; 1753-8157
    ISSN (online) 1753-8165
    ISSN 1753-8157
    DOI 10.1080/17538157.2021.1925676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Editorial: The Role of Metabolism in MSC-Mediated Immunomodulation.

    Pers, Yves-Marie / Jorgensen, Christian / Khoury, Maroun

    Frontiers in immunology

    2021  Volume 12, Page(s) 751865

    MeSH term(s) Humans ; Immunomodulation ; Mesenchymal Stem Cells/immunology ; Mesenchymal Stem Cells/metabolism
    Language English
    Publishing date 2021-08-26
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.751865
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  6. Article ; Online: Impact of platelet-derived mitochondria transfer in the metabolic profiling and progression of metastatic MDA-MB-231 human triple-negative breast cancer cells

    Lucas Cereceda / J. Cesar Cardenas / Maroun Khoury / Eduardo Silva-Pavez / Yessia Hidalgo

    Frontiers in Cell and Developmental Biology, Vol

    2024  Volume 11

    Abstract: Introduction: An active role of platelets in the progression of triple-negative breast cancer (TNBC) cells has been described. Even the role of platelet-derived extracellular vesicles on the migration of MDA-MB-231 cells has been reported. Interestingly, ...

    Abstract Introduction: An active role of platelets in the progression of triple-negative breast cancer (TNBC) cells has been described. Even the role of platelet-derived extracellular vesicles on the migration of MDA-MB-231 cells has been reported. Interestingly, upon activation, platelets release functional mitochondria into the extracellular environment. However, the impact of these platelet-derived mitochondria on the metabolic properties of MDA-MB-231 cells remains unclear.Methods: MDA-MB-231 and MDA-MB-231-Rho-0 cells were co-cultured with platelets, which were isolated from donor blood. Mitochondrial transfer was assessed through confocal microscopy and flow cytometry, while metabolic analyses were conducted using a Seahorse XF HS Mini Analyzer. The mito-chondrial DNA (mtDNA) copy number was determined via quantitative PCR (qPCR) following platelet co-culture. Finally, cell proliferation and colony formation assay were performed using crystal violet staining.Results and Discussion: We have shown that platelet-derived mitochondria are internalized by MDA-MB-231 cells in co-culture with platelets, increasing ATP production, oxygen (O2) consumption rate (OCR), cell proliferation, and metabolic adaptability. Additionally, we observed that MDA-MB-231 cells depleted from mtDNA restore cell proliferation in uridine/pyruvate-free cell culture medium and mitochondrial O2 consumption after co-culture with platelets, indicating a reconstitution of mtDNA facilitated by platelet-derived mitochondria. In conclusion, our study provides new insights into the role of platelet-derived mitochondria in the metabolic adaptability and progression of metastatic MDA-MB-231 TNBC cells.
    Keywords platelets ; platelet-derived mitochondria ; cancer ; mitochondria transfer ; metabolic adaptability ; Biology (General) ; QH301-705.5
    Subject code 570 ; 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Public health risk associated with the co-occurrence of aflatoxin B

    Daou, Rouaa / Hoteit, Maha / Bookari, Khlood / Joubrane, Karine / Khabbaz, Lydia Rabbaa / Ismail, Ali / Maroun, Richard G / El Khoury, André

    Frontiers in public health

    2023  Volume 10, Page(s) 1072727

    Abstract: Background: Aflatoxin B: Objectives: In Lebanon, few studies address aflatoxin B: Methods: In this work, a total of 198 samples of spices, herbs, and nuts were collected from different sites. Aflatoxin B: Results: Aflatoxin B: Conclusion: ... ...

    Abstract Background: Aflatoxin B
    Objectives: In Lebanon, few studies address aflatoxin B
    Methods: In this work, a total of 198 samples of spices, herbs, and nuts were collected from different sites. Aflatoxin B
    Results: Aflatoxin B
    Conclusion: The consumption of spices, herbs, and nuts in Lebanon could lead to an increase in health risks associated with aflatoxin B
    MeSH term(s) Aflatoxin B1/analysis ; Aflatoxin B1/toxicity ; Nuts/chemistry ; Public Health ; Lebanon ; Food Contamination/analysis ; Mycotoxins/analysis ; Mycotoxins/toxicity
    Chemical Substances ochratoxin A (1779SX6LUY) ; Aflatoxin B1 (9N2N2Y55MH) ; Mycotoxins
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1072727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Inhibition of Aflatoxin B1 Synthesis in

    Al Khoury, Anthony / El Khoury, André / Rocher, Ophélie / Hindieh, Pamela / Puel, Olivier / Maroun, Richard G / Atoui, Ali / Bailly, Jean-Denis

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: Plant extracts may represent an ecofriendly alternative to chemical fungicides to limit aflatoxin B1 (AFB1) contamination of foods and feeds. Mate ( ...

    Abstract Plant extracts may represent an ecofriendly alternative to chemical fungicides to limit aflatoxin B1 (AFB1) contamination of foods and feeds. Mate (
    Language English
    Publishing date 2022-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238550
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article ; Online: Aflatoxin B

    Daou, Rouaa / Joubrane, Karine / Khabbaz, Lydia Rabbaa / Maroun, Richard G / Ismail, Ali / El Khoury, André

    Food additives & contaminants. Part B, Surveillance

    2021  Volume 14, Issue 3, Page(s) 227–235

    Abstract: ... ...

    Abstract AFB
    MeSH term(s) Aflatoxin B1/analysis ; Food Contamination/analysis ; Ochratoxins/analysis ; Triticum
    Chemical Substances Ochratoxins ; ochratoxin A (1779SX6LUY) ; Aflatoxin B1 (9N2N2Y55MH)
    Language English
    Publishing date 2021-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2447868-4
    ISSN 1939-3229 ; 1939-3210
    ISSN (online) 1939-3229
    ISSN 1939-3210
    DOI 10.1080/19393210.2021.1933203
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    In stock of ZB MED Bonn / Germany

    Z 7795: Show issues

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  10. Article: Oral Administration as a Potential Alternative for the Delivery of Small Extracellular Vesicles.

    Donoso-Meneses, Darío / Figueroa-Valdés, Aliosha I / Khoury, Maroun / Alcayaga-Miranda, Francisca

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: Small extracellular vesicles (sEVs) have burst into biomedicine as a natural therapeutic alternative for different diseases. Considered nanocarriers of biological origin, various studies have demonstrated the feasibility of their systemic administration, ...

    Abstract Small extracellular vesicles (sEVs) have burst into biomedicine as a natural therapeutic alternative for different diseases. Considered nanocarriers of biological origin, various studies have demonstrated the feasibility of their systemic administration, even with repeated doses. However, despite being the preferred route of physicians and patients, little is known about the clinical use of sEVs in oral administration. Different reports show that sEVs can resist the degradative conditions of the gastrointestinal tract after oral administration, accumulating regionally in the intestine, where they are absorbed for systemic biodistribution. Notably, observations demonstrate the efficacy of using sEVs as a nanocarrier system for a therapeutic payload to obtain a desired biological (therapeutic) effect. From another perspective, the information to date indicates that food-derived vesicles (FDVs) could be considered future nutraceutical agents since they contain or even overexpress different nutritional compounds of the foods from which they are derived, with potential effects on human health. In this review, we present and critically analyze the current information on the pharmacokinetics and safety profile of sEVs when administered orally. We also address the molecular and cellular mechanisms that promote intestinal absorption and that command the therapeutic effects that have been observed. Finally, we analyze the potential nutraceutical impact that FDVs would have on human health and how their oral use could be an emerging strategy to balance nutrition in people.
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15030716
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